← Back to Search
The Protein Products Of The Myc And Myb Oncogenes And Adenovirus E1a Are Structurally Related
R. Ralston, J. Bishop
Published 1983 · Biology, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Structural and functional homologies have been found among proteins encoded by several retroviral oncogenes, demonstrating the existence of families of these genes1. Because the retroviral oncogenes have cellular homologues1,2, the existence of similar families among these ‘cellular oncogenes’ is also implied (for a review, see ref. 2). Cellular genes belonging to these families have been found in such evolutionarily distant species as humans3,4, fruit flies5,6, nematodes5 and brewer's yeast (E. Scolnick and S. Reed, personal communications), consistent with the hypothesis that these genes have evolved from a small number of ancestral sequences2. We extend these observations by showing here that the proteins encoded by the oncogenes myc, myb and adenovirus E1a are structurally related. Our findings suggest that oncogenes of RNA and DNA tumour viruses may in at least some instances share evolutionary origins and function according to common principles.
This paper references
Three loci related to the src oncogene and tyrosine-specific protein kinase activity in Drosophila
M. A. Simon (1983)
Transformation-defective mutant of adenovirus type 5 containing a single altered E1a mRNA species.
L. Carlock (1981)
How different amino acid sequences determine similar protein structures: the structure and evolutionary dynamics of the globins.
A. Lesk (1980)
DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster.
B. Shilo (1981)
Cold-sensitive expression of transformation by a host range mutant of type 5 adenovirus.
L. Babiss (1983)
Tertiary structural differences between microbial serine proteases and pancreatic serine enzymes
L. Delbaere (1975)
Expression of early adenovirus genes requires a viral encoded acidic polypeptide.
R. Ricciardi (1981)
Nuclear location of the putative transforming protein of avian myelocytomatosis virus
H. D. Abrams (1982)
Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.
D. Spector (1978)
Evolution of proteins formed by beta-sheets. II. The core of the immunoglobulin domains.
A. Lesk (1982)
Isolation of type 5 adenovirus mutants with a cold-sensitive host range phenotype: genetic evidence of an adenovirus transformation maintenance function.
Y. S. Ho (1982)
Identification of adenovirus-type 12 gene products involved in transformation and oncogenesis.
H. Jochemsen (1982)
Identification of human adenovirus early region 1 products by using antisera against synthetic peptides corresponding to the predicted carboxy termini.
S. Yee (1983)
RNA tumor viruses
R. Weiss (1982)
Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant
R. Wierenga (1983)
Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus
P. Donner (1982)
Tests for comparing related amino-acid sequences. Cytochrome c and cytochrome c 551 .
A. McLachlan (1971)
Empirical predictions of protein conformation.
P. Chou (1978)
Structure of two adenovirus type 12 transforming polypeptides and their evolutionary implications
M. Perricaudet (1980)
Cloning and characterization of different human sequences related to the onc gene (v-myc) of avian myelocytomatosis virus (MC29).
R. Dalla‐Favera (1982)
Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: The architecture of a transduced oncogene
Karl-Heinz Klempnauer (1982)
Nucleotide sequence to the v-myc oncogene of avian retrovirus MC29.
K. Alitalo (1983)
Transformation-deficient adenovirus mutant defective in expression of region 1A but not region 1B.
D. Solnick (1982)
Up with the times
M. Rowan-Robinson (1983)
Localization of the adenovirus E1Aa protein, a positive-acting transcriptional factor, in infected cells infected cells.
L. Feldman (1983)
Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells
N. Jones (1979)
Similar amino acid sequences: chance or common ancestry?
R. Doolittle (1981)
DNA tumor viruses
J. Tooze (1982)
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
H. Ruley (1983)
Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses
M. Perricaudet (1979)
Cellular oncogenes and retroviruses.
J. Bishop (1983)
Comparative model-building of the mammalian serine proteases.
J. Greer (1981)
Atlas of protein sequence and structure
M. A. Chang (1965)
Nucleotide sequence analysis of the chicken c-myc gene reveals homologous and unique coding regions by comparison with the transforming gene of avian myelocytomatosis virus MC29, delta gag-myc.
D. Watson (1983)
The taxonomy of protein structure.
M. Rossmann (1977)
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
H. Land (1983)
Homology among DNA-binding proteins suggests use of a conserved super-secondary structure
R. Sauer (1982)
Splice junctions: association with variation in protein structure.
C. Craik (1983)
This paper is referenced by
Complementation of transforming domains in E1a/myc chimaeras
R. Ralston (1991)
Fruit flies, yeasts, and onc genes: developmental biology and cancer research come together.
A. Levine (1984)
Cellular transformation by avian viruses.
D. Makowski (1985)
A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products
E. Morán (1988)
The regulation and expression of c-myc in normal and malignant cells.
K. Kelly (1986)
PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis
Jay R Radke (2018)
Sensitizes Cells to Macrophage Nitric Caspase-2-Mediated Mitochondrial Injury E1A Oncogene Enhancement of
J. L. Cook (2013)
The myc family of nuclear proto-oncogenes.
W. M. Lee (1989)
Structure and expression of B-myc, a new member of the myc gene family.
S. Ingvarsson (1988)
Altered protein glycosylation of rat 3Y1 cells induced by activated c‐myc gene
S. Hiraizumi (1991)
E1A Oncogene Enhancement of Caspase-2-Mediated Mitochondrial Injury Sensitizes Cells to Macrophage Nitric Oxide-Induced Apoptosis1
Jay R Radke (2008)
Properties of rat cells transformed by DNA plasmids containing adenovirus type 12 E1 DNA or specific fragments of the E1 region: comparison of transforming frequencies.
P. Gallimore (1985)
The pathogenesis of Burkitt's lymphoma.
I. Magrath (1990)
Oxide-Induced Apoptosis Sensitizes Cells to Macrophage Nitric Caspase-2-Mediated Mitochondrial Injury
Jay R Radke (2008)
Theoretical molecular biology: prospectives and perspectives.
R. Nussinov (1987)
Analysis of Proto-oncogene Expression During Liver Regeneration and Hepatocarcinogenesis
N. Fausto (1987)
Oncogenes in retroviruses and cells: biochemistry and molecular genetics.
K. Bister (1986)
Transient activation of c-myc protooncogene expression in Leydig cells by human chorionic gonadotropin.
T. Lin (1988)
Expression of the c-myb oncogene in human small cell lung carcinoma.
C. Griffin (1985)
Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals
E. Keath (1984)
Perspectives on clonogenic tumor cells, stem cells, and oncogenes.
R. Buick (1984)
Gene regulation: Repression of activators
A. Velcich (1984)
Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation.
H. Persson (1984)
Oncogenes: molecular probes for clinical application in malignant diseases.
R. Ascione (1986)
Definition of a region required for transformation in E1a of adenovirus 12.
M. Murphy (1987)
Adenovirus Gene Products that Affect Host Immune Mechanisms
P. R. Flomenberg (1989)
Sindbis virus infection increases hexose transport in quiescent cells.
R. Garry (1986)
Expression of MHC genes in adenovirus-tranformed cells
R. Vaessen (1984)
Oncogenes, suppressor genes, and carcinogenesis.
C. Willman (1987)
Structure and function of the genome of HTLV.
W. Haseltine (1985)
Increased proto-oncogene expression in peripheral blood lymphocytes from patients with systemic lupus erythematosus and other autoimmune diseases.
D. Boumpas (1986)
Regulation of heat shock protein 70 gene expression by c-myc
R. Kingston (1984)See more