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Imaging Macrophages With Nanoparticles.

R. Weissleder, M. Nahrendorf, M. Pittet
Published 2014 · Materials Science, Medicine

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Nanomaterials have much to offer, not only in deciphering innate immune cell biology and tracking cells, but also in advancing personalized clinical care by providing diagnostic and prognostic information, quantifying treatment efficacy and designing better therapeutics. This Review presents different types of nanomaterial, their biological properties and their applications for imaging macrophages in human diseases, including cancer, atherosclerosis, myocardial infarction, aortic aneurysm, diabetes and other conditions. We anticipate that future needs will include the development of nanomaterials that are specific for immune cell subsets and can be used as imaging surrogates for nanotherapeutics. New in vivo imaging clinical tools for noninvasive macrophage quantification are thus ultimately expected to become relevant to predicting patients' clinical outcome, defining treatment options and monitoring responses to therapy.
This paper references
10.1148/radiol.12111416
Assessment of disease activity in multiple sclerosis phenotypes with combined gadolinium- and superparamagnetic iron oxide-enhanced MR imaging.
T. Tourdias (2012)
10.1002/CHIN.201132203
Highly Magnetic Core—Shell Nanoparticles with a Unique Magnetization Mechanism.
Tae-Jong Yoon (2011)
10.1148/radiol.12121378
Science to practice: can macrophage infiltration serve as a surrogate marker for stem cell viability?
J. Bulte (2012)
10.1126/science.1230719
Leukocyte Behavior in Atherosclerosis, Myocardial Infarction, and Heart Failure
F. Swirski (2013)
10.1002/jbm.a.34635
Transport barriers and strategies of antitumor nanocarriers delivery system.
L. Zhang (2013)
10.1021/nl202721q
Compact zwitterion-coated iron oxide nanoparticles for biological applications.
H. Wei (2012)
10.1016/j.cell.2010.03.014
Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian (2010)
10.1126/science.1178331
Development of Monocytes, Macrophages, and Dendritic Cells
F. Geissmann (2010)
10.1097/00004424-199510000-00006
Cellular Uptake and Trafficking of a Prototypical Magnetic Iron Oxide Label In Vitro
E. Schulze (1995)
10.1016/j.nano.2011.08.009
Imaging of size-dependent uptake and identification of novel pathways in mouse Peyer's patches using fluorescent organosilica particles.
A. Awaad (2012)
10.1002/1522-2586(200012)12:6<905::AID-JMRI14>3.0.CO;2-5
New generation of monomer‐stabilized very small superparamagnetic iron oxide particles (VSOP) as contrast medium for MR angiography: Preclinical results in rats and rabbits
M. Taupitz (2000)
10.1371/journal.pone.0013167
Uniform Silica Coated Fluorescent Nanoparticles: Synthetic Method, Improved Light Stability and Application to Visualize Lymph Network Tracer
L. Cong (2010)
10.1021/ar200084x
Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy.
C. Tassa (2011)
balance, tolerance, and diversity
A. Mantovani (2010)
10.1148/RADIOLOGY.191.1.8134576
MR lymphography: study of a high-efficiency lymphotrophic agent.
R. Weissleder (1994)
10.2214/AJR.09.3107
In vivo MRI cell tracking: clinical studies.
J. Bulte (2009)
10.4161/onci.23034
A novel probe for the non-invasive detection of tumor-associated inflammation
A. Balducci (2013)
10.1172/JCI29881
Obesity induces a phenotypic switch in adipose tissue macrophage polarization.
C. Lumeng (2007)
10.1001/archneurol.2010.248
Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis.
D. Karussis (2010)
10.1148/radiol.10092473
Atherosclerotic plaque composition: analysis with multicolor CT and targeted gold nanoparticles.
D. Cormode (2010)
10.1016/j.jcmg.2008.08.009
Macrophage-specific lipid-based nanoparticles improve cardiac magnetic resonance detection and characterization of human atherosclerosis.
M. Lipinski (2009)
10.1161/STROKEAHA.112.673400
Early Change in Ferumoxytol-Enhanced Magnetic Resonance Imaging Signal Suggests Unstable Human Cerebral Aneurysm: A Pilot Study
D. Hasan (2012)
10.1021/bc900438a
Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.
C. Tassa (2010)
10.1002/eji.200425022
Intraocular injection of tamoxifen‐loaded nanoparticles: a new treatment of experimental autoimmune uveoretinitis
Y. de Kozak (2004)
10.1021/nl301967t
Single molecule magnetoresistance with combined antiferromagnetic and ferromagnetic electrodes.
A. Bagrets (2012)
10.1002/mrm.21029
In vivo MRI of cancer cell fate at the single‐cell level in a mouse model of breast cancer metastasis to the brain
C. Heyn (2006)
10.1006/exnr.1996.6350
Tumor Cell Endocytosis Imaging Facilitates Delineation of the Glioma–Brain Interface
C. Zimmer (1997)
10.1161/ATVBAHA.108.179705
Inflammation in Atherosclerosis
P. Libby (2012)
10.1002/(SICI)1522-2586(199902)9:2<228::AID-JMRI12>3.0.CO;2-K
Improved delineation of human brain tumors on MR images using a long‐circulating, superparamagnetic iron oxide agent
W. S. Enochs (1999)
10.1038/nnano.2010.164
An index for characterization of nanomaterials in biological systems.
Xin-Rui Xia (2010)
10.1038/nprot.2011.352
Synthesis of magnetic resonance–, X-ray– and ultrasound-visible alginate microcapsules for immunoisolation and noninvasive imaging of cellular therapeutics
B. Barnett (2011)
10.1016/j.cell.2011.11.004
Intravital Imaging
M. Pittet (2011)
In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging
UlrichFlögel (2008)
10.1172/JCI25048
Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes.
S. Turvey (2005)
10.1038/nm1316
In vivo imaging of islet transplantation
N. Evgenov (2006)
10.1083/JCB1795OIA13
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
M. Nahrendorf (2007)
10.1016/j.cell.2013.03.010
Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal
L. Carlin (2013)
10.1016/S1074-7613(02)00275-3
Arthritis critically dependent on innate immune system players.
H. Ji (2002)
10.1148/radiol.2512071018
Prostate cancer: detection of lymph node metastases outside the routine surgical area with ferumoxtran-10-enhanced MR imaging.
R. A. Heesakkers (2009)
Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction
辻岡 洋人 (2011)
10.1016/j.immuni.2011.02.016
Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands.
C. Shi (2011)
A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation.
M. Kircher (2003)
10.1039/B419004A
Molecular composition of iron oxide nanoparticles, precursors for magnetic drug targeting, as characterized by confocal Raman microspectroscopy.
I. Chourpa (2005)
10.1021/mp1000718
Iodinated NanoClusters as an inhaled computed tomography contrast agent for lung visualization.
Kristin L Aillon (2010)
10.1073/pnas.1213291110
Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources
T. Esipova (2012)
10.1161/CIRCULATIONAHA.108.796888
Molecular Imaging of Innate Immune Cell Function in Transplant Rejection
T. Christen (2009)
10.1172/JCI59643
Macrophage plasticity and polarization: in vivo veritas.
A. Sica (2012)
10.1016/j.jcis.2010.06.048
Superparamagnetic nanoclusters coated with oleic acid bilayers for stabilization of emulsions of water and oil at low concentration.
D. Ingram (2010)
10.1593/NEO.07940
Utility of a new bolus-injectable nanoparticle for clinical cancer staging.
M. Harisinghani (2007)
10.1038/nnano.2012.146
M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancer.
Debadyuti Ghosh (2012)
A Quarter Century of Sovereign Debt Management: An Overview
Lee C. Buchheit (2004)
10.1016/j.jacc.2010.09.023
Targeted iron oxide particles for in vivo magnetic resonance detection of atherosclerotic lesions with antibodies directed to oxidation-specific epitopes.
Karen C. Briley-Saebo (2011)
10.1038/nm1247
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo
M. Stroh (2005)
10.1021/la202190x
Phosphonate-anchored monolayers for antibody binding to magnetic nanoparticles.
Helly Benbenishty-Shamir (2011)
10.1002/JMRI.1880070629
Uptake of dextran‐coated monocrystalline iron oxides in tumor cells and macrophages
A. Moore (1997)
10.1016/j.tox.2011.05.006
The uptake and intracellular fate of a series of different surface coated quantum dots in vitro.
M. J. Clift (2011)
10.1016/j.neuroimage.2011.09.001
MRI signature in a novel mouse model of genetically induced adult oligodendrocyte cell death
T. Mueggler (2012)
10.1016/S0304-8853(99)00088-8
Magnetic fluid hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles
A. Jordan (1999)
10.1038/nbt920
Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping
S. Kim (2004)
10.1038/nnano.2007.217
Targeted delivery of magnetic aerosol droplets to the lung
P. Dames (2007)
10.1161/CIRCULATIONAHA.109.916346
Monocytes: protagonists of infarct inflammation and repair after myocardial infarction.
M. Nahrendorf (2010)
10.1016/j.addr.2012.10.002
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo.
H. Maeda (2013)
10.1126/science.1219179
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
C. Schulz (2012)
a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy
C. Tassa (2011)
10.1042/BJ20111708
Role and function of macrophages in the metabolic syndrome.
P. Bhargava (2012)
10.1038/nbt.1989
Therapeutic siRNA silencing in inflammatory monocytes
F. Leuschner (2011)
a new treatment of experimental autoimmune uveoretinitis
De Kozak (2004)
10.1161/CIRCIMAGING.112.973727
Molecular Imaging of Aortic Aneurysms
D. Buxton (2012)
application to in vivo bioimaging
S. A. Hilderbrand (2009)
10.1097/RLI.0b013e3181a0068b
Safety and Tolerability of Ultrasmall Superparamagnetic Iron Oxide Contrast Agent: Comprehensive Analysis of a Clinical Development Program
Hamm Bernd (2009)
10.1002/mrm.22702
19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells
T. Hitchens (2011)
10.1083/JCB.135.6.1551
Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins
V. Fincham (1996)
10.1016/j.immuni.2012.10.015
Angiotensin II drives the production of tumor-promoting macrophages.
V. Cortez-Retamozo (2013)
10.1063/1.2746064
Fe∕Fe oxide nanocomposite particles with large specific absorption rate for hyperthermia
Qi Zeng (2007)
10.1080/026520400288427
Gelatin nanoparticles by two step desolvation a new preparation method, surface modifications and cell uptake
C. J. Coester, K. Langer, H. Von Briesen, J. Kreut (2000)
a multimodality contrast agent platform
Cormode (2008)
10.1038/nm.2666
Self-Assembling Nanocomplexes by combining Ferumoxytol, Heparin And Protamine For Cell Tracking by MRI
Mya S. Thu (2012)
10.1016/j.jacc.2009.03.018
The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study. Evaluation using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in carotid disease.
T. Tang (2009)
10.1146/annurev-chembioeng-061010-114300
Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.
Vikash P. Chauhan (2011)
10.1002/mrm.10068
Detection of lymph node metastases by contrast‐enhanced MRI in an experimental model
P. Wunderbaldinger (2002)
10.1126/science.1226338
Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
Z. Cheng (2012)
10.2310/7290.2006.00009
Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials
F. Jaffer (2006)
10.1021/nl801958b
Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform.
David P. Cormode (2008)
10.1083/JCB.135.5.1249
A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
N. Araki (1996)
10.1039/b905927j
Upconverting luminescent nanomaterials: application to in vivo bioimaging.
S. Hilderbrand (2009)
10.1371/journal.pmed.0010066
Sensitive, Noninvasive Detection of Lymph Node Metastases
M. Harisinghani (2004)
10.3109/10611860008996862
Reduction of the Uptake by a Macrophagic Cell Line of Nanoparticles Bearing Heparin or Dextran Covalently Bound to Poly(methyl methacrylate)
N. Jaulin (2000)
10.1097/WCO.0b013e328337f4b5
New approaches to neuroimaging of central nervous system inflammation
G. Stoll (2010)
10.1126/science.1175202
Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
F. Swirski (2009)
10.1084/jem.20111009
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis
F. Leuschner (2012)
10.1039/b821775k
Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.
Kimberly A. Kelly (2009)
10.1038/nbt1159
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
R. Weissleder (2005)
10.1021/ja200120k
Large-scale synthesis of bioinert tantalum oxide nanoparticles for X-ray computed tomography imaging and bimodal image-guided sentinel lymph node mapping.
Myoung Hwan Oh (2011)
10.1080/026520400288427
Gelatin nanoparticles by two step desolvation--a new preparation method, surface modifications and cell uptake.
C. Coester (2000)
10.1021/la302446h
Surface coatings shape the protein corona of SPIONs with relevance to their application in vivo.
Angéla Jedlovszky-Hajdú (2012)
10.1063/1.326939
Magnetic materials and applications– A quarter‐century overview (invited)
I. Jacobs (1979)
10.1021/nl303144k
Modeling biological activities of nanoparticles.
V. Epa (2012)
10.1161/CIRCIMAGING.110.959866
Abdominal Aortic Aneurysm Growth Predicted by Uptake of Ultrasmall Superparamagnetic Particles of Iron Oxide: A Pilot Study
J. Richards (2011)
10.2214/AJR.152.1.167
Superparamagnetic iron oxide: pharmacokinetics and toxicity.
R. Weissleder (1989)
10.1038/nbt1105-1372
In vivo veritas
L. Zitvogel (2005)
10.2967/jnumed.108.060749
Quantification of Inflammation Within Rabbit Atherosclerotic Plaques Using the Macrophage-Specific CT Contrast Agent N1177: A Comparison with 18F-FDG PET/CT and Histology
F. Hyafil (2009)
10.1038/ni1306
Particularities of the vasculature can promote the organ specificity of autoimmune attack
B. Binstadt (2006)
drug delivery and diagnostics
M. Talekar (2011)
10.1111/j.1600-0404.1981.tb07742.x
PHYSICOCHEMICAL PROPERTIES
(1981)
10.1002/smll.201201531
Applications and potential toxicity of magnetic iron oxide nanoparticles.
G. Liu (2013)
10.1016/j.jcmg.2009.01.013
Noninvasive evaluation of cardiac allograft rejection by cellular and functional cardiac magnetic resonance.
Y. Wu (2009)
10.1159/000083766
Parenteral Iron Therapy in Treatment of Anemia in End-Stage Renal Disease Patients: A Comparative Study between Iron Saccharate and Gluconate
H. Sheashaa (2005)
10.1038/NMAT1571
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles
Oded Rabin (2006)
10.1056/NEJMoa0905680
Tumor-associated macrophages and survival in classic Hodgkin's lymphoma.
C. Steidl (2010)
10.1021/bc8004649
18F labeled nanoparticles for in vivo PET-CT imaging.
N. Devaraj (2009)
10.1002/adhm.201200051
Uptake and intracellular fate of fluorescent-magnetic glyco-nanoparticles.
J. Gallo (2012)
10.1172/JCI44339
Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.
J. Gaglia (2011)
10.1016/j.immuni.2010.05.007
Alternative activation of macrophages: mechanism and functions.
S. Gordon (2010)
10.1007/s10439-012-0630-4
Cationic Nanoparticles Have Superior Transvascular Flux into Solid Tumors: Insights from a Mathematical Model
T. Stylianopoulos (2012)
10.1161/CIRCIMAGING.112.974907
Ultrasmall Superparamagnetic Particles of Iron Oxide in Patients With Acute Myocardial Infarction: Early Clinical Experience
S. Alam (2012)
10.1161/01.CIR.0000068315.98705.CC
Accumulation of Ultrasmall Superparamagnetic Particles of Iron Oxide in Human Atherosclerotic Plaques Can Be Detected by In Vivo Magnetic Resonance Imaging
M. E. Kooi (2003)
10.1016/j.cell.2011.04.005
Macrophages in the Pathogenesis of Atherosclerosis
K. Moore (2011)
10.1016/j.clinimag.2009.07.004
Detection of lymph nodes in pelvic malignancies with Computed Tomography and Magnetic Resonance Imaging.
A. Saokar (2010)
10.1148/RADIOLOGY.197.2.7480707
MR imaging of phagocytosis in experimental gliomas.
C. Zimmer (1995)
10.1021/bm7014152
Synthesis and characterization of core-shell star copolymers for in vivo PET imaging applications.
K. Fukukawa (2008)
10.1097/01.rli.0000197669.80475.dd
Preclinical Safety and Pharmacokinetic Profile of Ferumoxtran-10, an Ultrasmall Superparamagnetic Iron Oxide Magnetic Resonance Contrast Agent
P. Bourrinet (2006)
10.1038/nm1571
Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography
F. Hyafil (2007)
10.1158/1078-0432.CCR-10-3420
MRI of Tumor-Associated Macrophages with Clinically Applicable Iron Oxide Nanoparticles
H. Daldrup-Link (2011)
10.1016/j.coi.2010.01.009
Macrophages, innate immunity and cancer: balance, tolerance, and diversity.
A. Mantovani (2010)
10.1148/radiol.12111863
Monocyte and/or macrophage infiltration of heart after myocardial infarction: MR imaging by using T1-shortening liposomes.
N. Naresh (2012)
10.1021/nn901869f
Microglial response to gold nanoparticles.
Eliza Hutter (2010)
10.5040/9781474247115.0051
The pilot study.
C. Baird (2000)
10.1073/pnas.0606281104
Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI
Vardan Amirbekian (2007)
10.1148/RADIOLOGY.175.2.2326475
Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging.
R. Weissleder (1990)
10.1161/CIRCRESAHA.111.300576
Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques
Maulik D. Majmudar (2013)
10.1161/ATVBAHA.110.221499
Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography–Computed Tomography
M. Nahrendorf (2011)
10.1148/radiol.2491071706
Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies.
G. Korosoglou (2008)
10.1158/2159-8274.CD-10-0028
Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.
D. DeNardo (2011)
10.1038/nature06917
Imaging in the era of molecular oncology
R. Weissleder (2008)
10.1021/bc800108v
Synthesis of 64Cu-labeled magnetic nanoparticles for multimodal imaging.
B. R. Jarrett (2008)
10.1097/CAD.0b013e32834a4554
Targeting of nanoparticles in cancer: drug delivery and diagnostics
M. Talekar (2011)
10.1016/j.biomaterials.2010.08.078
The biological properties of iron oxide core high-density lipoprotein in experimental atherosclerosis.
T. Skajaa (2011)
10.1038/74464
Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
M. Lewin (2000)
10.1006/exnr.1993.1156
MR Imaging of Slow Axonal Transport in Vivo
W. S. Enochs (1993)
10.1021/NL061498R
Properties of a versatile nanoparticle platform contrast agent to image and characterize atherosclerotic plaques by magnetic resonance imaging.
J. Frías (2006)
10.1006/JCIS.2001.7500
Nonpolymeric Coatings of Iron Oxide Colloids for Biological Use as Magnetic Resonance Imaging Contrast Agents.
D. Portet (2001)
10.3109/14017436909131926
CLINICAL STUDIES
W. Couldwell
10.1385/1-59745-369-2:3
Immunofluorescent labeling of proteins in cultured cells with quantum dot secondary antibody conjugates.
Richard L Ornberg (2007)
10.1200/JCO.2005.04.937
Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer.
W. Gradishar (2005)
10.1073/pnas.0915163107
Hybrid PET-optical imaging using targeted probes
M. Nahrendorf (2010)
10.1126/science.1204351
Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation
S. Jenkins (2011)
10.1021/nn303030t
Synthesis and in vivo pharmacokinetic evaluation of degradable shell cross-linked polymer nanoparticles with poly(carboxybetaine) versus poly(ethylene glycol) surface-grafted coatings.
A. Li (2012)
10.1021/NL0719832
Nonfunctionalized nanocrystals can exploit a cell's active transport machinery delivering them to specific nuclear and cytoplasmic compartments.
I. Nabiev (2007)
10.1021/nl1037903
Quantum dot and Cy5.5 labeled nanoparticles to investigate lipoprotein biointeractions via Förster resonance energy transfer.
T. Skajaa (2010)
10.1038/nature07205
Cancer-related inflammation
A. Mantovani (2008)
10.1097/01.rli.0000101027.57021.28
Macrophage Endocytosis of Superparamagnetic Iron Oxide Nanoparticles: Mechanisms and Comparison of Ferumoxides and Ferumoxtran-10
I. Raynal (2004)
10.1161/ATVBAHA.109.193086
Hybrid In Vivo FMT-CT Imaging of Protease Activity in Atherosclerosis With Customized Nanosensors
M. Nahrendorf (2009)
10.1039/c1nr10326a
Engineered nanoparticles for biomolecular imaging.
M. Mahmoudi (2011)
10.1161/CIRCULATIONAHA.106.663351
Fluorescence Tomography and Magnetic Resonance Imaging of Myocardial Macrophage Infiltration in Infarcted Myocardium In Vivo
D. Sosnovik (2007)
10.1093/eurheartj/ehp547
In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium.
K. Montet-Abou (2010)
10.1073/pnas.1113744109
Origins of tumor-associated macrophages and neutrophils
V. Cortez-Retamozo (2012)
insights from a mathematical model
T. Stylianopoulos (2012)
10.1038/nprot.2008.241
Combinatorial libraries of peptide dendrimers: design, synthesis, on-bead high-throughput screening, bead decoding and characterization
Noélie Maillard (2009)
10.1016/j.immuni.2010.08.012
Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors
J. Cros (2010)
10.1093/eurheartj/ehs366
Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magnetic resonance imaging approach.
A. Yilmaz (2013)
10.1002/anie.201003142
A nanoparticle size series for in vivo fluorescence imaging.
Z. Popović (2010)
10.1021/nn1013484
Quantitative nanostructure-activity relationship modeling.
D. Fourches (2010)
10.2147/IJN.S30320
Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers
Wahajuddin (2012)
10.1038/nm0103-123
Shedding light onto live molecular targets
R. Weissleder (2003)
10.1021/nn300974s
64Cu Core-labeled nanoparticles with high specific activity via metal-free click chemistry.
D. Zeng (2012)
10.1038/nature10138
CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
Bin-Zhi Qian (2011)
10.1073/pnas.1018154108
Scaling rules for diffusive drug delivery in tumor and normal tissues
J. W. Baish (2011)
10.4161/onci.19456
MR imaging of tumor-associated macrophages
H. Daldrup-Link (2012)
10.1016/1074-7613(95)90067-5
Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages.
C. Norbury (1995)
10.1038/nmat3877
A targeted approach to cancer imaging and therapy.
Chun Xing Li (2014)
10.1161/01.RES.0000265064.46075.31
Dual Channel Optical Tomographic Imaging of Leukocyte Recruitment and Protease Activity in the Healing Myocardial Infarct
M. Nahrendorf (2007)
10.1038/ni.2233
Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging
Wenxian Fu (2012)
10.1161/01.CIR.0000093185.16083.95
Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With &agr;v&bgr;3-Integrin–Targeted Nanoparticles
P. Winter (2003)
10.1016/J.BIOMATERIALS.2007.11.025
Intracellular delivery of core-shell fluorescent silica nanoparticles.
Jason E. Fuller (2008)
10.1161/CIRCULATIONAHA.111.075283
Noninvasive Assessment of Myocardial Inflammation by Cardiovascular Magnetic Resonance in a Rat Model of Experimental Autoimmune Myocarditis
H. Moon (2012)
mechanism and functions
S. Gordon (2010)
10.1038/icb.2011.20
Macropinocytosis: an endocytic pathway for internalising large gulps
J. P. Lim (2011)
10.1007/BF03259915
Pharmacokinetics and Toxicity of Bismuth Compounds
A. Slikkerveer (1989)
10.2967/jnumed.109.061846
The Advantages of Nanoparticles for PET
M. Welch (2009)
10.4044/JOMA1947.97.1-2_101
Early clinical experience with NMR-CT
I. Joja (1985)
10.1038/nrd3578
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
M. Lobatto (2011)
10.1021/NL047955Q
Dumbbell-like bifunctional Au-Fe3O4 nanoparticles.
Heng Yu (2005)
10.1038/nature11260
Myocardial infarction accelerates atherosclerosis
P. Dutta (2012)
magnetic nanoplatforms as drug carriers
Wahajuddin (2012)
protagonists of infarct inflammation and repair after myocardial infarction
M. Nahrendorf (2010)
10.1039/c2ib20174g
Clinically-translated silica nanoparticles as dual-modality cancer-targeted probes for image-guided surgery and interventions.
M. Bradbury (2013)
10.1002/adma.201102948
Multicore assemblies potentiate magnetic properties of biomagnetic nanoparticles.
Tae-Jong Yoon (2011)
Synthesis and characterization of core-shell star copolymers for in vivo
K Fukukawa (2008)
10.1007/s00395-009-0052-0
Multi-slice computed tomography with N1177 identifies ruptured atherosclerotic plaques in rabbits
J. V. Herck (2009)
10.1089/HUM.1995.6.12-1543
Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms.
N. Rainov (1995)
10.1039/c2cs15337h
Biological applications of magnetic nanoparticles.
M. Colombo (2012)
10.1016/J.BIOMATERIALS.2004.10.012
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
A. Gupta (2005)
10.1038/nrurol.2009.254
Lymphotropic nanoparticle enhanced MRI for the staging of genitourinary tumors
S. Mouli (2010)
10.1161/ATVBAHA.111.241844
A Leukocyte-Mimetic Magnetic Resonance Imaging Contrast Agent Homes Rapidly to Activated Endothelium and Tracks With Atherosclerotic Lesion Macrophage Content
M. McAteer (2012)
10.1056/NEJMOA022749
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer.
M. Harisinghani (2003)
10.1021/bc200405d
89Zr-labeled dextran nanoparticles allow in vivo macrophage imaging.
E. Keliher (2011)
10.1038/nbt1402
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
A. Akinc (2008)
detection of lymph node metastases outside the routine surgical area with ferumoxtran-10-enhanced MR imaging
Heesakkers (2009)
10.1002/anie.201206939
Intrinsically copper-64-labeled organic nanoparticles as radiotracers.
T. Liu (2012)
10.1002/MRM.1910290504
Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties
T. Shen (1993)
preclinical results in rats and rabbits
Taupitz (2000)
10.1038/nprot.2006.11
Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles
M. Pittet (2006)
10.1016/j.ccr.2012.02.022
Accessories to the crime: functions of cells recruited to the tumor microenvironment.
D. Hanahan (2012)
10.3762/bjnano.1.17
Magnetic nanoparticles for biomedical NMR-based diagnostics
H. Shao (2010)
10.1073/PNAS.0404307101
Imaging inflammation of the pancreatic islets in type 1 diabetes.
M. C. Denis (2004)



This paper is referenced by
10.1536/IHJ.14-150
Nanoparticle-mediated drug delivery system for cardiovascular disease.
T. Matoba (2014)
10.1080/19420862.2019.1602459
Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis
Dilip K. Challa (2019)
10.1088/1361-6528/aa8a3d
Nanoparticles target early-stage breast cancer metastasis in vivo.
Evgeniya Goldman (2017)
10.7150/thno.22764
Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution
B. Kevadiya (2018)
10.1002/jcb.28950
MUC‐1 aptamer targeted superparamagnetic iron oxide nanoparticles for magnetic resonance imaging of pancreatic cancer in vivo and in vitro experiment
Qi Zou (2019)
10.1007/s13204-020-01510-y
Fabrication and optimization of pH-sensitive mannose-anchored nano-vehicle as a promising approach for macrophage uptake
Mahwash Mukhtar (2020)
10.1088/1361-6528/aafa3a
Magnetometry based method for investigation of nanoparticle clearance from circulation in a liver perfusion model.
I. V. Zelepukin (2019)
10.1021/acs.nanolett.6b04523
Yeast Microcapsule-Mediated Targeted Delivery of Diverse Nanoparticles for Imaging and Therapy via the Oral Route.
X. Zhou (2017)
10.1039/c7bm00826k
Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles.
Xiaoying Xu (2017)
10.1016/J.JPHOTOCHEM.2017.10.008
Two-step photochemical inorganic approach to the synthesis of Ag-CeO2 nanoheterostructures and their photocatalytic activity on tributyltin degradation
E. Raudonytė-Svirbutavičienė (2018)
10.1039/c8nr00724a
Demonstration of cellular imaging by using luminescent and anti-cytotoxic europium-doped hafnia nanocrystals.
I. Villa (2018)
10.1016/j.talanta.2020.121351
On-chip analysis of magnetically labeled cells with integrated cell sorting and counting techniques.
H. Zhang (2020)
10.1080/09506608.2018.1554991
Gold nanotubes and nanorings: promising candidates for multidisciplinary fields
Umair Shamraiz (2019)
10.1063/1.4974803
Brownian particle-kinetics in a superparamagnetic ferrofluid subjected to static magnetic-field
S. B. Trisnanto (2017)
10.1186/s12645-017-0031-3
Cancer characterization and diagnosis with SERS-encoded particles
L. Guerrini (2017)
10.1007/s11307-017-1148-9
A Non-Peptidic S100A9 Specific Ligand for Optical Imaging of Phagocyte Activity In Vivo
T. Völler (2017)
10.1126/scitranslmed.aac6522
Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle
Miles A. Miller (2015)
10.1016/j.micron.2014.08.001
Field emission scanning electron microscopy (FE-SEM) as an approach for nanoparticle detection inside cells.
M. Havrdová (2014)
10.2217/NNM-2016-0208
Myeloid cells as orchestrators of the tumor microenvironment: novel targets for nanoparticular cancer therapy.
A. Tuettenberg (2016)
10.1038/ncomms14064
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease
E. Keliher (2017)
10.1016/J.PARTIC.2016.06.001
Magnetic nanoparticles for environmental and biomedical applications: A review
L. Mohammed (2017)
10.1016/j.coph.2014.08.002
Superparamagnetic iron oxide nanoparticles for MR imaging and therapy: design considerations and clinical applications.
Rongrong Jin (2014)
10.3390/informatics1010072
Molecular imaging of bacterial infections in vivo: the discrimination of infection from inflammation
Heather Eggleston (2014)
10.1021/acsami.6b03344
In Vivo Tracking of Phagocytic Immune Cells Using a Dual Imaging Probe with Gadolinium-Enhanced MRI and Near-Infrared Fluorescence.
E. Kim (2016)
10.1002/9781118987483.CH11
Safety of Nanomaterials
Nuray Gunduz (2016)
10.1002/jbm.a.36371
Tunable poly(methacrylic acid-co-acrylamide) nanoparticles through inverse emulsion polymerization.
J. X. Zhong (2018)
M1 macrophages promote aortic valve calcification mediated by microRNA-214/TWIST1 pathway in valvular interstitial cells.
Xiao-Fei Li (2016)
10.1016/j.biomaterials.2016.11.009
Targeting distinct myeloid cell populations in vivo using polymers, liposomes and microbubbles.
Can Ergen (2017)
10.1016/J.RADPHYSCHEM.2016.10.008
Silver nanoparticles in X-ray biomedical applications
Facundo Mattea (2017)
10.1016/J.TRAC.2016.05.002
Recent advances in the synthesis and characterization of nano-antimicrobials
M. C. Sportelli (2016)
10.1021/nn503948b
Guiding Brain Tumor Resection Using Surface-Enhanced Raman Scattering Nanoparticles and a Hand-Held Raman Scanner
Hazem Karabeber (2014)
10.2147/IJN.S115995
Docosahexaenoic acid liposomes for targeting chronic inflammatory diseases and cancer: an in vitro assessment
Amr Alaarg (2016)
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