Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Cooperative Interaction Between C-myc And Bcl-2 Proto-oncogenes
A. Fanidi, E. A. Harrington, G. Evan
Published 1992 · Biology, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
THE bcl-2 proto-oncogene is activated by translocation in a variety of B-lymphoid tumours and synergizes with the c-myc oncogene in tumour progression1. The mechanism of synergy is unclear but bcl-2 expression inhibits apoptosis2–6, a property presumably pertinent to its proto-oncogenic mode of action4. We have shown that the c-myc gene is a potent inducer of apoptosis, in addition to its established role in mitogenesis7. Here we show that expression of the bcl-2 protein, Bcl-2, specifically abrogates c-mvoinduced apoptosis without affecting the c-myc mitogenic function. This provides a novel mechanism for oncogene cooperation, of potential importance both in carcinogenesis and in the evolution of drug resistance in tumours.
This paper references
Complementation by BCL2 and C-HA-RAS oncogenes in malignant transformation of rat embryo fibroblasts.
John Calvin Reed (1990)
Induction of apoptosis (programmed cell death) in tumour cell lines by widely diverging stimuli.
S. Lennon (1990)
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)
Timothy J. McDonnell (1991)
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
D. Hockenbery (1990)
Apoptosis: Cell death in tissue regulation
A. Wyllie (1987)
Genetic mechanisms of drug resistance. A review.
P. Borst (1991)
DNA topoisomerase poisons as antitumor drugs.
L. Liu (1989)
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
D. Vaux (1988)
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
A. Strasser (1991)
Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.
D. Askew (1991)
The MYC protein activates transcription of the alpha‐prothymosin gene.
M. Eilers (1991)
Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells
M. Eilers (1989)
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
C. Sentman (1991)
Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.
F. Pezzella (1990)
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
A. Strasser (1990)
Studies on the interaction of the human c-myc protein with cell nuclei: p62c-myc as a member of a discrete subset of nuclear proteins
G. Evan (1985)
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line.
J. Morgenstern (1990)
Control of c-myc regulation in normal and neoplastic cells.
C. Spencer (1991)
Structure and polymorphism of human telomere-associated DNA
W. Brown (1990)
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
H. Land (1983)
The biochemistry of cell death by apoptosis.
W. Bursch (1990)
Induction of apoptosis in fibroblasts by c-myc protein
G. Evan (1992)
This paper is referenced by
Selection for c-myc Integration Sites in Polyclonal T-Cell Lymphomas
D. R. Broussard (2002)
Evodiamine, a constituent of Evodiae Fructus, induces anti‐proliferating effects in tumor cells
Xiao Fei (2003)
The landscape of somatic copy-number alteration across human cancers
R. Beroukhim (2010)
Effect of insulin stimulation on the proliferation and death of Chinese hamster ovary cells.
A. Sanfeliu (2000)
Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase.
J. Zhao (2003)
Increased gap junctional intercellular communication is directly related to the anti‐tumor effect of all‐trans‐retinoic acid plus tamoxifen in a human mammary cancer cell line
C. Sáez (2003)
Apoptosis in the Embryo and Tumorigenesis
John H. Fetting (1995)
Apoptosis and Cancer
Fruma Yehiely (2000)
Elucidating the Mechanism by which KRI-1/CCM1 Regulates Apoptosis Cell Non-Autonomously in Caenorhabditis elegans
E. M. Chapman (2018)
Characterisation of the Fit-1 common integration locus.
Barr Ni (1999)
BCL-2 expression in childhood leukemia versus spontaneous apoptosis, drug induced apoptosis, and in vitro drug resistance.
E. Haarman (1999)
Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death
S. Mazel (1996)
CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry.
A. Yi (1998)
Cancer‐A matter of life and cell death
G. Evan (1997)
Lack of induction of tissue transglutaminase but activation of the preexisting enzyme in c-Myc-induced apoptosis of CHO cells.
Z. Balajthy (1997)
Autoimmunity due to defective Nur77, Fas, and TNF-RI apoptosis.
J. Mountz (1996)
Antisense oligonucleotides complementary to immunoglobulin sequences of BCL-2/immunoglobulin fusion transcript induce apoptosis of t(14;18) lymphoma cells.
M. Smith (2000)
Cell survival and death programmes.
V. Chiarugi (1994)
Cloning, characterization and expression of two Xenopus bcl-2-like cell-survival genes.
J. Cruz-Reyes (1995)
A link between the antioxidant defense system and calcium: a proposal for the biochemical function of Bcl-2.
G. Bornkamm (1995)
The MYC oncogene as a cancer drug target.
H. Hermeking (2003)
different sensitivity to glucocorticoid-induced apoptosis BCL-2 expression and mitochondrial activity in leukemic cells
LA Smets (2002)
BCL-2 as therapeutic target for hematological malignancies
G. Perini (2018)
Progress in the Molecular Medicine of Cancer
S. Broder (1995)
Bax is a transcriptional target and mediator of c-myc-induced apoptosis.
K. Mitchell (2000)
Interferon-alpha 2b and vesnarinone influence levels of tumor necrosis factor-alpha, apoptosis, or interleukin 6 in ESKOL, a hairy cell leukemic cell line. A potential cytokine and oncogene relationship regulating apoptosis is suggested.
Waleed F. Khalaf (2002)
Rapid induction of the intrinsic apoptotic pathway by L‐glutamine starvation
Julie C Paquette (2005)
Bcl-2 expression and glucocorticoid-induced apoptosis of leukemic and lymphoma cells.
L. Smets (1996)
bcl‐2 expression in normal breast tissue during the menstrual cycle
J. C. Sabourin (1994)
Bcl-2 Protein Expression inLungCancer and CloseCorrelation withNeuroendocrine Differentiation
Shi-Xu Jiang (1996)
The functions of Myc in cell cycle progression and apoptosis.
Philipp Hendrik Steiner (1996)
Role of c-myc in tamoxifen-induced apoptosis estrogen-independent breast cancer cells.
Y. Kang (1996)See more