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Replication Stress And Cancer

H. Gaillard, Tatiana García-Muse, A. Aguilera
Published 2015 · Biology, Medicine
Referenced 1 time by Citationsy Users

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Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable cellular process that can lead to it. Any condition leading to high levels of DNA damage will result in replication stress, which is a source of genome instability and a feature of pre-cancerous and cancerous cells. Therefore, understanding the molecular basis of replication stress is crucial to the understanding of tumorigenesis. Although a negative aspect of replication stress is its prominent role in tumorigenesis, a positive aspect is that it provides a potential target for cancer therapy. In this Review, we discuss the link between persistent replication stress and tumorigenesis, with the goal of shedding light on the mechanisms underlying the initiation of an oncogenic process, which should open up new possibilities for cancer diagnostics and treatment.
This paper references
10.1016/j.molcel.2011.05.019
Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites.
E. Ozeri-Galai (2011)
10.1158/0008-5472.CAN-09-4267
Loss of DNA polymerase zeta enhances spontaneous tumorigenesis.
John P. Wittschieben (2010)
10.1038/ncb2773
MUS81 promotes common fragile site expression
Songmin Ying (2013)
10.1038/nsmb.1905
The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA
T. Thorslund (2010)
10.1073/pnas.0708097105
Replication stress induces tumor-like microdeletions in FHIT/FRA3B
Sandra Durkin (2008)
10.1038/nsmb1313
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks
K. Hanada (2007)
10.1016/S1097-2765(01)00173-3
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
I. García-Higuera (2001)
10.1038/90108
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
X. Xu (2001)
10.1016/j.cell.2010.11.055
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
P. Stephens (2011)
10.2174/1874-470211205010054
Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.
N. Nicolay (2012)
10.1146/annurev-genet-111212-133232
Causes of genome instability.
A. Aguilera (2013)
10.1016/j.cell.2010.03.012
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
Samuel F Bunting (2010)
10.1038/nchembio.573
Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.
P. Reaper (2011)
10.1037/021710
Breaking up is hard to do.
W. Stroebe (1983)
10.1056/NEJMc1410673
Breast-cancer risk in families with mutations in PALB2.
A. Antoniou (2014)
10.1016/S1535-6108(02)00017-X
A role for common fragile site induction in amplification of human oncogenes.
Asaf Hellman (2002)
mechanisms of instability revisited
M. Debatisse (2012)
10.1038/onc.2009.502
DNA Breaks at Fragile Sites Generate Oncogenic RET/PTC Rearrangements in Human Thyroid Cells
Manoj Gandhi (2010)
10.4161/cc.22581
RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures
Venkateswarlu Popuri (2012)
10.1038/nrc3537
End-joining, translocations and cancer
Samuel F Bunting (2013)
10.1126/science.1210214
Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations
A. Janssen (2011)
10.1016/j.molcel.2008.04.028
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.
T. Stracker (2008)
10.1016/j.cell.2014.01.001
ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
L. Toledo (2013)
10.1038/ncb2113
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells
Mathieu Tardat (2010)
10.1038/nature02352
Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity
S. McCulloch (2004)
10.1002/(SICI)1521-1878(199903)21:3<238::AID-BIES8>3.0.CO;2-3
Oxidative DNA damage, antioxidants, and cancer
A. Collins (1999)
10.1158/0008-5472.CAN-07-5873
Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.
X. Xu (2008)
10.1073/pnas.0701724104
Analysis of PALB2/FANCN-associated breast cancer families
M. Tischkowitz (2007)
10.1016/S0092-8674(00)81302-1
The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse
R. Hakem (1996)
10.1038/cdd.2014.16
Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation
M. Ogrunc (2014)
10.1016/j.molcel.2014.03.014
Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair
Michael R G Hodskinson (2014)
when RNA meets DNA
A. Aguilera (2014)
10.1038/nature08768
Signatures of mutation and selection in the cancer genome
G. Bignell (2010)
10.1038/sj.onc.1210273
Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas
M. Chen (2007)
10.1093/nar/gkt944
The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing
R. Frum (2014)
10.1038/nature05268
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
J. Bártková (2006)
10.1158/0008-5472.CAN-08-4559
Selective killing of cancer cells by suppression of geminin activity.
W. Zhu (2009)
10.1038/8743
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
X. Xu (1999)
10.1101/gad.234070.113
The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts.
Emilia Herrera-Moyano (2014)
10.1073/pnas.1311520111
Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells
Therese Wilhelm (2013)
10.1101/cshperspect.a016543
Transcription and recombination: when RNA meets DNA.
A. Aguilera (2014)
10.1038/ncomms2395
FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.
Kasper Fugger (2013)
10.1371/journal.pbio.0030401
Impaired DNA Replication within Progenitor Cell Pools Promotes Leukemogenesis
G. Bilousova (2005)
10.1038/nature05789
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
H. Bryant (2007)
10.1038/onc.2012.387
Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress
R. Jones (2013)
10.1038/ng1129
A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome
M. O’Driscoll (2003)
10.1111/j.1600-0404.1980.tb05230.x
ACTIVATION
M. Reivich (1980)
10.1016/j.celrep.2013.07.003
Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.
Benoît Le Tallec (2013)
10.1083/jcb.200404092
Deregulation of cyclin E in human cells interferes with prereplication complex assembly
Susanna Ekholm-Reed (2004)
10.1038/onc.2010.163
Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53
T. Fishler (2010)
10.1093/nar/gks1016
Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint
E. Zucca (2013)
10.1038/ncb1882
Replication stress induces sister-chromatid bridging at fragile site loci in mitosis
K. L. Chan (2009)
10.1038/sj.onc.1210989
Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study
P. K. Tsantoulis (2008)
10.1016/j.molcel.2010.06.026
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.
A. Adamo (2010)
10.1016/J.MOLCEL.2004.06.034
Expanded CAG repeats activate the DNA damage checkpoint pathway.
M. Lahiri (2004)
10.1083/jcb.201209002
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress
Yeon-Tae Jeong (2013)
10.1038/nrc3560
DNA helicases involved in DNA repair and their roles in cancer
R. Brosh (2013)
10.1101/GAD.279003
Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein.
M. Lomonosov (2003)
10.1128/MCB.24.13.5850-5862.2004
Functional Interaction of Monoubiquitinated FANCD2 and BRCA2/FANCD1 in Chromatin
X. Wang (2004)
10.1016/j.molcel.2014.01.032
Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion.
A. Manning (2014)
10.1021/bi2001054
The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.
A. Machwe (2011)
10.1016/J.MOLCEL.2006.09.010
Deregulated Replication Licensing Causes DNA Fragmentation Consistent with Head-to-Tail Fork Collision
I. Davidson (2006)
10.1016/j.cell.2014.03.048
RECQL5 Controls Transcript Elongation and Suppresses Genome Instability Associated with Transcription Stress
M. Saponaro (2014)
10.1038/onc.2011.326
Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis
L. Tho (2012)
10.1101/GAD.457807
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.
X. Ge (2007)
10.1093/JNCI/88.14.956
UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
Q. Wang (1996)
10.1038/nsmb.2189
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
M. Murga (2011)
10.1073/pnas.152321699
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
M. Kucherlapati (2002)
10.1016/j.molcel.2010.01.021
Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
E. Petermann (2010)
10.1016/j.tibs.2011.05.002
How dormant origins promote complete genome replication.
J. Blow (2011)
10.1128/MCB.00115-09
Human DNA Polymerase η Is Required for Common Fragile Site Stability during Unperturbed DNA Replication
L. Rey (2009)
10.1038/nm1599
Fen1 mutations result in autoimmunity, chronic inflammation and cancers
L. Zheng (2007)
10.1038/nrm3562
Regulation of PCNA–protein interactions for genome stability
N. Mailand (2013)
10.1016/j.molcel.2011.02.026
SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis.
Jia-Ren Lin (2011)
10.1038/sj.emboj.7600520
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re‐replication in Xenopus
A. Li (2005)
10.1158/0008-5472.CAN-08-0168
Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.
E. Larsen (2008)
10.1158/0008-5472.CAN-07-2837
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
M. Liontos (2007)
10.1038/nature12634
Mutational landscape and significance across 12 major cancer types
C. Kandoth (2013)
10.1016/j.ceb.2012.01.011
Activation of the replicative DNA helicase: breaking up is hard to do.
Dominik Boos (2012)
10.1016/S1097-2765(00)80035-0
Involvement of Brca2 in DNA repair.
K. Patel (1998)
10.1101/GAD.879201
Tumorigenesis in mice carrying a truncating Brca1 mutation.
T. Ludwig (2001)
10.1101/cshperspect.a014423
MYC and the control of DNA replication.
D. Dominguez-sola (2014)
10.1038/nsmb.1831
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
P. Bouwman (2010)
10.1038/ncb1984
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
Sandie Tuduri (2009)
10.1038/sj.onc.1204942
Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells
Kalli Koniaras (2001)
10.1016/J.CELL.2011.05.021
Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11
K. Schlacher (2011)
10.1186/1471-2164-10-59
Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites
Allison A Burrow (2008)
10.1073/pnas.0805685105
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks
A. Motegi (2008)
10.1128/MCB.00816-07
Transcription-Associated Recombination Is Dependent on Replication in Mammalian Cells
Ponnari Gottipati (2007)
10.1158/0008-5472.CAN-10-2062
NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells.
J. J. Lin (2010)
10.1158/0008-5472.CAN-10-2286
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner.
Oren Gilad (2010)
10.1038/nrm3567
Molecular mechanisms underlying RB protein function
F. Dick (2013)
10.1038/nature03485
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
V. Gorgoulis (2005)
10.1038/nature09745
Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site
A. Letessier (2011)
10.1093/hmg/ddr027
The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers.
Anne Blumrich (2011)
10.1371/journal.pgen.1003298
Essential Developmental, Genomic Stability, and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2
W. Shi (2013)
10.1093/HMG/DDI075
Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome.
M. Mann (2005)
10.1038/ncb1883
The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities
V. Naim (2009)
10.1016/j.molonc.2014.10.013
Untangling the ATR‐CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer
T. Abdel-Fatah (2015)
10.1038/ng1936
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
N. Shima (2007)
10.1158/0008-5472.CAN-13-1536-T
Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase.
Maohua Xie (2014)
10.1158/0008-5472.CAN-05-1862
Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice.
Q. Lin (2006)
10.1073/PNAS.0600298103
Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions.
H. Saeki (2006)
Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability, and cancer in mice
S. Volik (2004)
10.1016/j.molcel.2011.02.006
Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.
Tsuyoshi Kawabata (2011)
10.1021/cr400017y
Transcription-associated genome instability.
H. Gaillard (2013)
10.1083/jcb.201212058
Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates
K. Neelsen (2013)
10.1093/nar/gku170
A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression
Spencer W. Luebben (2014)
10.1038/nature13194
Stereospecific targeting of MTH1 by (S)-crizotinib as anticancer strategy
K. Huber (2014)
10.1038/ng747
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
J. Jonkers (2001)
10.1038/NCOMMS3355
Erratum: Corrigendum: The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
A. Douglas (2013)
10.1016/j.dnarep.2007.12.008
The consequences of Rad51 overexpression for normal and tumor cells.
H. Klein (2008)
10.1073/pnas.0609783104
Targeted deletion of Wwox reveals a tumor suppressor function
R. Aqeilan (2007)
10.1016/j.cell.2011.03.044
Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development
A. Bester (2011)
10.1038/nature13374
BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2
Vaibhav Bhatia (2014)
10.1038/nature08467
The DNA-damage response in human biology and disease
S. Jackson (2009)
10.1038/nature11935
Replication stress links structural and numerical cancer chromosomal instability
R. Burrell (2013)
10.1016/j.celrep.2014.03.069
FANCD2 and CtIP cooperate to repair DNA interstrand crosslinks.
O. Murina (2014)
Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma.
D. Millikin (1991)
10.1073/pnas.0803978105
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
A. Ibarra (2008)
10.1016/S0092-8674(02)01113-3
ATR Regulates Fragile Site Stability
A. Casper (2002)
10.1038/sj.emboj.7600315
ATR functions as a gene dosage‐dependent tumor suppressor on a mismatch repair‐deficient background
Yanan Fang (2004)
10.1101/GAD.1609107
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
Yiduo Hu (2007)
10.1146/annurev-genet-102108-134222
How the fanconi anemia pathway guards the genome.
G. Moldovan (2009)
10.1101/gad.241620.114
Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.
S. Hill (2014)
10.1016/j.molcel.2013.07.023
FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling.
G. Lossaint (2013)
10.1126/SCIENCE.1083430
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
L. Zou (2003)
10.1038/82548
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
G. Luo (2000)
10.1038/sj.onc.1208881
Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53
J. Seo (2005)
10.1016/J.CANLET.2004.07.021
Down-regulation of DNA polymerases κ, η, ι, and ζ in human lung, stomach, and colorectal cancers
Qiangrong Pan (2005)
10.1016/j.molcel.2011.10.013
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.
Anne Helmrich (2011)
10.1016/j.ccr.2012.05.015
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
K. Schlacher (2012)
10.1038/cr.2012.82
Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies
M. Steckel (2012)
10.1021/jm101488z
Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.
J. Charrier (2011)
10.1126/SCIENCE.6239375
Constitutive fragile sites and cancer.
J. Yunis (1984)
10.1038/nature09790
Aberrant chromosome morphology in human cells defective for Holliday junction resolution
Thomas Wechsler (2011)
10.1146/annurev.biochem.052308.103205
Eukaryotic chromosome DNA replication: where, when, and how?
H. Masai (2010)
10.1038/nature13181
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Helge Gad (2014)
10.1016/j.molcel.2015.01.011
BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair
Elodie Hatchi (2015)
10.1038/onc.2012.80
The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation
I. Murfuni (2013)
10.1128/MCB.01290-09
Human RECQ1 and RECQ4 Helicases Play Distinct Roles in DNA Replication Initiation
Saravanabhavan Thangavel (2010)
10.1091/MBC.12.8.2412
Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.
P. Pichierri (2001)
10.1038/emboj.2010.218
Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo
H. Niida (2010)
10.1634/stemcells.2007-0483
Reduced Mcm2 Expression Results in Severe Stem/Progenitor Cell Deficiency and Cancer
S. C. Pruitt (2007)
10.1038/nature05327
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
R. D. Micco (2006)
10.1038/nrc2998
DNA polymerases and cancer
S. Lange (2011)
10.1158/0008-5472.CAN-07-1161
Functional interplay of p53 and Mus81 in DNA damage responses and cancer.
Ashwin Pamidi (2007)
10.1073/pnas.062459899
HLTF gene silencing in human colon cancer
Helen R Moinova (2002)
10.1016/j.celrep.2014.01.009
Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks.
R. Buisson (2014)
10.1038/nsmb.2076
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
L. Toledo (2011)
10.1016/S0092-8674(00)81034-X
The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers
Masataka Ohta (1996)
10.1084/jem.20112147
An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation
A. López-Contreras (2012)
10.1038/sj.onc.1205175
Oncogenic potential of the DNA replication licensing protein CDT1
E. Arentson (2002)
a paradigm of ataxia telangiectasia
Barlow (1996)
10.1016/j.molcel.2009.06.021
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.
R. Paulsen (2009)
10.1101/GAD.10.19.2411
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.
Y. Xu (1996)
10.1038/nature13537
Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis
A. Sabò (2014)
10.1016/S1535-6108(04)00080-7
Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme.
L. Rahman (2004)
10.1016/S1097-2765(03)00099-6
A p53-dependent checkpoint pathway prevents rereplication.
C. Vaziri (2003)
10.1007/s00412-010-0304-7
Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes
Erin K Schwartz (2011)
10.1038/nrm1493
Checking on DNA damage in S phase
J. Bartek (2004)
10.1016/j.cell.2013.06.051
KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors
J. Black (2013)
10.1101/gad.226373.113
Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template.
K. Neelsen (2013)
Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability.
Vessela Vassileva (2002)
10.1073/pnas.1109720108
Chromosome missegregation in human cells arises through specific types of kinetochore–microtubule attachment errors
Sarah L. Thompson (2011)
10.1016/j.cell.2012.08.033
c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells
Zuqin Nie (2012)
10.1038/ncb2793
ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis
V. Naim (2013)
10.1093/nar/gku276
Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks
E. Bolderson (2014)
10.1101/GAD.1586007
Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.
P. Aggarwal (2007)
10.1101/GAD.14.4.397
ATR disruption leads to chromosomal fragmentation and early embryonic lethality.
E. Brown (2000)
10.1038/onc.2013.352
Predictive biomarkers for cancer therapy with PARP inhibitors
J. Michels (2014)
10.1038/nature03445
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
H. Farmer (2005)
10.1073/pnas.1111378108
Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase
M. Kawasumi (2011)
10.1038/nature03482
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
J. Bártková (2005)
10.1073/PNAS.090013497
Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity.
D. Gisselsson (2000)
10.1038/nature13295
BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks
Nicholas A. Willis (2014)
10.1038/nature08822
The landscape of somatic copy-number alteration across human cancers
R. Beroukhim (2010)
10.1038/ncb1145
ATR and ATM regulate the timing of DNA replication origin firing
D. Shechter (2004)
10.1038/nsmb.2155
Molecular profiling of common fragile sites in human fibroblasts
B. L. Tallec (2011)
10.1016/j.celrep.2013.04.002
Cdc45 is a critical effector of myc-dependent DNA replication stress.
S. Srinivasan (2013)
10.1073/PNAS.93.23.13084
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
A. Elson (1996)
Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice.
Scott Houghtaling (2005)
10.1038/nsmb1267
Role for BLM in replication-fork restart and suppression of origin firing after replicative stress
S. L. Davies (2007)
10.1038/nature10802
DNA breaks and chromosome pulverization from errors in mitosis
Karen Crasta (2012)
10.1158/1541-7786.MCR-12-0491
Diminished Origin-Licensing Capacity Specifically Sensitizes Tumor Cells to Replication Stress
Kristin M. Zimmerman (2013)
10.1101/GAD.1103403
Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice.
Scott Houghtaling (2003)
Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors.
S. Corbin (2002)
10.1083/jcb.200403106
Loss of Geminin induces rereplication in the presence of functional p53
M. Melixetian (2004)
10.1038/sj.emboj.7601777
BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges
Kok-Lung Chan (2007)
10.1101/GAD.14.12.1448
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
Q. Liu, (2000)
10.1038/nature05953
Non-transcriptional control of DNA replication by c-Myc
D. Dominguez-sola (2007)
10.1371/journal.pgen.1002386
Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
M. S. Domínguez-Sánchez (2011)
10.1016/j.molcel.2011.09.002
BRCA1 is required for postreplication repair after UV-induced DNA damage.
S. Pathania (2011)
10.1126/science.1243211
Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells
L. Costantino (2014)
10.1093/nar/gks054
DNA polymerase zeta is required for proliferation of normal mammalian cells
S. Lange (2012)
10.1146/ANNUREV.GENET.41.042007.165900
Chromosome fragile sites.
Sandra Durkin (2007)
10.1038/ng1297-423
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
Frances Connor (1997)
10.1038/ncb1337
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
A. Jazayeri (2006)
10.1016/S0092-8674(00)80086-0
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
C. Barlow (1996)
10.1016/J.CUB.2014.06.016
DNA Replication and Oncogene-Induced Replicative Stress
Stephanie A. Hills (2014)
10.1016/j.cell.2013.01.006
Identification of Early Replicating Fragile Sites that Contribute to Genome Instability
J. Barlow (2013)
10.1016/j.tig.2011.10.003
Common fragile sites: mechanisms of instability revisited.
M. Debatisse (2012)
Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.
A. Menoyo (2001)
10.1016/j.cell.2012.08.026
Transcriptional Amplification in Tumor Cells with Elevated c-Myc
C. Lin (2012)
10.1146/annurev.biochem.77.070306.102408
Structural and functional relationships of the XPF/MUS81 family of proteins.
Alberto Ciccia (2008)
where, when, and how? Annu
H. Masai (2010)
10.1038/ng.2981
Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins
Y. Gong (2014)
10.1038/NATURE12369
Replication stress links structural and numerical cancer chromosomal instability (vol 494, pg 492, 2013)
R. Burrell (2013)



This paper is referenced by
10.20381/ruor-21208
The Role of Norrie Disease Pseudoglioma (Ndp) in Cerebellar Development/Tumorigenesis and Its Relationship with the Sonic Hedgehog Pathway
Nicholas Tokarew (2017)
10.1073/pnas.2005160117
Stressed DNA replication generates stressed DNA
H. Klein (2020)
10.18632/oncotarget.22984
INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis
Shin-Ai Lee (2017)
10.3390/cancers12102848
Ubiquitin and Ubiquitin-Like Proteins Are Essential Regulators of DNA Damage Bypass
Nicole A Wilkinson (2020)
10.3892/ijo.2017.4108
Cooperative oncogenic effect and cell signaling crosstalk of co-occurring HER2 and mutant PIK3CA in mammary epithelial cells
L. Dong (2017)
10.1016/j.jcmgh.2019.01.009
Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer
N. Currey (2019)
10.1038/s41389-020-0194-3
ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma
M. Andersson (2020)
10.1016/j.semcdb.2020.09.001
Human CtIP: A 'double agent' in DNA repair and tumorigenesis.
Nour L Mozaffari (2020)
10.3390/ijms18122611
Around and beyond 53BP1 Nuclear Bodies
A. Fernandez-Vidal (2017)
10.1016/j.cell.2017.07.043
Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses
Stephan Hamperl (2017)
10.1016/j.canlet.2016.09.024
Inhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy.
A. Massey (2016)
10.1083/jcb.201908192
E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells
H. Duan (2020)
The relationship of CDK 18 expression in breast cancer to clinicopathological parameters and therapeutic response
G. Barone (2018)
Determining individual chromosome missegregation rates and the responses to aneuploidy in human cells
Jospeh Thomas Worrall (2018)
10.1038/s41594-018-0170-1
Transcription-dependent regulation of replication dynamics modulates genome stability
Marion Blin (2018)
10.1158/1078-0432.CCR-17-3022
Surviving Ovarian Cancer: An Affair between Defective DNA Repair and RB1
G. Peng (2017)
10.1080/15384101.2017.1383578
Inherited DNA lesions determine G1 duration in the next cell cycle
Aleksandra Lezaja (2018)
10.3390/molecules23112789
Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
Roopa Thapar (2018)
10.1016/B978-0-12-801238-3.65423-5
Basic Principles of DNA Repair in Toxicology
A. Dutta (2018)
10.1101/2020.11.28.397430
FiberAI: A Deep Learning model for automated analysis of nascent DNA Fibers
Azam Mohsin (2020)
Title : DNA damage repair and survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy
Livia Ronchetti (2017)
10.1177/1758835920956900
Inhibition of ATR-Chk1 signaling blocks DNA double-strand-break repair and induces cytoplasmic vacuolization in metastatic osteosarcoma
Xiaoyang Li (2020)
10.1093/nar/gkw132
New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress
Amaia Ercilla (2016)
10.1101/028100
Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila
Yulong Li () (2016)
10.1158/1541-7786.MCR-18-0575
The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability
Emanuela Tumini (2018)
10.1186/s13059-016-1042-9
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
N. Kanu (2016)
10.1016/j.molcel.2016.06.031
A Long Noncoding RNA Regulates Sister Chromatid Cohesion.
Francesco P. Marchese (2016)
10.1016/j.tig.2017.09.003
Alternative Lengthening of Telomeres: DNA Repair Pathways Converge.
A. Sobinoff (2017)
10.7150/ijbs.31484
ASB6 Promotes the Stemness Properties and Sustains Metastatic Potential of Oral Squamous Cell Carcinoma Cells by Attenuating ER Stress
Kai-Feng Hung (2019)
10.1101/738328
Fork Pausing Complex Engages Topoisomerases at the Replisome
M. Shyian (2019)
10.1016/j.canlet.2020.09.016
Reality CHEK: Understanding the biology and clinical potential of CHK1.
Fiifi Neizer-Ashun (2020)
10.7150/thno.48675
Recognition of G-quadruplex topology through hybrid binding with implications in cancer theranostics
Y. V. Suseela (2020)
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