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Water-soluble Rhamnose-coated Fe3O4 Nanoparticles.

Lenaic Lartigue, Khalid Oumzil, Yannick Guari, J. Larionova, C. Guérin, Jean-Louis Montero, V. Barragan-Montero, C. Sangregorio, A. Caneschi, C. Innocenti, T. Kalaivani, P. Arosio, A. Lascialfari
Published 2009 · Chemistry, Medicine

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Water-soluble biocompatible rhamnose-coated Fe(3)O(4) nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.



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