Online citations, reference lists, and bibliographies.

A Brain-specific MicroRNA Regulates Dendritic Spine Development

G. Schratt, Fabian Tuebing, E. Nigh, Christina G. Kane, M. Sabatini, M. Kiebler, M. Greenberg
Published 2006 · Biology, Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
MicroRNAs are small, non-coding RNAs that control the translation of target messenger RNAs, thereby regulating critical aspects of plant and animal development. In the mammalian nervous system, the spatiotemporal control of mRNA translation has an important role in synaptic development and plasticity. Although a number of microRNAs have been isolated from the mammalian brain, neither the specific microRNAs that regulate synapse function nor their target mRNAs have been identified. Here we show that a brain-specific microRNA, miR-134>, is localized to the synapto-dendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines—postsynaptic sites of excitatory synaptic transmission. This effect is mediated by miR-134 inhibition of the translation of an mRNA encoding a protein kinase, Limk1, that controls spine development. Exposure of neurons to extracellular stimuli such as brain-derived neurotrophic factor relieves miR-134 inhibition of Limk1 translation and in this way may contribute to synaptic development, maturation and/or plasticity.
This paper references
10.1261/rna.5235104
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.
G. Meister (2004)
10.1038/nature03076
A pancreatic islet-specific microRNA regulates insulin secretion
M. Poy (2004)
10.1016/S0896-6273(01)00551-7
Chemotropic Responses of Retinal Growth Cones Mediated by Rapid Local Protein Synthesis and Degradation
D. S. Campbell (2001)
10.1016/S0896-6273(01)00295-1
Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons
G. Aakalu (2001)
10.1016/S0960-9822(02)00809-6
Identification of Tissue-Specific MicroRNAs from Mouse
M. Lagos-Quintana (2002)
10.1523/JNEUROSCI.11-09-02881.1991
Evidence that protein constituents of postsynaptic membrane specializations are locally synthesized: analysis of proteins synthesized within synaptosomes
A. Rao (1991)
10.1038/ng1421
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression
J. Mansfield (2004)
10.1016/S0896-6273(00)80868-5
Molecular Insights into mRNA Transport and Local Translation in the Mammalian Nervous System
M. Kiebler (2000)
10.1038/nature02617
Structural basis of long-term potentiation in single dendritic spines
Masanori Matsuzaki (2004)
10.1146/annurev.neuro.24.1.299
Protein synthesis at synaptic sites on dendrites.
O. Steward (2001)
10.1038/nn1381
Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons
Yuanyuan Ji (2005)
array reveals extensive regulation of microRNAs during brain development
M. Lagos-Quintana (2003)
10.1371/journal.pbio.0020098
Sequence-Specific Inhibition of Small RNA Function
G. Hutvágner (2004)
10.1146/annurev.cellbio.15.1.185
Proteins of the ADF/cofilin family: essential regulators of actin dynamics.
J. Bamburg (1999)
A
A. M. Krichevsky
10.1371/journal.pbio.0020363
Human MicroRNA Targets
B. John (2004)
10.1186/gb-2004-5-3-r13
Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
L. Sempere (2003)
10.1101/lm.54603
BDNF and activity-dependent synaptic modulation.
B. Lu (2003)
- and siRNA - induced RNA silencing
G. Hutvagner (2004)
10.1261/rna.5980303
A microRNA array reveals extensive regulation of microRNAs during brain development.
A. Krichevsky (2003)
10.1038/nrn987
Regulation of transcription factors by neuronal activity
A. E. West (2002)
10.1126/science.1091903
MicroRNAs Modulate Hematopoietic Lineage Differentiation
Chang-zheng Chen (2004)
10.1146/annurev.neuro.22.1.295
Neurotrophins and synaptic plasticity.
A. McAllister (1999)
10.1038/nrn942
Synaptic tagging — who's it?
K. Martin (2002)
10.1016/S0092-8674(04)00045-5
MicroRNAs Genomics, Biogenesis, Mechanism, and Function
D. Bartel (2004)
10.1074/jbc.M103237200
Brain-derived Neurotrophic Factor Enhances Neuronal Translation by Activating Multiple Initiation Processes
N. Takei (2001)
10.1093/nar/gki364
MicroInspector: a web tool for detection of miRNA binding sites in an RNA sequence
V. Rusinov (2005)
10.1016/S0896-6273(02)00758-4
Abnormal Spine Morphology and Enhanced LTP in LIMK-1 Knockout Mice
Yanghong Meng (2002)
10.1038/nrg1379
MicroRNAs: small RNAs with a big role in gene regulation
L. He (2004)
10.1523/JNEUROSCI.1739-04.2004
BDNF Regulates the Translation of a Select Group of mRNAs by a Mammalian Target of Rapamycin-Phosphatidylinositol 3-Kinase-Dependent Pathway during Neuronal Development
G. Schratt (2004)
10.1073/pnas.2333854100
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
J. Kim (2003)
10.1038/nature02255
A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans
R. Johnston (2003)
10.1186/gb-2004-5-9-r68
Microarray analysis of microRNA expression in the developing mammalian brain
E. Miska (2004)
10.1016/j.neuron.2004.11.016
Bidirectional Activity-Dependent Morphological Plasticity in Hippocampal Neurons
U. Nägerl (2004)
10.1038/35104061
Dentritic spines : structure, dynamics and regulation
H. Hering (2001)
10.1126/science.1109020
MicroRNAs Regulate Brain Morphogenesis in Zebrafish
A. Giraldez (2005)
10.1126/science.273.5280.1402
A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity
H. Kang (1996)
10.1038/nature02871
The functions of animal microRNAs
V. Ambros (2004)
10.1038/nature02752
MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode
Sarah Chang (2004)
10.1016/S0092-8674(03)00231-9
bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila
J. Brennecke (2003)
10.1126/stke.2003.204.pl12
Coupling the Iron-Responsive Element to GFP--An Inducible System to Study Translation in a Single Living Cell
Bernhard Goetze (2003)
10.1073/pnas.121146698
Local translation of classes of mRNAs that are targeted to neuronal dendrites
J. Eberwine (2001)
10.1016/S0896-6273(02)01023-1
Localized Synaptic Potentiation by BDNF Requires Local Protein Synthesis in the Developing Axon
X. Zhang (2002)
10.1016/j.neuron.2004.09.013
Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity
R. J. Kelleher (2004)
10.1016/S0896-6273(02)00906-6
Spine Motility Phenomenology, Mechanisms, and Function
T. Bonhoeffer (2002)
10.1016/j.neuron.2004.09.022
Induction of Spine Growth and Synapse Formation by Regulation of the Spine Actin Cytoskeleton
K. Zito (2004)



This paper is referenced by
10.1371/journal.pone.0023423
Axotomy-Induced miR-21 Promotes Axon Growth in Adult Dorsal Root Ganglion Neurons
Iain T. Strickland (2011)
10.1016/B978-0-12-407178-0.00003-X
Signaling endosomes and growth cone motility in axon regeneration.
Michael B Steketee (2012)
10.4161/epi.5.2.11160
Shaping the oligodendrocyte identity by epigenetic control
Yang Yu (2010)
10.1002/9781118836507.CH07
Inhibition of Cyclic Nucleotide Phosphodiesterases to Regulate Memory
Han-ting Zhang (2014)
Title : Extracellular microRNAs as messengers in the central and peripheral nervous system
Hannah Scott (2017)
10.1007/s11033-016-4054-3
The roles of non-coding RNAs in Parkinson’s disease
Maryam Majidinia (2016)
10.1111/j.1476-5381.2012.02225.x
RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects.
Zhenzhen Wang (2013)
10.3389/fphar.2018.01364
The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder
Xiaoying Zhang (2018)
10.1093/nar/gky1235
Temporospatial guidance of activity-dependent gene expression by microRNA: mechanisms and functional implications for neural plasticity
Dylan Kiltschewskij (2019)
10.18452/18616
Interactome of TNRC6 W-motifs and their conserved Role in miRNA-mediated silencing
Marta Mauri (2017)
10.1016/j.yexcr.2014.10.022
The miR-134 attenuates the expression of transcription factor FOXM1 during pluripotent NT2/D1 embryonal carcinoma cell differentiation.
Yan Chen (2015)
10.1111/cns.12589
Lentivirus-Mediated Overexpression of MicroRNA-210 Improves Long-Term Outcomes after Focal Cerebral Ischemia in Mice.
Lili Zeng (2016)
10.32657/10356/54900
Biogenesis and function of microRNA miR-124.
Manish Muhuri (2013)
10.1101/lm.039578.115
Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome.
Katelin F. Hansen (2016)
10.1007/978-3-642-20763-1_19
Analysis of the Conservative Motifs in Promoters of miRNA Genes, Expressed in Different Tissues of Mammalians
Oleg V. Vishnevsky (2011)
10.1083/jcb.201108159
Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation
María Verónica Baez (2011)
10.1016/j.ejcb.2015.05.011
Non-coding mechanisms of local mRNA translation in neuronal dendrites.
Kerstin Weiss (2015)
10.1002/wdev.223
Tiny giants of gene regulation: experimental strategies for microRNA functional studies
Bruno R. Steinkraus (2016)
10.1007/978-1-4939-2754-8_14
Protocol for High-Throughput miRNA Profiling of the Rat Brain
Sharon L. Hollins (2016)
10.1038/srep26781
miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a
Qian Xue (2016)
10.1016/j.omtn.2016.11.003
miR-134: A Human Cancer Suppressor?
Jingyu Pan (2017)
10.1002/9781118540770.CH22
Cutting Edge Approaches for the Identification and the Functional Investigation of miRNAs in Brain Science
E. Carapella de Luca (2017)
10.1038/nrn2763
microRNAs at the synapse
Gerhard Schratt (2009)
10.1007/978-3-642-04298-0_10
microRNAs in Sporadic Alzheimer’s Disease and Related Dementias
Sébastien S. Hébert (2010)
10.1016/j.bbadis.2014.04.004
Cerebellar ataxia and functional genomics: Identifying the routes to cerebellar neurodegeneration.
Cleo J. L. M. Smeets (2014)
Bipolar disorder: Microrna profiling and genetics comparison with schizophrenia in a Malaysian population / Lim Chor Hong
Chor Hong Lim (2016)
10.1016/j.neuroscience.2019.03.027
Exposure to enriched environment rescues anxiety-like behavior and miRNA deregulated expression induced by perinatal malnutrition while altering oligodendrocyte morphology
Bruno G Berardino (2019)
10.1007/s00359-010-0520-x
RNA localization in neurite morphogenesis and synaptic regulation: current evidence and novel approaches
Martin Mikl (2010)
10.1155/2012/810370
Sensory Deprivation and Brain Plasticity
Maurice Ptito (2012)
10.1002/dneu.22309
Epithelial microRNA-9a regulates dendrite growth through Fmi-Gq signaling in Drosophila sensory neurons.
Yan Wang (2016)
10.1007/978-1-4614-5107-5_10
Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities.
Anthony K L Leung (2013)
10.1186/1471-2164-13-561
Alternative mRNA fates identified in microRNA-associated transcriptome analysis
A. Carroll (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar