Online citations, reference lists, and bibliographies.
← Back to Search

Enzymatic Degradation Of Dynasan 114 SLN – Effect Of Surfactants And Particle Size

C. Olbrich, O. Kayser, R. Mueller
Published 2002 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
The degradation velocity of solid lipid nanoparticles (SLN) is – apart from drug diffusion – an important parameter determining drug release in vivo. To assess the effect of stabilizers systematically, Dynasan 114 SLN were produced with ionic surfactants (e.g. cholic acid sodium salt (NaCh), sodium dodecyl sulfate (SDS), cetylpyridiniumchloride (CPC)) and steric stabilizers (Tween 80, Poloxamer 188, 407 and Poloxamine 908) including a mixture of cholic acid sodium salt and Poloxamer 407. In addition, the size effects were investigated. The degradation velocity was measured using an in vitro lipase assay. SLN stabilized with lecithin and NaCh showed the fastest, Tween 80 the intermediate and the high molecular weight Poloxamer 407 the slowest degradation. Size effects were less pronounced for fast degrading particles (e.g. those stabilized with NaCh). No difference in the size range of 180–300-nm was observed, but a distinctly slower degradation of 800-nm SLN could be detected. For slowly degrading particles, more pronounced size effects were found. Size effects are more difficult to assess when the PCS diameters are similar, but small fractions of micrometer particles are present, besides the nanometer bulk population. The measured FFA formation is then a superposition of particles degrading at different speeds due to differences in the shape of the size distribution. Admixing of Poloxamer to NaCh had no delaying effect on the degradation of the Dynasan 114 SLN, indicating an influence of the nature of the lipid matrix that is affecting the stabilizers affinity to and anchoring onto the SLN surface.
This paper references
10.1016/S0939-6411(97)00150-1
Solid lipid nanoparticles (SLN) for controlled drug delivery--drug release and release mechanism.
A. Zur Mühlen (1998)
10.1016/0378-5173(95)04286-5
Crystallization tendency and polymorphic transitions in triglyceride nanoparticles
H. Bunjes (1996)
10.1016/S0304-4165(99)00157-9
Re-establishing the long circulatory behaviour of poloxamine-coated particles after repeated intravenous administration: applications in cancer drug delivery and imaging.
S. Moghimi (1999)
10.1016/0927-7765(95)01238-9
Adsorption from lipase-surfactant solutions onto methylated silica surfaces
K. Wannerberger (1996)
10.1016/S0378-5173(02)00035-2
Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)--effect of surfactants, storage time and crystallinity.
C. Olbrich (2002)
10.1002/ELPS.11501401214
Colloidal carriers for intravenous drug targeting: Plasma protein adsorption patterns on surface‐modified latex particles evaluated by two‐dimensional polyacrylamide gel electrophoresis
T. Blunk (1993)
10.1016/S0378-5173(01)00660-3
Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages.
N. Schöler (2001)
10.1016/S0001-8686(00)00046-4
Interactions between a lipase and charged surfactants--a comparison between bulk and interfaces.
K. Holmberg (2000)
Solid lipid nanoparticles (SLN) : an alternative colloidal carrier system for controlled drug delivery
R. Mueller (1995)
10.1038/343771A0
Structure of human pancreatic lipase
F. Winkler (1990)
10.1016/S0168-3659(99)00223-0
Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties.
V. Jenning (2000)
10.1016/S0939-6411(00)00087-4
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
R. Mueller (2000)
10.1016/0142-9612(95)93258-F
Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence.
I. Grizzi (1995)
10.1073/PNAS.97.2.811
Cationic microparticles: A potent delivery system for DNA vaccines.
M. Singh (2000)
10.1016/S0168-3659(00)00226-1
Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1.
J. Kazzaz (2000)
10.1016/S0378-5173(98)00404-9
Enzymatic degradation of SLN-effect of surfactant and surfactant mixtures.
C. Olbrich (1999)



This paper is referenced by
10.1016/J.COCIS.2009.11.006
The influence of emulsion structure and stability on lipid digestion
M. Golding (2010)
A DESCRIPTIVE REVIEW ON VARIOUS LIPIDS AND TECHNIQUES USED IN FORMULATION OF SOLID LIPID NANOPARTICLES
Sukhwinder Singh (2016)
Nanopartículas lipídicas sólidas Solid lipid nanoparticles
M. Luisa (2008)
Formulation, gastrointestinal transit studies and absorption of amphotericin B-containing solid lipid nanoparticles in rats
Hilda Amekyeh (2016)
10.1002/med.20201
Nanoparticulate devices for brain drug delivery
C. Celia (2011)
10.1080/02786826.2011.648287
Aerosol Synthesis of Lipid Nanoparticles: Relating Crystallinity to Simulated Evaporation Rates
Manish Shetty (2012)
10.1007/s11051-012-1113-0
In vitro digestion of curcuminoid-loaded lipid nanoparticles
A. Noack (2012)
10.1049/iet-nbt.2009.0004
Effects of poly (lactic-co-glycolic acid) as a co-emulsifier on the preparation and hypoglycaemic activity of insulin-loaded solid lipid nanoparticles.
S. Wang (2009)
10.1016/j.ejpb.2014.06.011
Design and evaluation of solid lipid nanoparticles modified with peptide ligand for oral delivery of protein drugs.
T. Fan (2014)
Development of lipid based depot formulations using interferon-beta-1b as a model protein
Christian Neuhofer (2015)
10.1039/c1fo10193e
Potential biological fate of ingested nanoemulsions: influence of particle characteristics.
D. J. Mcclements (2012)
Lipid Nanoparticles at the Current Stage and Prospects – A Review
Christo Tzachev (2013)
10.1201/9781420006636.CH36
Solid Lipid Nanoparticles for Anti-Tumor Drug Delivery
H. L. Wong (2006)
10.1021/jf800159e
Influence of lipid physical state on the in vitro digestibility of emulsified lipids.
Lucile Bonnaire (2008)
10.3929/ETHZ-A-004907963
Poly(propylene sulfide) nanoparticles as drug carriers
A. Rehor (2005)
10.1533/9781845696603.3.502
Controlling lipid bioavailability using emulsion-based delivery systems.
D. J. Mcclements (2009)
FORMULATION AND EVALUATION OF SILIBININ LOADED SOLID LIPID NANOPARTICLES FOR PERORAL USE TARGETING LOWER PART OF GASTROINTESTINAL TRACT
A. A. Sadiq (2014)
10.1039/c4fo00965g
Functional food microstructures for macronutrient release and delivery.
J. Norton (2015)
10.1016/j.jconrel.2017.04.032
Drug release studies from lipid nanoparticles in physiological media by a new DSC method
Elin Roese (2017)
10.1007/978-3-030-34544-0_13
Solid Lipid Nanoparticles
A. Jain (2020)
10.1039/c0fo00111b
Review of in vitro digestion models for rapid screening of emulsion-based systems.
D. J. Mcclements (2010)
10.1080/10408390701764245
Controlling Lipid Bioavailability through Physicochemical and Structural Approaches
D. J. Mcclements (2009)
10.1016/j.ijpharm.2012.03.030
Influence of precursor solvent properties on matrix crystallinity and drug release rates from nanoparticle aerosol lipid matrices.
A. A. Pawar (2012)
10.1016/j.jcis.2017.06.022
Single-component solid lipid nanocarriers prepared with ultra-long chain amphiphilic lipids.
W. Wei (2017)
10.1002/9783527610419.NTLS0257
Solid Lipid Nanoparticles to Improve Brain Drug Delivery
P. Blasi (2012)
The Effect of Tripalmitin Crystallinity on Emulsion Lipid In Vitro Digestion
Sally Huynh (2014)
10.1002/9781118444726.CH4
Solid Lipid Nanoparticles for Drug Delivery
S. Joseph (2013)
10.1016/j.colsurfb.2010.12.014
Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: influences of fatty acids.
Shuyu Xie (2011)
10.3390/molecules23061472
Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease
Aubrie O’Rourke (2018)
10.1016/j.colsurfb.2008.08.018
Effect of PLGA as a polymeric emulsifier on preparation of hydrophilic protein-loaded solid lipid nanoparticles.
Shuyu Xie (2008)
10.1002/jps.24044
Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram.
G. Leyva-Gómez (2014)
10.1002/CHIN.201327225
Solid lipid Nanoparticles for Oral delivery of Poorly Soluble Drugs
G. Reddy (2010)
See more
Semantic Scholar Logo Some data provided by SemanticScholar