Online citations, reference lists, and bibliographies.
← Back to Search

Control Of Apoptosis And Mitotic Spindle Checkpoint By Survivin

F. Li, G. Ambrosini, E. Chu, J. Plescia, S. Tognin, P. Marchisio, D. Altieri
Published 1998 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Progression of the cell cycle and control of apoptosis (programmed cell death) are thought to be intimately linked processes, acting to preserve homeostasis and developmental morphogenesis. Although proteins that regulate apoptosis have been implicated in restraining cell-cycle entry and controlling ploidy (chromosome number), the effector molecules at the interface between cell proliferation and cell survival have remained elusive. Here we show that a new inhibitor of apoptosis (IAP) protein,, survivin, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin–microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. These results indicate that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.
This paper references
10.1111/j.1749-6632.1975.tb19196.x
PURIFICATION OF TUBULIN AND ASSOCIATED HIGH MOLECULAR WEIGHT PROTEINS FROM PORCINE BRAIN AND CHARACTERIZATION OF MICROTUBULE ASSEMBLY IN VITRO *
G. Borisy (1975)
10.1016/0092-8674(77)90257-4
The display of microtubules in transformed cells
M. Osborn (1977)
10.1083/JCB.115.3.717
Tau protein binds to microtubules through a flexible array of distributed weak sites
K. Butner (1991)
10.1016/0955-0674(94)90059-0
Cell cycle checkpoints.
A. Murray (1994)
10.1016/0955-0674(94)90119-8
Microtubule organization and dynamics dependent on microtubule-associated proteins.
N. Hirokawa (1994)
10.1016/0955-0674(95)80066-2
Apoptosis and the cell cycle.
G. Evan (1995)
10.1126/science.7871434
A p53-dependent mouse spindle checkpoint
S. Cross (1995)
10.1074/jbc.270.45.27058
Interaction Site of GTP Binding Gh (Transglutaminase II) with Phospholipase C (*)
K. C. Hwang (1995)
10.1074/JBC.270.47.28419
Cell Cycle-dependent Regulation of the Cyclin B1 Promoter (*)
A. Hwang (1995)
10.1002/j.1460-2075.1995.tb00130.x
Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression.
J. Zwicker (1995)
10.1073/PNAS.93.10.4974
Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.
A. Uren (1996)
10.1038/379349A0
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
Peter Listen (1996)
10.1101/GAD.10.20.2621
Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.
A. Minn (1996)
10.1016/S0092-8674(00)81873-5
Programmed Cell Death in Animal Development
M. Jacobson (1997)
10.1038/40901
X-linked IAP is a direct inhibitor of cell-death proteases
Q. Deveraux (1997)
10.1038/NM0897-917
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
G. Ambrosini (1997)
10.1093/emboj/16.23.6914
The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspases
N. Roy (1997)
10.1093/emboj/16.15.4628
The anti‐apoptosis function of Bcl‐2 can be genetically separated from its inhibitory effect on cell cycle entry
David C.S. Huang (1997)
10.1038/42867
Double identity for proteins of the Bcl-2 family
John Calvin Reed (1997)
10.1038/32688
Mutations of mitotic checkpoint genes in human cancers
D. Cahill (1998)
10.1074/jbc.273.18.11177
Induction of Apoptosis and Inhibition of Cell Proliferation bysurvivin Gene Targeting*
G. Ambrosini (1998)
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.
I. Tamm (1998)
10.1016/S1074-7613(00)80550-6
Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.
F. Andrade (1998)
Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas.
C. D. Lu (1998)
Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation.
C. Adida (1998)



This paper is referenced by
10.3390/biomedicines9070806
A Novel Recombinant Fcγ Receptor-Targeted Survivin Combines with Chemotherapy for Efficient Cancer Treatment
Chiao-Chieh Wu (2021)
10.1007/s00280-021-04242-0
Foretinib induces G2/M cell cycle arrest, apoptosis, and invasion in human glioblastoma cells through c-MET inhibition
Narges K. Gortany (2021)
10.7150/ijms.51497
A novel prognostic factor TIPE2 inhibits cell proliferation and promotes apoptosis in pancreatic ductal adenocarcinoma (PDAC)
Yuqi Sun (2021)
10.3390/cancers13174497
Development of Multi-Scale X-ray Fluorescence Tomography for Examination of Nanocomposite-Treated Biological Samples
Si Chen (2021)
10.3390/ph14030230
Carnosic Acid Induces Apoptosis and Inhibits Akt/mTOR Signaling in Human Gastric Cancer Cell Lines
W. El-Huneidi (2021)
10.3390/cancers13071650
Noninvasive Urine-Based Tests to Diagnose or Detect Recurrence of Bladder Cancer
Marine Charpentier (2021)
Correlating the Immunohistochemical Expression of β-Catenin, Fascin and Survivin with the Pathogenetic Paradigm Observed in Pleomorphic Adenoma, Muco-Epidermoid Carcinoma, and Adenoid Cystic Carcinoma
Kaorey Nivedita (2021)
10.1038/s41419-021-04026-7
DEPDC1B regulates the progression of human chordoma through UBE2T-mediated ubiquitination of BIRC5
Liang Wang (2021)
10.1038/s41598-021-81563-3
Depletion of Survivin suppresses docetaxel-induced apoptosis in HeLa cells by facilitating mitotic slippage
Teng Han (2021)
10.1038/s41598-020-78208-2
Survivin and caspases serum protein levels and survivin variants mRNA expression in sepsis
Marianna Miliaraki (2021)
10.25179/TJEM.2020-77471
Investigation of Survivin Promoter-31 G/C Polymorphism and Survivin Levels in Acromegaly
M. Ilhan (2021)
10.1038/s41598-020-79736-7
BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration
L. Xu (2021)
10.1186/s12935-021-01873-4
MicroRNAs as the critical regulators of Doxorubicin resistance in breast tumor cells
A. Zangouei (2021)
10.3390/cancers13040624
Tumor Suppressor Protein p53 and Inhibitor of Apoptosis Proteins in Colorectal Cancer—A Promising Signaling Network for Therapeutic Interventions
Ömer Güllülü (2021)
10.1186/s41021-021-00192-4
MicroRNAs as the critical regulators of cisplatin resistance in gastric tumor cells
A. Zangouei (2021)
10.1038/s41467-021-21753-9
Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
Annika Meiners (2021)
10.3892/ol.2020.11690
Expression of anti-apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression
A. Stavropoulos (2020)
10.1002/ANGE.201915400
Funktionelle Inhibition der krebsrelevanten Interaktion von Survivin und Histon H3 mit einem Guanidiniumcarbonylpyrrol‐Liganden
Cecilia Vallet (2020)
10.1016/j.blre.2020.100671
Unraveling survivin expression in chronic myeloid leukemia: Molecular interactions and clinical implications.
P. S. Bernardo (2020)
10.1016/bs.ircmb.2019.12.001
Bcl-2 family proteins, beyond the veil.
J. Glab (2020)
10.1002/anie.201915400
Functional Disruption of the Cancer‐Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand
Cecilia Vallet (2020)
10.1155/2020/8886914
An Integrative Analysis Reveals the Potential Mechanism between Herbal Medicine Yinchen and Immunoregulation in Hepatocellular Carcinoma
Zhuomao Mo (2020)
10.1016/J.CBPC.2019.108637
Survival of silk worm, Bombyx mori in azaserine induced oxidative stress.
Venkatesh Mandyam.D. (2020)
10.1186/s12917-020-02317-3
Phase-I trial of survivin inhibition with EZN-3042 in dogs with spontaneous lymphoma
D. Thamm (2020)
10.1016/j.bbrc.2020.03.160
The 5' untranslated region of the anti-apoptotic protein Survivin contains an inhibitory upstream AUG codon.
C. Palavecino (2020)
10.1186/s13046-020-01581-3
Sur-X, a novel peptide, kills colorectal cancer cells by targeting survivin-XIAP complex
Wan-xia Fang (2020)
10.30574/wjarr.2020.5.1.0108
The investigation of toxic, genotoxic and cytotoxic effects of various nanoparticles in Allium cepa and Caenorhabditis elegans test systems
Atacı Gamze (2020)
10.1101/2020.09.16.300293
Single cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis
A. Bais (2020)
10.1016/j.bbagrm.2020.194480
URH49 exports mRNA by remodeling complex formation and mediating the NXF1-dependent pathway.
K. Fujita (2020)
10.1016/j.ygeno.2020.09.053
Unraveling novel survivin mRNA transcripts in cancer cells using an in-house developed targeted high-throughput sequencing approach.
Panagiotis G Adamopoulos (2020)
10.1038/s41598-020-61275-w
Replicative conditioning of Herpes simplex type 1 virus by Survivin promoter, combined to ERBB2 retargeting, improves tumour cell-restricted oncolysis
Emanuele Sasso (2020)
10.1016/j.jpba.2020.113288
Flavokawain A inhibits prostate cancer cells by inducing cell cycle arrest and cell apoptosis and regulating the glutamine metabolism pathway.
K. Wang (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar