Online citations, reference lists, and bibliographies.
← Back to Search

Cytotoxic T Lymphocytes And Glucocorticoids Activate An Endogenous Suicide Process In Target Cells

D. Ucker
Published 1987 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Cytotoxic T lymphocytes (CTL) induce a cytolytic process in target cells which, like the glucocorticoid-mediated cytolysis of immature thymocytes, effects a rapid and characteristic degradation of chromosomal DNA. I have explored the possibility that these two lethal processes share a common pathway by studying the suscepti-bility of glucocorticoid-resistant mutants to CTL-mediated killing. Here, I report that an unusual thymoma mutant, which has normal hormone receptor activity, is resistant to both glucocorticoids and CTL. The failure to be killed by CTL is not due to an inability of this 'deathless' mutant to be recognized. Further, a single-step reversion can restore sensitivity to both glucocorticoids and CTL. The genetic locus thus identified may reveal one element of an endogenous suicide pathway that can be triggered by different effectors. Unlike complement-mediated lysis, the processes of glucocorticoid- and CTL-mediated cytolysis seem to require that target cells be active in their own death.

This paper is referenced by
prevents apoptosis in mature human eosinophils Analysis of the survival of mature human eosinophils: interleukin-5
Yuji Yamaguchi (2011)
An sem analysis of the interaction between lymphokine‐activated killer cells and tumor targets
G. Arancia (1989)
Follicular dendritic cells and apoptosis: Life and death in the germinal centre
E. Lindhout (1995)
Anti-CD3 antibody-induced activated killer cells subsets of killer cells that mediate fast or slow lytic reactions.
C. Ting (1990)
Nerve growth factor suppresses apoptosis of murine neutrophils.
Y. Kannan (1992)
Increase in intracellular Ca(2+) concentrations and the corresponding intracellular acidification are early steps for induction of apoptosis by geranylgeraniol in HL60 cells.
Y. Masuda (2007)
Immunoregulatory placental functions in normal and pathological pregnancies.
G. Chaouat (1988)
Cellular turnover at the chondro‐osseous junction of growth plate cartilage: Analysis by serial sections at the light microscopical level
C. Farnum (1989)
Peptides from the N-terminal end of bovine lactoferrin induce apoptosis in human leukemic (HL-60) cells.
M. K. Roy (2002)
Enhanced expression of Fas ligand is associated with aburatubolactam C-induced apoptosis in human Jurkat T cells.
M. A. Bae (1998)
Transfection of a T-cell line with neo increases dexamethasone cytotoxicity.
F. de Cuevillas (1990)
Follicular dendritic cells and apoptosis: Life and death in the germinal centre
E. Lindhout (2004)
Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress.
D. McConkey (1988)
A review on biomolecular basis of the role of psychological stress in the development and progression of cancer
M. E. Sobhani (2010)
Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL.
M. H. Jang (2002)
Glucocorticoid-induced apoptosis.
C. Distelhorst (1997)
An endonuclease responsible for apoptosis.
S. Tanuma (1996)
Liver disease in the alcoholic.
C. Leevy (1993)
Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils.
Y. Yamaguchi (1991)
Apoptotic cell death during renal transplant rejection.
D. Gouldesbrough (1990)
Fas ligand, death gene
MJ Pinkoski (1999)
Cell death induced by topoisomerase inhibitors. Role of calcium in mammalian cells.
R. Bertrand (1991)
Primary central nervous system lymphomas—an update
K. Jellinger (2005)
A Differential Molecular Biology Search for Genes Preferentially Expressed in Functional T Lymphocytes: The CTLA Genes
J. Brunet (1988)
Dexamethasone and suramin inhibit cell proliferation and interleukin-6-mediated immunoglobulin secretion in human lymphoid and multiple myeloma cell lines.
R. T. Shiao (1995)
Cytoprotective effect of 2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone (CMEP-NQ) is mediated by the inhibition of BAK-dependent mitochondrial apoptosis pathway
D. Jun (2018)
How do cytotoxic T lymphocytes work in vivo?
A. Mullbacher (1987)
Cyclosporin A renders target cells resistant to immune cytolysis
S. D. Hudnall (1991)
Chapter 2 Glucocorticoids, hippocampal damage and the glutamatergic synapse
R. M. Sapolsky (1990)
Novel histopathologic findings in a surviving case of hemolytic uremic syndrome after bone marrow transplantation.
M. Arends (1989)
Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the rat
Y. Li (1998)
Distribution of lymphocyte subtypes in liver transplant recipients.
N. Rayes (1997)
See more
Semantic Scholar Logo Some data provided by SemanticScholar