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Microenvironmental Regulation Of Tumor Progression And Metastasis
Daniela F. Quail, J. Joyce
Published 2013 · Biology, Medicine
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Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive therapeutic target with reduced risk of resistance and tumor recurrence. However, specifically disrupting the pro-tumorigenic TME is a challenging undertaking, as the TME has diverse capacities to induce both beneficial and adverse consequences for tumorigenesis. Furthermore, many studies have shown that the microenvironment is capable of normalizing tumor cells, suggesting that re-education of stromal cells, rather than targeted ablation per se, may be an effective strategy for treating cancer. Here we discuss the paradoxical roles of the TME during specific stages of cancer progression and metastasis, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.
This paper references
Transplacental carcinogenesis by stilbestrol.
J. Folkman (1971)
Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients.
Junliang Fu (2007)
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
M. Bissell (2011)
Myeloid Cells Contribute to Tumor Lymphangiogenesis
Adrian Zumsteg (2009)
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
J. Condeelis (2006)
Tissue factor pathway inhibitor reduces experimental lung metastasis of B16 melanoma.
A. Amirkhosravi (2002)
Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors
Anne-Katrine Bonde (2011)
Myofibroblasts and mechano-regulation of connective tissue remodelling
J. Tomasek (2002)
Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors
H. Shime (2012)
CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
Bin-Zhi Qian (2011)
Microenvironmental regulation of metastasis
J. Joyce (2009)
Cancer immunotherapy via dendritic cells
K. Palucka (2012)
Autonomic nerve development contributes to prostate cancer progression.
J. Bauman (2013)
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
F Calvo (2013)
Expression of RORgammat marks a pathogenic regulatory T cell subset in human colon cancer
NR Blatner (2012)
Fibroblasts in cancer
R. Kalluri (2006)
Impact of tumor‐associated macrophages on invasive ductal carcinoma of the pancreas head
K. Yoshikawa (2012)
Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination
B. Robinson (2009)
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
R. Kaplan (2005)
Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts.
E. Zeisberg (2007)
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma.
O. Hamid (2013)
Deciphering and reversing tumor immune suppression.
GregÂ T. Motz (2013)
Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma
X. Zhang (2013)
Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
G. Semenza (2013)
Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.
J. Palumbo (2005)
In vivo imaging in cancer.
J. Condeelis (2010)
Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium
AF Olumi (2000)
Lessons from the cancer
L. A. Garraway (2013)
Interaction of tumor cells and lymphatic vessels in cancer progression
A. Alitalo (2012)
BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury
M. Zeisberg (2003)
Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.
D. DeNardo (2011)
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis.
S. Schoppmann (2002)
Nivolumab plus ipilimumab in advanced melanoma.
J. Wolchok (2013)
Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo.
W. Zhu (2006)
Cancer incidence and risk factors after solid organ transplantation
C. Vajdic (2009)
Global burden of cancers attributable to infections in 2008: a review and synthetic analysis.
C. de Martel (2012)
Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism1
A. Mazzoni (2002)
Tumor‐associated lympho‐monocytes from neoplastic effusions are immunologically defective in comparison with patient autologous PBMCs but are capable of releasing high amounts of various cytokines
G. Mantovani (1997)
Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer.
S. Braun (2000)
Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
V. Luga (2012)
Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy.
N. Halama (2011)
Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer
N. Blatner (2012)
Immune microenvironments in solid tumors: new targets for therapy.
S. Shiao (2011)
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
Q. Chen (2011)
Role of macrophage targeting in the antitumor activity of trabectedin.
G. Germano (2013)
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A Mani (2008)
Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas.
K. Brown (2005)
Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance.
A. Sangiovanni (2004)
Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.
Dagmar Schumacher (2013)
Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors.
J. Wyckoff (2007)
Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
D. Kerjaschki (2006)
“Re-educating” tumor-associated macrophages by targeting NF-κB
T. Hagemann (2008)
The immune contexture in human tumours: impact on clinical outcome
W. Fridman (2012)
Clinical opportunities and challenges in targeting tumour dormancy
Jonathan A. Hensel (2013)
Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge
F. Zijl (2009)
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
H. Peinado (2012)
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
Rikke B. Holmgaard (2013)
A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth
Binzhi Qian (2009)
Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas
R. Kerbel (2008)
Intra-tumour heterogeneity: a looking glass for cancer?
A. Marusyk (2012)
Fibroblasts as architects of cancer pathogenesis.
Timothy Marsh (2013)
Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer
J. Pierga (2003)
Faculty Opinions recommendation of IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity.
R. Vile (2001)
IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
V. Shankaran (2001)
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.
E. Calle (2003)
Targeting the tumor microenvironment: from understanding pathways to effective clinical trials.
H. Fang (2013)
Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate
B. Orr (2012)
Interactions between cancer stem cells and their niche govern metastatic colonization
Ilaria Malanchi (2012)
Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer.
N. H. Stoecklein (2008)
Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis
Dingcheng Gao (2008)
Models, mechanisms and clinical evidence for cancer dormancy
J. Aguirre-Ghiso (2007)
Hallmarks of Cancer: The Next Generation
D. Hanahan (2011)
Role of Angiogenesis in Human Tumor Dormancy: Animal Models of the Angiogenic Switch
G. Naumov (2006)
Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization.
E. Redente (2010)
Combining immunotherapy and targeted therapies in cancer treatment
M. Vanneman (2012)
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.
Xin Lu (2011)
Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells1
D. Gabrilovich (2001)
Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
S. Yamazaki (2011)
Circulating tumour cells in non-metastatic breast cancer: a prospective study.
A. Lucci (2012)
Functions of natural killer cells
É. Vivier (2008)
Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian (2010)
Influence of low oxygen tensions on macrophage polarization.
M. Escribese (2012)
Coordinated regulation of myeloid cells by tumours
D. Gabrilovich (2012)
Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice.
Ana M. Gil-Bernabé (2012)
HIF-1a regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
Inflammation and cancer: back to Virchow?
F. Balkwill (2001)
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop.
S. Goswami (2005)
Preoperative thrombocytosis predicts poor survival in patients with glioblastoma.
M. Brockmann (2007)
Circulating tumour cells in non-metastatic breast cancer: a prospective study
A Lucci (2012)
Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155.
Xing Cai (2012)
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors
K. E. Hunter (2014)
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis.
J. Joyce (2004)
Lysyl oxidase is essential for hypoxia-induced metastasis
Janine T. Erler (2006)
Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma.
O. W. Petersen (2003)
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation
J. Landsberg (2012)
Lessons from the Cancer Genome
L. Garraway (2013)
Intravital imaging of cell movement in tumours
J. Condeelis (2003)
Immunity, Inflammation, and Cancer
S. Grivennikov (2010)
Mesenchymal Stem Cells Provide an Advantageous Tumor Microenvironment for the Restoration of Cancer Stem Cells
Kanako Nishimura (2012)
Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease1
P. Sinha (2005)
Induced and natural regulatory T cells in human cancer
T. Whiteside (2012)
Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy?
M. De Palma (2009)
Alternative activation of tumor-associated macrophages by IL-4
H. Wang (2010)
Tumor angiogenesis: therapeutic implications.
J. Folkman (1971)
Treg Cells in Cancer: A Case of Multiple Personality Disorder
P. Bos (2012)
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent.
K. D. de Visser (2005)
Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics.
N. Dumont (2013)
Cancer incidence in New York State acquired immunodeficiency syndrome patients.
B. Gallagher (2001)
Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer
H. Boehmer (2012)
Epithelial-Mesenchymal Transitions in Development and Disease
J. Thiery (2009)
Exploring the full spectrum of macrophage activation
D. Mosser (2010)
Adhesion Mechanisms in Platelet Function
Z. Ruggeri (2007)
Contribution of platelets to tumour metastasis
Laurie J. Gay (2011)
Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A
J. Conejo-Garcia (2004)
Opposing Roles of Mitogenic and Stress Signaling Pathways in the Induction of Cancer Dormancy
A. C. Ranganathan (2006)
Tumor angiogenesis: molecular pathways and therapeutic targets
S. Weis (2011)
Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.
Jaclyn E. Sceneay (2012)
Novel cancer immunotherapy agents with survival benefit: recent successes and next steps
P. Sharma (2011)
IL-2–dependent adaptive control of NK cell homeostasis
G. Gasteiger (2013)
The metastatic niche: adapting the foreign soil
B. Psaila (2009)
Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse.
G. Bates (2006)
Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition.
Dingcheng Gao (2012)
Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids.
J. Roodhart (2011)
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
A. Bergamaschi (2008)
Incidence of de-novo breast cancer in women chronically immunosuppressed after organ transplantation
T. Stewart (1995)
Nerve-Cancer Interactions in the Stromal Biology of Pancreatic Cancer
I. E. Demir (2012)
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer.
T. Shree (2011)
Improved survival with ipilimumab in patients with metastatic melanoma.
F. S. Hodi (2010)
CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients
Andrew J. Rech (2012)
Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host.
Cunren Liu (2007)
Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow
Y. Katayama (2006)
EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma.
D. Liu (2002)
Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer
G. Ayala (2008)
Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer1
B. Almand (2001)
The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites
Hua Gao (2012)
Accessories to the crime: functions of cells recruited to the tumor microenvironment.
D. Hanahan (2012)
Cancer and viral infections in immunocompromised individuals
T. Schulz (2009)
VEGFR1-activity-independent metastasis formation
M. Dawson (2009)
Risk of colorectal high-grade dysplasia and cancer in a prospective observational cohort of patients with inflammatory bowel disease.
L. Beaugerie (2013)
IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
G. Gasteiger (2013)
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
Kristin M Nieman (2011)
Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis.
Myriam Labelle (2011)
Adoptive immunotherapy for cancer: harnessing the T cell response
N. Restifo (2012)
Impact of pretreatment thrombocytosis on survival in primary breast cancer.
S. Taucher (2003)
Detection of minimal residual disease in blood and bone marrow in early stage breast cancer
Jang-Fang Kuo (2011)
A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer
M. Morse (2004)
Inflammation and Increased Aromatase Expression Occur in the Breast Tissue of Obese Women with Breast Cancer
P. Morris (2011)
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
A. Facciabene (2011)
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.
C. Murdoch (2004)
Non-Cell-Autonomous Tumor Suppression by p53
Amaia Lujambio (2013)
The role of myeloid cells in the promotion of tumour angiogenesis
C. Murdoch (2008)
CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
S. Gende (2011)
Exosomes mediate stromal mobilization of autocrine WntPCP signaling in
V. Luga (2012)
Natural selection of tumor variants in the generation of “tumor escape” phenotypes
H. Khong (2002)
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
S. Biswas (2010)
The polarization of immune cells in the tumour environment by TGFβ
R. Flavell (2010)
Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial
B. Escudier (2004)
Tumor Induction of VEGF Promoter Activity in Stromal Cells
D. Fukumura (1998)
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.
Rose Du (2008)
Bone marrow–derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
S Purhonen (2008)
Tumor entrained neutrophils inhibit seeding in the premetastatic lung.
Z. Granot (2011)
Mesenchymal stem cells in tumor development
B. Cuiffo (2012)
Adaptive immunity maintains occult cancer in an equilibrium state
Catherine M. Koebel (2007)
Tumour-associated macrophages and cancer.
J. Cook (2013)
Perineural invasion is an independent predictor of outcome in colorectal cancer.
C. Liebig (2009)
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
S. Pyonteck (2013)
Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?
L. Coussens (2013)
Macrophage regulation of tumor responses to anticancer therapies.
M. De Palma (2013)
Circulating tumour cells in non-metastatic breast cancer: a prospective study. The lancet oncology
A Lucci (2012)
Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16
W. Li (2014)
Neutrophils in the activation and regulation of innate and adaptive immunity
A. Mantovani (2011)
The perivascular niche regulates breast tumor dormancy
Cyrus M Ghajar (2013)
Tumor-associated neutrophils: friend or foe?
Z. Fridlender (2012)
Critical steps in hematogenous metastasis: an overview.
A. Chambers (2001)
Adipocytes impair leukemia treatment in mice.
James W. Behan (2009)
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.
Neta Erez (2010)
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival.
X. Liao (2012)
Dendritic Cell–Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity
T. I. Näslund (2013)
Metastasis: from dissemination to organ-specific colonization
D. Nguyen (2009)
The evolution of the cancer niche during multistage carcinogenesis
M. Barcellos-Hoff (2013)
Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape
S. Chouaib (2012)
Treating cancer by targeting the immune system.
P. Hwu (2010)
Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy
C. Diaz-Montero (2008)
Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies.
C. Lewis (2005)
Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
David Lyden (2001)
Probing the Microenvironment of Mammary Tumors Using Multiphoton Microscopy
M. Sidani (2006)
Mechanisms linking tumor cell-associated procoagulant function to tumor dissemination.
J. Palumbo (2008)
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
Susanna Purhonen (2008)
Inflammation and cancer: back to Virchow? Lancet
F Balkwill (2001)
The immunosuppressive tumour network: myeloid‐derived suppressor cells, regulatory T cells and natural killer T cells
D. Lindau (2013)
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
C. Corzo (2010)
Mesenchymal to Epithelial Transition in Development and Disease
Christine L Chaffer (2007)
HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
CA Corzo (2010)
Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment.
Y. Zhang (2012)
Human Bone Marrow‐Derived Mesenchymal Stem Cells Suppress Human Glioma Growth Through Inhibition of Angiogenesis
I. A. Ho (2013)
IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion.
V. Gocheva (2010)
Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy.
G. Naumov (2002)
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
R. Schreiber (2011)
Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells
Y. Shirota (2012)
Partial Mesenchymal to Epithelial Reverting Transition in Breast and Prostate Cancer Metastases
Y. Chao (2011)
The significant role of mast cells in cancer
K. Khazaie (2011)
History of myeloid-derived suppressor cells
J. Talmadge (2013)
Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling
S. Coniglio (2012)
Agonistic CD40 Antibodies and Cancer Therapy
R. Vonderheide (2013)
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices*
A. Naba (2011)
Immune Surveillance Properties of Human NK Cell-Derived Exosomes
L. Lugini (2012)
High frequency of tumor‐infiltrating FOXP3+ regulatory T cells predicts improved survival in mismatch repair‐proficient colorectal cancer patients
D. Frey (2010)
Macrophage binding to receptor VCAM1 transmits survival signals in
Q. Chen (2005)
Models, mechanisms and clinical evidence for cancer dormancy
J. A. Aguirre (2007)
Molecular mechanisms and clinical applications of angiogenesis
P. Carmeliet (2011)
Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer
C. Lawton (2012)
Tumors as organs: complex tissues that interface with the entire organism.
M. Egeblad (2010)
Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1.
R. Catena (2013)
This paper is referenced by
LncRNA HOTAIR in Tumor Microenvironment: What Role?
G. Botti (2019)
Foxo3a-mediated overexpression of microRNA-622 suppresses tumor metastasis by repressing hypoxia-inducible factor-1α in erk-responsive lung cancer
C. Cheng (2015)
Tumor-associated macrophages : role in tumorigenesis and 2 immunotherapy implications 3
Shunyao Zhu (2020)
mTOR at the Transmitting and Receiving Ends in Tumor Immunity
Yakir Guri (2018)
Tumor metastasis: moving new biological insights into the clinic
Liling Wan (2013)
The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis
Kun Xu (2016)
Γ-Ionizing radiation-induced activation of the EGFR–p38/ERK–STAT3/CREB-1–EMT pathway promotes the migration/invasion of non-small cell lung cancer cells and is inhibited by podophyllotoxin acetate
J. H. Cho (2015)
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.
L. Akkari (2016)
Bronchial Artery Angiogenesis Drives Lung Tumor Growth.
L. Eldridge (2016)
Protective and recuperative effects of 3-bromopyruvate on immunological, hepatic and renal homeostasis in a murine host bearing ascitic lymphoma: Implication of niche dependent differential roles of macrophages.
S. Yadav (2018)
Gremlin1 Delivered by Mesenchymal Stromal Cells Promoted Epithelial-Mesenchymal Transition in Human Esophageal Squamous Cell Carcinoma
Dongxi Hong (2018)
Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells.
Atsuro Saijo (2018)
IL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis
E. Ferretti (2018)
α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells.
D. Sun (2018)
Potential impact of invasive surgical procedures on primary tumor growth and metastasis
M. Alieva (2018)
Hereditary Breast Cancer Genetics and Risk Prediction Techniques
H. Carley (2018)
The Ewing Sarcoma Secretome and Its Response to Activation of Wnt/beta-catenin Signaling *
Allegra G. Hawkins (2018)
Photodynamic Therapy Based on Nanoscale Metal-Organic Frameworks: From Material Design to Cancer Nanotherapeutics.
Qun Guan (2018)
Development of a Novel 3D Tumor-tissue Invasion Model for High-throughput, High-content Phenotypic Drug Screening
T. J. Puls (2018)
Double-exclusive liquid repellency (double-ELR): an enabling technology for rare phenotype analysis.
Chao Li (2018)
Mimicking Human Pathophysiology in Organ‐on‐Chip Devices
O. Yesil-Celiktas (2018)
Legumain protease-activated tuftsin-functionalized nanoparticles for dual-targeting TAMs and cancer chemotherapy.
H. Peng (2020)
Cancer chemoprevention with nuts.
M. Falasca (2014)
Efferocytosis creates a tumor microenvironment supportive of tumor survival and metastasis.
D. Vaught (2015)
tumoricidal immune response that is adoptively transferable papillomavirus-associated head and neck cancer induces Intraperitoneal oxidative stress in rabbits with
Annette Rossmann (2014)
Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer
A. Berg (2016)
Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment
Sarah Ouahoud (2020)
Nicaraven Attenuates Postoperative Systemic Inflammatory Responses-Induced Tumor Metastasis
X. Zhang (2019)
Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity
Manpreet Sambi (2017)
Next-Generation Pathology — Surveillance of Tumor Microecology asood
Björn Koos (2015)
Folate receptor targeting of radiolabeled liposomes reduces intratumoral liposome accumulation in human KB carcinoma xenografts
E. Christensen (2018)
Role of microRNAs in remodeling the tumor microenvironment (Review)
Z. Pan (2019)See more