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Treatment And Outcome Of Brain Metastasis As First Site Of Distant Metastasis From Breast Cancer

W. Boogerd, A. Hart, I. Tjahja
Published 2004 · Medicine

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Twenty-eight consecutive patients with breast cancer were analyzedwho presented with a single brain metastasis asfirst site of distant metastasis. The response tosurgery with postoperative radiation therapy (RT) (9 patients)and to non-surgical therapy as first-line treatment was100% and 89% respectively with a significant differencein median recurrence-free intervals of 23 months andof 5 months respectively (p=0.033). Retreatmentof a local relapse by surgery (± RT,± chemotherapy) or by non-surgical treatment resulted ina response in 6 of the 7 operatedpatients and in 5 of the 6 non-operatedpatients with a median duration of response of7 months (range 2–20 months) and of 3months (range 2–4 months) respectively. The overall mediansurvival of the 28 patients with a singlebrain metastasis was 16 months (range 2–39 months).The median survival in the primarily operated patientswas 23 months, in the primarily not-operated group10 months, and in the never-operated group 9months. In comparison, the response to non-surgical treatmentin 20 consecutive patients who presented with multiplebrain metastases as first site of distant metastasiswas 55% with a median recurrence free intervalof 4 months. The median survival in thisgroup was 4 months, which was significantly shorterthan survival of patients with single brain metastasis(p=0.0036). These results suggest that breastcancer patients with a single brain metastasis asfirst presentation of relapse constitute a specific subgroupwith a favorable response to treatment and along survival especially if they can be treatedby surgery with postoperative RT.
This paper references
Brain metastases in breast
Paterson AHG
patients receiving adjuvant chemotherapy
W Boogerd (1982)
10.1016/0360-3016(80)90195-9
The palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group.
B. Borgelt (1980)
10.1007/BF00163539
Characteristics of patients with short and long survivals after detection of intracranial metastases from breast cancer
C. Kamby (2004)
10.3171/JNS.1996.84.5.0748
Surgery versus radiosurgery in the treatment of brain metastasis.
A. K. Bindal (1996)
10.1002/ANA.410330605
Treatment of single brain metastasis: Radiotherapy alone or combined with neurosurgery
Charles J. Vecht (1993)
10.1002/1097-0142(197911)44:5<1913::AID-CNCR2820440554>3.0.CO;2-D
The natural history of breast cancer patients with brain metastases
A. Distefano (1979)
10.3171/JNS.1993.79.2.0210
Surgical treatment of multiple brain metastases.
R. Bindal (1993)
10.2482/HAIGAN.38.205
Patients with Brain Metastases after Lung Cancer Surgery.
T. Bessho (1998)
10.1055/b-0034-97860
Systemic chemotherapy.
V. Klimek (2000)
10.1016/0014-2964(81)90254-1
Oestrogen receptors, sites of metastatic disease and survival in recurrent breast cancer.
J. Stewart (1981)
10.3171/JNS.1995.83.4.0600
Reoperation for recurrent metastatic brain tumors.
R. Bindal (1995)
10.1002/1097-0142(19810715)48:2<384::AID-CNCR2820480227>3.0.CO;2-8
Intracerebral metastases in solid‐tumor patients: Natural history and results of treatment
S. Zimm (1981)
10.1007/BF00050693
Patterns of metastasis and natural courses of breast carcinoma
Yeu-Tsu Margaret Lee (2004)
An autopsy study of metastatic sites of breast cancer.
E. Viadana (1973)
10.1002/1097-0142(19820215)49:4<651::AID-CNCR2820490408>3.0.CO;2-X
Brain metastases in breast cancer patients receiving adjuvant chemotherapy
A. Paterson (1982)
10.1007/BF01053937
Brain metastases in breast cancer; natural history, prognostic factors and outcome
W. Boogerd (2005)
10.1016/0360-3016(83)90226-2
The influence of surgery and radiation therapy on patients with brain metastases.
F. Hendrickson (1983)
10.1002/1097-0142(19920215)69:4<972::AID-CNCR2820690423>3.0.CO;2-P
Response of brain metastases from breast cancer to systemic chemotherapy
W. Boogerd (1992)
10.1056/NEJM199002223220802
A randomized trial of surgery in the treatment of single metastases to the brain.
R. Patchell (1990)
The natural history of breast
A DiStefano
Brain metastases from solid extracranial tumors
RP Moser (1993)



This paper is referenced by
10.1007/s12282-010-0207-8
Radiation therapy for brain metastases in breast cancer patients
H. Aoyama (2011)
10.1159/000067443
Chemotherapy for Breast Cancer Brain Metastases
M. Fenner (2002)
10.1023/A:1006490200335
Fractionated Radiosurgery for Brain Metastases in 43 Patients with Breast Carcinoma
G. Lederman (2004)
10.1038/bjc.2012.440
Brain-only metastatic breast cancer is a distinct clinical entity characterised by favourable median overall survival time and a high rate of long-term survivors
A. Berghoff (2012)
10.1016/j.ijrobp.2007.11.052
Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome: in regard to Evans et al. (Int J Radiat Oncol Biol Phys 2007;69:1024-1031).
J. Bussink (2008)
10.1016/J.IJROBP.2007.07.2361
In Reply to Dr. Dizdar et al.
R. Scodan (2008)
10.1007/978-1-59259-317-0_21
Neuro-Oncologic Complications of Breast Cancer
W. Boogerd (2003)
10.1007/PL00003282
Stereotactic irradiation of brain metastases
H. Pape (2016)
10.1007/s12282-011-0276-3
Improvement of survival and prospect of cure in patients with metastatic breast cancer
Y. Cheng (2011)
10.1093/neuonc/nos113
Challenging the current paradigm of melanoma progression: brain metastasis as isolated first visceral site.
M. Ma (2012)
10.1016/J.HOC.2007.03.009
Brain metastases: old problem, new strategies.
T. Nguyen (2007)
10.2325/JBCS.12.221
Two cases with long-term disease-free survival after resection and radiotherapy for solitary brain metastasis from breast cancer with extensive nodal metastases
S. Saisho (2005)
10.1007/s11060-016-2075-3
Brain metastasis in breast cancer: a comprehensive literature review
R. Rostami (2016)
10.2147/BCTT.S71781
BP-C1 in the treatment of patients with stage IV breast cancer: a randomized, double-blind, placebo-controlled multicenter study and an additional open-label treatment phase
S. Larsén (2014)
10.1200/JCO.2015.33.15_SUPPL.E12086
BP-C1 in treatment of patients with stage IV breast cancer: A randomized, double-blind, placebo-controlled multicenter study and additional open-label treatment phase.
S. Larsén (2015)
Breast Cancer: Targets and Therapy Dovepress
()
10.1177/030089160709300207
Late Brain Metastases from Breast Cancer: Clinical Remarks on 11 Patients and Review of the Literature
M. Piccirilli (2007)
10.1007/s00280-010-1242-z
Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors
R. J. Morgan (2010)
10.1016/J.RADONC.2005.06.004
Lymphopenia: a new independent prognostic factor for survival in patients treated with whole brain radiotherapy for brain metastases from breast carcinoma.
L. Claude (2005)
10.1007/978-1-59745-412-4_22
Neurologic Complications of Breast Cancer
W. Boogerd (2008)
10.1634/THEONCOLOGIST.8-3-241
A role for curative surgery in the treatment of selected patients with metastatic breast cancer.
S. Singletary (2003)
10.1111/j.1743-7563.2008.00192.x
Optimizing the management of advanced breast cancer in the Asia–Pacific region: Role of clinical trials and treatment guidelines
Shin-Cheh Chen (2008)
10.1007/s00066-004-1299-x
Treatment of Cerebral Metastases from Breast Cancer with Stereotactic Radiosurgery
S. Combs (2004)
10.1177/030089160909500610
Brain Metastases Secondary to Breast Cancer: Symptoms, Prognosis and Evolution
D. Oltean (2009)
10.1700/1217.13502
Brain metastases in breast cancer: analysis of the role of HER2 status and treatment in the outcome of 94 patients.
E. Fokas (2012)
10.1007/s11060-004-8093-6
Brain metastases: epidemiology and pathophysiology
I. Gavrilovic (2004)
10.1177/030089161209800615
Brain Metastases in Breast Cancer: Analysis of the Role of HER2 Status and Treatment in the Outcome of 94 Patients
E. Fokas (2012)
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