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The Effect Of Glutamate Receptor Blockade On Anoxic Depolarization And Cortical Spreading Depression

M. Lauritzen, A. Hansen
Published 1992 · Biology, Medicine

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We examined the effect of blockade of N-methyl-d-aspartate (NMDA) and non-NMDA subtype glutamate receptors on anoxic depolarization (AD) and cortical spreading depression (CSD). [K+]e and the direct current (DC) potential were measured with microelectrodes in the cerebral cortex of barbiturate-anesthetized rats. NMDA blockade was achieved by injection of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate [MK-801; 3 and 10 mg/kg] or amino-7-phosphonoheptanoate (APH; 4.5 and 10 mg/kg). Non-NMDA receptor blockade was achieved by injection of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline (NBQX; 10 and 20 mg/kg). MK-801 and APH blocked CSD, while NBQX did not. In control rats, the latency from circulatory arrest to AD was 2.1 ± 0.1 min, while the amplitude of the DC shift was 21 ± 1 mV, and [K+]e increased to 50 ± 6 mM. All variables remained unchanged in animals treated with MK-801, APH, or NBQX. Finally, MK-801 (14 mg/kg) and NBQX (40 mg/kg) were given in combination to examine the effect of total glutamate receptor blockade on AD. This combination slightly accelerated the onset of AD, probably owing to circulatory failure. In conclusion, AD was unaffected by glutamate receptor blockade. In contrast, NMDA receptors play a crucial role for CSD.
This paper references
10.1113/jphysiol.1963.sp007087
Acidic amino acids with strong excitatory actions on mammalian neurones
D. R. Curtis (1963)
10.1111/j.1471-4159.1959.tb12636.x
COMPOUNDS IN BRAIN EXTRACTS CAUSING SPREADING DEPRESSION OF CEREBRAL CORTICAL ACTIVITY AND CONTRACTION OF CRUSTACEAN MUSCLE
A. V. Harreveld (1959)
10.1016/0013-4694(87)90213-6
Ketamine blockade of cortical spreading depression in rats.
N. Gorelova (1987)
vation of extracellular levels of glutamate and aspartate in rat hippocampus during transient cerebral ischemia moni ­ tored by intracerebral microdialysis
H Benveniste (1984)
10.1152/PHYSREV.1985.65.1.101
Effect of anoxia on ion distribution in the brain.
A. Hansen (1985)
Compounds in brain extracts causing spreading depression of cerebral cortical activity and contraction of crustacean muscle.
A. van Harreveld (1959)
Quis­ qualate, kainate and NMDA can Initiate spreading depres­ sion in the turtle cerebellum
M Lauritzen (1988)
10.1111/j.1471-4159.1965.tb04243.x
AMINO ACID RELEASE FROM THE CEREBRAL CORTEX DURING SPREADING DEPRESSION AND ASPHYXIATION *
A. Harreveld (1965)
The behaviour of extracellular ions during spreading depression
C Nicholson (1981)
10.1016/0006-8993(88)90620-8
Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum
M. Lauritzen (1988)
10.1002/NEU.480020103
Glutamate release from the retina during spreading depression.
A. van Harreveld (1970)
10.1016/0166-2236(87)90115-9
Cortical spreading depression as a putative migraine mechanism
M. Lauritzen (1987)
10.1016/0006-8993(90)91276-M
Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures
R. Giffard (1990)
10.1016/0304-3940(88)90015-8
Requirement of NMDA receptor/channels for intracellular high-energy phosphates and the extent of intraneuronal calcium buffering in cultured mouse hippocampal neurons
I. Módy (1988)
10.1016/0006-8993(90)91277-N
Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation
G. Tombaugh (1990)
Do the excit ­ atory amino acids aspartate and glutamate generate spread ­ ing depressions in vivo ?
D Scheller (1990)
10.1111/J.1748-1716.1978.TB06079.X
The extracellular potassium concentration in brain cortex following ischemia in hypo- and hyperglycemic rats.
A. Hansen (1978)
10.1016/0006-8993(80)90238-3
The increase in extracellular potassium concentration in the ischemic brain in relation to the preischemic functional activity and cerebral metabolic rate
J. Astrup (1980)
10.1111/j.1471-4159.1984.tb05396.x
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis
H. Benveniste (1984)
Acidosis reduces receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cul­ tures
RG Giffard (1990)
NMDA antagonists block cortical spreading depression but not anoxic depolar­ ization. In: Frontiers in f.xcitatory Amino Acid Research (Cavalheiro EA
AJ Hansen (1988)
10.1126/SCIENCE.2154034
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
M. Sheardown (1990)
Do the excit­ atory amino acids aspartate and glutamate generate spread­ ing depressions in vivo? In: Pharmacology of Cerebral Isch­ emia
D Scheller (1990)
10.1126/SCIENCE.6093256
Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.
R. Simon (1984)
The quinoxalinediones, a new series of potent and selective non-NMDA receptor antagonists
MJ Sheardown (1989)
10.1152/jn.1947.10.6.409
Further observations on the spreading depression of activity in the cerebral cortex.
A. Leao (1947)
10.1016/0006-8993(87)91652-0
Systemic ketamine blocks cortical spreading depression but does not delay the onset of terminal anoxic depolarization in rats
Jose Hernándéz-Cáceres (1987)
Glutamate and spreading depression in chick retina.
P. Gardino (1983)
The neuropro ­ tective effect of the NMDA antagonist MK 801 and non ­ NMDA antagonist NBQX is not explained by an effect on anoxic depolarization , and only MK 801 inhibits spreading depression
M Lauritzen (1991)
10.1002/ANA.410250412
N‐methyl‐D‐aspartate antagonists: Ready for clinical trial in brain ischemia?
G. Albers (1989)
10.1152/JN.1987.57.3.869
Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices.
I. Módy (1987)
NMDA antagonists block cortical spreading depression but not anoxic depolar ­ ization
AJ Hansen (1988)
10.1002/ANA.410240411
The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat
C. K. Park (1988)
10.1038/jcbfm.1989.20
Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis
B. Siesjö (1989)
10.1016/0006-8993(90)90101-G
Ketamine blockade of spreading depression: rapid development of tolerance
T. Amemori (1990)
Cereb Blood Flow Metab 11 (suppl 2):S222 Leao AAP (1944) Spreading depression of activity in the cerebral
J depression (1944)
10.1016/0006-8993(88)90690-7
Evidence for a role of the N-methyl-d-aspartate (NMDA) receptor in cortical spreading depression in the rat
R. Marrannes (1988)
10.1038/jcbfm.1990.14
Cortical Spreading Depression is Associated with Arachidonic Acid Accumulation and Preservation of Energy Charge
M. Lauritzen (1990)
10.1111/j.1600-0404.1988.tb03697.x
Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia
H. Benveniste (1988)
10.1016/0006-8993(91)90699-V
K+ efflux pathways and neurotransmitter release associated to hippocampal ischemia: effects of glucose and of K+ channel blockers
P. Schaeffer (1991)
The mechanism and applications of Leão's spreading depression of electroencephalographic activity
J. Bures (1974)
10.1152/JN.1944.7.6.359
SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX
A. A. P. Leo (1944)
10.1111/J.1748-1716.1981.TB06920.X
Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex.
A. Hansen (1981)
10.1073/PNAS.83.18.7104
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
E. H. Wong (1986)



This paper is referenced by
10.1007/978-3-7091-6892-9_19
Death of cultured telencephalon neurons induced by glutamate is reduced by the peptide derivative Cerebrolysin.
B. Hutter-Paier (1996)
10.1097/00004647-199609000-00016
Evidence against High Extracellular Glutamate Promoting the Elicitation of Spreading Depression by Potassium
T. Obrenovitch (1996)
10.3171/jns.1997.87.6.0916
Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke.
A. Rawanduzy (1997)
THE SE POUR LE DIPLOME D'ETAT DE DOCTEUR EN MEDECINE
P. Sabatier (2013)
10.1007/978-3-319-04981-6_23
How spreading depolarization can be the pathophysiological correlate of both migraine aura and stroke.
Jens P. Dreier (2015)
Neuro-chemical analysis of cortical spreading depolarizations after severe traumatic brain injury : a continuum from a physiologic response to a metabolic crisis?
B. Balança (2015)
10.1089/NEU.1997.14.677
Is high extracellular glutamate the key to excitotoxicity in traumatic brain injury?
T. Obrenovitch (1997)
10.1254/FPJ.111.309
ラット海馬スライスにおけるSpreading depressionに対する新規カルシウム拮抗薬KB-2796の作用
啓吾 高木 (1998)
10.1016/S0165-0173(99)00083-1
Perspectives on spreading depression
H. Martins-Ferreira (2000)
10.1016/S0301-0082(00)00037-X
Ionic mechanisms underlying differential vulnerability to ischemia in striatal neurons
D. Centonze (2001)
10.18869/ACADPUB.SHEFA.2.1.56
Assessment of AMPA Receptor Antagonist Administration on Spatial Memory of Juvenile Rats Induced Repetitive Spreading Depression
احمد علی لطفی نیا (2014)
Uncoupling of £ow and metabolism induced by sodium nitroprusside in rat cerebral cortex
Osamu Inoue (2003)
Neurovascular Pharmacology of Prospective Antimigraine Drugs
K. Chan (2011)
10.1093/brain/awaa242
Functional gene networks reveal distinct mechanisms segregating in migraine families.
A. Rasmussen (2020)
10.1016/0006-8993(95)00692-J
Tolerance to ketamine-induced blockade of cortical spreading depression transfers to MK-801 but not to AP5 in rats
A. Rashidy-pour (1995)
10.1002/HIPO.10181
P/Q Ca2+ channel blockade stops spreading depression and related pyramidal neuronal Ca2+ rise in hippocampal organ culture
P. Kunkler (2004)
10.1523/JNEUROSCI.14-09-05635.1994
Mild acidosis delays hypoxic spreading depression and improves neuronal recovery in hippocampal slices
G. Tombaugh (1994)
10.1517/13543776.8.11.1425
Basic fibroblast growth factor: a potential therapeutic agent for the treatment of acute neurodegenerative disorders and vascular insufficiency
J. Moyer (1998)
Regulation of spreading depression events in brain slices by astrocyte metabolism
J. Seidel (2011)
10.1212/WNL.0b013e3182824e66
A randomized controlled trial of intranasal ketamine in migraine with prolonged aura
S. Afridi (2013)
10.1016/0304-3940(94)90540-1
Effects of glycine receptor antagonism on spreading depression in the rat
H. Martin (1994)
10.1016/0006-8993(96)00689-0
Protective effect of MK-801 on the anoxia-aglycemia induced damage in the fluorocitrate-treated hippocampal slice of the rat
H. Nakanishi (1996)
10.1046/j.1471-4159.1995.64041884.x
Intracerebral Microdialysis: Electrophysiological Evidence of a Critical Pitfall
T. Obrenovitch (1995)
10.1046/j.1526-4610.2001.111006084.x
Migraine With Aura After Administration of Sublingual Nitroglycerin Tablets
J. Bánk (2001)
10.1007/978-1-4684-0001-4_3
Growth Factors and Cerebral Ischemia
I. Ay (2001)
10.1152/JN.00186.2005
Repetitive spreading depression-like events result in cell damage in juvenile hippocampal slice cultures maintained in normoxia.
J. Pomper (2006)
10.1161/01.STR.25.11.2258
Competitive N‐Methyl‐D‐Aspartate Receptor Blockade Reduces Brain Injury Following Transient Focal Ischemia in Cats
T. Nishikawa (1994)
10.1038/jcbfm.1994.100
Prevention of Periinfarct Direct Current Shifts with Glutamate Antagonist NBQX following Occlusion of the Middle Cerebral Artery in the Rat
G. Mies (1994)
Na 1 Dependence and the Role of Glutamate Receptors and Na 1 Channels in Ion Fluxes During Hypoxia of Rat Hippocampal Slices
M. M. Üller (2000)
10.1097/00003246-199706000-00022
Comparative analysis of brain protection by N-methyl-D-aspartate receptor antagonists after transient focal ischemia in cats.
M. Miyabe (1997)
10.1152/JN.1998.80.3.1514
Similar propagation of SD and hypoxic SD-like depolarization in rat hippocampus recorded optically and electrically.
P. Aitken (1998)
10.1038/jcbfm.2010.191
Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury
M. Lauritzen (2011)
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