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Substance P And Analgesia

John M. Stewart, CARL J. Getto, K. Neldner, E. Reeve, WILLIAM A. Krivoy, E. Zimmermann
Published 1976 · Chemistry, Medicine

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SUBSTANCE P (SP)1 has long been known to have marked effects on the central nervous system (CNS). Lembeck2 suggested that SP might be a transmitter of primary sensory impulses, an hypothesis supported by subsequent investigators3,4. Early work on SP was carried out using natural material, which unless highly purified, is known to be contaminated with bradykin or some other kinin-like material5. As bradykinin also has marked effects on the CNS, experiments carried out using impure SP may be misleading. This may account for some of the conflicting observations that exist regarding the action of SP on sensory transmission, and may also explain its interaction with opioids. Whereas impure SP has been shown to antagonise morphine6, synthetic SP was found to substitute effectively for morphine in mice chronically treated with morphine7. SP does not act like morphine in the field-stimulated guinea pig ileum8 and does not combine with morphine receptors9. Furthermore, SP has been reported to be the most potent algogenic substance known on the human blister base10. Recent reports on the characterisation and activity of enkephalin11,12 suggested that enkephalin may be acting as an analogue of SP. We have therefore examined SP for morphine-like activity.
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Intrathecal substance P depresses spinal motor and sensory responses to stimulation of nociceptive afferents — Antagonism by naloxone
T. Doi (2004)
The primary afferent nociceptor and neuropeptide gene expression : importance in experimental arthritis
L. Donaldson (1994)
Non-opiate analgesia following stressful acoustic stimulation
M. Szikszay (1985)
Differential effects of C- and N-terminal substance P metabolites on the release of amino acid neurotransmitters from the spinal cord: potential role in nociception
S. R. Skilling (1990)
The Impact of the Neuropeptide Substance P (SP) Fragment SP1-7 on Chronic Neuropathic Pain
A. Jonsson (2015)
Opposite effects of naloxone on substance P-induced changes in brain dopa synthesis and in locomotor activity in rats
J. Garcı́a-Sevilla (2005)
Effects of pain, morphine and naloxone on the duration of animal hypnosis
G. Carli (1981)
Analgesic activities of spinal cord substance P antagonists implicate substance P as a neurotransmitter of pain sensation
M. Piercey (1986)
Interactions Between Substance P and Nicotinic Acetylcholine Receptors in Pain Control Mechanisms in the Rat
J. Rı́o (1987)
Effect of substance P on medial forebrain bundle self-stimulation in rats following intracerebral administration
J. M. Goldstein (1977)
Activity of VIP, somatostatin and other peptides in the mouse vas deferens assay
A. Kastin (1978)
Warum versagen Substanz P (NK1)-Rezeptorantagonisten in der Schmerztherapie?
M. Herbert (2002)
in the Rostral Ventromedial Medulla NK-1 Receptors Modulate the Excitability of on Cells
S. Khasabov (2015)
Analgesic activity of substance P in rats: tolerance and cross-tolerance with enkephalin.
J. Naranjo (1984)
Alteration of shock titration thresholds in the cat following intrathecal substance P administration
D. L. Wolf (1984)
Capsaicin: actions on nociceptive C-fibres and therapeutic potential
B. Lynn (1990)
BDNF Produces Analgesia in the Formalin Test and Modifies Neuropeptide Levels in Rat Brain and Spinal Cord Areas Associated With Nociception
J. Siuciak (1995)
Circulating immunoreactive substance P in man
P. Skrabanek (1976)
Substance P and antinociception
M. Hall (1983)
Pharmacologic actions of capsaicin: apparent involvement of substance P and serotonin.
R. M. Virus (1979)
Neuropeptide processing in pathophysiology.
J. Stewart (1993)
Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals
Å. Ljungdahl (1978)
Dorsal column stimulation induces release of serotonin and substance P in the cat dorsal horn.
B. Linderoth (1992)
Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: a pivotal role in stress-induced analgesia
M. T. Lee (2020)
Substance P-induced analgesia in the rat
J. Mohrland (1979)
Substance P: does it produce analgesia or hyperalgesia?
P. Oehme (1980)
Depletion of substance P-like immunoreactivity in the cat dental pulp by antidromic nerve stimulation.
B. Gazelius (1981)
Behavioural and antinociceptive effects of intrathecally injected substance P analogues in mice.
C. Post (1985)
Recent Advances in Temporomandibular Disorders and Orofacial Pain
J. Fricton (1991)
Activity at phencyclidine and mu opioid sites mediates the hyperalgesic and antinociceptive properties of the N-terminus of substance P in a model of visceral pain
V. Goettl (1994)
Enkephalins and endorphins.
R. Miller (1978)
6 – Neurobiology of β-Endorphin and Related Peptides
J. Holaday (1981)
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