Online citations, reference lists, and bibliographies.
← Back to Search

HIV-1 Superinfection Despite Broad CD8+ T-cell Responses Containing Replication Of The Primary Virus

M. Altfeld, T. Allen, Xu G. Yu, M. Johnston, D. Agrawal, B. Korber, D. Montefiori, D. O’Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, P. Goulder, C. Brander, E. Rosenberg, B. Walker
Published 2002 · Biology

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Early treatment of acute HIV-1 infection followed by treatment interruptions has shown promise for enhancing immune control of infection. A subsequent loss of control, however, allows the correlates of protective immunity to be assessed. Here we show that sudden breakthrough of plasma viraemia occurred after prolonged immune containment in an individual infected with HIV-1 at a time when 25 distinct CD8+ T-cell epitopes in the viral proteins Gag, RT, Integrase, Env, Nef, Vpr, Vif and Rev were being targeted. Sequencing of the virus in plasma and cells showed that superinfection with a second clade-B virus was coincident with the loss of immune control. This sudden increase in viraemia was associated with a decline in half of the CD8+ T-cell responses. The declining CD8+ T-cell responses were coupled with sequence changes relative to the initial virus that resulted in impaired recognition. Our data show that HIV-1 superinfection can occur in the setting of a strong and broadly directed virus-specific CD8+ T-cell response. The lack of cross-protective immunity for closely related HIV-1 strains, despite persistent recognition of multiple CD8 epitopes, has important implications for public health and vaccine development.
This paper references
10.1016/0092-8674(91)90037-Y
Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein
M. D. Val (1991)
10.1128/JVI.68.9.6103-6110.1994
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
P. Borrow (1994)
10.1128/jvi.68.7.4650-4655.1994
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
R. Koup (1994)
10.1126/SCIENCE.283.5403.857
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.
J. Schmitz (1999)
10.1084/JEM.189.6.991
Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques
Xia Jin (1999)
10.1172/JCI7371
HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy.
G. Ortiz (1999)
10.1056/NEJM199905273402114
Control of HIV despite the discontinuation of antiretroviral therapy.
J. Lisziewicz (1999)
10.1128/JVI.73.9.7524-7532.1999
Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen
T. Hanke (1999)
Understanding the genetic diversity of HIV-1.
F. McCutchan (2000)
10.1073/PNAS.97.7.3382
Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes.
A. Oxenius (2000)
10.1038/35030124
Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
T. Allen (2000)
10.1097/00002030-200001070-00004
Multiple sites in HIV-1 reverse transcriptase associated with virological response to combination therapy
H. Precious (2000)
10.1086/315202
Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection.
U. Malhotra (2000)
10.1038/35035103
Immune control of HIV-1 after early treatment of acute infection
E. Rosenberg (2000)
10.1126/SCIENCE.290.5491.486
Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination.
D. Barouch (2000)
10.1128/JVI.74.18.8541-8549.2000
Identification of Dominant Optimal HLA-B60- and HLA-B61-Restricted Cytotoxic T-Lymphocyte (CTL) Epitopes: Rapid Characterization of CTL Responses by Enzyme-Linked Immunospot Assay
Marcus A. Altfeld (2000)
10.1128/JVI.75.21.10200-10207.2001
Neutralizing Antibodies Associated with Viremia Control in a Subset of Individuals after Treatment of Acute Human Immunodeficiency Virus Type 1 Infection
D. Montefiori (2001)
10.1126/SCIENCE.1058915
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
R. Amara (2001)
10.1038/415331a
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity
J. Shiver (2002)
10.1128/JVI.76.17.8690-8701.2002
Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses following Acute HIV-1 Infection
Xu G. Yu (2002)
10.1038/415335a
Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
D. Barouch (2002)
10.1056/NEJMOA020263
A patient with HIV-1 superinfection.
S. Jost (2002)
10.1128/JVI.76.15.7444-7452.2002
Intersubtype Human Immunodeficiency Virus Type 1 Superinfection following Seroconversion to Primary Infection in Two Injection Drug Users
A. Ramos (2002)
10.1038/nm0302-207
AIDS vaccine models: Challenging challenge viruses
M. Feinberg (2002)
10.1128/JVI.76.8.4108-4112.2002
Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication
T. Allen (2002)
10.1038/417095a
HIV preferentially infects HIV-specific CD4+ T cells
D. Douek (2002)



This paper is referenced by
10.1101/2020.06.13.20130252
Prevalence of IgG antibodies to SARS-CoV-2 in Wuhan -implications for the ability to produce long-lasting protective antibodies against SARS-CoV-2
T. Liu (2020)
Emerging Themes in Epidemiology
R. Baggaley (2020)
10.1126/science.abc4776
SARS-CoV-2 infection protects against rechallenge in rhesus macaques
Abishek Chandrashekar (2020)
10.1201/9781317212942-21
Mucosal immune responses to microbes in genital tract
A. Iwasaki (2020)
10.1016/s2352-3018(19)30264-4
HIV controllers: to treat or not to treat? Is that the right question?
N. Noël (2019)
10.13028/75z5-2237
Innate Detection of HIV-1 in Myeloid Dendritic Cells
S. McCauley (2018)
10.1128/JVI.01436-18
Mechanisms of Abrupt Loss of Virus Control in a Cohort of Previous HIV Controllers
Miriam Rosás-Umbert (2018)
10.3389/fmicb.2018.01634
Variable Effect of HIV Superinfection on Clinical Status: Insights From Mathematical Modeling
Ágnes Móréh (2018)
10.1371/journal.ppat.1007222
HIV control: Is getting there the same as staying there?
P. Goulder (2018)
10.1136/bmjopen-2017-016954
Cross-sectional comparative study of risky sexual behaviours among HIV-infected persons initiated and waiting to start antiretroviral therapy in rural Rakai, Uganda
Lydia Jacenta Nakiganda (2017)
10.1007/s11684-017-0594-8
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design
Yang Gao (2017)
10.1534/genetics.117.300284
Donor-Recipient Identification in Para- and Poly-phyletic Trees Under Alternative HIV-1 Transmission Hypotheses Using Approximate Bayesian Computation
E. Romero-Severson (2017)
10.3389/fimmu.2017.01581
Mucosal IgA Responses: Damaged in Established HIV Infection—Yet, Effective Weapon against HIV Transmission
V. Kulkarni (2017)
10.1016/j.ebiom.2017.04.005
Comprehensive Characterization of Humoral Correlates of Human Immunodeficiency Virus 1 Superinfection Acquisition in High-risk Kenyan Women
K. Ronen (2017)
Role of envelope compactness and glycosylation in HIV-1 resistance to neutralising antibody responses
Thandeka Moyo (2017)
10.1186/s12977-017-0340-y
Erratum to: HIV integration sites in latently infected cell lines: evidence of ongoing replication
J. Symons (2017)
10.1093/imammb/dqw014
Dynamical properties and thresholds of an HIV model with super-infection.
N. J. Malunguza (2017)
10.1186/s12981-017-0176-5
Killed whole-HIV vaccine; employing a well established strategy for antiviral vaccines
C. Kang (2017)
10.1097/QAI.0000000000001420
Dual Infection Contributes to Rapid Disease Progression in Men Who Have Sex With Men in China
H. Luan (2017)
10.1097/QAD.0000000000001237
HIV-associated neurocognitive disorder is associated with HIV-1 dual infection
Gabriel A. Wagner (2016)
10.1146/annurev-immunol-032414-112315
Exploiting Mucosal Immunity for Antiviral Vaccines.
A. Iwasaki (2016)
10.1007/978-3-319-32889-8_1
Background and Significance
Joseph J. Frantiska (2016)
10.1186/s12977-016-0325-2
HIV integration sites in latently infected cell lines: evidence of ongoing replication
J. Symons (2016)
10.1101/071050
Inference of direction, diversity, and frequency of HIV-1 transmission using approximate Bayesian computation
E. Romero-Severson (2016)
10.1371/journal.pone.0166746
Deciphering Multiplicity of HIV-1C Infection: Transmission of Closely Related Multiple Viral Lineages
V. Novitsky (2016)
10.1159/000445852
Human Immunodeficiency Virus (HIV)
岩野真依 (2016)
Role of local or systemic Schistosoma infections in driving inflammation and HIV risk in women enrolled in the CAPRISA 004 cohort.
Sahil Tulsi (2016)
HIV Type 1 Superinfecion with a Dual-Tropic Virus and Rapid Progression to AIDS: A Case Report
G. Gottlieb (2016)
10.1038/mtm.2016.68
Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies
S. Fuchs (2016)
10.1186/s12977-016-0317-2
First Phase I human clinical trial of a killed whole-HIV-1 vaccine: demonstration of its safety and enhancement of anti-HIV antibody responses
Eunsil Choi (2016)
10.1097/QAD.0000000000000740
Evaluation of postpartum HIV superinfection and mother-to-child transmission
A. Redd (2015)
10.1038/nm.3932
HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders
H. Janes (2015)
See more
Semantic Scholar Logo Some data provided by SemanticScholar