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Microenvironmental Regulation Of Tumor Progression And Metastasis

Daniela F. Quail, J. Joyce
Published 2013 · Biology, Medicine

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Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive therapeutic target with reduced risk of resistance and tumor recurrence. However, specifically disrupting the pro-tumorigenic TME is a challenging undertaking, as the TME has diverse capacities to induce both beneficial and adverse consequences for tumorigenesis. Furthermore, many studies have shown that the microenvironment is capable of normalizing tumor cells, suggesting that re-education of stromal cells, rather than targeted ablation per se, may be an effective strategy for treating cancer. Here we discuss the paradoxical roles of the TME during specific stages of cancer progression and metastasis, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.
This paper references
10.1056/NEJM197108122850711
Transplacental carcinogenesis by stilbestrol.
J. Folkman (1971)
10.1053/J.GASTRO.2007.03.102
Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients.
Junliang Fu (2007)
10.1038/nm.2328
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
M. Bissell (2011)
10.1371/journal.pone.0007067
Myeloid Cells Contribute to Tumor Lymphangiogenesis
Adrian Zumsteg (2009)
10.1016/j.cell.2006.01.007
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
J. Condeelis (2006)
10.1055/S-0037-1613114
Tissue factor pathway inhibitor reduces experimental lung metastasis of B16 melanoma.
A. Amirkhosravi (2002)
10.1186/1471-2407-12-35
Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors
Anne-Katrine Bonde (2011)
10.1038/nrm809
Myofibroblasts and mechano-regulation of connective tissue remodelling
J. Tomasek (2002)
10.1073/pnas.1113099109
Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors
H. Shime (2012)
10.1038/nature10138
CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
Bin-Zhi Qian (2011)
10.1038/nrc2618
Microenvironmental regulation of metastasis
J. Joyce (2009)
10.1038/nrc3258
Cancer immunotherapy via dendritic cells
K. Palucka (2012)
10.1038/aja.2013.113
Autonomic nerve development contributes to prostate cancer progression.
J. Bauman (2013)
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
F Calvo (2013)
Expression of RORgammat marks a pathogenic regulatory T cell subset in human colon cancer
NR Blatner (2012)
10.1038/nrc1877
Fibroblasts in cancer
R. Kalluri (2006)
10.1111/j.1349-7006.2012.02411.x
Impact of tumor‐associated macrophages on invasive ductal carcinoma of the pancreas head
K. Yoshikawa (2012)
10.1158/1078-0432.CCR-08-2179
Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination
B. Robinson (2009)
10.1038/nature04186
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
R. Kaplan (2005)
10.1158/0008-5472.CAN-07-3127
Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts.
E. Zeisberg (2007)
10.1056/NEJMoa1305133
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma.
O. Hamid (2013)
10.1016/j.immuni.2013.07.005
Deciphering and reversing tumor immune suppression.
Greg T. Motz (2013)
10.1016/j.cell.2013.07.036
Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma
X. Zhang (2013)
10.1038/onc.2012.578
Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
G. Semenza (2013)
10.1182/BLOOD-2004-06-2272
Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.
J. Palumbo (2005)
10.1101/cshperspect.a003848
In vivo imaging in cancer.
J. Condeelis (2010)
10.1186/bcr138
Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium
AF Olumi (2000)
Lessons from the cancer
L. A. Garraway (2013)
10.1038/onc.2011.602
Interaction of tumor cells and lymphatic vessels in cancer progression
A. Alitalo (2012)
10.1038/nm888
BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury
M. Zeisberg (2003)
10.1158/2159-8274.CD-10-0028
Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.
D. DeNardo (2011)
10.1016/S0002-9440(10)64255-1
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis.
S. Schoppmann (2002)
10.1056/NEJMoa1302369
Nivolumab plus ipilimumab in advanced melanoma.
J. Wolchok (2013)
10.1016/J.YEXMP.2005.07.004
Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo.
W. Zhu (2006)
10.1002/ijc.24439
Cancer incidence and risk factors after solid organ transplantation
C. Vajdic (2009)
10.1016/S1470-2045(12)70137-7
Global burden of cancers attributable to infections in 2008: a review and synthetic analysis.
C. de Martel (2012)
10.4049/jimmunol.168.2.689
Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism1
A. Mazzoni (2002)
10.1002/(SICI)1097-0215(19970529)71:5<724::AID-IJC6>3.0.CO;2-T
Tumor‐associated lympho‐monocytes from neoplastic effusions are immunologically defective in comparison with patient autologous PBMCs but are capable of releasing high amounts of various cytokines
G. Mantovani (1997)
10.1056/NEJM200002243420801
Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer.
S. Braun (2000)
10.1016/j.cell.2012.11.024
Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
V. Luga (2012)
10.1158/0008-5472.CAN-11-0268
Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy.
N. Halama (2011)
10.1126/scitranslmed.3004566
Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer
N. Blatner (2012)
10.1101/gad.169029.111
Immune microenvironments in solid tumors: new targets for therapy.
S. Shiao (2011)
10.1016/j.ccr.2011.08.025
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
Q. Chen (2011)
10.1016/j.ccr.2013.01.008
Role of macrophage targeting in the antitumor activity of trabectedin.
G. Germano (2013)
10.1016/j.cell.2008.03.027
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A Mani (2008)
10.1016/J.AMJSURG.2004.11.014
Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas.
K. Brown (2005)
10.1053/J.GASTRO.2003.12.049
Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance.
A. Sangiovanni (2004)
10.1016/j.ccr.2013.05.008
Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.
Dagmar Schumacher (2013)
10.1158/0008-5472.CAN-06-1823
Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors.
J. Wyckoff (2007)
10.1038/nm1340
Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
D. Kerjaschki (2006)
10.1084/jem.20080108
“Re-educating” tumor-associated macrophages by targeting NF-κB
T. Hagemann (2008)
10.1038/nrc3245
The immune contexture in human tumours: impact on clinical outcome
W. Fridman (2012)
10.1038/nrclinonc.2012.207
Clinical opportunities and challenges in targeting tumour dormancy
Jonathan A. Hensel (2013)
10.1038/onc.2009.253
Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge
F. Zijl (2009)
10.1038/nm.2753
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
H. Peinado (2012)
10.1084/jem.20130066
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
Rikke B. Holmgaard (2013)
10.1371/journal.pone.0006562
A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth
Binzhi Qian (2009)
10.1073/pnas.0804876105
Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas
R. Kerbel (2008)
10.1038/nrc3261
Intra-tumour heterogeneity: a looking glass for cancer?
A. Marusyk (2012)
10.1016/j.bbadis.2012.10.013
Fibroblasts as architects of cancer pathogenesis.
Timothy Marsh (2013)
10.1038/sj.bjc.6601121
Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer
J. Pierga (2003)
10.3410/f.1001166.15874
Faculty Opinions recommendation of IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity.
R. Vile (2001)
10.1038/35074122
IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
V. Shankaran (2001)
10.1056/NEJMOA021423
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.
E. Calle (2003)
10.1158/0008-5472.CAN-13-0661
Targeting the tumor microenvironment: from understanding pathways to effective clinical trials.
H. Fang (2013)
10.1038/onc.2011.312
Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate
B. Orr (2012)
10.1038/nature10694
Interactions between cancer stem cells and their niche govern metastatic colonization
Ilaria Malanchi (2012)
10.1016/j.ccr.2008.04.005
Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer.
N. H. Stoecklein (2008)
10.1126/science.1150224
Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis
Dingcheng Gao (2008)
10.1038/nrc2256
Models, mechanisms and clinical evidence for cancer dormancy
J. Aguirre-Ghiso (2007)
10.1016/j.cell.2011.02.013
Hallmarks of Cancer: The Next Generation
D. Hanahan (2011)
10.4161/cc.5.16.3018
Role of Angiogenesis in Human Tumor Dormancy: Animal Models of the Angiogenic Switch
G. Naumov (2006)
10.2353/ajpath.2010.090879
Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization.
E. Redente (2010)
10.1038/nrc3237
Combining immunotherapy and targeted therapies in cancer treatment
M. Vanneman (2012)
10.1016/j.ccr.2011.11.002
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.
Xin Lu (2011)
10.4049/jimmunol.166.9.5398
Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells1
D. Gabrilovich (2001)
10.1016/j.cell.2011.09.053
Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
S. Yamazaki (2011)
10.1016/S1470-2045(12)70209-7
Circulating tumour cells in non-metastatic breast cancer: a prospective study.
A. Lucci (2012)
10.1038/ni1582
Functions of natural killer cells
É. Vivier (2008)
10.1016/j.cell.2010.03.014
Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian (2010)
10.1016/j.imbio.2012.07.002
Influence of low oxygen tensions on macrophage polarization.
M. Escribese (2012)
10.1038/nri3175
Coordinated regulation of myeloid cells by tumours
D. Gabrilovich (2012)
10.1182/blood-2011-08-376426
Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice.
Ana M. Gil-Bernabé (2012)
HIF-1a regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
Corzo (2010)
10.1016/S0140-6736(00)04046-0
Inflammation and cancer: back to Virchow?
F. Balkwill (2001)
10.1158/0008-5472.CAN-04-1853
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop.
S. Goswami (2005)
10.1215/15228517-2007-013
Preoperative thrombocytosis predicts poor survival in patients with glioblastoma.
M. Brockmann (2007)
Circulating tumour cells in non-metastatic breast cancer: a prospective study
A Lucci (2012)
10.1093/jmcb/mjs044
Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155.
Xing Cai (2012)
10.1038/onc.2013.142
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors
K. E. Hunter (2014)
10.1016/S1535-6108(04)00111-4
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis.
J. Joyce (2004)
10.1038/nature04695
Lysyl oxidase is essential for hypoxia-induced metastasis
Janine T. Erler (2006)
10.1016/S0002-9440(10)63834-5
Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma.
O. W. Petersen (2003)
10.1038/nature11538
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation
J. Landsberg (2012)
10.1016/j.cell.2013.03.002
Lessons from the Cancer Genome
L. Garraway (2013)
10.1038/nrc1231
Intravital imaging of cell movement in tumours
J. Condeelis (2003)
10.1016/j.cell.2010.01.025
Immunity, Inflammation, and Cancer
S. Grivennikov (2010)
10.1159/000337296
Mesenchymal Stem Cells Provide an Advantageous Tumor Microenvironment for the Restoration of Cancer Stem Cells
Kanako Nishimura (2012)
10.4049/jimmunol.174.2.636
Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease1
P. Sinha (2005)
10.1517/14712598.2012.707184
Induced and natural regulatory T cells in human cancer
T. Whiteside (2012)
10.1016/j.bbcan.2009.04.001
Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy?
M. De Palma (2009)
10.4161/cc.9.24.14322
Alternative activation of tumor-associated macrophages by IL-4
H. Wang (2010)
10.1056/NEJM197111182852108
Tumor angiogenesis: therapeutic implications.
J. Folkman (1971)
10.1126/scitranslmed.3005283
Treg Cells in Cancer: A Case of Multiple Personality Disorder
P. Bos (2012)
10.1016/J.CCR.2005.04.014
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent.
K. D. de Visser (2005)
10.1593/NEO.121950
Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics.
N. Dumont (2013)
10.1093/AJE/154.6.544
Cancer incidence in New York State acquired immunodeficiency syndrome patients.
B. Gallagher (2001)
10.1038/nrd3683
Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer
H. Boehmer (2012)
10.1016/j.cell.2009.11.007
Epithelial-Mesenchymal Transitions in Development and Disease
J. Thiery (2009)
10.1038/NRI2788
Exploring the full spectrum of macrophage activation
D. Mosser (2010)
10.1161/01.RES.0000267878.97021.ab
Adhesion Mechanisms in Platelet Function
Z. Ruggeri (2007)
10.1038/nrc3004
Contribution of platelets to tumour metastasis
Laurie J. Gay (2011)
10.1038/nm1097
Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A
J. Conejo-Garcia (2004)
10.4161/cc.5.16.3109
Opposing Roles of Mitogenic and Stress Signaling Pathways in the Induction of Cancer Dormancy
A. C. Ranganathan (2006)
10.1038/nm.2537
Tumor angiogenesis: molecular pathways and therapeutic targets
S. Weis (2011)
10.1158/0008-5472.CAN-11-3873
Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.
Jaclyn E. Sceneay (2012)
10.1038/nrc3153
Novel cancer immunotherapy agents with survival benefit: recent successes and next steps
P. Sharma (2011)
10.1084/jem.20122571
IL-2–dependent adaptive control of NK cell homeostasis
G. Gasteiger (2013)
10.1038/nrc2621
The metastatic niche: adapting the foreign soil
B. Psaila (2009)
10.1200/JCO.2006.05.9584
Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse.
G. Bates (2006)
10.1158/0008-5472.CAN-11-2905
Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition.
Dingcheng Gao (2012)
10.1016/j.ccr.2011.08.010
Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids.
J. Roodhart (2011)
10.1002/path.2278
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
A. Bergamaschi (2008)
10.1016/S0140-6736(95)91618-0
Incidence of de-novo breast cancer in women chronically immunosuppressed after organ transplantation
T. Stewart (1995)
10.3389/fphys.2012.00097
Nerve-Cancer Interactions in the Stromal Biology of Pancreatic Cancer
I. E. Demir (2012)
10.1101/gad.180331.111
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer.
T. Shree (2011)
10.1056/NEJMoa1003466
Improved survival with ipilimumab in patients with metastatic melanoma.
F. S. Hodi (2010)
10.1126/scitranslmed.3003330
CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients
Andrew J. Rech (2012)
10.1182/BLOOD-2006-09-046201
Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host.
Cunren Liu (2007)
10.1016/j.cell.2005.10.041
Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow
Y. Katayama (2006)
10.1016/S1535-6108(02)00072-7
EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma.
D. Liu (2002)
10.1158/1078-0432.CCR-08-1164
Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer
G. Ayala (2008)
10.4049/jimmunol.166.1.678
Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer1
B. Almand (2001)
10.1016/j.cell.2012.06.035
The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites
Hua Gao (2012)
10.1016/j.ccr.2012.02.022
Accessories to the crime: functions of cells recruited to the tumor microenvironment.
D. Hanahan (2012)
10.1002/ijc.24741
Cancer and viral infections in immunocompromised individuals
T. Schulz (2009)
10.1038/nature08254
VEGFR1-activity-independent metastasis formation
M. Dawson (2009)
10.1053/j.gastro.2013.03.044
Risk of colorectal high-grade dysplasia and cancer in a prospective observational cohort of patients with inflammatory bowel disease.
L. Beaugerie (2013)
10.1084/jem.20122462
IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
G. Gasteiger (2013)
10.1038/nm.2492
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Kristin M Nieman (2011)
10.1016/j.ccr.2011.09.009
Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis.
Myriam Labelle (2011)
10.1038/nri3191
Adoptive immunotherapy for cancer: harnessing the T cell response
N. Restifo (2012)
10.1055/S-0037-1613413
Impact of pretreatment thrombocytosis on survival in primary breast cancer.
S. Taucher (2003)
10.1002/cncr.26089
Detection of minimal residual disease in blood and bone marrow in early stage breast cancer
Jang-Fang Kuo (2011)
10.1186/1479-5876-3-9
A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer
M. Morse (2004)
10.1158/1940-6207.CAPR-11-0110
Inflammation and Increased Aromatase Expression Occur in the Breast Tissue of Obese Women with Breast Cancer
P. Morris (2011)
10.1038/nature10169
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
A. Facciabene (2011)
10.1182/BLOOD-2004-03-1109
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.
C. Murdoch (2004)
10.1016/j.cell.2013.03.020
Non-Cell-Autonomous Tumor Suppression by p53
Amaia Lujambio (2013)
10.1038/nrc2444
The role of myeloid cells in the promotion of tumour angiogenesis
C. Murdoch (2008)
CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
S. Gende (2011)
Exosomes mediate stromal mobilization of autocrine WntPCP signaling in
V. Luga (2012)
10.1038/ni1102-999
Natural selection of tumor variants in the generation of “tumor escape” phenotypes
H. Khong (2002)
10.1038/ni.1937
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
S. Biswas (2010)
10.1038/nri2808
The polarization of immune cells in the tumour environment by TGFβ
R. Flavell (2010)
10.1186/1479-5876-3-10
Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial
B. Escudier (2004)
10.1016/S0092-8674(00)81731-6
Tumor Induction of VEGF Promoter Activity in Stromal Cells
D. Fukumura (1998)
10.1016/j.ccr.2008.01.034
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.
Rose Du (2008)
Bone marrow–derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
S Purhonen (2008)
10.1016/j.ccr.2011.08.012
Tumor entrained neutrophils inhibit seeding in the premetastatic lung.
Z. Granot (2011)
10.4161/cam.20875
Mesenchymal stem cells in tumor development
B. Cuiffo (2012)
10.1038/nature06309
Adaptive immunity maintains occult cancer in an equilibrium state
Catherine M. Koebel (2007)
10.1016/j.coph.2013.05.017
Tumour-associated macrophages and cancer.
J. Cook (2013)
10.1200/JCO.2009.22.4949
Perineural invasion is an independent predictor of outcome in colorectal cancer.
C. Liebig (2009)
10.1038/nm.3337
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
S. Pyonteck (2013)
10.1126/science.1232227
Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?
L. Coussens (2013)
10.1016/j.ccr.2013.02.013
Macrophage regulation of tumor responses to anticancer therapies.
M. De Palma (2013)
Circulating tumour cells in non-metastatic breast cancer: a prospective study. The lancet oncology
A Lucci (2012)
10.1038/onc.2013.14
Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16
W. Li (2014)
10.1038/nri3024
Neutrophils in the activation and regulation of innate and adaptive immunity
A. Mantovani (2011)
10.1038/ncb2767
The perivascular niche regulates breast tumor dormancy
Cyrus M Ghajar (2013)
10.1093/carcin/bgs123
Tumor-associated neutrophils: friend or foe?
Z. Fridlender (2012)
10.1016/S1055-3207(18)30063-2
Critical steps in hematogenous metastasis: an overview.
A. Chambers (2001)
10.1158/0008-5472.CAN-09-0800
Adipocytes impair leukemia treatment in mice.
James W. Behan (2009)
10.1016/j.ccr.2009.12.041
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.
Neta Erez (2010)
10.1056/NEJMoa1207756
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival.
X. Liao (2012)
10.4049/jimmunol.1203082
Dendritic Cell–Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity
T. I. Näslund (2013)
10.1038/nrc2622
Metastasis: from dissemination to organ-specific colonization
D. Nguyen (2009)
10.1038/nrc3536
The evolution of the cancer niche during multistage carcinogenesis
M. Barcellos-Hoff (2013)
10.3389/fimmu.2012.00021
Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape
S. Chouaib (2012)
10.1056/NEJMe1006416
Treating cancer by targeting the immune system.
P. Hwu (2010)
10.1007/s00262-008-0523-4
Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy
C. Diaz-Montero (2008)
10.1016/S0002-9440(10)62038-X
Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies.
C. Lewis (2005)
10.1038/nm1101-1194
Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
David Lyden (2001)
10.1007/s10911-006-9021-5
Probing the Microenvironment of Mammary Tumors Using Multiphoton Microscopy
M. Sidani (2006)
10.1055/s-2008-1079255
Mechanisms linking tumor cell-associated procoagulant function to tumor dissemination.
J. Palumbo (2008)
10.1073/pnas.0710516105
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
Susanna Purhonen (2008)
Inflammation and cancer: back to Virchow? Lancet
F Balkwill (2001)
10.1111/imm.12036
The immunosuppressive tumour network: myeloid‐derived suppressor cells, regulatory T cells and natural killer T cells
D. Lindau (2013)
10.1084/jem.20100587
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
C. Corzo (2010)
10.1159/000101298
Mesenchymal to Epithelial Transition in Development and Disease
Christine L Chaffer (2007)
HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
CA Corzo (2010)
10.1158/0008-5472.CAN-12-0294
Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment.
Y. Zhang (2012)
10.1002/stem.1247
Human Bone Marrow‐Derived Mesenchymal Stem Cells Suppress Human Glioma Growth Through Inhibition of Angiogenesis
I. A. Ho (2013)
10.1101/gad.1874010
IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion.
V. Gocheva (2010)
Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy.
G. Naumov (2002)
10.1126/science.1203486
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
R. Schreiber (2011)
10.4049/jimmunol.1101304
Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
Y. Shirota (2012)
10.1007/s12307-011-0085-4
Partial Mesenchymal to Epithelial Reverting Transition in Breast and Prostate Cancer Metastases
Y. Chao (2011)
10.1007/s10555-011-9286-z
The significant role of mast cells in cancer
K. Khazaie (2011)
10.1038/nrc3581
History of myeloid-derived suppressor cells
J. Talmadge (2013)
10.2119/molmed.2011.00217
Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling
S. Coniglio (2012)
10.1158/1078-0432.CCR-12-2064
Agonistic CD40 Antibodies and Cancer Therapy
R. Vonderheide (2013)
10.1074/mcp.M111.014647
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices*
A. Naba (2011)
10.4049/jimmunol.1101988
Immune Surveillance Properties of Human NK Cell-Derived Exosomes
L. Lugini (2012)
10.1002/ijc.24989
High frequency of tumor‐infiltrating FOXP3+ regulatory T cells predicts improved survival in mismatch repair‐proficient colorectal cancer patients
D. Frey (2010)
Macrophage binding to receptor VCAM1 transmits survival signals in
Q. Chen (2005)
Models, mechanisms and clinical evidence for cancer dormancy
J. A. Aguirre (2007)
10.1038/nature10144
Molecular mechanisms and clinical applications of angiogenesis
P. Carmeliet (2011)
10.1016/J.YONC.2012.05.018
Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer
C. Lawton (2012)
10.1016/j.devcel.2010.05.012
Tumors as organs: complex tissues that interface with the entire organism.
M. Egeblad (2010)
10.1158/2159-8290.CD-12-0476
Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1.
R. Catena (2013)



This paper is referenced by
10.3390/ijms20092279
LncRNA HOTAIR in Tumor Microenvironment: What Role?
G. Botti (2019)
10.18632/oncotarget.5826
Foxo3a-mediated overexpression of microRNA-622 suppresses tumor metastasis by repressing hypoxia-inducible factor-1α in erk-responsive lung cancer
C. Cheng (2015)
Tumor-associated macrophages : role in tumorigenesis and 2 immunotherapy implications 3
Shunyao Zhu (2020)
10.3389/fimmu.2018.00578
mTOR at the Transmitting and Receiving Ends in Tumor Immunity
Yakir Guri (2018)
10.1038/nm.3391
Tumor metastasis: moving new biological insights into the clinic
Liling Wan (2013)
10.1186/s13058-016-0674-8
The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis
Kun Xu (2016)
10.1007/s13277-015-4548-y
Γ-Ionizing radiation-induced activation of the EGFR–p38/ERK–STAT3/CREB-1–EMT pathway promotes the migration/invasion of non-small cell lung cancer cells and is inhibited by podophyllotoxin acetate
J. H. Cho (2015)
10.1101/gad.270439.115
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.
L. Akkari (2016)
10.1158/0008-5472.CAN-16-1131
Bronchial Artery Angiogenesis Drives Lung Tumor Growth.
L. Eldridge (2016)
10.1016/j.biopha.2018.01.149
Protective and recuperative effects of 3-bromopyruvate on immunological, hepatic and renal homeostasis in a murine host bearing ascitic lymphoma: Implication of niche dependent differential roles of macrophages.
S. Yadav (2018)
10.1159/000491060
Gremlin1 Delivered by Mesenchymal Stromal Cells Promoted Epithelial-Mesenchymal Transition in Human Esophageal Squamous Cell Carcinoma
Dongxi Hong (2018)
10.1016/j.canlet.2018.02.016
Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells.
Atsuro Saijo (2018)
10.1080/2162402X.2017.1397249
IL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis
E. Ferretti (2018)
10.1016/j.biopha.2018.02.062
α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells.
D. Sun (2018)
10.1007/s10585-018-9896-8
Potential impact of invasive surgical procedures on primary tumor growth and metastasis
M. Alieva (2018)
10.1007/978-3-319-56673-3_5
Hereditary Breast Cancer Genetics and Risk Prediction Techniques
H. Carley (2018)
10.1074/mcp.RA118.000596
The Ewing Sarcoma Secretome and Its Response to Activation of Wnt/beta-catenin Signaling *
Allegra G. Hawkins (2018)
10.1002/asia.201801221
Photodynamic Therapy Based on Nanoscale Metal-Organic Frameworks: From Material Design to Cancer Nanotherapeutics.
Qun Guan (2018)
10.1038/s41598-018-31138-6
Development of a Novel 3D Tumor-tissue Invasion Model for High-throughput, High-content Phenotypic Drug Screening
T. J. Puls (2018)
10.1039/c8lc00584b
Double-exclusive liquid repellency (double-ELR): an enabling technology for rare phenotype analysis.
Chao Li (2018)
10.1002/adbi.201800109
Mimicking Human Pathophysiology in Organ‐on‐Chip Devices
O. Yesil-Celiktas (2018)
10.1016/j.colsurfb.2020.111442
Legumain protease-activated tuftsin-functionalized nanoparticles for dual-targeting TAMs and cancer chemotherapy.
H. Peng (2020)
10.1093/jnci/dju238
Cancer chemoprevention with nuts.
M. Falasca (2014)
10.14800/ccm.666
Efferocytosis creates a tumor microenvironment supportive of tumor survival and metastasis.
D. Vaught (2015)
tumoricidal immune response that is adoptively transferable papillomavirus-associated head and neck cancer induces Intraperitoneal oxidative stress in rabbits with
Annette Rossmann (2014)
10.18632/oncotarget.12004
Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer
A. Berg (2016)
10.3390/ijms21113888
Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment
Sarah Ouahoud (2020)
10.1245/s10434-019-08076-2
Nicaraven Attenuates Postoperative Systemic Inflammatory Responses-Induced Tumor Metastasis
X. Zhang (2019)
10.2147/BCTT.S130838
Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity
Manpreet Sambi (2017)
Next-Generation Pathology — Surveillance of Tumor Microecology asood
Björn Koos (2015)
10.2147/IJN.S182579
Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts
E. Christensen (2018)
10.3892/ijo.2019.4952
Role of microRNAs in remodeling the tumor microenvironment (Review)
Z. Pan (2019)
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