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Recent Advances In Vaccine Adjuvants
M. Singh, D. O'hagan
Published 2004 · Medicine
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New generation vaccines, particularly those based on recombinant proteins and DNA, are likely to be less reactogenic than traditional vaccines but are also less immunogenic. Therefore, there is an urgent need for the development of new and improved vaccine adjuvants. Adjuvants can be broadly separated into two classes based on their principal mechanisms of action: vaccine delivery systems and immunostimulatory adjuvants. Vaccine-delivery systems generally are particulate (e.g., emulsions, microparticles, iscoms, and liposomes)and function mainly to target associated antigens into antigen-resenting cells. In contrast, immunostimulatory adjuvants are derived predominantly from pathogens and often represent pathogen-ssociated molecular patterns (e.g., lipopolysaccaride, monophosphoryl lipid A, CpG DNA), which activate cells of the innate immune system. Recent progress in innate immunity is beginning to yield insight into the initiation of immune responses and the ways in which immunostimulatory adjuvants may enhance this process. The discovery of more potent adjuvants may allow the development of prophylactic and therapeutic vaccines against cancers and chronic infectious diseases. In addition, new adjuvants may also allow vaccines to be delivered mucosally.
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Archaeosomes as Self-adjuvanting Delivery Systems for Cancer Vaccines*
L. Krishnan (2003)
Augmentation of Cell-Mediated Immunity to Virus
E. Woodahl (2004)
Adjuvant effect of green propolis on humoral immune response of bovines immunized with bovine herpesvirus type 5.
G. Fischer (2007)
New adjuvants: EU regulatory developments
D. Sesardic (2007)
Bioinformatics for immunomics
D. Flower (2010)
Activation of invariant Natural Killer T lymphocytes in response to the α-galactosylceramide analogue KRN7000 encapsulated in PLGA-based nanoparticles and microparticles.
Elodie Macho Fernandez (2012)
Interleukin-6 has differential influence on the ability of adjuvant formulations to potentiate antibody responses to a Plasmodium falciparum blood-stage vaccine.
G. Hui (2007)
Cell-Penetrating Peptide Penetratin as a Potential Tool for Developing Effective Nasal Vaccination Systems.
Keiya Muto (2016)
Size effect of amphiphilic poly(γ-glutamic acid) nanoparticles on cellular uptake and maturation of dendritic cells in vivo.
F. Shima (2013)
Vaccination de volontaires sains avec le vaccin contre la fièvre jaune afin de caractériser la réponse immunitaire protectrice
R. Therrien (2008)
[Development of vaccine adjuvants using polymeric nanoparticles and their potential applications for anti-HIV vaccine].
T. Akagi (2007)
Engineering vaccines and niches for immune modulation.
Alberto Purwada (2014)
Der Malaria-Impfstoffkandidat GMZ2 : Beurteilung der Sicherheit und der humoralen Immunantwort im Rahmen einer Phase-Ib-Studie in Gabun
Carolin Eva Treut (2015)
Adjuvants in malaria vaccine development strategies: a review
Josiah Ogise (2016)
Selection of Adjuvants for Enhanced Vaccine Potency
W. Wang (2011)
The immunogenicity-enhancing effect of emulsion vaccine adjuvants is independent of the dispersion type and antigen release rate--a revisit of the role of the hydrophile-lipophile balance (HLB) value.
Y. Yang (2005)
Analysis of Quil A-phospholipid mixtures using drift spectroscopy.
P. Demana (2007)
UNIVERSIDADE FEDERAL DE PELOTAS Programa de Pós-Graduação em Biotecnologia Agrícola
G. Fischer (2007)
Enhancement of immunoprotective effect of CpG-ODN by formulation with polyphosphazenes against E. coli septicemia in neonatal chickens.
A. Taghavi (2009)
Nanoparticle Delivery Systems in Cancer Vaccines
Yogita Krishnamachari (2010)
Immunogenicity and protective efficacy of the recombinant Pasteurella lipoprotein E and outer membrane protein H from Pasteurella multocida A:3 in mice.
S. Okay (2012)
Immunostimulatory effects and delivery of oligodeoxynucleotides containing CpG motifs (CpG-ODN) in neonatal broiler chickens
Azita Joze Taghavi Shirazi (2007)
Antimicrobial peptides as mucosal adjuvants.
Lindsey C Pingel (2007)
A rapid, three-step process for the preformulation of a recombinant ricin toxin A-chain vaccine.
Laura J. Peek (2007)
Immunomodulation produced by a green propolis extract on humoral and cellular responses of mice immunized with SuHV-1.
G. Fischer (2007)
USE OF BIODEGRADABLE MICRO AND NANO-PARTICLES IN VACCINE DELIVERY
Mukty Sinha (2011)
Comparative Analysis of the Molecular Adjuvants and Their Binding Efficiency with CR1
B. Saranya (2015)
S. Mallapragada (2008)
Development of a high-throughput screening platform to study the adsorption of antigens onto aluminum-containing adjuvants.
Vanessa Jully (2015)See more