Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Exhaled Nitric Oxide, Serum ECP And Airway Responsiveness In Mild Asthmatic Children.

G. Piacentini, A. Bodini, S. Costella, Y. Suzuki, L. Zerman, C. Peterson, A. Boner
Published 2000 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The purpose of the present study was to assess the possible relationships between exhaled nitric oxide (ENO), a circulating marker of eosinophil activation, serum eosinophil cationic protein (SECP), level of airway responsiveness to methacholine and lung function in asthmatic children, as well as to compare these markers between children with and without inhaled steroid therapy. In a cross-sectional study ENO, SECP and bronchial hyperresponsiveness to methacholine were evaluated in a group of 57 asthmatic children (21 without and 36 with regulator inhaled steroid therapy; aged 6-13 yrs). ENO was significantly lower in steroid treated children (p<0.01). No significant differences between steroid treated and untreated children were observed for the provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second (FEV1; PC20), SECP and FEV1. In the whole study population significant increase correlations were observed between PC20 and SECP (r=-0.329, p=0.013) and between ENO and FEV1% of predicted (r=-0.348, p<0.01). In the group not receiving inhaled steroids the inverse relationship between PC20 and SECP was more evident (r=-0.581, p<0.001). In the steroid-treated group a significant inverse relationship was observed between ENO and FEV1 (r=-0.426, p=0.0011). The level of exhaled nitric oxide and the relationships between lung function, bronchial reactivity and markers of inflammation are different between steroid-treated and untreated asthmatic children. This has implications for the monitoring of asthma in childhood.
This paper references
10.1046/j.1365-2222.1999.00014.x
Betamethasone prevents virus‐induced airway inflammation but not airway hyperresponsiveness in guinea pigs
A. Leusink-Muis (1999)
10.1183/09031936.97.10092120
Water vapour and carbon dioxide decrease nitric oxide readings.
T. W. van der Mark (1997)
10.1164/AJRCCM/142.1.91
Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage. The effects of antiasthmatic treatment with budesonide or terbutaline.
E. Adelroth (1990)
10.1164/AJRCCM.153.6.8665033
Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract.
S. Kharitonov (1996)
10.1016/0091-6749(93)90006-2
Antigen avoidance in a mountain environment: influence on basophil releasability in children with allergic asthma.
G. Piacentini (1993)
Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society.
P. J. Sterk (1993)
10.1111/j.1365-2222.1997.tb00741.x
Asthma, bronchial hyperreactivity and mediator release in children with birch pollinosis. ECP and EPX levels are not related to bronchial hyperreactivity
H. A. Ferdousi (1997)
10.1016/S0091-6749(05)80185-X
Increased bronchial hyperresponsiveness after inhaling salbutamol during 1 year is not caused by subsensitization to salbutamol.
C. V. van Schayck (1990)
10.1016/0091-6749(91)90160-P
Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness.
B. Bradley (1991)
Expired Nitric Oxide in Stable Asthmatic Patients does not Relate to Parameter of Disease Severity
NHT ten Hacken (1996)
10.1016/0091-6749(91)90251-I
Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity.
C. Walker (1991)
10.1164/AJRCCM/137.1.62
Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity.
A. Wardlaw (1988)
Exhaled and nasal nitric oxide measurements : recommendations
S. Kharitonov (1997)
10.1016/S0022-3476(97)80062-5
Corticosteroids decrease exhaled nitric oxide in children with acute asthma.
E. Baraldi (1997)
Exhaled Nitric Oxide Production and Increased Airway Responsiveness in Asthma Reflect Different Inflammatory Pathways
DA Taylor (1996)
Inflammatory cell and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage : the effects of antiasthmatic treatment with budesonide or terbutalide
HA Ferdousi
10.1046/j.1365-2222.1998.00194.x
Serum eosinophil cationic protein in asthma: what does it mean?
Kips (1998)
10.1164/AJRCCM.157.1.ED-19
Inflammation and airway function in asthma: what you see is not necessarily what you get.
K. Haley (1998)
10.1111/j.1398-9995.1996.tb02113.x
The degree of natural allergen exposure modifies eosinophil activity markers in the circulation of patients with mild asthma
E. Fernvik (1996)
10.1164/AJRCCM/140.6.1745
Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity.
P. Jeffery (1989)
10.1164/AJRCCM/146.2.500
Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness.
A. Bentley (1992)
10.1183/09031936.96.09020196
Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients.
S. Kharitonov (1996)
10.1183/09031936.96.09112231
Eosinophils and eosinophil-derived proteins in children with moderate asthma.
M. Hoekstra (1996)
Increased amount of nitric oxide in exhaled air of asthmatics.
K. Alving (1993)
Report of the Working Party Standardization of Lung Function tests, European Community for Steel and Coal. Official Statement of the
P J Sterk (1993)
10.1016/0091-6749(81)90132-9
Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance.
F. Hargreave (1981)
10.1164/AJRCCM/145.4_PT_1.922
Characteristics of the inflammation in biopsies from large airways of subjects with asthma and subjects with chronic airflow limitation.
S. Ollerenshaw (1992)
10.1002/(SICI)1099-0496(199711)24:5<312::AID-PPUL2>3.0.CO;2-K
Exhaled nitric oxide measurements in normal and asthmatic children
C. A. Byrnes (1997)
Nitric oxide in exhaled air is a new marker of airway inflammation.
S. Kharitonov (1996)
10.1016/S0091-6749(95)70148-6
Evaluation of serum eosinophilic cationic protein as a marker of disease activity in chronic asthma.
A. Ferguson (1995)
10.1164/AJRCCM/142.6_PT_1.1407
Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma.
M. Azzawi (1990)
10.1183/09031936.96.09061134
Exhaled nitric oxide during acute changes of airways calibre in asthma.
Pierre Garnier (1996)
10.1183/09031936.97.10071683
Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force.
S. Kharitonov (1997)
Exhaled nitric oxide: a marker of inflammation
SA Kharitonov (1996)
10.1136/thx.53.2.91
Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.
A. Jatakanon (1998)
10.1136/thx.51.3.233
Exhaled nitric oxide: a new lung function test.
P. Barnes (1996)
10.1164/AJRCCM.157.3.9709064
Exhaled nitric oxide correlates with airway hyperresponsiveness in steroid-naive patients with mild asthma.
L. Dupont (1998)
10.1378/CHEST.96.5.988
Bronchial hyperresponsiveness in asthmatic children. Correlation with macrophages and eosinophils in broncholavage fluid.
A. Ferguson (1989)
10.1164/AJRCCM.153.1.8542158
Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients.
S. Kharitonov (1996)
10.1164/ajrccm/143.5_pt_1.1200
Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry.
B. Heard (1991)
10.1164/AJRCCM.159.1.9706006
Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma.
S. Lim (1999)
10.1183/09031936.96.09081665
Bronchial brush biopsies for studies of epithelial inflammation in stable asthma and nonobstructive chronic bronchitis.
G. Riise (1996)
10.1111/j.1365-2249.1991.tb05809.x
Sputum eosinophils from asthmatics express ICAM‐1 and HLA‐DR
T. Hansel (1991)
10.1183/09031936.96.09122671
Nitric oxide in exhaled air.
J. Lundberg (1996)
10.1016/0167-5699(95)80128-6
Nitric oxide and asthmatic inflammation.
P. Barnes (1995)
10.1164/AJRCCM/136.2.379
Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects.
J. Kirby (1987)



This paper is referenced by
10.1111/j.1365-2222.2005.02279.x
High fractional concentration of nitric oxide in exhaled air despite steroid treatment in asthmatic children
M. Pijnenburg (2005)
10.3904/KJM.2017.92.5.458
Relationship between Bronchodilator Response, Airway Hyperresponsiveness, and Exhaled Nitric Oxide Levels in Patients with Suspected Bronchial Asthma
Sang-Yu Oh (2017)
10.3889/oamjms.2018.113
Eosinophil Cationic Protein Concentrations among Crop and Dairy Farmers with Asthma
S. Stoleski (2018)
10.1136/thorax.56.11.857
Exhaled nitric oxide levels in non-allergic and allergic mono- or polysensitised children with asthma
M. Silvestri (2001)
10.1016/j.amjms.2020.04.024
The Effect of Vidian Neurectomy on Pulmonary Function in Patients with Allergic Rhinitis and Chronic Rhinosinusitis with Nasal Polyps.
Gulibositan Maimaitiaili (2020)
10.1136/thorax.58.6.494
Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma
L. P. Malmberg (2003)
10.1136/thorax.57.6.518
Exhaled nitric oxide levels in atopic children: relation to specific allergic sensitisation, AHR, and respiratory symptoms
J. Leuppi (2002)
The development of exhaled breath condensate: a noninvasive method of measuring airway inflammation
P.P.R. Rosias (2008)
10.1111/j.1365-2222.2007.02897.x
Exhaled nitric oxide in childhood asthma: a review
M. Pijnenburg (2008)
10.1186/1824-7288-38-74
Clinical application of exhaled nitric oxide measurement in pediatric lung diseases
A. Manna (2012)
10.5580/e4c
Role of Eosinophil Cationic Protein in Asthma and Confounding Factors.
A. A. Samarai (2008)
10.1097/00000539-200110000-00019
Salbutamol Prevents the Increase of Respiratory Resistance Caused by Tracheal Intubation During Sevoflurane Anesthesia in Asthmatic Children
P. Scalfaro (2001)
10.1067/MAI.2003.13
Exhaled nitric oxide and atopy in children.
M. Miraglia del Giudice (2003)
10.1016/J.RMED.2006.01.012
Relationship between exhaled nitric oxide levels and compliance with inhaled corticosteroids in asthmatic children.
M. Katsara (2006)
10.4168/aair.2013.5.3.155
Relationships Between Exhaled Nitric Oxide and Atopy Profiles in Children With Asthma
Won-Nyung Jang (2013)
10.1378/chest.12-3098
Guideline-recommended fractional exhaled nitric oxide is a poor predictor of health-care use among inner-city children and adolescents receiving usual asthma care.
M. McCormack (2013)
10.1016/B978-032304289-5.10011-6
Chapter 11 – Noninvasive Tests, Exhaled Nitric Oxide, and Exhaled Breath Condensate—Do They Help Diagnose Asthma?
G. Whelan (2008)
10.1016/j.alit.2017.02.009
Phenotypic analysis of asthma in Japanese athletes.
Keisuke Tsukioka (2017)
10.1002/PPUL.20056
Childhood asthma: Exhaled markers of airway inflammation, asthma control score, and lung function tests
P. Rosias (2004)
10.1034/j.1398-9995.2003.00229.x
Assessment of inhaled BDP‐dose dependency of exhaled nitric oxide and local and serum eosinophilic markers in steroids‐naive nonatopic asthmatics
R. Dal Negro (2003)
10.1183/09031936.02.01582001
Changes of exhaled nitric oxide during steroid treatment of childhood asthma
J. Beck-Ripp (2002)
10.1016/B978-0-7216-3695-5.50059-6
Chapter 55 – Asthma in the Preschool Child
M. Weinberger (2006)
10.1007/s11882-013-0364-x
Will Symptom-Based Therapy Be Effective for Treating Asthma in Children?
Marianne Nuijsink (2013)
10.1081/JAS-200027862
Fractional Exhaled Nitric Oxide (FENO), Lung Function and Airway Hyperresponsiveness in Naïve Atopic Asthmatic Children
M. M. del Giudice (2004)
10.1067/MAI.2002.126378
Plasma concentration of thymus and activation-regulated chemokine is elevated in childhood asthma.
T. Leung (2002)
10.1081/JAS-200027838
Exhaled Nitric Oxide in Relation to the Clinical Features of Childhood Asthma
T. Warke (2004)
10.7581/PARD.2012.22.3.282
Relationships between Fraction of Nitric Oxide, Airway Hyperresponsiveness, Blood Eoshinophil Counts and Serum Eosinophil Cationic Protein in Asthmatic Children
Hyeon Seok Seo (2012)
10.1111/j.1365-2222.2005.02263.x
High levels and gender difference of exhaled nitric oxide in Chinese schoolchildren
G. Wong (2005)
10.1016/j.jaci.2007.11.008
Exhaled nitric oxide distinguishes between subgroups of preschool children with respiratory symptoms.
A. Moeller (2008)
Exhaled nitric oxide : Variability and association with bronchial hyperresponsiveness and atopy
H. Ekroos (2008)
10.1016/S1081-1206(10)62237-5
Asthma treatment with inhaled corticosteroids versus antileukotrienes: what exhaled nitric oxide studies do and do not tell us.
M. Dykewicz (2001)
10.1097/01.ALL.0000010978.62527.4E
The nose-lung interaction in allergic rhinitis and asthma: united airways disease
G. Passalacqua (2001)
See more
Semantic Scholar Logo Some data provided by SemanticScholar