← Back to Search
Biodegradation Of Iron Oxide Nanocubes: High-resolution In Situ Monitoring.
Lénaic Lartigue, D. Alloyeau, Jelena Kolosnjaj-Tabi, Y. Javed, P. Guardia, A. Riedinger, C. Péchoux, T. Pellegrino, C. Wilhelm, F. Gazeau
Published 2013 · Materials Science, Medicine
Download PDFAnalyze on Scholarcy
The long-term fate of nanomaterials in biological environment represents a critical matter, which determines environmental effects and potential risks for human health. Predicting these risks requires understanding of nanoparticle transformations, persistence, and degradation, some issues somehow ignored so far. Safe by design, inorganic nanostructures are being envisioned for therapy, yet fundamental principles of their processing in biological systems, change in physical properties, and in situ degradability have not been thoroughly assessed. Here we report the longitudinal visualization of iron oxide nanocube transformations inflicted by the intracellular-like environment. Structural degradation of individual nanocubes with two different surface coatings (amphiphilic polymer shell and polyethylene glycol ligand molecules) was monitored at the atomic scale with aberration-corrected high-resolution transmission electron microscopy. Our results suggest that the polymer coating controls surface reactivity and that availability and access of chelating agents to the crystal surface govern the degradation rate. This in situ study of single nanocube degradation was compared to intracellular transformations observed in mice over 14 days after intravenous injection, revealing the role of nanoparticle clustering, intracellular sorting within degradation compartments, and iron transfer and recycling into ferritin storage proteins. Our approach reduces the gap between in situ nanoscale observations in mimicking biological environments and in vivo real tracking of nanoparticle fate.
This paper references
Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia.
Jean-Paul Fortin (2007)
Water-Dispersible Ferrimagnetic Iron Oxide Nanocubes with Extremely High r2 Relaxivity for Highly Sensitive
N. Lee (2012)
Intracellular processing of proteins mediated by biodegradable polyelectrolyte capsules.
Pilar Rivera-Gil (2009)
Comparative structural and chemical studies of ferritin cores with gradual removal of their iron contents.
N. Gálvez (2008)
Surface functionalization of single superparamagnetic iron oxide nanoparticles for targeted magnetic resonance imaging.
E. Amstad (2009)
Different Microtubule Motors Move Early and Late Endocytic Compartments
S. Loubéry (2008)
Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment.
P. Guardia (2012)
Water-dispersible ferrimagnetic iron oxide nanocubes with extremely high r₂ relaxivity for highly sensitive in vivo MRI of tumors.
N. Lee (2012)
A general map of iron metabolism and tissue-specific subnetworks.
V. Hower (2009)
Time evolution of the nanoparticle protein corona.
E. Casals (2010)
A New Superstructure in Gamma-Ferric Oxide
G. W. V. Oosterhout (1958)
Nanomagnetism reveals the intracellular clustering of iron oxide nanoparticles in the organism.
M. Levy (2011)
Hydrophobic Nanocrystals Coated with an Amphiphilic Polymer Shell: A General Route to Water Soluble Nanocrystals
T. Pellegrino (2004)
Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos.
Tian-dong Xia (2011)
Surface defects on plate-shaped silver nanoparticles contribute to its hazard potential in a fish gill cell line and zebrafish embryos.
S. George (2012)
Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia.
K. H. Bae (2012)
Electron nanodiffraction and high-resolution electron microscopy studies of the structure and composition of physiological and pathological ferritin.
C. Quintana (2004)
Following Ostwald ripening in nanoalloys by high-resolution imaging with single-atom chemical sensitivity
D. Alloyeau (2012)
C. Ricolleau (2012)
Direct imaging and chemical analysis of unstained DNA origami performed with a transmission electron microscope.
D. Alloyeau (2011)
Nanomaterials in the environment: from materials to high-throughput screening to organisms.
Courtney R. Thomas (2011)
Quantitative super-resolution imaging uncovers reactivity patterns on single nanocatalysts.
Xiaochun Zhou (2012)
Controlled synthesis of iron oxide nanoparticles over a wide size range.
P. Guardia (2010)
Shape Control of Colloidal Metal Nanocrystals
A. Tao (2008)
Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution.
M. Dobrovolskaia (2008)
"Nanohybrids" based on pH-responsive hydrogels and inorganic nanoparticles for drug delivery and sensor applications.
A. Riedinger (2011)
Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
T. Cedervall (2007)
Ferritins: dynamic management of biological iron and oxygen chemistry.
Xiaofeng S. Liu (2005)
Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.
S. Ohkuma (1978)
Transformations of nanomaterials in the environment.
G. Lowry (2012)
Environmental transformations of silver nanoparticles: impact on stability and toxicity.
C. Levard (2012)
Superparamagnetic iron oxide: pharmacokinetics and toxicity.
R. Weissleder (1989)
Pharmacokinetics of Pegylated Liposomal Doxorubicin
A. Gabizon (2003)
Biodegradation of magnetite dextran nanoparticles in the rat. A histologic and biophysical study.
E. Okon (1994)
Long term in vivo biotransformation of iron oxide nanoparticles.
M. Levy (2011)
High Resolution Imaging A RTIC LE LARTIGUE
C. Ricolleau (2013)
Managing magnetic nanoparticle aggregation and cellular uptake: a precondition for efficient stem-cell differentiation and MRI tracking.
D. Fayol (2013)
Degradability of superparamagnetic nanoparticles in a model of intracellular environment: follow-up of magnetic, structural and chemical properties.
M. Levy (2010)
Cellular Uptake and Trafficking of a Prototypical Magnetic Iron Oxide Label In Vitro
E. Schulze (1995)
A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging
A. Arbab (2005)
The evolution of the protein corona around nanoparticles: a test study.
M. Lundqvist (2011)
Water solubilization of hydrophobic nanocrystals by means of poly(maleic anhydride-alt-1-octadecene)
R. D. Corato (2008)
Iron metabolism and toxicity.
G. Papanikolaou (2005)
High Resolution Imaging A RTIC LE LARTIGUE
C. Ricolleau (2013)
Nanomagnetic sensing of blood plasma protein interactions with iron oxide nanoparticles: impact on macrophage uptake.
Lénaic Lartigue (2012)
Ferritin protein nanocages use ion channels, catalytic sites, and nucleation channels to manage iron/oxygen chemistry.
Elizabeth C. Theil (2011)
Magnetic resonance of nanoparticles in a ferrofluid: evidence of thermofluctuational effects
F. Gazeau (1999)
Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with superparamagnetic iron oxide nanoparticles
D. Kedziorek (2010)
Magnetosome-like ferrimagnetic iron oxide nanocubes for highly sensitive MRI of single cells and transplanted pancreatic islets
N. Lee (2011)
Nanoscale magnetism control via surface and exchange anisotropy for optimized ferrimagnetic hysteresis.
S. H. Noh (2012)
Transmission Electron Microscopy of Shape-Controlled Nanocrystals and Their Assemblies
Z. Wang (2000)
Fatty acid salts as stabilizers in size- and shape-controlled nanocrystal synthesis: the case of inverse spinel iron oxide.
M. Kovalenko (2007)
This paper is referenced by
Preparation and biodistribution of 59Fe-radiolabelled iron oxide nanoparticles
Martina Pospíšilová (2017)
Observing the colloidal stability of iron oxide nanoparticles in situ.
Ryan Hufschmid (2019)
An off-on fluorescence probe targeting mitochondria based on oxidation-reduction response for tumor cell and tissue imaging
Hanchun Yao (2017)
Tailored functionalization of iron oxide nanoparticles for MRI, drug delivery, magnetic separation and immobilization of biosubstances.
K. Holá (2015)
Duality of Iron Oxide Nanoparticles in Cancer Therapy: Amplification of Heating Efficiency by Magnetic Hyperthermia and Photothermal Bimodal Treatment.
A. Espinosa (2016)
Basic Principles of In Vivo Distribution, Toxicity, and Degradation of Prospective Inorganic Nanoparticles for Imaging
Jelena Kolosnjaj-Tabi (2017)
Design strategies for shape‐controlled magnetic iron oxide nanoparticles
A. G. Roca (2019)
Development of a protocol to assess cell internalization and tissue uptake of magnetic nanoparticles by AC Biosusceptometry
Caio C. Quini (2019)
Highly cohesive dual nanoassemblies for complementary multiscale bioimaging.
A. Faucon (2014)
Magnetic Fluid Hyperthermia Based on Magnetic Nanoparticles: Physical Characteristics, Historical Perspective, Clinical Trials, Technological Challenges, and Recent Advances
H. Etemadi (2020)
Scalable High-Affinity Stabilization of Magnetic Iron Oxide Nanostructures by a Biocompatible Antifouling Homopolymer.
G. Luongo (2017)
A Single Picture Explains Diversity of Hyperthermia Response of Magnetic Nanoparticles
Iván Conde-Leborán (2015)
Assembly of Iron Oxide Nanocubes for Enhanced Cancer Hyperthermia and Magnetic Resonance Imaging
Minjung Cho (2017)
Biomolecule and anion adsorption by brucite-like Fe(II) hydroxide nanosheet: Potential of mean force analysis
Alexey A. Tsukanov (2018)
Combinatorial delivery of superparamagnetic iron oxide nanoparticles (γFe2O3) and doxorubicin using folate conjugated redox sensitive multiblock polymeric nanocarriers for enhancing the chemotherapeutic efficacy in cancer cells.
Chetan Nehate (2017)
A general approach to the synthesis and detailed characterization of magnetic ferrite nanocubes.
Yaolin Xu (2015)
Recent advances in functional nanostructures as cancer photothermal therapy
E. A. Hussein (2018)
Functionalized cobalt ferrite cubes: toxicity, interactions and mineralization into ferritin proteins
Kanwal Akhtar (2020)
ROS self-generation and hypoxia self-enhanced biodegradable magnetic nanotheranostics for targeted tumor therapy
Jinghua Li (2020)
Macrophage functionality and homeostasis in response to oligoethyleneglycol-coated IONPs: Impact of a dendritic architecture.
A. Casset (2019)
Applications of Iron Oxide Nanoparticles in the Magnetic Resonance Imaging for the Cancer Diagnosis
Kanwal Akhtar (2021)
Isoniazid@Fe2O3‐Nanocontainer mit antibakterieller Wirkung auf Tuberkulose‐Mykobakterien
P. Leidinger (2015)
Magnetic Vortices as Efficient Nano Heaters in Magnetic Nanoparticle Hyperthermia
N. A. Usov (2017)
Prospects for magnetic nanoparticles in systemic administration: synthesis and quantitative detection.
L. Gutiérrez (2014)
Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies.
K. Ulbrich (2016)
Application of gold nanoparticles for gastrointestinal cancer theranostics: A systematic review.
Mohan Singh (2015)
Functionalization of strongly interacting magnetic nanocubes with (thermo)responsive coating and their application in hyperthermia and heat-triggered drug delivery.
Hamilton Kakwere (2015)
Massive Intracellular Biodegradation of Iron Oxide Nanoparticles Evidenced Magnetically at Single-Endosome and Tissue Levels.
François Mazuel (2016)
Intracellular Fate of Hydrophobic Nanocrystal Self‐Assemblies in Tumor Cells
A. Nicolas-Boluda (2020)
Magnetic Silica-Coated Iron Oxide Nanochains as Photothermal Agents, Disrupting the Extracellular Matrix, and Eradicating Cancer Cells
Jelena Kolosnjaj-Tabi (2019)
Degradation of magnetite nanoparticles in biomimetic media
Sarah Briceño (2017)
Iron oxide-based multifunctional nanoparticulate systems for biomedical applications: a patent review (2008 – present)
M. El-Hammadi (2015)See more