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C-H Activation Of Methyl Arenes In The MnO2-mediated Aroylation Of N-chlorosulfoximines.

D. Priebbenow, C. Bolm
Published 2014 · Chemistry, Medicine

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An investigation into the reactivity profile of N-halogenated sulfoximines has led to the development of a new method for the synthesis of N-aroylated sulfoximines. This protocol involves the manganese oxide promoted C-H activation of methyl arenes to form an aroyl intermediate which then reacts readily with N-chlorosulfoximines to form a series of valuable aroyl sulfoximine derivatives in high yields.
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