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Ir(I)-catalyzed Enantioselective Secondary Sp3 C-H Bond Activation Of 2-(alkylamino)pyridines With Alkenes.

S. Pan, K. Endo, T. Shibata
Published 2011 · Chemistry, Medicine

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A cationic Ir(I)-tolBINAP complex catalyzed an enantioselective C-C bond formation initiated by secondary sp(3) C-H bond cleavage adjacent to a nitrogen atom. The reaction of 2-(alkylamino)pyridines with various alkenes gave chiral amines in good yields with high enantiomeric excesses.
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