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Use Of A Mydriatic Cocktail With A Wick For Preoperative Mydriasis In Cataract Surgery: A Prospective Randomised Controlled Trial

S. Sengupta, K. Subramoney, R. Srinivasan, B. Nongrum, V. Agarwal, D. Pandian, T. Suchismitha, S. Kaliaperumal
Published 2010 · Medicine

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PurposeTo investigate the efficacy of a standardised wick soaked in a mydriatic cocktail regimen and compare it with the pre-existing regimen of topical dilating drops.DesignProspective, two armed, randomised, double blind, parallel assignment efficacy studyParticipantsIn all, 150 eyes of 150 patients were dilated using the dilating cocktail regimen by using a Weck cell sponge. The control group comprised of 75 eyes of 75 patients dilated using the conventional mydriatic regimen.InterventionsA specially prepared mydriatic cocktail regimen consisting of 1 : 1 : 1 : 1 ratio of 2.5% phenylephrine, 0.5% moxifloxacin, 1% cyclopentolate, and 0.03% flurbiprofen eye drops was prepared. A standard sized wick (1 cm × 2 mm) made of Weck cell sponge was soaked in the cocktail for a minute and placed in the lower fornix with sterile forceps. In the control group, eyes were dilated with the above drops using topical instillation in every 15 min. The mydriasis was measured at 15, 30, and 45 min after instillation using the Procyon pupillometer under scotopic conditions (0.04 lux). The intraoperative maintenance of mydriasis was measured with calipers after nucleus delivery and after intraocular lens implantation.Main outcome measuresPupillary diameters at the end of 15, 30, and 45 min, and intraoperative maintenance of mydriasis in the two groups were compared using unpaired t-test.ResultsThere was a statistically significant difference (P<0.001) in dilation achieved at the end of 45 min in both groups. There was also a significant difference of 1-mm dilation between the two groups after nucleus delivery (P< 0.001), and a difference of 1.41 mm after intraocular lens implantation, which was statistically significant (P<0.001).ConclusionsThese results show that the mydriatic cocktail regimen delivered with a wick is a useful, economical, and timesaving regimen compared with the conventional method of preoperative mydriasis using topical drops.
This paper references
10.1136/bjo.85.1.21
Anterior capsular contraction after cataract surgery in eyes of diabetic patients
S. Kato (2001)
[Capsule contraction syndrome].
E. Rakowska (1999)
10.1016/S0161-6420(98)94030-1
Comparative pupil dilation using phenylephrine alone or in combination with tropicamide.
M. Eyeson-Annan (1998)
10.1111/j.1442-9071.2006.01272.x
Pupil dilation using a pledget sponge: a randomized controlled trial
A. McCormick (2006)
10.1016/S0378-5173(99)00072-1
Formulation and in vivo evaluation of ocular insert containing phenylephrine and tropicamide.
Y. Lee (1999)
10.1016/S0886-3350(13)80004-1
Capsule contraction syndrome
J. Davison (1993)
Randomized double-blind study of phenylephrine 2.5% vs 10% on pupillary dilation.
Y. Yospaiboon (2004)
Anti inflammatory effects and aqueous humour concentration of various non steroidal anti inflammatory drugs in extra capsular surgery
V Hessener (1996)
10.1177/112067210001000209
The Efficacy of 2.5% Phenylephrine and Flurbiprofen Combined in Inducing and Maintaining Pupillary Dilatation during Cataract Surgery
F. Öztürk (2000)
10.1055/S-2008-1035191
Entzündungshemmende Effekte und Kammerwasserkonzentrationen verschiedener nichtsteroidaler Antiphlogistika bei extrakapsulärer Kataraktchirurgie
V. Hessemer (1996)
10.1016/S0886-3350(03)00236-0
Use of a wick to deliver preoperative mydriatics for cataract surgery
Lindsay Ong-Tone (2003)
anti inflammatory drugs in extra capsular surgery
VT Thaller (1996)
10.1038/eye.1999.17
Reliability of drop size from multi-dose eye drop bottles: is it cause for concern?
E. J. German (1999)
10.1111/J.1600-0420.2004.00241.X
Evaluation of surgical performance with intracameral mydriatics in phacoemulsification surgery.
A. Behndig (2004)
10.1038/eye.2000.157
The effect of pre-operative topical flurbiprofen or diclofenac on pupil dilatation
V. T. Thaller (2000)
Comparison of pupillary dilation using phenylephrine alone or in combination with tropicamide
ML Eyeson-Annan (1998)
10.1016/S0008-4182(05)80118-8
Evaluation of a new preoperative ophthalmic solution.
T. Hirowatari (2005)
Systematic study of factors affecting eye drop size and dosing variability.
Z. Šklubalová (2005)
10.3928/1542-8877-19940201-07
Comparative efficacy of diclofenac and flurbiprofen for maintenance of pupillary dilatation during cataract surgery.
M. Sachdev (1994)
[TPD ophthalmic solution (mixture of tropicamide, phenylephrine hydrochloride, and diclofenac sodium) for cataract surgery].
T. Hirowatari (2002)
10.1016/S0886-3350(13)80909-1
Preoperative pupil fatigue
W. Power (1992)



This paper is referenced by
METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC ANALYSIS OF BROMFENAC IN RABBIT PLASMA
V. Kamdar (2014)
10.1016/j.colsurfb.2010.07.029
Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC.
E. Gonzalez-Mira (2010)
10.1038/eye.2015.47
Pupil dilation using drops vs gel: a comparative study
E. Moisseiev (2015)
RAPID UPLC METHOD FOR ESTIMATION OF BROMFENAC AND APPLICATION TO EYE DROPS
Bhavani Boddeda (2013)
10.18579/JPCRKC/2012/11/1/79336
A Prospective, Randomized Controlled Study to Evaluate the Efficacy of Topical Flurbiprofen in Maintaining Intraoperative Mydriasis during Small Incision Cataract Surgery
R. Priyalatha (2012)
10.4155/tde.15.73
Ophthalmic applications of lipid-based drug nanocarriers: an update of research and patenting activity.
R. Pignatello (2015)
10.1038/eye.2011.76
Editor's choice—top papers of 2010
A. Lotery (2011)
10.1038/eye.2010.44
Use of a mydriatic cocktail with a wick for preoperative mydriasis in cataract surgery: a prospective randomised controlled trial
J. Luck (2010)
10.3980/j.issn.2222-3959.2013.06.11
Comparative study measuring the dilatory effect of a mydriatic device (Mydriasert(®)) versus topical drops.
Manuel Saenz-de-Viteri (2013)
Improved Pupil Dilation With Medication-Soaked Pledget
Nikki Lynn Thomas (2013)
10.2174/2211738503666150630185230
Design and Ocular Tolerance of Flurbiprofen Loaded Nanosuspension
Bhavani Boddeda (2015)
10.1186/1471-2415-13-83
Comparing the efficacy of mydriatic cocktail-soaked sponge and conventional pupil dilation in patients using tamsulosin – a randomized controlled trial
J. Hargitai (2013)
10.1016/j.aorn.2013.06.005
Improved pupil dilation with medication-soaked pledget sponges.
Celeste Weddle (2013)
10.1038/eye.2010.45
Reply to Luck
S. Sengupta (2010)
10.4103/ijo.IJO_262_17
Efficacy and safety of intraoperative intracameral mydriasis in manual small incision cataract surgery - A randomized controlled trial
K. Ajay (2017)
10.9734/bjmmr/2016/26630
Cataract Surgery in Asian Countries – An Overview
Thanigasalam Thevi (2016)
10.1016/j.jcjo.2012.01.007
Anaesthetic plus dilating gel improves pupil dilation for cataract surgery.
Delan Jinapriya (2012)
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