Online citations, reference lists, and bibliographies.
← Back to Search

Sequence And Organization Of The Human Mitochondrial Genome

S. Anderson, A. Bankier, B. Barrell, M. H. D. Bruijn, A. Coulson, J. Drouin, I. Eperon, D. Nierlich, B. Roe, F. Sanger, P. Schreier, A. Smith, R. Staden, I. Young
Published 1981 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
This paper references
10.1093/NAR/6.3.831
The use of exonuclease III for preparing single stranded DNA for use as a template in the chain terminator sequencing method.
A. Smith (1979)
10.1016/0092-8674(77)90075-7
Mapping of mitochondrial DNA of individual sheep and goats: Rapid evolution in the D loop region
W. B. Upholt (1977)
10.1016/0022-2836(79)90441-8
Mechanism of mitochondrial DNA replication in mouse L-cells: RNA priming during the initiation of heavy-strand synthesis.
A. Gillum (1979)
10.1073/PNAS.76.4.1663
Nucleotide sequence of the mitochondrial structural gene for subunit 9 of yeast ATPase complex.
L. A. Hensgens (1979)
10.1038/272375a0
Methylation of single-stranded DNA in vitro introduces new restriction endonuclease cleavage sites
B. Gronenborn (1978)
10.1016/0022-2836(80)90354-X
Cloning of human mitochondrial DNA in Escherichia coli.
J. Drouin (1980)
10.1016/S0022-2836(75)80187-2
Evidence for complete symmetrical transcription in vivo of mitochondrial DNA in HeLa cells.
W. Murphy (1975)
10.1093/NAR/8.16.3673
A new computer method for the storage and manipulation of DNA gel reading data.
R. Staden (1980)
10.1093/NAR/8.21.4927
The 3'-terminal sequence of the small subunit ribosomal RNA from hamster mitochondria.
R. Baer (1980)
10.1093/NAR/4.11.4037
Sequence data handling by computer.
R. Staden (1977)
10.1016/0092-8674(78)90257-X
The mitochondrial genome of yeast
P. Borst (1978)
10.1073/PNAS.76.12.6534
Five TGA "stop" codons occur within the translated sequence of the yeast mitochondrial gene for cytochrome c oxidase subunit II.
T. Fox (1979)
10.1093/nar/6.1.1
Site specific endonuclease from Fusobacterium nucleatum
A. Lui (1979)
10.1016/S0022-2836(66)80022-0
Codon--anticodon pairing: the wobble hypothesis.
F. Crick (1966)
10.1073/PNAS.68.8.1757
Symmetrical in vivo transcription of mitochondrial DNA in HeLa cells.
Y. Aloni (1971)
10.1073/PNAS.77.6.3164
Different pattern of codon recognition by mammalian mitochondrial tRNAs.
B. Barrell (1980)
10.1093/NAR/8.8.1731
A short primer for sequencing DNA cloned in the single-stranded phage vector M13mp2.
S. Anderson (1980)
10.1016/0378-1119(80)90108-0
The genetic code in bovine mitochondria: sequence of genes for the cytochrome oxidase subunit II and two tRNAs.
I. Young (1980)
10.1038/290465A0
Distinctive features of the 5′-terminal sequences of the human mitochondrial mRNAs
Julio Montoya (1981)
10.1038/282189A0
A different genetic code in human mitochondria
B. Barrell (1979)
10.1093/NAR/5.3.1013
Further procedures for sequence analysis by computer.
R. Staden (1978)
10.1016/0092-8674(80)90350-5
The tRNA genes punctuate the reading of genetic information in human mitochondrial DNA
D. Ojala (1980)
10.1016/0022-2836(79)90440-6
Mechanism of mitochondrial DNA replication in mouse L-cells: localization and sequence of the light-strand origin of replication.
P. Martens (1979)
10.1073/PNAS.75.2.677
Displacement-loop replication initiation sequence in animal mitochondrial DNA exists as a family of discrete lengths.
A. Gillum (1978)
10.1073/PNAS.76.8.3784
Use of the UGA terminator as a tryptophan codon in yeast mitochondria.
G. Macino (1979)
10.1093/NAR/6.2.455
Mammalian mitochondrial transfer RNAs: chromatographic properties, size and origin.
L. Aujame (1979)
10.1016/0092-8674(80)90637-6
Assembly of the mitochondrial membrane system: Sequence analysis of a yeast mitochondrial ATPase gene containing the oli-2 and oli-4 loci
G. Macino (1980)
Purification and properties of a specific Escherichia coli ribonuclease which cleaves a tyrosine transfer ribonucleic acid presursor.
H. Robertson (1972)
10.1016/0378-1119(80)90086-4
Nucleotide sequence of a cloned fragment of rat mitochondrial DNA containing the replication origin.
Sekiya Takao (1980)
10.1073/PNAS.75.2.735
Human mitochondrial DNA: analysis of 7S DNA from the origin of replication.
W. Brown (1978)
A computer program to search for tRNA genes.
R. Staden (1980)
The transcription map of human mitochondrial DNA implicates transfer RNA excision as a major processing event.
J. Battey (1980)
10.1016/0022-2836(76)90077-2
Amino acid specificity of the transfer RNA species coded for by HeLa cell mitochondrial DNA.
D. C. Lynch (1976)
Assembly of the mitochondrial membrane system. DNA sequence and organization of the cytochrome b gene in Saccharomyces cerevisiae D273-10B.
F. Nóbrega (1980)
Assembly of the mitochondrial membrane system. Sequence of the oxi 2 gene of yeast mitochondrial DNA.
B. Thalenfeld (1980)
10.1038/286460A0
Distinctive sequence of human mitochondrial ribosomal RNA genes
I. Eperon (1980)
10.1038/277192A0
Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication
S. Crews (1979)
10.1016/0022-2836(80)90196-5
Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.
F. Sanger (1980)
10.1016/0092-8674(80)90164-6
Precise localization and nucleotide sequence of the two mouse mitochondrial rRNA genes and three immediately adjacent novel tRNA genes
R. A. Etten (1980)
10.1038/NEWBIO233035A0
Tyrosine tRNA precursor molecule polynucleotide sequence.
S. Altman (1971)
10.1016/0022-2836(78)90269-3
Mechanism of mitochondrial DNA replication in mouse L-cells: kinetics of synthesis and turnover of the initiation sequence.
D. Bogenhagen (1978)
10.1016/0014-5793(78)80145-8
The use of thin acrylamide gels for DNA sequencing
F. Sanger (1978)
10.1016/S0092-8674(80)80053-5
The sequences of the small ribosomal RNA gene and the phenylalanine tRNA gene are joined end to end in human mitochondrial DNA
S. Crews (1980)
10.1073/PNAS.77.6.3167
Codon recognition rules in yeast mitochondria.
S. Bonitz (1980)
10.1073/PNAS.77.6.3159
Novel features in the genetic code and codon reading patterns in Neurospora crassa mitochondria based on sequences of six mitochondrial tRNAs.
J. Heckman (1980)
10.1093/NAR/8.22.5213
A mammalian mitochondrial serine transfer RNA lacking the "dihydrouridine" loop and stem.
M. De Bruijn (1980)
10.1073/PNAS.75.4.1759
"Two out of three": an alternative method for codon reading.
U. Lagerkvist (1978)
10.1021/BI00551A013
Primary structure of AUA-specific isoleucine transfer ribonucleic acid from Escherichia coli.
Y. Kuchino (1980)
10.1016/0092-8674(79)90352-0
Assembly of the mitochondrial membrane system: sequences of yeast mitochondrial valine and an unusual threonine tRNA gene
M. Li (1979)
10.1038/290470A0
tRNA punctuation model of RNA processing in human mitochondria
D. Ojala (1981)
10.1007/978-3-642-81287-3_18
Amino Acid Sequence of the Putative Protonophore of the Energy-Transducing ATPase Complex
W. Sebald (1978)
10.1073/pnas.74.12.5463
DNA sequencing with chain-terminating inhibitors.
F. Sanger (1977)
Assembly of the mitochondrial membrane system. The DNA sequence of a mitochondrial ATPase gene in Saccharomyces cerevisiae.
G. Macino (1979)
10.1016/0968-0004(77)90252-3
Structure and function of mitochondrial DNA
P. Borst (1977)
10.1093/NAR/8.12.2605
Mapping of nascent light and heavy strand transcripts on the physical map of HeLa cell mitochondrial DNA.
P. Cantatore (1980)
10.1073/PNAS.76.7.3289
Initiator tRNAs have a unique anticodon loop conformation.
P. Wrede (1979)
10.1016/0022-2836(79)90068-8
A fast and simple method for sequencing DNA cloned in the single-stranded bacteriophage M13.
P. Schreier (1979)
10.1016/0022-2836(80)90136-9
DNA sequence of a T4 transfer RNA gene cluster.
K. Fukada (1980)
10.1016/0022-2836(74)90355-6
Mechanism of mitochondrial DNA replication in mouse L-cells: asynchronous replication of strands, segregation of circular daughter molecules, aspects of topology and turnover of an initiation sequence.
A. Berk (1974)



This paper is referenced by
10.1371/journal.pone.0058367
Metabolic Adaptation to Chronic Inhibition of Mitochondrial Protein Synthesis in Acute Myeloid Leukemia Cells
Bozhena Jhas (2013)
10.1016/B978-0-12-374513-2.00014-2
Mitochondrial DNA Analysis
J. Butler (2012)
10.3390/genes2010169
Enlightenment of Yeast Mitochondrial Homoplasmy: Diversified Roles of Gene Conversion
F. Ling (2011)
10.1093/nar/27.1.143
Update of the Human MitBASE database
M. Attimonelli (1999)
10.1016/S0014-5793(99)00115-5
Mitochondrial DNA sequence diversity in Russians
V. Orekhov (1999)
10.20517/jtgg.2018.05
MERRF and MELAS: current gene therapy trends and approaches
Ciara Ann Agresti (2018)
10.1038/NPG.ELS.0000809
Genetic Code: Introduction
K. Watanabe (2002)
10.1007/PL00006418
Phylogeographic Patterns and Evolution of the Mitochondrial DNA Control Region in Two Neotropical Cats (Mammalia, Felidae)
E. Eizirik (1998)
10.1111/J.1601-5223.1993.00245.X
Cytochrome b nucleotide sequence variation among the Atlantic Alcidae.
V. Friesen (1993)
10.1007/978-94-009-7049-6_27
The Structure of the Metal Centers in Cytochrome c Oxidase
T. H. Stevens (1983)
10.2307/1308971
Genes and Phenes in Tetrahymena
D. L. Nanney (1982)
10.1046/j.1529-8817.2004.00100.x
MtDNA Profile of West Africa Guineans: Towards a Better Understanding of the Senegambia Region
A. Rosa (2004)
10.3390/cells9102181
Epitranscriptomics of Mammalian Mitochondrial Ribosomal RNA
I. Laptev (2020)
10.5402/2012/251723
Novel m.15434C>A (p.230L>I) Mitochondrial Cytb Gene Missense Mutation Associated with Dilated Cardiomyopathy
S. Zarrouk Mahjoub (2012)
10.1016/j.fsigen.2010.01.012
Titanic's unknown child: the critical role of the mitochondrial DNA coding region in a re-identification effort.
R. Just (2011)
Cytoplasmic inheritanceand its effects on development and performance
' L.C.Smith (2019)
10.1016/j.mito.2020.02.005
Characterization of background noise in MiSeq MPS data when sequencing human mitochondrial DNA from various sample sources and library preparation methods.
Jennifer A McElhoe (2020)
10.1093/nar/gky852
Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication
T. J. Cluett (2018)
10.5772/37919
An Evolutionary Biology Approach to Understanding Neurological Disorders
Azhari Aziz (2012)
10.1007/s10709-020-00107-1
Complete mitochondrial genome of a blue-tailed skink Plestiodon capito (Reptilia, Squamata, Scincidae) and comparison with other Scincidae lizards.
M. Chen (2020)
10.1016/j.ajhg.2016.08.014
Recurrent De Novo Dominant Mutations in SLC25A4 Cause Severe Early-Onset Mitochondrial Disease and Loss of Mitochondrial DNA Copy Number
K. Thompson (2016)
10.1002/(SICI)1098-2744(199607)16:3<165::AID-MC7>3.0.CO;2-G
Expression of oxidative phosphorylation genes in renal tumors and tumoral cell lines
H. Faure‐Vigny (1996)
10.1023/A:1005638231195
Biochemical and molecular basis for mitochondrial cardiomyopathy in neonates and children
J. Marín-García (2004)
10.1016/j.bbrc.2020.05.141
Phosphorylation of mitochondrial transcription factor B2 controls mitochondrial DNA binding and transcription.
Alicia M Bostwick (2020)
10.1111/J.1365-2605.2005.00515.X
The impact of mitochondrial genetics on male infertility.
J. S. St John (2005)
10.1186/s12864-018-5123-x
Big data analysis of human mitochondrial DNA substitution models: a regression approach
Keren Levinstein Hallak (2018)
10.1080/23802359.2020.1787271
The complete mitochondrial genome of Quasipaa exilispinosa (Anura: Dicroglossidae)
Yanqing Wu (2020)
10.1146/annurev.es.18.110187.001413
EVOLUTION OF ANIMAL MITOCHONDRIAL DNA: RELEVANCE FOR POPULATION BIOLOGY AND SYSTEMATICS
C. Moritz (1987)
10.1016/0968-0004(82)90015-9
Structure of intrinsic membrane proteins
R. Capaldi (1982)
Selfish DNA: a sexually-transmitted nuclear parasite.
D. Hickey (1982)
10.1038/298867A0
E. coli F1-ATPase interacts with a membrane protein component of a proton channel
J. Walker (1982)
10.1007/BF01115250
The serine codons UCX and AGY are not interchangeable in the mammalian mitochondrial genomes
A. Hénaut (1982)
See more
Semantic Scholar Logo Some data provided by SemanticScholar