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Histamine Regulates T-cell And Antibody Responses By Differential Expression Of H1 And H2 Receptors

M. Jutel, Takeshi Watanabe, S. Klunker, M. Akdis, O. Thomet, J. Małolepszy, T. Żak-Nejmark, R. Koga, Takashi Kobayashi, K. Blaser, C. Akdis
Published 2001 · Biology, Medicine

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Many pathological processes, including those causing allergies and autoimmune diseases, are associated with the presence of specialized subsets of T helper cells (TH1 and TH2) at the site of inflammation. The diversity of TH1 and TH2 function is not predetermined but depends on signals that drive the cells towards either subset. Histamine, released from effector cells (mast cells and basophils) during inflammatory reactions can influence immune response. Here we report that histamine enhances TH1-type responses by triggering the histamine receptor type 1 (H1R), whereas both TH1- and TH2-type responses are negatively regulated by H2R through the activation of different biochemical intracellular signals. In mice, deletion of H1R results in suppression of interferon (IFN)-γ and dominant secretion of TH2 cytokines (interleukin (IL)-4 and IL-13). Mutant mice lacking H2R showed upregulation of both TH1 and TH2 cytokines. Relevant to T-cell cytokine profiles, mice lacking H1R displayed increased specific antibody response with increased immunoglobulin-ε (IgE) and IgG1, IgG2b and IgG3 compared with mice lacking H2R. These findings account for an important regulatory mechanism in the control of inflammatory functions through effector-cell-derived histamine.
This paper references
A method for sexing living Fulmars in the hand
G. M. Dunnet (1961)
The Geographical Variation of the Fulmar (Fulmarus glacialis) and the Zones of Marine Environment in the North Atlantic
F. Salomonsen (1965)
Selective display of histamine receptors on lymphocytes.
W. Roszkowski (1977)
Nest failures in the Fulmar : the effect of observers
J. C. Ollason (1980)
The role of cyclic AMP in modulating cytotoxic T lymphocytes. II. Sequential changes during culture in responsiveness of cytotoxic lymphocytes to cyclic AMP-active agents.
M. Plaut (1983)
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
T. Mosmann (1986)
Histamine modulation of lymphocyte biology: membrane receptors, signal transduction, and functions.
Beer Dj (1987)
Histamine modulation of lymphocyte biology: membrane receptors, signal transduction, and functions.
D. Beer (1987)
Protective immunity and eosinophilia in IgE-deficient SJA/9 mice infected with Nippostrongylus brasiliensis and Trichinella spiralis.
N. Watanabe (1988)
cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells.
T. J. Novak (1990)
Expression cloning of a cDNA encoding the bovine histamine H1 receptor.
M. Yamashita (1991)
Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.
G. Del Prete (1991)
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma.
D. Robinson (1992)
Molecular basis for the interaction of histamine with the histamine H2 receptor.
I. Gantz (1992)
Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist.
E. Vannier (1993)
Molecular pharmacological aspects of histamine receptors.
R. Leurs (1995)
Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures.
M. Jutel (1995)
Effect of Wind on Field Metabolic Rates of Breeding Northern Fulmars
R. W. Furness (1996)
Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors.
I. Inoue (1996)
Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils
M. Jutel (1996)
cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes.
J. Bodor (1996)
Functional diversity of helper T lymphocytes
A. Abbas (1996)
Induction of NFAT-mediated Transcription by G-coupled Receptors in Lymphoid and Non-lymphoid Cells (*)
V. Boss (1996)
Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors
T. Akehikowatanabe (1996)
Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities.
A. Faith (1997)
Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells.
F. Sallusto (1997)
Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
C. S. Lantz (1998)
Role of interleukin 10 in specific immunotherapy.
C. Akdis (1998)
Population dynamics of large herbivores: variable recruitment with constant adult survival.
J. Gaillard (1998)
Long-term changes in zooplankton and the climate of the North Atlantic
B. Planque (1998)
The role of IL - 10 in speci ® c immunotherapy
C. A. Akdis (1998)
The role of IL - 10 in speci ® c immunotherapy
C. A. Akdis (1998)
E. Post (1999)
Augmentation of Antigen Receptor–mediated Responses by Histamine H1 Receptor Signaling
Yasmin Banu (1999)
Estimating the contributions of population density and climatic fluctuations to interannual variation in survival of Soay sheep
J. M. Milner (1999)
Induction and regulation of the IgE response
D. Corry (1999)
IL‐10‐induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy
C. Akdis (1999)
Expansion of a grey seal ( Halichoerus grypus ) breeding colony: changes in pupping site use at the Isle of May, Scotland
P. Pomeroy (2000)
Role of histamine H1 receptor in pain perception: a study of the receptor gene knockout mice
Jalal Izadi Mobarakeh (2000)
Fisheries: Climate variability and North Sea cod
C. O'Brien (2000)
Population dynamical consequences of climate change for a small temperate songbird.
B. Saether (2000)
Development of Th1-type immune responses requires the type I cytokine receptor TCCR
Q. Chen (2000)
Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice.
T. Kobayashi (2000)
A molecular basis for T cell suppression by IL‐10: CD28‐associated IL‐10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3‐kinase binding
C. Akdis (2000)
Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice.
J. I. Mobarakeh (2000)
Climate change causes contrasting trends in reproductive performance of planktivorous and piscivorous alcids
A. Kitaysky (2000)
Abnormal function and morphological regulation of the gastric mucosa in histamine H 2 receptor - de ® cient mice
T. Kobayashi (2000)

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