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A Gene Mapping To The Sex-determining Region Of The Mouse Y Chromosome Is A Member Of A Novel Family Of Embryonically Expressed Genes

J. Gubbay, J. Collignon, P. Koopman, B. Capel, A. Economou, A. Münsterberg, N. Vivian, P. Goodfellow, R. Lovell-Badge
Published 1990 · Biology, Medicine

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A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.
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