Online citations, reference lists, and bibliographies.
← Back to Search

Impact Of Nanotechnology On Drug Delivery.

O. Farokhzad, R. Langer
Published 2009 · Medicine, Materials Science

Cite This
Download PDF
Analyze on Scholarcy
Share
Nanotechnology is the engineering and manufacturing of materials at the atomic and molecular scale. In its strictest definition from the National Nanotechnology Initiative, nanotechnology refers to structures roughly in the 1-100 nm size regime in at least one dimension. Despite this size restriction, nanotechnology commonly refers to structures that are up to several hundred nanometers in size and that are developed by top-down or bottom-up engineering of individual components. Herein, we focus on the application of nanotechnology to drug delivery and highlight several areas of opportunity where current and emerging nanotechnologies could enable entirely novel classes of therapeutics.
This paper references
10.4161/cbt.3.7.918
Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles
S. Pun (2004)
10.1038/nbt876
Small-scale systems for in vivo drug delivery
David A. LaVan (2003)
10.1016/S0022-2836(65)80093-6
Diffusion of univalent ions across the lamellae of swollen phospholipids.
A. Bangham (1965)
10.1038/nbt872
The 'right' size in nanobiotechnology
G. Whitesides (2003)
10.1038/263797A0
Polymers for the sustained release of proteins and other macromolecules
R. Langer (1976)
10.1016/0014-5793(87)80506-9
Large unilamellar liposomes with low uptake into the reticuloendothelial system
T. Allen (1987)
10.1016/j.biomaterials.2008.09.056
Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery.
Y. Patil (2009)
10.1038/sj.clpt.6100400
Nanoparticles in Medicine: Therapeutic Applications and Developments
L. Zhang (2008)
10.1016/0014-5793(90)81016-H
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
A. Klibanov (1990)
Drug delivery and targeting.
R. Langer (1998)
10.1038/nrc1566
Cancer nanotechnology: opportunities and challenges
M. Ferrari (2005)
10.1117/12.841168
Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery
Travis A. Pecorelli (2010)
10.1517/17425247.3.3.311
Nanoparticle–aptamer bioconjugates for cancer targeting
O. Farokhzad (2006)
10.1073/pnas.0711714105
Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
F. Gu (2008)
10.1073/PNAS.0601755103
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.
O. Farokhzad (2006)
10.1038/nbt1332
Exploiting lymphatic transport and complement activation in nanoparticle vaccines
S. T. Reddy (2007)
10.1021/nn700408z
Hydrogen-bonding layer-by-layer-assembled biodegradable polymeric micelles as drug delivery vehicles from surfaces.
Byeong-Su Kim (2008)
10.1093/JNCI/DJJ070
Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers.
M. Dreher (2006)
10.1016/j.tibtech.2008.06.007
Does a targeting ligand influence nanoparticle tumor localization or uptake?
K. Pirollo (2008)
10.1021/BC700227Z
PLGA nanoparticle--peptide conjugate effectively targets intercellular cell-adhesion molecule-1.
N. Zhang (2008)
10.1126/SCIENCE.7434025
pH-sensitive liposomes: possible clinical implications.
M. Yatvin (1980)
10.1007/s11095-008-9697-x
Intravascular Delivery of Particulate Systems: Does Geometry Really Matter?
P. Decuzzi (2008)
10.1126/SCIENCE.2218494
New methods of drug delivery.
R. Langer (1990)
10.1021/mp800051m
Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
F. Alexis (2008)
10.5040/9781526510136.chapter-011
By the right.
L. Robert (1988)
10.1016/J.ADDR.2012.09.011
Delivery of molecular and cellular medicine to solid tumors.
R. Jain (2012)
10.1126/SCIENCE.8128245
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
Antibody Targeting of Liposomes : Cell Specificity Obtained by Conjugation of F ( ab ' ) 2 to Vesicle Surface
A. Ziegler (2011)
10.1038/nmat2202
Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles.
Ayush Verma (2008)
10.1158/0008-5472.CAN-05-4199
Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models.
D. Kirpotin (2006)
10.1021/nn700198y
Inducible RNA interference-mediated gene silencing using nanostructured gene delivery arrays.
D. G. Mann (2008)
10.1038/nrd1581
Pharmaceutical patent challenges — time for reassessment?
G. Glass (2004)
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
Y. Matsumura (1986)
10.1158/1535-7163.MCT-07-0615
Antitumor activity of an epithelial cell adhesion molecule–targeted nanovesicular drug delivery system
Sajid. Hussain (2007)
10.1073/pnas.0801763105
The effect of particle design on cellular internalization pathways
Stephanie E. A. Gratton (2008)
10.1038/nbt1006-1211
The emerging nanomedicine landscape
Volker Wagner (2006)
10.1038/288602A0
Targeting to cells of fluorescent liposomes covalently coupled with monoclonal antibody or protein A
L. Leserman (1980)



This paper is referenced by
10.3390/PR4040047
The Influence of Viscosity on the Static and Dynamic Properties of PS-PEO Covered Emulsion Drops
Damith P Rozairo (2016)
10.1039/c3nr05400d
Pharmacoinformatic approaches to understand complexation of dendrimeric nanoparticles with drugs.
V. Jain (2014)
10.1039/C4TC01809E
Simultaneous size and color tuning of polymer microparticles in a single-step microfluidic synthesis: particles for fluorescence labeling
Nikunjkumar Visaveliya (2015)
10.1007/978-3-319-22626-2_7
The Future of Glass-ionomers
Joshua James Cheetham (2016)
Transport and retention of silver nanoparticles in granular media filtration
Ijung Kim (2014)
10.1016/j.msec.2014.10.059
Release of quercetin from micellar nanoparticles with saturated and unsaturated core forming polyesters--a combined computational and experimental study.
Salman Hassanzadeh (2015)
10.2147/IJN.S20473
Nanoparticles prepared from the water extract of Gusuibu (Drynaria fortunei J. Sm.) protects osteoblasts against insults and promotes cell maturation
Chung-King Hsu (2011)
10.1007/978-1-4614-9164-4_10
Porous Silicon Nanoparticles
Hélder A. Santos (2013)
10.2478/rnan-2013-0001
Engineered RNA Nanodesigns for Applications in RNA Nanotechnology
Kirill A Afonin (2013)
10.1002/jbm.b.33887
A self-deploying drug release device using polymeric films.
Taro Kondo (2018)
10.1016/j.jtcme.2017.01.001
Characterization of Calcined Jade and its immunomodulatory effect on macrophage isolated from Swiss albino mice
Asif Elahi (2017)
10.4028/www.scientific.net/AMM.130-134.1663
Colon-Targeted Drug Delivery Microparticles Prepared Using Electrohydrodynamic Atomization
D. Yu (2011)
10.1080/1061186X.2018.1523418
Development of nanoparticulate systems with action in breast and ovarian cancer: nanotheragnostics.
Fabiana de Sousa Cunha (2019)
10.1016/j.biomaterials.2015.01.063
Dual-function nanosystem for synergetic cancer chemo-/radiotherapy through ROS-mediated signaling pathways.
Lizhen He (2015)
10.1586/14737140.2015.990889
Synthetic high-density lipoprotein-like nanoparticles for cancer therapy
L. Foit (2015)
10.1016/j.colsurfb.2010.07.047
Preparation and physicochemical characterization of naproxen-PLGA nanoparticles.
Y. Javadzadeh (2010)
10.1016/j.nano.2015.02.020
Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy.
M. Lobatto (2015)
10.1002/ADFM.201301015
Gold Nanocage-Based Dual Responsive "Caged Metal Chelator" Release System: Noninvasive Remote Control with Near Infrared for Potential Treatment of Alzheimer's Disease
Peng Shi (2013)
10.1016/j.apsb.2018.03.008
Nanoparticles with high payloads of pipemidic acid, a poorly soluble crystalline drug: drug-initiated polymerization and self-assembly approach
Elisabetta Pancani (2018)
10.2174/1871520611009010070
Barminomycin, a model for the development of new anthracyclines.
K. Kimura (2010)
Nano Fabricated 3D Extracellular Matrix (ECM) Scaffolds to alter the Cancer Cell Behavior
G. Punchihewa (2012)
10.1039/c5nr01695a
Solvent selection causes remarkable shifts of the "Ouzo region" for poly(lactide-co-glycolide) nanoparticles prepared by nanoprecipitation.
M. Beck-Broichsitter (2015)
10.1002/smll.201804028
Metalloporphyrin Complex-Based Nanosonosensitizers for Deep-Tissue Tumor Theranostics by Noninvasive Sonodynamic Therapy.
A. Ma (2019)
10.1002/chem.201404382
Cathepsin-B induced controlled release from peptide-capped mesoporous silica nanoparticles.
C. de la Torre (2014)
Nanodiamondsasvehiclesfor systemicandlocalizeddrug delivery
R. Lam (2009)
10.1007/s10544-012-9678-z
Modeling and experiments of magneto-nanosensors for diagnostics of radiation exposure and cancer
Dokyoon Kim (2013)
10.1371/journal.pone.0066128
Targeted Drug Delivery Systems Mediated by a Novel Peptide in Breast Cancer Therapy and Imaging
R. Lu (2013)
Fabrication of 3-Dimensional Polymeric Drug Delivery Systems
Y. Chen (2017)
10.1002/smll.201301174
Synthesis and biomedical applications of copper sulfide nanoparticles: from sensors to theranostics.
S. Goel (2014)
10.1038/nrd2591
Strategies in the design of nanoparticles for therapeutic applications
Robby A. Petros (2010)
10.1021/nn303955n
Noninvasive optical imaging of nanomedicine biodistribution.
S. Kunjachan (2013)
10.1021/nn500136z
Vascular Targeting of Nanocarriers: Perplexing Aspects of the Seemingly Straightforward Paradigm
Melissa D. Howard (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar