← Back to Search
From Bench To Clinic With Apoptosis-based Therapeutic Agents
Published 2000 · Medicine
Download PDFAnalyze on Scholarcy
A retrospective look at the basis of human disease pathogenesis almost always reveals an apoptotic component that either contributes to disease progression or accounts for it. What makes this field particularly exciting is the breadth of therapeutic opportunities that are on offer. The pace of apoptosis research has raised expectations that therapeutics will follow soon. But many of the organizations that are best placed to take advantage of these discoveries consider the ability to modulate the life or death of a cell for the purpose of disease treatment as perhaps being 'too good to be true'. Nevertheless, practical therapeutics that modulate apoptosis will no doubt appear in the clinic or on the shelf in the next few years.
This paper references
Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors*
M. García-Calvo (1998)
Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein
Adita M. Vocero-Akbani (1999)
Steering anti-cancer drugs away from the TRAIL
S. Nagata (2000)
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
M. Muzio (1996)
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells.
J. L. Wang (2000)
A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
Nancy A. Thornberry (1992)
Peptidomimetic Fluoromethylketone Rescues Mice from Lethal Endotoxic Shock
Stephen R. Grobmyer (1999)
Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.
S. Hymowitz (1999)
TRAIL receptor-2 signals apoptosis through FADD and caspase-8
J. Bodmer (2000)
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
M. Boldin (1996)
TRAIL: a molecule with multiple receptors and control mechanisms.
T. Griffith (1998)
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
N. Thornberry (1997)
Apo 2 L / TRAIL - dependent recruitment of endogenous FADD and caspase - 8 to death receptors 4 and 5
M. R. Sprick (2000)
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
J. Yuan (1993)
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
Y. Goldberg (1996)
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
M. Jo (2000)
Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation.
M. Daemen (1999)
Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma.
J. Waters (2000)
Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice.
H. Schlagbauer-Wadl (2000)
Caspase inhibition reduces apoptosis and increases survival of nigral transplants
G. Schierle (1999)
Control of apoptosis signaling by Apo2 ligand.
S. Marsters (1999)
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
F. Gervais (1999)
Molecular determinants of response to TRAIL in killing of normal and cancer cells.
K. Kim (2000)
Bcl - 2 antisense plus dacarbazine therapy for malignant melanoma
B. Jansen (2000)
death gene ced - 3 encodes a protein similar to mammalian interleukin - 1 b - converting enzyme
D. W. Nicholson (1993)
A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice.
A. Farber (1999)
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.
F. Kischkel (2000)
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
K. Kuida (1996)
Neuroprotection by a caspase inhibitor in acute bacterial meningitis
J. Braun (1999)
Cholangiocarcinomas express fas ligand and disable the fas receptor
F. Que (1999)
Splicing and dicing apoptosis genes
John Calvin Reed (1999)
p53 mutations in human cancers.
M. Hollstein (1991)
Human ICE/CED-3 Protease Nomenclature
E. Alnemri (1996)
A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis
R. Cursio (1999)
Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury
M. Mocanu (2000)
Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation
F. Gervais (1999)
Caspase structure, proteolytic substrates, and function during apoptotic cell death
Dw Nicholson (1999)
Regulation of lymphocyte survival by the bcl-2 gene family.
S. Cory (1995)
Mammalian caspases: structure, activation, substrates, and functions during apoptosis.
W. Earnshaw (1999)
Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury
A. Yakovlev (1997)
Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo
H. Walczak (1999)
Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family
M. Endres (1998)
Apoptosis induced by death receptors.
P. Schneider (2000)
The Bcl-2 protein family: arbiters of cell survival.
J. Adams (1998)
Intracerebral injection of caspase-3 inhibitor prevents neuronal apoptosis after kainic acid-evoked status epilepticus.
A. Kondratyev (2000)
The Apo 2 L / TRAIL system : therapeutic opportunities
S. Nagata (2000)
Differential Localization and Regulation of Death and Decoy Receptors for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Human Melanoma Cells1
X. Zhang (2000)
Death receptors: signaling and modulation.
A. Ashkenazi (1998)
Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model.
M. Li (2000)
Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats
I. Sánchez (1999)
Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site
R. Takimoto (2000)
Prevention of lymphocyte cell death in sepsis improves survival in mice.
R. Hotchkiss (1999)
A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.
S. Hymowitz (2000)
bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
Burkhard Jansen (1998)
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
D. Nicholson (1995)
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.
M. Sprick (2000)
Molecular cloning of the interleukin-1 beta converting enzyme.
D. Cerretti (1992)
Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality*
D. Lee (2000)
A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells.
U. Zangemeisterwittke (2000)
Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides
J. Taylor (1999)
Bcl-2 family proteins
John Calvin Reed (1998)
Cell death attenuation by `Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex
D. Rasper (1998)
Safety and antitumor activity of recombinant soluble Apo2 ligand.
A. Ashkenazi (1999)
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
D. Veis (1993)
Mechanisms and functions of cell death.
R. Ellis (1991)
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
M. Thome (1997)
This paper is referenced by
Revisiting the conversion of muscle into meat and the underlying mechanisms.
A. Ouali (2006)
The saintly side of Smac/DIABLO: giving anticancer drug-induced apoptosis a boost
C. R. Arnt (2003)
Two mechanisms of caspase 9 processing in double-stranded RNA- and virus-triggered apoptosis
M. Iordanov (2005)
Analyse de l'expression de la caspase-3 et de son transcrit alternatif caspase-3s dans le cancer du sein
F. Végran (2005)
Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa.
S. Corrochano (2008)
Structural Perspectives on BCL-2 Family of Proteins
E. Gavathiotis (2014)
University of Groningen Apoptosis and colorectal cancer . Studies on pathogenesis and potential therapeutic targets
J. Koornstra (2006)
Scalable asymmetric synthesis of a key fragment of Bcl-2/Bcl- xL inhibitors
Sylvain Laclef (2014)
Phototherapy-Induced Antitumor Immunity: Long-Term Tumor Suppression Effects via Photoinactivation of Respiratory Chain Oxidase-Triggered Superoxide Anion Burst.
Cuixia Lu (2016)
Luminescent lanthanide reporters: new concepts for use in bioanalytical applications.
Johanna Vuojola (2014)
WORMS , LIFE AND DEATH
R. Horvitz (2002)
Differential sensitivity of murine myeloid FDC-P1 cells and apoptosis resistant mutant(s) to anticancer drugs.
N. Singh (2001)
Apoptosis and cell death channels in prostate cancer.
J. V. Tapia-Vieyra (2001)
Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin
A. Berezov (2012)
Study of CAPE effect on apoptosis induction in AGS human gastric cancer cell line
Nematallah Amini-Sarteshnizi (2016)
Knockdown of long non-coding RNA linc00511 suppresses proliferation and promotes apoptosis of bladder cancer cells via suppressing Wnt/β-catenin signaling pathway
J. Li (2018)
Explorer Why is apoptosis important to clinicians ?
Cyclopalladated compounds containing 2,6-lutidine: Synthesis, spectral and biological studies.
Gislaine A da Cunha (2019)
Cancer Cell International Rel/nuclear Factor-kappa B Apoptosis Pathways in Human Cervical Cancer Cells Cervical Cancerhela Cellsnf-κbxrel3cisplatinapoptosisanti-apoptosis
Marlene Shehata ()
Alpinia pricei rhizome extracts induce apoptosis of human carcinoma KB cells via a mitochondria-dependent apoptotic pathway.
H. Yang (2008)
Expression of livin in gastric cancer and induction of apoptosis in SGC-7901 cells by shRNA-mediated silencing of livin gene.
T-S Wang (2010)
Effects of the Herbal Medicine in Animal Models for Treatment of Sciatic Nerve Impairment: A Review of Animal Study Reports
C. Lee (2016)
Fault Diagnosis Engineering of Digital Circuits Can Identify Vulnerable Molecules in Complex Cellular Pathways
A. Abdi (2008)
Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade.
K. Watanabe (2012)
Redox regulation in plant programmed cell death.
M. D. de Pinto (2012)
Advances in the non-surgical treatment of melanoma
P. Hersey (2002)
Vida y muerte de la célula: las señales intracelulares
M. Costas (2006)
Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents.
Y. Peng (2012)
Death Domain Interactions in Death Receptor Signaling
M. L. Bender (2005)
Role of caspases in male infertility.
T. Said (2004)
Nitric Oxide—Releasing NSAIDs
S. Fiorucci (2001)
Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells
Q. He (2002)See more