Online citations, reference lists, and bibliographies.
← Back to Search

Deficiency Of A Glycoprotein Component Of The Dystrophin Complex In Dystrophic Muscle

J. Ervasti, K. Ohlendieck, S. Kahl, M. Gaver, K. Campbell
Published 1990 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Dystrophin, the protein encoded by the Duchenne muscular dystrophy (DMD) gene, exists in a large oligomeric complex. We show here that four glycoproteins are integral components of the dystrophin complex and that the concentration of one of these is greatly reduced in DMD patients. Thus, the absence of dystrophin may lead to the loss of a dystrophin-associated glycoprotein, and the reduction in this glycoprotein may be one of the first stages of the molecular pathogenesis of muscular dystrophy.
This paper references
10.1016/0022-510X(85)90103-0
Lectin blotting of human muscle: Identification of a high molecular weight glycoprotein which is absent or altered in Duchenne muscular dystrophy
M. J. Capaldi (1985)
10.1038/227680A0
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
U. Laemmli (1970)
Biochim. biophys
N Alloislo (1985)
10.1016/0092-8674(88)90503-X
α-actinins and the DMD protein contain spectrin-like repeats
M. Davison (1988)
Evidence for the association of dystrophin with the transverse tubular system in skeletal muscle.
C. Knudson (1988)
10.1172/JCI110275
Deficiency of skeletal membrane protein band 4.1 in homozygous hereditary elliptocytosis. Implications for erythrocyte membrane stability.
G. Tchernia (1981)
Erythrocyte membranes 2. Recent clinical and experimental advances. Proceedings of the second workshop, Ann Arbor, Michigan, September 28, 1980.
W. C. Kruckeberg (1981)
10.1038/335735A0
Increased protein degradation results from elevated free calcium levels found in muscle from mdx mice
P. R. Turner (1988)
10.1016/0092-8674(88)90383-2
The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein
M. Koenig (1988)
Hereditary elliptocytosis and related disorders.
J. Palek (1985)
10.1083/JCB.96.4.1008
Purification of morphologically intact triad structures from skeletal muscle
R. Mitchell (1983)
10.1016/0022-510X(84)90114-X
Altered binding of Ricinus communis I lectin by muscle membranes in Duchenne muscular dystrophy
M. J. Capaldi (1984)
10.1038/334154A0
The homologue of the Duchenne locus is defective in X-linked muscular dystrophy of dogs
B. Cooper (1988)
10.1038/337176A0
Conversion of mdx myofibres from dystrophin-negative to -positive by injection of normal myoblasts
T. Partridge (1989)
Brother/sister pairs affected with early-onset, progressive muscular dystrophy: molecular studies reveal etiologic heterogeneity.
U. Francke (1989)
10.1002/ANA.410200109
Membrane defects in duchenne dystrophy: Protease affecting sarcoplasmic reticulum
B. Nagy (1986)
Characterization of the 1,4-dihydropyridine receptor using subunit-specific polyclonal antibodies. Evidence for a 32,000-Da subunit.
A. Sharp (1989)
10.1007/BF00278857
Analysis of the red cell membrane in a family with hereditary elliptocytosis — total or partial of protein 4.1
N. Alloisio (2004)
Identification and characterization of the high affinity [3H]ryanodine receptor of the junctional sarcoplasmic reticulum Ca2+ release channel.
K. Campbell (1987)
10.1038/338259A0
Association of dystrophin and an integral membrane glycoprotein
K. Campbell (1989)
10.1016/0092-8674(87)90579-4
Dystrophin: The protein product of the duchenne muscular dystrophy locus
E. Hoffman (1987)
10.1038/333466A0
The Duchenne muscular dystrophy gene product is localized in sarcolemma of human skeletal muscle
E. Zubrzycka-Gaarn (1988)
Purified ryanodine receptor from skeletal muscle sarcoplasmic reticulum is the Ca2+-permeable pore of the calcium release channel.
T. Imagawa (1987)
10.1016/0005-2736(85)90392-X
Red cell membrane sialoglycoptein β in homozygous and heterozygous 4.1(−) hereditary elliptocytosis
N. Alloisio (1985)
10.1002/CM.970090208
A monoclonal antibody to the Ca2+-ATPase of cardiac sarcoplasmic reticulum cross-reacts with slow type I but not with fast type II canine skeletal muscle fibers: an immunocytochemical and immunochemical study.
A. O. Jorgensen (1988)
10.1002/AJMG.1320320328
Estimate of the proportion of Duchenne muscular dystrophy with autosomal recessive inheritance.
M. Zatz (1989)
10.1002/ANA.410040205
Duchenne dystrophy: Focal alterations in the distribution of concanavalin a binding sites at the muscle cell surface
E. Bonilla (1978)
10.1016/0092-8674(88)90065-7
Duchenne muscular dystrophy: Deficiency of dystrophin at the muscle cell surface
E. Bonilla (1988)
10.1038/333863A0
Immunoelectron microscopic localization of dystrophin in myofibres
Simon C Watkins (1988)
10.1056/NEJM198805263182104
Characterization of dystrophin in muscle-biopsy specimens from patients with Duchenne's or Becker's muscular dystrophy.
E. Hoffman (1988)
10.1111/j.1471-4159.1987.tb05584.x
Monoclonal Antibodies Against the Voltage‐Sensitive Sodium Channel from Rat Skeletal Muscle: Mapping Antibody Binding Sites
J. Casadei (1987)
10.1038/333861A0
Immunostaining of skeletal and cardiac muscle surface membrane with antibody against Duchenne muscular dystrophy peptide
K. Arahata (1988)
10.1128/JVI.62.9.3474-3483.1988
Use of synthetic peptides to map the antigenic determinants of glycoprotein D of herpes simplex virus.
N. Strynadka (1988)



This paper is referenced by
10.1038/nature01573
Defective membrane repair in dysferlin-deficient muscular dystrophy
Dimple Bansal (2003)
10.1083/jcb.201212142
Cellular and molecular mechanisms underlying muscular dystrophy
F. Rahimov (2013)
10.1016/0960-8966(94)90068-X
Dystrophin-deficient myofibers are vulnerable to mast cell granule-induced necrosis
J. R. Gorospe (1994)
10.1016/0022-510X(93)90191-Z
Abnormal localization of laminin subunits in muscular dystrophies
Y. Hayashi (1993)
10.1016/0006-291X(92)90242-D
Alterations of protein degradation and 2-D protein pattern in muscle cells of MDX and DMD origin.
A. Kaemper (1992)
10.1007/BF00869001
Prednisone can protect against exercise-induced muscle damage
S. J. Jacobs (2004)
10.1111/j.1440-1681.2006.04393.x
MECHANOSENSITIVE ION CHANNELS IN SKELETAL MUSCLE: A LINK IN THE MEMBRANE PATHOLOGY OF MUSCULAR DYSTROPHY
J. Lansman (2006)
10.1074/jbc.272.45.28771
Dystrophin-Glycoprotein Complex Is Monomeric and Stabilizes Actin Filaments in Vitro through a Lateral Association*
I. N. Rybakova (1997)
10.1016/S0005-2736(97)00283-6
Oligomerization of beta-dystroglycan in rabbit diaphragm and brain as revealed by chemical crosslinking.
D. M. Finn (1998)
10.1007/s100720050054
Functional roles of dystrophin and of associated proteins. New insights for the sarcoglycans
R. Betto (1999)
10.1385/JMN:17:1:71
Dysferlin protein analysis in limb-girdle muscular dystrophies
M. Vainzof (2007)
10.1016/S0968-0004(00)01731-X
The complexities of dystroglycan.
S. Winder (2001)
10.1016/J.IJOM.2007.04.002
Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma.
A. Lyons (2007)
10.1007/s10974-009-9197-6
Proteomic profiling of x-linked muscular dystrophy
C. Lewis (2009)
10.1093/HMG/4.7.1163
A common missense mutation in the adhalin gene in three unrelated Brazilian families with a relatively mild form of autosomal recessive limb-girdle muscular dystrophy.
M. R. Bueno (1995)
10.1002/jcb.22581
Characterization of an Importin α/β‐recognized nuclear localization signal in β‐dystroglycan
Bárbara Lara-Chacón (2010)
A new model for the dystrophin associated protein complex in striated muscles
Eric K Johnson (2012)
Isolation of primary myoblasts and characterization of the endoplasmic reticulum stress response in wild-type and mdx mice
Yuk Wah Kwok (2014)
10.1161/01.CIR.90.1.369
Utrophin Localization in Normal and Dystrophin‐Deficient Heart
F. Pons (1994)
10.1093/BRAIN/119.6.1895
Clinical and molecular analysis of a large family with three distinct phenotypes of progressive muscular dystrophy.
S. Illarioshkin (1996)
10.1091/MBC.01-09-0446
Utrophin binds laterally along actin filaments and can couple costameric actin with sarcolemma when overexpressed in dystrophin-deficient muscle.
I. N. Rybakova (2002)
10.1051/medsci/201733s116
Muscle Membrane Serendipity conference : Past, Present, and Future Conference - 20-23 juillet 2017, Iowa City
V. Allamand (2017)
10.1038/352815A0
Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs
G. Acsadi (1991)
10.1016/j.ajpath.2015.03.017
Restoration of Functional Glycosylation of α-Dystroglycan in FKRP Mutant Mice Is Associated with Muscle Regeneration.
Hiroyuki Awano (2015)
10.1212/WNL.0000000000001519
Clinical and genetic spectrum in limb-girdle muscular dystrophy type 2E
C. Semplicini (2015)
10.1002/jcb.25218
Localization of α‐Dystrobrevin in Cajal Bodies and Nucleoli: A New Role for α‐Dystrobrevin in the Structure/Stability of the Nucleolus
Hernández-Ibarra Jose Anselmo (2015)
10.1186/s13395-020-00244-3
High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy
Cynthia Shu (2020)
10.1016/0014-5793(95)01176-F
Direct binding of Torpedo syntrophin to dystrophin and the 87 kDa dystrophin homologue
Timothy M. Dwyer (1995)
10.1074/JBC.271.7.3817
Differential Heparin Inhibition of Skeletal Muscle -Dystroglycan Binding to Laminins (*)
E. A. Pall (1996)
10.1203/00006450-199609000-00013
Wheat Kernel Ingestion Protects from Progression of Muscle Weakness in mdx Mice, an Animal Model of Duchenne Muscular Dystrophy
C. Hübner (1996)
10.1074/jbc.M110.178988
A Dystroglycan/Plectin Scaffold Mediates Mechanical Pathway Bifurcation in Lung Epithelial Cells*
Desire Takawira (2010)
10.1023/A:1018627705273
REVIEW: The membrane--cytoskeleton interface: the role of dystrophin and utrophin
S. Winder (2004)
See more
Semantic Scholar Logo Some data provided by SemanticScholar