Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Regulation Of Protein Synthesis During Heat Shock
Published 1981 · Chemistry, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
When the cells or tissues of most eukaryotes are exposed to elevated temperatures, they respond with the vigorous induction of a small number of ‘heat shock’ proteins (hsps). I report here investigations on the responses of two very different organisms, the fruit fly Drosophila melanogaster and the yeast Saccharomyces cerevisiae. Although both organisms achieve a very rapid shift in protein synthesis, they do so in very different ways. In Drosophila, heat shock induces a mechanism of translational control which both promotes the translation of hs mRNAs and specifically represses the translation of pre-existing mRNAs. Yeast cells, in contrast, do not possess a special mechanism to sequester pre-existing messages from translation. Instead, most of these messages simply disappear rapidly from the cell, while those that are retained continue to be translated.
This paper references
Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs.
A. Tissières (1974)
Unequal meiotic recombination within tandem arrays of yeast ribosomal DNA genes
T. Petes (1980)
Analysis of drosophila mRNA by in situ hybridization: Sequences transcribed in normal and heat shocked cultured cells
A. Spradling (1975)
EXPERIMENTAL ACTIVATION OF SPECIFIC LOCI IN POLYTENE CHROMOSOMES OF DROSOPHILA.
Ritossa Fm (1964)
Differential stability of cytoplasmic RNA in a Drosophila cell line.
J. Lengyel (1977)
Localization of RNA from heat-induced polysomes at puff sites in Drosophila melanogaster.
S. McKenzie (1975)
A response of protein synthesis to temperature shift in the yeast Saccharomyces cerevisiae.
M. Miller (1979)
Secondary structure of bacteriophage f2 ribonucleic acid and the initiation of in vitro protein biosynthesis.
H. Lodish (1970)
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
U. Laemmli (1970)
Recovery of protein synthesis after heat shock: prior heat treatment affects the ability of cells to translate mRNA.
N. Petersen (1981)
Evidence for transcriptional regulation of orotidine-5'-phosphate decarboxylase in yeast by hybridization of mRNA to the yeast structural gene cloned in Escherichia coli.
M. Bach (1979)
Structure, translation, and metabolism of the cytoplasmic copia ribonucleic acid of Drosophila melanogaster.
S. Falkenthal (1980)
Alterations in translatable ribonucleic acid after heat shock of Saccharomyces cerevisiae.
L. McAlister (1980)
Translational control of protein synthesis.
H. Lodish (1976)
Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.
R. Laskey (1975)
Translational control of protein synthesis in response to heat shock in D. melanogaster cells
R. Storti (1980)
The induction of gene activity in drosophila by heat shock
M. Ashburner (1979)
An efficient mRNA-dependent translation system from reticulocyte lysates.
H. Pelham (1976)
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
P. Thomas (1980)
Translational efficiency of heat-induced messages in Drosophila melanogaster cells.
S. Lindquist (1980)
This paper is referenced by
Editorial: In memory of Susan Lindquist.
B. Bevis (2019)
Cloning and sequencing of Schizosaccharomyces pombe car1 gene encoding arginase. Expression of the arginine anabolic and catabolic genes in response to arginine and related metabolites
C. van Huffel (1994)
Characterization of the yeast ARG5,6 gene: determination of the nucleotide sequence, analysis of the control region and of ARG5,6 transcript
C. Boonchird (2004)
Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert.
W. Wallace (1991)
S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP
K. Normington (1989)
Constitutive and Induced Synthesis of Heat Shock Proteins in Transplantable Hepatomas
L. Schiaffonati (1987)
Saccharomyces cerevisiae. Gene products that promote mRNA turnover in
P. Leeds (2013)
Protein Breakdown and the Heat-Shock Response
S. Goff (1988)
Protein misfolding and temperature up-shift cause G1 arrest via a common mechanism dependent on heat shock factor in Saccharomyces cerevisiae
E. Trotter (2001)
Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability.
N. Theodorakis (1987)
Expression of a yeast glycolytic gene is subject to dosage limitation.
Patrick A. Moore (1990)
Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response
H. Kim (2016)
Stress mRNA Metabolism inCanavanine-Treated Chicken Embryo
C. White (1984)
3 – Mechanism of Translational Control in Heat-Shocked Drosophila Cells
D. Ballinger (1985)
Modulation of Heat Shock Protein Synthesis in Two Human Melanoma Cell Lines
A. Delpino (1984)
Restriction of poliovirus RNA translation in a human monocytic cell line.
J. López-Guerrero (1989)
HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions
Y. Zhang (2015)
SUF12 suppressor protein of yeast. A fusion protein related to the EF-1 family of elongation factors.
P. G. Wilson (1988)
The levels of yeast gluconeogenic mRNAs respond to environmental factors.
J. J. Mercado (1994)
Translation of brain messenger ribonucleic acids in homologous, heterologous and mixed cell free systems
M. Murthy (1983)
Heat sensitivity and protein synthesis during heat-shock in the tobacco hornworm,Manduca sexta
C. M. Fittinghoff (2004)
Heat shock protein synthesis and restriction fragment length polymorphism in a virulent and a weakly virulent strain of Leptosphaeria maculans
U. Chakraborty (1992)
Induced thermotolerance and expression of heat shock protein 70 in sea cucumber Apostichopus japonicus
Y. Dong (2009)
Cooperative Binding of Heat Shock Factor to the Yeast HSP82 Promoter In Vivo and In Vitro
A. M. Erkine (1999)
The expression of stress proteins in response to temperature extremes in insects
G. Yocum (1992)
HSP 70 gene expression in Trypanosoma cruzi is regulated at different levels
E. F. de Carvalho (1990)
Stress (heat shock) proteins and rheumatic disease
N. P. Hurst (2004)
Autoregulation of the Heat-Shock Response
S. Lindquist (1993)
Generation of an ilv bradytrophic phenocopy in yeast by antisense RNA
W. Xiao (2004)
reticulocytes . HSP 70 and globin synthesis in chicken Heat shock-induced translational control of
Sunandita S. Banerji ()
Differential Regulation of the 70 K Heat Shock Gene and Related Genes in Saccharomyces cerevisiae
Marian S. ELLWOODt ()
Messenger RNA degradation in Saccharomyces cerevisiae.
A. J. Brown (1988)See more