Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Enhancement Of Nasal Salmon Calcitonin Absorption By Lauroylcarnitine Chloride In Rats

S. Kagatani, Tatsuki Shinoda, M. Fukui, Tadayoshi Ohmura, S. Hasumi, T. Sonobe
Published 2004 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
AbstractPurpose. We investigated optimum formulation characteristics in the nasal absorption of salmon calcitonin (sCT) by incorporation of acylcarnitines. Methods. Nasal sCT formulations were administered to anesthetized rats. Plasma calcium level was measured and pharmacological bioavailability (P.bioav) was calculated. Results. Nasal sCT absorption was significantly enhanced by carnitines with acyl groups of 12 or more carbon atoms. Enhancement by lauroylcarnitine chloride (LCC) was observed at its critical micelle concentration and reached a plateau at the concentration of 0.1%. Optimal absorption was achieved at a molar ratio of LCC to sCT of 5:1. Enhancement was not influenced by osmolarity and maximum enhancement was obtained at pHs 3.1 and 4.0. Conclusions. The 12-carbon LCC was the strongest enhancer among acylcarnitines. Micelle formation played a key role in this enhancement effect.
This paper references
10.1023/A:1015838508656
Relationship Between Drug Absorption Enhancing Activity and Membrane Perturbing Effects of Acylcarnitines
E. Lecluyse (2004)
10.1002/JPS.2600590616
Potentiometric titration of monomeric and micellar acylcarnitines.
S. Yalkowsky (1970)
10.1021/JM00053A024
Hemicholinium and related lipids: inhibitors of protein kinase C.
G. Kumaravel (1993)
10.1073/PNAS.82.21.7419
Nasal absorption of insulin: enhancement by hydrophobic bile salts.
G. Gordon (1985)
10.1016/0378-5173(94)00158-2
Effects of proteolytic enzyme inhibitors on nasal absorption of salmon calcitonin in rats
K. Morimoto (1995)
10.1007/BF00558516
Nasal administration of glucagon and human calcitonin to healthy subjects: a comparison of powders and spray solutions and of different enhancing agents
A. Pontiroli (2004)
10.1016/0002-8703(79)90440-X
Role of carnitine in fatty acid metabolism of normal and ischemic myocardium.
L. Opie (1979)
In vitro effects of long-chain acylcarnitines on the permeability, transepithelial electrical resistance and morphology of rat colonic mucosa.
E. Lecluyse (1993)
10.1152/AJPGI.1986.251.3.G332
Acylcarnitines: drug absorption-enhancing agents in the gastrointestinal tract.
J. Fix (1986)
10.1002/JPS.2600760502
Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep.
J. Longenecker (1987)
10.1016/0378-5173(81)90009-0
Effect of surfactants on the nasal absorption of insulin in rats
Hirai Shinichiro (1981)
10.1016/0378-5173(89)90057-4
Vaginal administration of gentamicin to rats. Pharmaceutical and morphological studies using absorption enhancers
J. Richardson (1989)
10.1023/A:1018992716621
The Bioavailability of Intranasal Salmon Calcitonin in Healthy Volunteers with and Without a Permeation Enhancer
W. Lee (2004)
In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine.
J. Hochman (1994)



This paper is referenced by
10.1016/S0378-5173(03)00039-5
Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats.
C. Dufès (2003)
10.1016/S0378-5173(98)00132-X
Nasal absorption kinetics of human growth hormone enhanced by acylcarnitines in rats
S. Kagatani (1998)
10.1080/02652040010000334
Characterization of calcitonin-containing liposome formulations for intranasal delivery
S. L. Law, C. L. Shih (2001)
10.1080/02652040010000334
Characterization of calcitonin-containing liposome formulations for intranasal delivery.
S. Law (2001)
10.1023/A:1013330815253
Enhanced Bioavailability of Calcitonin Formulated with Alkylglycosides Following Nasal and Ocular Administration in Rats
F. Ahsan (2004)
Absorption Enhancing Excipients in Systemic Nasal Drug Delivery
E. Maggio (2014)
10.3109/10611869808997878
Efficacy, safety and mechanism of cyclodextrins as absorption enhancers in nasal delivery of peptide and protein drugs.
E. Marttin (1998)
10.1002/jgm.749
The use of absorption enhancers to enhance the dispersibility of spray‐dried powders for pulmonary gene therapy
H-Y Li (2005)
10.2165/00003088-200342130-00003
Absorption Enhancers for Nasal Drug Delivery
S. Davis (2003)
10.1016/S0378-5173(03)00090-5
Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: comparison with hydroxypropyl- and dimethyl-beta-cyclodextrins.
Prapasri Sinswat (2003)
10.1016/J.IJPHARM.2007.01.027
Absorption enhancement of poorly absorbed hydrophilic compounds from various mucosal sites by combination of mucolytic agent and non-ionic surfactant.
Shinya Takatsuka (2007)
10.3109/03639040903059342
Noninvasive delivery systems for peptides and proteins in osteoporosis therapy: a retroperspective
H. Hoyer (2010)
Absorption enhancing excipients in systemic nasal drug delivery.
Aegis Therapeutics Llc (2014)
10.1023/A:1011952804479
Nasal Absorption Kinetic Behavior of Azetirelin and Its Enhancement by Acylcarnitines in Rats
S. Kagatani (2004)
10.1211/0022357056073
Effect of chitosan on the intranasal absorption of salmon calcitonin in sheep
M. Hinchcliffe (2005)
10.1016/S0378-5173(02)00597-5
Sucrose cocoate, a component of cosmetic preparations, enhances nasal and ocular peptide absorption.
F. Ahsan (2003)
Semantic Scholar Logo Some data provided by SemanticScholar