Online citations, reference lists, and bibliographies.
← Back to Search

DNA Microarrays In Drug Discovery And Development

C. Debouck, P. Goodfellow
Published 1999 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
DNA microarrays can be used to measure the expression patterns of thousands of genes in parallel, generating clues to gene function that can help to identify appropriate targets for therapeutic intervention. They can also be used to monitor changes in gene expression in response to drug treatments. Here, we discuss the different ways in which microarray analysis is likely to affect drug discovery.
This paper references
10.1097/00041552-199401000-00016
Human angiotensin receptor subtypes.
S. Rd (1994)
10.1038/360161A0
A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors
D. Oksenberg (1992)
10.1126/SCIENCE.281.5376.533
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
N. Gray (1998)
10.1074/jbc.271.21.12511
Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts (*)
F. Drake (1996)
Discovery and analysis of inflammatory diseaserelated genes using cDNA microarrays
R. A. Heller (1997)
10.1073/PNAS.92.25.11480
Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage.
X Wang (1995)
10.1016/S0006-291X(05)80288-8
Cloning and characterization of a human angiotensin II type 1 receptor.
D. Bergsma (1992)
10.1038/380243A0
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
D. Qu (1996)
10.1097/00041552-199401000-00016
Human angiotensin receptor subtypes.
R. Smith (1994)
Nature Biotechnol
A Persidis (1998)
10.1073/PNAS.94.6.2150
Discovery and analysis of inflammatory disease-related genes using cDNA microarrays.
R. Heller (1997)
10.1038/355632A0
Sequence identification of 2,375 human brain genes
M. Adams (1992)
10.1073/PNAS.95.21.12208
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.
G. Bertilsson (1998)
A single amino - acid difference confers major pharmacological variation between human and rodent 5 - HT 1 B receptors
D. Oksenberg (1992)
10.1073/PNAS.84.24.8903
Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor.
C. Debouck (1987)
10.1073/PNAS.93.20.10614
Parallel human genome analysis: microarray-based expression monitoring of 1000 genes.
M. Schena (1996)
10.1126/SCIENCE.278.5338.680
Exploring the metabolic and genetic control of gene expression on a genomic scale.
J. DeRisi (1997)
10.1038/4478
Gene expression informatics —it's all in your mine
D. Bassett (1999)
10.1016/0167-0115(96)88033-5
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
D. Qu (1996)
10.1128/JB.174.1.1-7.1992
Environmental signals controlling expression of virulence determinants in bacteria.
J. Mekalanos (1992)
The genetics of cancer — a 3 D model
K. A. Cole (1999)
10.1101/GR.6.6.492
Novel gene transcripts preferentially expressed in human muscles revealed by quantitative hybridization of a high density cDNA array.
G. Piétu (1996)
10.1038/4466
The genetics of cancer—a 3D model
K. Cole (1999)



This paper is referenced by
10.3745/KIPSTD.2010.17D.3.175
Applying Particle Swarm Optimization for Enhanced Clustering of DNA Chip Data
Minsoo Lee (2010)
10.1517/14728222.6.3.363
Functional genomics in neuropsychiatric disorders and in neuropharmacology
E. Castrén (2002)
10.1016/S0168-1656(02)00137-2
Bioinformatics methods for the analysis of expression arrays: data clustering and information extraction.
J. Tamames (2002)
10.1016/S0022-1759(01)00303-9
Analysis of cellular adhesion by microarray expression profiling.
V. Brenner (2001)
10.1109/CIBCB.2004.1393963
A/sup 4/C: an adaptive artificial ants clustering algorithm
X. Xu (2004)
10.1097/00005176-200210003-00002
Research Agenda for Pediatric Gastroenterology, Hepatology and Nutrition: Molecular Basis of Gastrointestinal Diseases: Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation
D. Perlmutter (2002)
10.1016/S0079-6468(08)70056-0
The impact of genomics on drug discovery.
L. J. Beeley (2000)
10.1016/j.bios.2008.07.005
Particle flow assays for fluorescent protein microarray applications.
Marta Bally (2009)
10.2144/05391RR01
Correlation between microarray DNA hybridization efficiency and the position of short capture probe on the target nucleic acid.
R. Peytavi (2005)
10.1093/BIB/2.4.329
Microarray Probe Selection Strategies
S. Tomiuk (2001)
10.1046/j.1365-2958.2002.03084.x
GeneChip® expression analysis of the iron starvation response in Pseudomonas aeruginosa: identification of novel pyoverdine biosynthesis genes
U. Ochsner (2002)
10.1002/adma.201404568
Single-layer transition metal dichalcogenide nanosheet-based nanosensors for rapid, sensitive, and multiplexed detection of DNA.
Y. Zhang (2015)
10.1016/J.MPMED.2013.10.014
Emerging infectious diseases
H. R. Doorn (2014)
10.1371/journal.pone.0149086
A Model-Based Joint Identification of Differentially Expressed Genes and Phenotype-Associated Genes
Samuel Sunghwan Cho (2016)
10.1152/PHYSIOLGENOMICS.2001.5.3.147
Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation.
M. R. Saban (2001)
10.1002/CVDE.200806739
A Substrate‐Independent Approach for the Surface Immobilization of Oligonucleotides using Aldehyde Functionalized Surfaces
J. McGettrick (2009)
10.1038/14222
Observing the living genome
P. Brown (1999)
10.1080/00032710701792901
Light Induced Surface Corrosion of Gallium Arsenide for Immobilization of Oligonucleotide Probes
Yun Hua Ye (2008)
Empirical evaluation of a new method for calculating signal to noise ratio ( SNR ) for 1 microarray data analysis 2
Zhili He (2008)
10.1016/B978-044450974-1/50003-3
Chapter 3 – Planar Waveguides for Fluorescence Biosensors
K. Sapsford (2002)
10.1021/bp0504288
Differential Gene Expression Profiles and Real‐Time Measurements of Growth Parameters in Saccharomyces cerevisiae Grown in Microliter‐Scale Bioreactors Equipped with Internal Stirring
P. Boccazzi (2006)
10.1021/la403192p
A simple, fast, and sensitive assay for the detection of DNA, thrombin, and adenosine triphosphate based on Dual-Hairpin DNA structure.
X. He (2013)
10.1002/ELSC.200620169
cDNA Labeling Strategies for Microarrays Using Fluorescent Dyes
J. H. Do (2007)
10.3390/ijms12053303
Nanomedicine: Application Areas and Development Prospects
H. Boulaiz (2011)
10.2217/14622416.7.7.1025
Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix database.
B. Ganter (2006)
10.1006/NBDI.2000.0347
Genes, Gene Expression, and Behavior
S. E. Hyman (2000)
10.1080/078538902320322565
In silico approaches to microarray-based disease classification and gene function discovery
F. Azuaje (2002)
The development of microbead-based immunoassays: an application of the electronic taste chip
M. D. Rodriguez (2003)
10.1517/14622416.3.4.527
Protein microarrays: challenges and promises.
A. Talapatra (2002)
Genomics and Proteomics: A Signal Tour
P. Vaidyanathan (2004)
10.1136/gut.48.5.598
Helicobacter pylori infection induced alteration of gene expression in human gastric cells
C. C. Chiou (2001)
10.1016/S0924-4204(02)85004-1
Analyse globale des transcrits: Vers une nouvelle approche de la microbiologie ?
F. Hommais (2002)
See more
Semantic Scholar Logo Some data provided by SemanticScholar