Online citations, reference lists, and bibliographies.
← Back to Search

Supercritical Fluid Processing Of Materials From Aqueous Solutions: The Application Of SEDS To Lactose As A Model Substance

S. Palakodaty, P. York, J. Pritchard
Published 2004 · Medicine, Chemistry

Cite This
Download PDF
Analyze on Scholarcy
AbstractPurpose. The objective of the work was to study the factors influencing the crystallisation of α-lactose monohydrate from aqueous solution using the Solution Enhanced Dispersion by Supercritical Fluids (SEDS) technique. Methods. An aqueous solution of α-lactose monohydrate is dispersed with a homogeneous mixture of carbon dioxide-ethanol/methanol using a co-axial nozzle. Crystallised lactose particles were analysed for water content by Karl-Fisher analysis, anomeric composition by Differential Scanning Calorimetry (DSC) and characterised for crystallinity by powder X-ray diffraction and morphology by scanning electron microscopy. Results. Water content in the lactose recrystallised with ethanol was higher compared to the product obtained with methanol as cosolvent. Rate of crystallisation could be altered by varying the CO2 flow thereby modifying the water content in the lactose. At low flow rates of CO2, the crystallisation occurred in a cosolvent rich antisolvent phase causing rapid crystallisation whereas high flow rates of CO2 favoured a much slower crystallisation mechanism in the water rich phase. As a consequence, the morphology changed from thin long bands to large agglomerated chunks with mean particle size between 5 and 31 microns. Conclusions. The SEDS process is an efficient method for forming micron sized particles of water-soluble compounds with controlled physico-chemical properties.
This paper references
Some Physico-Chemical Properties of Lactose: I. The Spontaneous Crystallization of Supersaturated Solutions of Lactose
B. L. Herrington (1934)
Mass-Transfer Operations
R. E. Treybal (1955)
Formation of microporous polymer fibers and oriented fibrils by precipitation with a compressed fluid antisolvent
D. Dixon (1993)
Determination of the volumetric gas-liquid mass transfer coefficients at pressures up to 5 MPa
M. Bichari (1996)
The Binary System Carbon Dioxide-Water under Pressure.
R. Wiebe (1941)
Isothermal liquid-vapor equilibriums for system methanol-water
M. L. McGlashan (1976)
Gas-liquid equilibrium for ethanol-water-carbon dioxide mixtures at elevated pressures
M. L. Gilbert (1986)
Phase equilibria for carbon dioxide-ethanol-water system at elevated pressures
J. Lim (1994)
The binary system H 2 O-CO 2 at high temperatures and pressures
S. Takenouchi (1964)
Thermodynamic properties of aqueous non-electrolyte mixtures II. Vapour pressures and excess Gibbs energies for water + ethanol at 303.15 to 363.15 K determined by an accurate static method
R. Pemberton (1978)
Formation of microparticulate protein powder using a supercritical fluid antisolvent
S. Yeo (1993)
Solubilities of carbon dioxide in methanol and methanol-water at high pressures: experimental data and modeling
T. Chang (1985)
A New Two-Constant Equation of State
D. Peng (1976)

This paper is referenced by
The nanoscale characterization and interparticulate interactions of pharmaceutical materials
Jennifer C. Hooton (2003)
Micronization of water-soluble or alcohol-soluble pharmaceuticals and model compounds with a low-temperature Bubble Dryer®
R. Sievers (2003)
CO2 and Fluorinated Solvent‐Based Technologies for Protein Microparticle Precipitation from Aqueous Solutions
M. Sarkari (2003)
Organische Nanopartikel in wässriger Phase – Theorie, Experiment und Anwendung
Dieter Dr. Horn (2001)
Preparation and characterization of solid dispersions of itraconazole by using aerosol solvent extraction system for improvement in drug solubility and bioavailability
S. Lee (2005)
Systematic investigations of calcium phosphates produced by wet chemistry method and supercritical processing techniques
A. Salimi (2013)
Control of Physical Forms of Drug Particles for Pulmonary Delivery by Spray Drying and Supercritical Fluid Processing
H. H. Tong (2006)
Enhanced drug dissolution using evaporative precipitation into aqueous solution.
Marazban Sarkari (2002)
Optimisation of powders for pulmonary delivery using supercritical fluid technology.
Mahboob Rehman (2004)
Phase equilibria for the CO2 + methanol + sulfathiazole system at high pressure
A. Kordikowski (2002)
Particle Formation Using Supercritical Carbon Dioxide
L. Ginneken (2003)
Polymorph Control of Sulfathiazole in Supercritical CO2
A. Kordikowski (2004)
Cefuroxime axetil solid dispersions prepared using solution enhanced dispersion by supercritical fluids
S. W. Jun (2005)
Are pharmaceutics really going supercritical?
I. Pasquali (2008)
Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects
H. M. Mansour (2010)
Pharmaceutical and Biological Materials Processing with Supercritical Fluids
P. York (2002)
Multilayer PVA adsorption onto hydrophobic drug substrates to engineer drug-rich microparticles.
F. Buttini (2008)
Supercritical fluid technology: a promising approach in pharmaceutical research
Priti Girotra (2013)
Particle Engineering for Improved Pulmonary Drug Delivery Through Dry Powder Inhalers
Waseem Kaialy (2015)
Preparation of pharmaceutical powders using supercritical fluid technology : pharmaceutical applications and physicochemical characterisation of powders
S. Velaga (2004)
Dry Powders for Pulmonary Delivery of Peptides and Proteins
H. Okamoto (2002)
Preparation of budesonide and budesonide-PLA microparticles using supercritical fluid precipitation technology
T. Martin (2008)
Engineering of particles for inhalation
Chonladda Pitchayajittipong (2009)
Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique.
T. Okuda (2013)
Supercritical fluid processing of proteins: lysozyme precipitation from aqueous solution
S. Moshashaée (2003)
Dry powders of stable protein formulations from aqueous solutions prepared using supercritical CO(2)-assisted aerosolization.
S. Sellers (2001)
Preparation of water soluble drugs-loaded microparticles using modified solution enhanced dispersion by supercritical CO2
Yanzhi Zhang (2012)
Back to basics: the development of a simple, homogenous, two-component dry-powder inhaler formulation for the delivery of budesonide using miscible vinyl polymers.
F. Buttini (2008)
Precipitation and Characterization of Chelerythrine Microparticles by the Supercritical Antisolvent Process
H. Hong (2008)
Micronization of Polyethylene Wax in an Extrusion Process using Supercritical Carbon Dioxide
Nowrin Raihan Abedin (2011)
Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds
R. K. Kankala (2018)
Particle formation by rapid expansion of supercritical solutions
Chandra Vemavarapu (2002)
See more
Semantic Scholar Logo Some data provided by SemanticScholar