Online citations, reference lists, and bibliographies.
← Back to Search

Internal Dynamics Of A Supramolecular Nanofiber

Julia H. Ortony, C. Newcomb, John B Matson, Liam C. Palmer, P. Doan, B. Hoffman, S. Stupp
Published 2014 · Materials Science, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
A large variety of functional self-assembled supramolecular nanostructures have been reported over recent decades.1 The experimental approach to these systems initially focused on the design of molecules for specific interactions that lead to discrete geometric structures.1–4 Recently, kinetics and mechanistic pathways of self-assembly have been investigated,6,7 but there remains a major gap in our understanding of internal conformational dynamics and their links to function. This challenge has been addressed through computational chemistry with the introduction of molecular dynamics (MD) simulations, which yield information on molecular fluctuations over time.5–7 Experimentally, it has been difficult to obtain analogous data with sub-nanometer spatial resolution. Thus, there is a need for experimental dynamics measurements, to confirm and guide computational efforts and to gain insight into the internal motion in supramolecular assemblies. Using site-directed spin labeling and electron paramagnetic resonance (EPR) spectroscopy, we measured conformational dynamics through the 6.7 nm cross-section of a self-assembled nanofiber in water and provide unique insight for the design of supramolecular functional materials.
This paper references
10.1021/jp074420n
Molecular simulation study of peptide amphiphile self-assembly.
Y. Velichko (2008)
10.1016/J.JMB.2005.08.066
Molecular dynamics simulations of Alzheimer's β-amyloid protofilaments
N. Buchete (2005)
10.1002/(SICI)1097-0282(1998)47:2<153::AID-BIP4>3.0.CO;2-T
TOAC, a nitroxide spin‐labeled, achiral Cα‐tetrasubstituted α‐amino acid, is an excellent tool in material science and biochemistry
C. Toniolo (1998)
10.1016/j.biomaterials.2011.09.093
A hybrid nanofiber matrix to control the survival and maturation of brain neurons.
Shantanu Sur (2012)
10.1002/PRO.5560020312
Thioflavine T interaction with synthetic Alzheimer's disease β‐amyloid peptides: Detection of amyloid aggregation in solution
H. Levine (1993)
10.1126/SCIENCE.1097789
Self-Assembled Hexa-peri-hexabenzocoronene Graphitic Nanotube
J. Hill (2004)
10.1073/PNAS.0402801101
Phospholamban structural dynamics in lipid bilayers probed by a spin label rigidly coupled to the peptide backbone.
C. Karim (2004)
10.1021/ja110966y
Atomistic molecular dynamics simulations of peptide amphiphile self-assembly into cylindrical nanofibers.
One-Sun Lee (2011)
10.1126/science.1187409
Atomic-Level Characterization of the Structural Dynamics of Proteins
D. Shaw (2010)
10.1126/SCIENCE.8211140
Molecular dynamics simulations of a lipid bilayer and of hexadecane: an investigation of membrane fluidity.
R. Venable (1993)
10.1126/science.1157834
Large-Scale Molecular Dynamics Simulations of Self-Assembling Systems
M. Klein (2008)
10.1021/ar8000926
Molecular self-assembly into one-dimensional nanostructures.
Liam C. Palmer (2008)
Self-assembly at all
GM Whitesides (2002)
10.1126/SCIENCE.1070821
Self-Assembly at All Scales
G. Whitesides (2002)
10.1021/JA060573X
Self-assembly of peptide-amphiphile nanofibers: the roles of hydrogen bonding and amphiphilic packing.
S. E. Paramonov (2006)
10.1074/jbc.M205659200
Structural and Dynamic Features of Alzheimer's Aβ Peptide in Amyloid Fibrils Studied by Site-directed Spin Labeling*
M. Török (2002)
Molecular Simulation Study of Peptide Amphiphile SelfAssembly
YS Velichko (2008)
10.1021/BI960482K
Motion of spin-labeled side chains in T4 lysozyme. Correlation with protein structure and dynamics.
H. Mchaourab (1996)
Author manuscript; available in PMC
10.1038/ncomms4321
Cell death versus cell survival instructed by supramolecular cohesion of nanostructures
C. Newcomb (2014)
10.1126/science.1191035
Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
P. Gilbert (2010)
10.1006/JMRA.1996.0113
Nonlinear-Least-Squares Analysis of Slow-Motion EPR Spectra in One and Two Dimensions Using a Modified Levenberg–Marquardt Algorithm
David E. Budil (1996)
10.1126/science.1063187
Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers
J. D. Hartgerink (2001)
10.1002/anie.201100202
Electrostatic control of bioactivity.
J. Goldberger (2011)



This paper is referenced by
10.1021/nn502393u
Gd(III)-Labeled Peptide Nanofibers for Reporting on Biomaterial Localization in Vivo
Adam T. Preslar (2014)
10.1002/anie.201802238
Supramolecular Copolymerization as a Strategy to Control the Stability of Self-Assembled Nanofibers.
B. Thota (2018)
10.1002/SMTD.201700358
Peptide‐Based Nanocarriers for Cancer Therapy
G. Wei (2018)
Self-Assembly of Peptide-Polymer Conjugates for the Formation of Functional Biomaterials via Molecular Dynamics Simulations
Iris Fu (2015)
10.1002/adma.201601776
A Powerful CD8+ T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant.
Z. Luo (2017)
10.1002/marc.201700834
Silk and Silk-Like Supramolecular Materials.
Tanner D Fink (2018)
10.1038/srep07791
Hierarchical Assembly of a Dual-responsive Macroscopic Insulated Molecular Wire Bundle in a Gradient System
Yujie Sheng (2015)
10.1021/jacs.6b01570
Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties
Elena Pazos (2016)
10.1039/c7cc08127h
Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell.
Ronja Otter (2018)
10.1039/c8cc04818e
Impact of the water-compatible periphery on the dynamic and structural properties of benzene-1,3,5-tricarboxamide based amphiphiles.
S. M. C. Schoenmakers (2018)
10.1021/la503399x
Solvent effects on kinetic mechanisms of self-assembly by peptide amphiphiles via molecular dynamics simulations.
Iris Fu (2015)
10.1016/j.cis.2016.07.003
Molecular and structural basis of low interfacial energy of complex coacervates in water.
Y. Jho (2017)
10.1021/acs.accounts.7b00297
Supramolecular Assembly of Peptide Amphiphiles
Mark P. Hendricks (2017)
10.1039/C8PY00689J
Recent progress in the electron paramagnetic resonance study of polymers
Kaleem-ur-Rahman Naveed (2018)
10.1021/acs.biomac.5b01573
Self-Assembly of the Toll-Like Receptor Agonist Macrophage-Activating Lipopeptide MALP-2 and of Its Constituent Peptide.
V. Castelletto (2016)
10.1002/IJCH.201900018
Dissipative Self‐Assembly of Peptides
M. Tena-Solsona (2019)
10.1021/acs.langmuir.7b01023
Nonresonant and Local Field Effects in Peptidic Nanostructures Bearing Oligo(p-phenylenevinylene) Units.
Herdeline Ann M Ardoña (2017)
10.1039/c5sc02319j
Surface water retardation around single-chain polymeric nanoparticles: critical for catalytic function?† †Electronic supplementary information (ESI) available: Synthetic procedures, CD- and IR spectra, additional information on ODNP and EPR spectra. See DOI: 10.1039/c5sc02319j
P. Stals (2016)
10.1080/17425247.2016.1208649
Advances in the use of prodrugs for drug delivery to the eye
Pranjal S. Taskar (2017)
DNA origami-based biomolecular organizing platforms
B. Rosier (2019)
10.1126/sciadv.1500827
Spontaneous structural transition and crystal formation in minimal supramolecular polymer model
Galit Fichman (2016)
10.1021/ja510182x
Guest-driven inflation of self-assembled nanofibers through hollow channel formation.
Yanqiu Wang (2014)
10.1039/c4cc08942a
Translation of the assembling trajectory by preorganisation: a study of the magnetic properties of 1D polymeric unpaired electrons immobilised on a discrete nanoscopic scaffold.
Vakayil K Praveen (2015)
10.1039/c4cc06340f
Esterase-activated release of naproxen from supramolecular nanofibres.
M. Conda-Sheridan (2014)
10.1016/b978-0-12-814024-6.00007-8
EPR studies of bionanomaterials
Tatyana I. Smirnova (2019)
10.1039/C5RA03290C
A supramolecular hydrogel self-assembled from pentafluorobenzyl-dipeptide
Shu-Min Hsu (2015)
10.1088/0034-4885/79/7/076601
The physics of pulling polyproteins: a review of single molecule force spectroscopy using the AFM to study protein unfolding.
M. L. Hughes (2016)
10.1039/c7ob01081h
Supramolecular control of heme binding and electronic states in multi-heme peptide assemblies.
H Christopher Fry (2017)
10.1021/acs.biomac.7b00951
Structure-Dependent Antimicrobial Theranostic Functions of Self-Assembled Short Peptide Nanoagents.
Inhye Kim (2017)
10.1039/c5sm00459d
Self-assembly of a dual functional bioactive peptide amphiphile incorporating both matrix metalloprotease substrate and cell adhesion motifs.
A. Dehsorkhi (2015)
10.1016/j.tips.2019.08.003
Drug Delivery with Designed Peptide Assemblies.
Matthew J Sis (2019)
10.1021/acs.macromol.9b00300
Insights into the Kinetics of Supramolecular Comonomer Incorporation in Water
René P M Lafleur (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar