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Lethal Effect Of The Anti-Fas Antibody In Mice

J. Ogasawara, R. Watanabe-Fukunaga, M. Adachi, A. Matsuzawa, T. Kasugai, Y. Kitamura, N. Itoh, T. Suda, S. Nagata
Published 1993 · Biology, Medicine

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DURING mammalian development, many cells are programmed to die1,2 most mediated by apoptosis3. The Fas antigen4 coded by the structural gene for mouse lymphoproliferation mutation (lpr)5,6, is a cell surface protein belonging to the tumour necrosis factor/nerve growth factor receptor family7,8, and mediates apoptosis7. The Fas antigen messenger RNA is expressed in the thymus, liver, heart, lung and ovary8. We prepared a monoclonal antibody against mouse Fas antigen, which immunoprecipitated the antigen (Mr 45K) and had cytolytic activity against cell lines expressing mouse Fas antigen. We report here that staining of mouse thymocytes with the antibody indicated that thymocytes from the wild-type and lpr cg mice expressed the Fas antigen, whereas little expression of the Fas antigen was found in lpr mice. Intraperitoneal administration of the anti-Fas antibody into mice rapidly killed the wild-type mice but neither lpr nor lpr cg mice. Biochemical, histological and electron microscope analyses indicated severe damage of the liver by apoptosis. These findings suggest that the Fas antigen is important in programmed cell death in the liver, and may be involved in fulminant hepatitis in some cases.
This paper references
10.1016/B978-0-12-462002-5.50008-X
Hepatitis B virus biology and pathogenesis.
F. Chisari (1992)
10.1002/0471142735
Current protocols in immunology
E. J. Coligan (1991)
10.1182/BLOOD.V79.12.3300.BLOODJOURNAL79123300
Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype.
M. H. Falk (1992)
Nephritogenicity of the lprcg gene on the MRL background.
M. Kimura (1992)
10.1016/0092-8674(91)90614-5
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
N. Itoh (1991)
10.1016/0003-2697(92)90165-4
Immunodetection of biotinylated lymphocyte-surface proteins by enhanced chemiluminescence: a nonradioactive method for cell-surface protein analysis.
T. Meier (1992)
10.1073/PNAS.90.5.1756
Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.
M. Adachi (1993)
10.1038/356314A0
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
R. Watanabe-Fukunaga (1992)
10.1126/SCIENCE.3764421
Shock and tissue injury induced by recombinant human cachectin.
K. Tracey (1986)
Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.
Y. Hirata (1989)
10.1084/JEM.169.5.1747
A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
S. Yonehara (1989)
10.1084/JEM.167.6.1987
Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice
A. Waage (1988)
10.1016/S0074-7696(08)62312-8
Cell death: the significance of apoptosis.
A. Wyllie (1980)
Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia.
M. Eskandari (1992)
10.1084/JEM.165.3.657
Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice
V. Lehmann (1987)
The genetic mapping of a defective LPS response gene in C3H/HeJ mice.
J. Watson (1978)
10.1038/356397A0
Social controls on cell survival and cell death
M. Raff (1992)
The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.
R. Watanabe-Fukunaga (1992)
10.1016/s0021-9258(19)50076-x
Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.
A. Oehm (1992)
Stable hamster-mouse hybridomas producing IgG and IgM hamster monoclonal antibodies of defined specificity.
F. Sánchez-Madrid (1983)
10.1016/0140-6736(90)90735-N
Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia
K-M. Debatin (1990)
10.1016/S0168-8278(88)80004-7
Preferential distribution of apoptotic bodies in acinar zone 3 of normal human and rat liver.
A. Benedetti (1988)
10.1126/SCIENCE.2787530
Monoclonal antibody-mediated tumor regression by induction of apoptosis.
B. Trauth (1989)
10.1084/JEM.177.1.195
Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity
E. Rouvier (1993)
10.1073/PNAS.87.24.9620
Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication.
N. Kobayashi (1990)
10.1146/ANNUREV.CB.07.110191.003311
Mechanisms and functions of cell death.
R. Ellis (1991)



This paper is referenced by
10.1038/cddis.2016.45
Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure
A. Komarov (2016)
10.1007/978-3-642-79437-7
Apoptosis in Immunology
G. Kroemer (1995)
Failure Via Induction of TNF-from Lipopolysaccharide-Induced Liver Adenoviral Infection Decreases Mortality
Hunninghake (2003)
10.1038/sj.cdd.4401870
Dissection of the NF-κB signalling cascade in transgenic and knockout mice
M. Pasparakis (2006)
10.1183/09031936.96.09061293
The role of apoptosis in the pathogenesis and treatment of diseases.
E. Solary (1996)
Improving the response to molecular targeting of the TRAIL death receptors in colon cancer cells
B. Pennarun (2010)
10.1201/9780203909508.CH4
Effector Cells and Mechanisms of the GVL Effect
Y. Jiang (2000)
Target cell-restricted triggering of the CD95 (APO-1/Fas) death receptor with bispecific antibody fragments.
G. Jung (2001)
10.1097/00024382-200205000-00004
The Atrial Natriuretic Peptide as a Regular of Kupffer Cell Functions
A. Kiemer (2002)
10.1161/01.CIR.0000018651.89208.69
Sensitivity to Apoptosis Signal, Clearance Rate, and Ultrastructure of Fas Ligand-Induced Apoptosis in In Vivo Adult Cardiac Cells
K. Hayakawa (2002)
10.1253/CIRCJ.66.1060
Oxidized low density lipoprotein potentiation of Fas-induced apoptosis through lectin-like oxidized-low density lipoprotein receptor-1 in human umbilical vascular endothelial cells.
T. Imanishi (2002)
10.1038/sj.gt.3302260
Simultaneous stimulation of Fas-mediated apoptosis and blockade of costimulation prevent autoimmune diabetes in mice induced by multiple low-dose streptozotocin
Y. Jin (2004)
10.1152/AJPLUNG.00120.2004
Fas/FasL-mediated apoptosis in perinatal murine lungs.
M. D. De Paepe (2004)
10.1358/DOF.2005.030.07.915915
Apoptosis-based therapies for hematological malignancies
A. Petronelli (2005)
10.3892/OR.15.2.409
mHFE7A, a newly identified monoclonal antibody to Fas, induces apoptosis in human melanoma cells in vitro and delays the growth of melanoma xenotransplants.
K. Hiramoto (2006)
This information is current as and Function in CTL The Regulation of CD 95 Ligand Expression
J. Li (1998)
10.1016/j.cell.2007.07.019
Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals
J. Dong (2007)
Inhibitor T Cells Is Unaffected by a Pan-Caspase + The Contraction Phase of Virus-Specific CD 8
A. Nussbaum (2004)
Fas Ligand-exprimierende humane dendritische Zellen zur Induktion von T-Zelltoleranz: Phänotypische und funktionelle Charakterisierung
S. Hoves (2004)
10.1080/10428190310001646879
Aggressive Natural Killer Cell Leukemia/Lymphoma: Case Report, use of Telesynergy™ and Review of the Literature
J. Murdock (2004)
Acaspase-activatedDNase that degradesDNA duringapoptosis , and its inhibitor ICAD
P. Thomas ()
10.1360/982005-744
Combination ofCTLA4-FasL gene transfer and allogeneic bone marrow transplantation led to durable macrochimerism and donor-specific tolerance in mouse model
Yougang Feng (2005)
10.1038/sj.bjc.6602516
Indomethacin-induced activation of the death receptor-mediated apoptosis pathway circumvents acquired doxorubicin resistance in SCLC cells
D. J. de Groot (2005)
10.1007/s10495-005-1055-4
The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
A. M. Elsharkawy (2005)
10.1152/AJPGI.00054.2005
Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole.
Y. Lu (2005)
10.1111/j.1462-5822.2006.00846.x
Systemic macrophage and neutrophil destruction by secondary necrosis induced by a bacterial exotoxin in a Gram‐negative septicaemia
A. do Vale (2007)
10.1016/S0083-6729(04)67016-6
Interferon-gamma and TRAIL in human breast tumor cells.
C. Ruiz de Almodóvar (2004)
Prostate Cancer Cells -related Apoptosis-inducing Ligand Pathway in α Factor Expression of Members of the Tumor Necrosis
Supriya Sridhar (2013)
10.1186/1476-8518-2-3
The effects of chemotherapeutics on cellular metabolism and consequent immune recognition
M. Newell (2004)
10.1016/S0002-9440(10)64404-5
Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-mediated apoptosis.
A. Ishigami (2002)
10.1016/j.ygyno.2012.07.125
Therapeutic targeting of the TNF superfamily: a promising treatment for advanced endometrial adenocarcinoma.
Shyam Thangaraju (2012)
10.1016/S0041-1345(02)03464-4
Reperfusion injury after warm ischemia or cold storage of the liver: role of apoptotic cell death.
H. Jaeschke (2002)
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