Online citations, reference lists, and bibliographies.
← Back to Search

Peroxynitrite: Biochemistry, Pathophysiology And Development Of Therapeutics

C. Szabo, H. Ischiropoulos, R. Radi
Published 2007 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Peroxynitrite — the product of the diffusion-controlled reaction of nitric oxide with superoxide radical — is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition of its formation or its decomposition have been shown to be of benefit include vascular diseases, ischaemia–reperfusion injury, circulatory shock, inflammation, pain and neurodegeneration. In this Review, we first discuss the biochemistry and pathophysiology of peroxynitrite and then focus on pharmacological strategies to attenuate the toxic effects of peroxynitrite. These include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.
This paper references
Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives.
H. Rubbo (1994)
Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis
A. B. Hancock (1996)
Structure activity relationships of peroxynitrite scavengers an approach to nitric oxide neurotoxicity.
J. Althaus (1994)
10.1042/0264-6021:3590139
Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation.
N. Riobo (2001)
10.1042/BJ3030295
Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion.
A. van der Vliet (1994)
10.1002/1529-0131(200107)44:7<1534::AID-ART276>3.0.CO;2-#
Localization of 3-nitrotyrosine to rheumatoid and normal synovium.
P. Mapp (2001)
10.1016/S0076-6879(99)01102-7
Mitochondria, nitric oxide, and peroxynitrite.
C. Richter (1999)
10.1007/BF03402167
Part I: Pathogenetic Role of Peroxynitrite in the Development of Diabetes and Diabetic Vascular Complications: Studies With FP15, A Novel Potent Peroxynitrite Decomposition Catalyst
C. Szabo (2002)
10.1016/S0003-4975(02)03953-X
A novel peroxynitrite decomposer catalyst (FP-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion in pigs.
C. Bianchi (2002)
10.3171/JNS.2004.101.4.0669
Neuroprotective effect of peroxynitrite decomposition catalyst and poly(adenosine diphosphate-ribose) polymerase inhibitor alone and in combination in rats with focal cerebral ischemia.
S. Sharma (2004)
10.1152/PHYSREV.00029.2006
Nitric oxide and peroxynitrite in health and disease.
P. Pacher (2007)
10.1523/JNEUROSCI.21-13-04582.2001
Neuroprotection from Delayed Postischemic Administration of a Metalloporphyrin Catalytic Antioxidant
G. Mackensen (2001)
10.1021/TX960102W
Quantitation of 8-oxoguanine and strand breaks produced by four oxidizing agents.
L. Kennedy (1997)
10.1124/JPET.103.064154
A Newly Identified Role for Superoxide in Inflammatory Pain
Zhi-Qiang Wang (2004)
10.1021/CR0307087
Chemistry of peroxynitrites as compared to peroxynitrates.
S. Goldstein (2005)
10.1124/jpet.106.108100
A Role for Nitric Oxide-Mediated Peroxynitrite Formation in a Model of Endotoxin-Induced Shock
S. Cuzzocrea (2006)
10.1016/J.ABB.2004.09.015
Macrophage-derived peroxynitrite diffusion and toxicity to Trypanosoma cruzi.
M. Álvarez (2004)
10.1038/sj.bjp.0700872
The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock
B. Zingarelli (1997)
10.4049/jimmunol.167.6.3470
The Central Nervous System Inflammatory Response to Neurotropic Virus Infection Is Peroxynitrite Dependent1
D. Hooper (2001)
10.1016/S0891-5849(98)00139-7
Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation.
L. Virág (1998)
10.1016/J.AUTREV.2004.11.011
Immunogenicity of an inflammation-associated product, tyrosine nitrated self-proteins.
H. Ohmori (2005)
10.1016/j.febslet.2005.04.071
Peroxynitrite‐mediated matrix metalloproteinase‐2 activation in human hepatic stellate cells
K. Migita (2005)
10.1074/jbc.273.48.31860
Peroxynitrite Induces Covalent Dimerization of Epidermal Growth Factor Receptors in A431 Epidermoid Carcinoma Cells*
A. van der Vliet (1998)
10.1016/S0006-2952(99)00309-3
Ebselen as a peroxynitrite scavenger in vitro and ex vivo.
A. Daiber (2000)
10.1002/jnr.20853
Nitric oxide and peroxynitrite induce cellular death in bovine chromaffin cells: Evidence for a mixed necrotic and apoptotic mechanism with caspases activation
S. Vicente (2006)
10.2337/DIABETES.55.03.06.DB05-1417
Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes.
S. Devaraj (2006)
10.1016/S0014-5793(99)00073-3
Protection against peroxynitrite
G. Arteel (1999)
10.1007/s004010050977
Inducible nitric oxide synthase expression in human cerebral infarcts
C. Forster (1999)
10.1073/PNAS.93.5.1753
DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.
C. Szabo (1996)
10.1016/S0891-5849(00)00325-7
Nitric oxide-dependent modification of the sarcoplasmic reticulum Ca-ATPase: localization of cysteine target sites.
R. Viner (2000)
10.1016/S0014-5793(01)02726-0
Nitrotyrosine mimics phosphotyrosine binding to the SH2 domain of the src family tyrosine kinase lyn
C. Mallozzi (2001)
10.1016/J.FREERADBIOMED.2004.09.027
Tempol diverts peroxynitrite/carbon dioxide reactivity toward albumin and cells from protein-tyrosine nitration to protein-cysteine nitrosation.
D. Fernandes (2005)
10.1074/JBC.M404317200
Trypanosoma brucei and Trypanosoma cruzi Tryparedoxin Peroxidases Catalytically Detoxify Peroxynitrite via Oxidation of Fast Reacting Thiols*
M. Trujillo (2004)
10.1152/AJPHEART.2001.281.6.H2289
Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase.
I. Turko (2001)
10.1016/S0925-4439(98)00082-9
Release of cytochrome c from heart mitochondria is induced by high Ca2+ and peroxynitrite and is responsible for Ca(2+)-induced inhibition of substrate oxidation.
V. Borutaite (1999)
10.1016/S0014-5793(99)01498-2
Protection against peroxynitrite by cocoa polyphenol oligomers
G. Arteel (1999)
10.1016/J.ABB.2003.08.025
Peroxynitrite modulates acidic fibroblast growth factor (FGF-1) activity.
P. Bagnasco (2003)
10.1080/10715760500539139
Mitochondria produce reactive nitrogen species via an arginine-independent pathway
Z. Lacza (2006)
Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity.
L. Virág (1999)
10.1074/jbc.M509480200
Nitration of Tyrosine 92 Mediates the Activation of Rat Microsomal Glutathione S-Transferase by Peroxynitrite*
Y. Ji (2006)
10.3892/IJMM.12.2.153
PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma.
Z. Lacza (2003)
10.1006/BBRC.1995.1561
Endogenous peroxynitrite is involved in the inhibition of mitochondrial respiration in immuno-stimulated J774.2 macrophages.
C. Szabo (1995)
10.1042/BJ3220167
Pathways of peroxynitrite oxidation of thiol groups.
C. Quijano (1997)
10.1080/07420520600650703
Biological Time‐Dependent Difference in Effect of Peroxynitrite Demonstrated by the Mouse Hot Plate Pain Model
S. Altuğ (2006)
10.1074/jbc.M112451200
Nitric Oxide (NO) Induces Nitration of Protein Kinase Cε (PKCε), Facilitating PKCε Translocation via Enhanced PKCε-RACK2 Interactions
Z. Balafanova (2002)
10.1084/JEM.192.12.1731
Enhanced Peroxynitrite Formation Is Associated with Vascular Aging
B. van der Loo (2000)
10.1016/J.EJPHAR.2006.08.007
TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion.
M. Khattab (2006)
10.1074/JBC.M210806200
Expression of Inducible Nitric-oxide Synthase and Intracellular Protein Tyrosine Nitration in Vascular Smooth Muscle Cells
D. Fries (2003)
Mn porphyrin - based SOD mimic , Mnte - 2 - Pyp 5 + , targets mouse heart mitochondria
I. Spasojevic (2007)
10.1016/S0891-5849(02)01327-8
Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration.
V. Stewart (2003)
10.1080/02713680490513146
Peroxynitrite decomposition catalyst, FP15, and poly(ADP-ribose) polymerase inhibitor, PJ34, inhibit leukocyte entrapment in the retinal microcirculation of diabetic rats
R. Sugawara (2004)
10.1081/DMR-100101922
Peroxynitrite inactivates prostacyclin synthase by heme-thiolate-catalyzed tyrosine nitration.
M. Zou (1999)
10.1074/JBC.M102417200
Activation of Matrix Metalloproteinases by Peroxynitrite-induced Protein S-Glutathiolation via Disulfide S-Oxide Formation*
T. Okamoto (2001)
10.1016/S0014-5793(98)00413-X
Rapid and irreversible inhibition of creatine kinase by peroxynitrite
E. Konorev (1998)
10.1046/j.1471-4159.1995.64051965.x
Effect of Peroxynitrite on the Mitochondrial Respiratory Chain: Differential Susceptibility of Neurones and Astrocytes in Primary Culture
J. Bolaños (1995)
10.1016/J.ABB.2003.10.011
Triuret: a novel product of peroxynitrite-mediated oxidation of urate.
K. M. Robinson (2004)
10.2337/DIABETES.51.8.2561
Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound.
R. Bottino (2002)
Effects of endotoxin on human myocardial contractility involvement of NO and peroxynitrite
A. J. Lokuta (1996)
10.1161/01.CIR.0000165503.08661.E5
Antioxidative Effects of Exercise Training in Patients With Chronic Heart Failure: Increase in Radical Scavenger Enzyme Activity in Skeletal Muscle
A. Linke (2005)
in NOD mice is associated with the formation of peroxynitrite in pancreatic islet β - cells
W. L. Suarez-Pinzon (1997)
10.2337/DIABETES.53.10.2574
A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection.
A. Olcott (2004)
10.1016/J.CBPB.2005.05.037
Survival pathways triggered by peroxynitrite in cells belonging to the monocyte/macrophage lineage.
O. Cantoni (2005)
10.1023/A:1014832520809
Effect of R-(-)-Deprenyl and Harmaline on Dopamine- and Peroxynitrite-Induced Membrane Permeability Transition in Brain Mitochondria
C. S. Lee (2004)
10.1016/S0891-5849(00)00249-5
Peroxynitrite scavenging by metalloporphyrins and thiolates.
J. Crow (2000)
Peroxynitrite-induced nitrotyrosination of proteins is blocked by direct 5-lipoxygenase inhibitor zileuton.
M. Coffey (2001)
10.1016/J.FREERADBIOMED.2005.02.026
Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling.
S. Rhee (2005)
10.1016/S0735-1097(98)00660-3
Effects of endotoxin on human myocardial contractility involvement of nitric oxide and peroxynitrite.
M. Flesch (1999)
10.1517/13543784.9.3.607
Ebselen: prospective therapy for cerebral ischaemia
M. Parnham (2000)
10.1042/BJ20020154
Oxidation of nitric oxide by oxomanganese-salen complexes: a new mechanism for cellular protection by superoxide dismutase/catalase mimetics.
M. Sharpe (2002)
10.1016/S0002-9440(10)64677-9
Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions.
J. Liu (2001)
10.1097/00024382-200116020-00008
Effects of combined selective iNOS inhibition and peroxynitrite blockade during endotoxemia in pigs.
F. Ploner (2001)
Inducible NO synthase expression in human cerebral infarcts
C. S. Baker (1999)
10.1016/0003-9861(91)90224-7
Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide.
R. Radi (1991)
10.1523/JNEUROSCI.22-09-03484.2002
Peroxynitrite Mediates Neurotoxicity of Amyloid β-Peptide1–42- and Lipopolysaccharide-Activated Microglia
Z. Xie (2002)
10.1016/J.NIOX.2005.11.001
Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation.
J. Niles (2006)
10.1016/S0014-5793(98)00053-2
Protein oxidation, tyrosine nitration, and inactivation of sarcoplasmic reticulum Ca2+‐ATPase in low‐frequency stimulated rabbit muscle
B. M. Klebl (1998)
10.1016/S0014-2999(97)01325-3
Amelioration by mercaptoethylguanidine of the vascular and energetic failure in haemorrhagic shock in the anesthetised rat.
B. Zingarelli (1997)
10.1073/pnas.0502255102
Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells
J. Herzog (2005)
10.1016/S0165-0173(99)00014-4
Neurodegenerative disorders: the role of peroxynitrite
F. Torreilles (1999)
10.1006/ABBI.2000.2247
Mechanisms of peroxynitrite decomposition catalyzed by FeTMPS, a bioactive sulfonated iron porphyrin.
R. Shimanovich (2001)
10.1016/S0378-4274(02)00508-8
Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention.
L. Virág (2003)
10.1016/S0891-5849(02)00980-2
A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.
Z. Vujasković (2002)
10.1074/JBC.M501977200
Peroxynitrite Is a Potent Inhibitor of NF-κB Activation Triggered by Inflammatory Stimuli in Cardiac and Endothelial Cell Lines*
S. Levrand (2005)
10.1111/J.1523-1755.2004.66035.X
Endothelial dysfunction as a modifier of angiogenic response in Zucker diabetic fat rat: amelioration with Ebselen.
O. Gealekman (2004)
10.1073/PNAS.0500307102
Uric acid protects against secondary damage after spinal cord injury.
G. Scott (2005)
10.1073/PNAS.0400518101
Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry.
E. Padalko (2004)
Formation of F2-isoprostanes during the oxidation of human low density lipoprotein by peroxynitrite.
K. Moore (1995)
10.1074/jbc.M009429200
Reaction of Peroxynitrite with Mn-Superoxide Dismutase
C. Quijano (2001)
10.1073/PNAS.0506541103
Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression.
M. Wright (2006)
10.1016/J.FREERADBIOMED.2003.10.011
Reactions of desferrioxamine with peroxynitrite-derived carbonate and nitrogen dioxide radicals.
S. Bartesaghi (2004)
10.1021/JA005856I
Mn(II)-texaphyrin as a catalyst for the decomposition of peroxynitrite.
R. Shimanovich (2001)
10.1002/jnr.20027
Oxidation of vitamin E and vitamin C and inhibition of brain mitochondrial oxidative phosphorylation by peroxynitrite
G. Vatassery (2004)
10.1016/J.FREERADBIOMED.2005.04.014
Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: modeling the impact of superoxide dismutase and nitric oxide diffusion.
C. Quijano (2005)
10.1074/jbc.274.35.24664
Reaction of Peroxynitrite with Reduced Nicotinamide Nucleotides, the Formation of Hydrogen Peroxide*
M. Kirsch (1999)
10.1074/jbc.273.38.24521
The Ortho Effect Makes Manganese(III)Meso-Tetrakis(N-Methylpyridinium-2-yl)Porphyrin a Powerful and Potentially Useful Superoxide Dismutase Mimic*
I. Batinić-Haberle (1998)
10.1016/J.CYTOGFR.2006.01.003
High-mobility group box 1 (HMGB1) protein: friend and foe.
L. Ulloa (2006)
10.1124/JPET.105.083493
Protective Mechanisms of a Metalloporphyrinic Peroxynitrite Decomposition Catalyst, WW85, in Rat Cardiac Transplants
G. Pieper (2005)
10.1016/J.TIPS.2005.04.003
Nitrosative stress and pharmacological modulation of heart failure.
P. Pacher (2005)
10.1161/01.CIR.0000156461.81529.D7
Increased Nitration of Sarcoplasmic Reticulum Ca2+-ATPase in Human Heart Failure
A. Lokuta (2005)
10.1096/fj.03-1096fje
Peroxynitrite mediates calcium‐dependent mitochondrial dysfunction and cell death via activation of calpains
M. Whiteman (2004)
10.1006/JAUT.2001.0507
An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice.
W. Suarez-Pinzon (2001)
10.1021/BI971894B
Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues.
L. A. MacMillan-Crow (1998)
Activation of protein kinase C zeta by peroxynitrite regulates LKB 1 - dependent AMP - activated protein kinase in cultured endothelial cells
Z. Xie (2005)
Endothelial NO synthase in vascular disease : from marvel to menace
U. Forstermann (2006)
10.1073/pnas.212645999
Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors
G. Scott (2002)
10.1016/J.BBRC.2004.01.046
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration.
K. Ito (2004)
10.1161/01.ATV.0000189159.96900.d9
Peroxynitrite Causes Endoplasmic Reticulum Stress and Apoptosis in Human Vascular Endothelium: Implications in Atherogenesis
J. Dickhout (2005)
10.1111/j.1749-6632.2002.tb04072.x
A Reassessment of the Peroxynitrite Scavenging Activity of Uric Acid
M. Whiteman (2002)
10.1016/j.mad.2006.09.005
The peroxynitrite decomposition catalyst FP15 improves ageing-associated cardiac and vascular dysfunction
T. Radovits (2007)
10.1016/S0891-5849(01)00509-3
Peroxynitrite-dependent activation of src tyrosine kinases lyn and hck in erythrocytes is under mechanistically different pathways of redox control.
C. Mallozzi (2001)
10.1007/s00775-006-0101-1
Decomposition of reactive oxygen species by copper(II) bis(1-pyrazolyl)methane complexes
I. Schepetkin (2006)
Structure activity relationships of peroxynitrite scavengers an approach to NO neurotoxicity
J. S. Althaus (1994)
10.1164/AJRCCM.160.2.9807160
Role of peroxynitrite in airway microvascular hyperpermeability during late allergic phase in guinea pigs.
H. Sugiura (1999)
10.1016/J.FREERADBIOMED.2004.10.037
Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway.
S. Shiva (2005)
10.1074/JBC.M108190200
Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite*
S. Savvides (2002)
and islet allograft rejection
S. Del Guerra (2004)
10.1161/CIRCULATIONAHA.105.556233
Nebivolol Reduces Nitroxidative Stress and Restores Nitric Oxide Bioavailability in Endothelium of Black Americans
R. Mason (2005)
10.1523/JNEUROSCI.18-03-00923.1998
Nitric Oxide and Superoxide Contribute to Motor Neuron Apoptosis Induced by Trophic Factor Deprivation
A. Estevez (1998)
10.1053/GAST.2002.35391
HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice.
P. Sappington (2002)
10.1152/AJPRENAL.0071.2001
Oxidative and nitrosative stress in acute renal ischemia.
E. Noiri (2001)
NO - induced mitochondrial dysfunction : implications for neurodegeneration
J. B. Schulz (2003)
10.1152/AJPCELL.1994.266.3.C628
Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells.
M. J. Kuchan (1994)
10.1152/AJPHEART.01293.2005
Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.
S. Xu (2006)
10.1016/B978-012370420-7/50005-8
The Biological Chemistry of Peroxynitrite
R. Radi (2000)
10.1161/01.CIR.0000048192.52098.DD
Potent Metalloporphyrin Peroxynitrite Decomposition Catalyst Protects Against the Development of Doxorubicin-Induced Cardiac Dysfunction
P. Pacher (2003)
10.1016/S0008-6363(02)00786-1
Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation.
H. Sohn (2003)
10.4049/jimmunol.171.2.528
Cutting Edge: MHC Class II-Restricted Peptides Containing the Inflammation-Associated Marker 3-Nitrotyrosine Evade Central Tolerance and Elicit a Robust Cell-Mediated Immune Response 1
H. Birnboim (2003)
10.1007/s007020200038
The anti-parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells
W. Maruyama (2002)
10.1042/BST0340965
Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation.
D. Salvemini (2006)
10.1152/AJPLUNG.1994.267.3.L242
Concurrent generation of nitric oxide and superoxide damages surfactant protein A.
I. Y. Haddad (1994)
10.1016/j.brainres.2004.02.083
Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice
M. Selley (2005)
10.1074/jbc.M602814200
Reversible Post-translational Modification of Proteins by Nitrated Fatty Acids in Vivo*
C. Batthyány (2006)
10.1159/000085465
Peroxynitrite Modulates Release of Inflammatory Mediators from Guinea Pig Lung Mast Cells Activated by Antigen-Antibody Reaction
J. Kim (2005)
10.1016/S0014-4800(03)00015-7
Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis.
B. Naidu (2003)
10.1073/PNAS.97.17.9753
Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock.
H. Macarthur (2000)
10.1074/JBC.M112451200
Nitric oxide (NO) induces nitration of protein kinase Cepsilon (PKCepsilon ), facilitating PKCepsilon translocation via enhanced PKCepsilon -RACK2 interactions: a novel mechanism of no-triggered activation of PKCepsilon.
Z. Balafanova (2002)
10.1159/000046876
Peroxynitrite-Mediated Mitochondrial Dysfunction
J. Boczkowski (2001)
10.1111/j.1468-1331.2006.01207.x
Cabergoline scavenges peroxynitrite enhanced by l‐DOPA therapy in patients with Parkinson's disease
C. Isobe (2006)
10.1191/096032701680350578
Effect of peroxynitrite on glutaredoxin
G. Aykaç-Toker (2001)
10.1073/PNAS.93.21.11853
Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.
L. A. MacMillan-Crow (1996)
10.1016/S0891-5849(02)01111-5
Peroxynitrite reactions and formation in mitochondria.
R. Radi (2002)
10.1126/SCIENCE.290.5493.985
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions.
B. Giasson (2000)
10.1074/jbc.M306101200
Pro-thrombotic State Induced by Post-translational Modification of Fibrinogen by Reactive Nitrogen Species*
Caryn Vadseth (2004)
10.1002/HEP.510290354
Peroxynitrite formation during rat hepatic allograft rejection
Y. Yamaguchi (1999)
10.1161/01.RES.78.6.1051
Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite.
C. Szabo (1996)
10.1016/0005-2736(92)90135-9
Peroxynitrite inhibits sodium uptake in rat colonic membrane vesicles.
M. Bauer (1992)
10.1016/J.YJMCC.2006.01.010
Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium.
T. Rork (2006)
10.1074/JBC.M008456200
Carbon Dioxide Stimulates the Production of Thiyl, Sulfinyl, and Disulfide Radical Anion from Thiol Oxidation by Peroxynitrite*
M. Bonini (2001)
10.1074/jbc.272.44.27812
Glutathione Peroxidase Protects against Peroxynitrite-mediated Oxidations
H. Sies (1997)
10.1023/B:JOBB.0000041755.22613.8D
Deadly Conversations: Nuclear-Mitochondrial Cross-Talk
V. Dawson (2004)
10.1021/BI060474W
Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.
C. Sacksteder (2006)
10.1161/CIRCULATIONAHA.106.625061
Nitrative Inactivation of Thioredoxin-1 and Its Role in Postischemic Myocardial Apoptosis
L. Tao (2006)
10.1016/0014-5793(95)00984-H
Peroxynitrite‐mediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia‐reperfusion injury
C. Szabo (1995)
NO inhibits mitochondrial NADH : ubiquinone reductase activity through peroxynitrite formation
N. A. Riobo (2001)
10.1152/AJPCELL.00299.2003
Effects of peroxynitrite on sarco/endoplasmic reticulum Ca2+ pump isoforms SERCA2b and SERCA3a.
A. Grover (2003)
10.1097/00000542-200304000-00020
Deactivation of Norepinephrine by Peroxynitrite as a New Pathogenesis in the Hypotension of Septic Shock
K. Takakura (2003)
10.1016/S0891-5849(98)00142-7
Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in carrageenan-induced pleurisy.
S. Cuzzocrea (1999)
10.1186/1471-2210-4-20
Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats
Y. I. Chirino (2004)
10.1016/J.FREERADBIOMED.2006.04.028
Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite.
G. Ferrer-Sueta (2006)
Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide.
T. Oury (1993)
Protection by selenoprotein P in human plasma against peroxynitrite-mediated oxidation and nitration.
G. Arteel (1998)
10.1074/JBC.272.14.9030
Mercaptoethylguanidine and Guanidine Inhibitors of Nitric-oxide Synthase React with Peroxynitrite and Protect against Peroxynitrite-induced Oxidative Damage*
C. Szabo (1997)
10.1038/83241
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
F. Soriano (2001)
10.1023/A:1006817207166
Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: Evidence against a stress-mediated response
E. Cable (2004)
10.1089/ARS.2006.8.529
Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise.
A. Y. Seo (2006)
10.1016/J.BIOCHI.2005.06.016
Biochemical properties of cytochrome c nitrated by peroxynitrite.
B. Jang (2006)
10.3892/IJMM.15.5.871
Na+,K+-ATPase activity is inhibited in cultured intestinal epithelial cells by endotoxin or nitric oxide.
Y. Suzuki (2005)
10.1007/BF03402168
Part II: Beneficial Effects of the Peroxynitrite Decomposition Catalyst FP15 in Murine Models of Arthritis and Colitis
J. Mabley (2002)
10.1097/00024382-199911001-00128
Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion.
S. Cuzzocrea (2000)
10.1097/00000542-200412000-00017
Propofol Attenuates Peroxynitrite-mediated DNA Damage and Apoptosis in Cultured Astrocytes: An Alternative Protective Mechanism
R. Acquaviva (2004)
10.1186/1471-2202-3-13
Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages
C. Muscoli (2002)
10.1016/S0165-5728(00)00242-3
A catalyst of peroxynitrite decomposition inhibits murine experimental autoimmune encephalomyelitis
A. Cross (2000)
10.1016/S0378-4274(02)00511-8
Defenses against peroxynitrite: selenocompounds and flavonoids.
L. Klotz (2003)
10.1016/J.LFS.2005.02.018
Pindolol is a potent scavenger of reactive nitrogen species.
E. Fernandes (2005)
10.1016/J.FREERADBIOMED.2005.06.015
Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3.
D. H. Platt (2005)
10.1016/S0378-4274(02)00507-6
Multiple pathways of peroxynitrite cytotoxicity.
C. Szabo (2003)
10.2741/2127
Mitochondrial nitric oxide synthase.
P. Ghafourifar (2005)
10.4049/jimmunol.169.8.4568
Enhanced Activity of Human IL-10 After Nitration in Reducing Human IL-1 Production by Stimulated Peripheral Blood Mononuclear Cells1
Jon L. Freels (2002)
10.1016/J.BBABIO.2004.03.016
Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols.
G. Brown (2004)
10.1016/J.TRANSPROCEED.2004.03.050
Tempol, an intracelullar free radical scavenger, reduces liver injury in hepatic ischemia-reperfusion in the rat.
B. Sepodes (2004)
10.1021/TX015571Z
The Mechanism by which 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (tempol) diverts peroxynitrite decomposition from nitrating to nitrosating species.
M. Bonini (2002)
10.1016/J.MRFMMM.2004.01.006
Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways.
J. Mabley (2004)
10.1021/BI00011A008
Sensitivity of the essential zinc-thiolate moiety of yeast alcohol dehydrogenase to hypochlorite and peroxynitrite.
J. Crow (1995)
10.1096/fj.05-4875fje
S‐glutathiolation by peroxynitrite of p21ras at cysteine‐118 mediates its direct activation and downstream signaling in endothelial cells
Nicolas Clavreul (2006)
10.1073/pnas.0307446101
Nitric oxide, oxidants, and protein tyrosine nitration
R. Radi (2004)
10.1074/JBC.M213302200
Reactions of Manganese Porphyrins with Peroxynitrite and Carbonate Radical Anion*
G. Ferrer-Sueta (2003)
10.1073/PNAS.87.4.1620
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
J. Beckman (1990)
10.1074/jbc.273.18.11038
Production of Nitric Oxide by Mitochondria*
C. Giulivi (1998)
10.1016/S1053-2498(02)00556-9
Critical role of reactive nitrogen species in lung ischemia-reperfusion injury.
B. Naidu (2003)
Development of autoimmune
W. L. Suarez-Pinzon
10.1073/pnas.141222598
Nitration of succinyl-CoA:3-oxoacid CoA-transferase in rats after endotoxin administration
S. Marcondes (2001)
Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
R. Radi (1991)
10.1007/s00134-004-2427-x
Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition
N. Nin (2004)
10.1016/S0891-5849(00)00373-7
Unraveling peroxynitrite formation in biological systems.
R. Radi (2001)
10.1038/35025109
Peroxynitrite reductase activity of bacterial peroxiredoxins
R. Bryk (2000)
10.1038/nrd1718
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
P. Jagtap (2005)
10.1161/01.RES.83.1.85
Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury.
B. Zingarelli (1998)
Quantitative analysis of cardiac 3L - nitrotyrosine during acute allograft rejection in an experimental heart
B. Van der Loo (1999)
10.1016/S0014-5793(01)02511-X
Peroxynitrite activates mitogen‐activated protein kinase (MAPK) via a MEK‐independent pathway: a role for protein kinase C
S. Bapat (2001)
10.1006/ABBI.1995.1493
DNA Damage and Oxidation of Thiols Peroxynitrite Causes in Rat Thymocytes
M. G. Salgo (1995)
10.1006/ABBI.1994.1013
Inhibition of mitochondrial electron transport by peroxynitrite.
R. Radi (1994)
10.1016/J.FREERADBIOMED.2005.11.001
Corrigendum to “Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: Modeling the impact of superoxide dismutase and nitric oxide diffusion” [Free Radic. Biol. Med. 39:728–741; 2005]
C. Quijano (2006)
10.1016/0014-5793(93)81790-7
The oxidation of α‐tocopherol in human low‐density lipoprotein by the simultaneous generation of superoxide and nitric oxide
N. Hogg (1993)
10.1201/9781420027167
Nitric Oxide, Cell Signaling, and Gene Expression
E. Cadenas (2005)
10.1074/JBC.M909978199
Cytochrome c Nitration by Peroxynitrite*
A. Cassina (2000)
10.1021/BI0474620
Time course and site(s) of cytochrome c tyrosine nitration by peroxynitrite.
C. Batthyány (2005)
10.1096/fj.04-1913fje
Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst
I. Obrosova (2005)
10.1021/TX980076X
Radical nature of peroxynitrite reactivity.
S. Lymar (1998)
The role of mitochondrial dysfunction and neuronal NO in animal models of neurodegenerative diseases
F. Torreilles (1997)
AEOL-10150 (Aeolus).
R. Orrell (2006)
10.1111/J.1574-695X.2006.00203.X
MnTBAP, a synthetic metalloporphyrin, inhibits production of tumor necrosis factor-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages cells via inhibiting oxidative stress-mediating p38 and SAPK/JNK signaling.
G. Tumurkhuu (2007)
10.1073/PNAS.95.7.3566
Diffusion of peroxynitrite across erythrocyte membranes.
A. Denicola (1998)
10.1089/ARS.2006.8.639
Peroxynitrite induces an alternative NF-kappaB activation pathway in L8 rat myoblasts.
M. Bar-Shai (2006)
10.1007/s00210-006-0123-9
Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis
M. Bezerra (2006)
10.1016/J.EJPHAR.2004.08.033
Effects of the peroxynitrite decomposition catalyst, FeTMPyP, on function of corpus cavernosum from diabetic mice.
M. Nangle (2004)
10.1016/S0006-291X(02)02060-0
Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding.
D. Newman (2002)
10.1074/jbc.M305895200
Reaction of Human Hemoglobin with Peroxynitrite
Natalia Romero (2003)
Stroke - Acute Ischemic NXY Treatment ( SAINT I ) Trial Investigators . NXY - 059 for acute ischemic stroke
E. E. Cable (2006)
10.1046/j.1471-4159.2003.01639.x
Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis
A. Wu (2003)
10.1046/J.1523-1755.2000.00046.X
Increased nitrotyrosine staining in kidneys from patients with diabetic nephropathy.
R. Thuraisingham (2000)
10.1038/320454A0
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
R. J. Gryglewski (1986)
10.1073/PNAS.94.26.14243
Peroxynitrite rapidly permeates phospholipid membranes.
S. S. Marla (1997)
10.1152/AJPLUNG.1994.266.6.L628
Peroxynitrite inhibition of oxygen consumption and sodium transport in alveolar type II cells.
P. Hu (1994)
10.1523/JNEUROSCI.21-20-08053.2001
Induction of α-Synuclein Aggregation by Intracellular Nitrative Insult
E. Paxinou (2001)
10.1097/00004872-200107000-00008
Effects of chronic N-acetylcysteine treatment on the actions of peroxynitrite on aortic vascular reactivity in hypertensive rats
A. Cabassi (2001)
10.1111/j.1471-4159.2004.02964.x
Alteration of cytosolic free calcium homeostasis by SIN‐1: high sensitivity of L‐type Ca2+ channels to extracellular oxidative/nitrosative stress in cerebellar granule cells
Yolanda Gutiérrez-Martín (2005)
10.1016/S0014-2999(02)01980-5
Pneumococcal meningitis in the rat: evaluation of peroxynitrite scavengers for adjunctive therapy.
S. Kastenbauer (2002)
10.1096/fj.00-0521fje
Peroxynitrite induces integrin‐dependent adhesion of human neutrophils to endothelial cells via activation of the Raf‐1/MEK/Erk pathway
C. Zouki (2001)
A role for NO - mediated peroxynitrite formation in a model of endotoxin induced shock
S. Cuzzocrea (2006)
10.1152/AJPLUNG.00001.2002
Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure.
M. J. Hunt (2002)
10.1016/0014-2999(96)00140-9
Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema.
D. Salvemini (1996)
10.1016/J.JACC.2004.01.047
Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats.
S. Lancel (2004)
10.1073/PNAS.95.5.2659
Peroxynitrite decomposition catalysts: therapeutics for peroxynitrite-mediated pathology.
D. Salvemini (1998)
10.2337/DIABETES.54.3.727
Functional and molecular defects of pancreatic islets in human type 2 diabetes.
S. del Guerra (2005)
10.1016/J.BBAGEN.2004.01.005
Inhibition of Na+/Ca2+ exchanger by peroxynitrite in microsomes of pulmonary smooth muscle: role of matrix metalloproteinase-2.
S. Chakraborti (2004)
10.1016/J.FREERADBIOMED.2004.09.008
Redox-dependent effects of nitric oxide on microvascular integrity in oxygen-induced retinopathy.
M. Beauchamp (2004)
10.1074/JBC.M106393200
Peroxynitrite Is an Essential Component of Cytokines Production Mechanism in Human Monocytes through Modulation of Nuclear Factor-κB DNA Binding Activity*
B. Matata (2002)
10.1189/jlb.69.5.815
Peroxynitrite mediates cytokine‐induced IL‐8 gene expression and production by human leukocytes
C. Zouki (2001)
10.1161/01.RES.87.3.241
Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure.
P. Ferdinandy (2000)
10.1042/BJ3190013
Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen.
K. Briviba (1996)
10.1097/01.TA.0000174858.79847.6D
Mercaptoethylguanidine inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expressions induced in rats after fluid-percussion brain injury.
S. Moochhala (2005)
10.1089/152308601300185188
Mechanisms of cell signaling by nitric oxide and peroxynitrite: from mitochondria to MAP kinases.
A. Levonen (2001)
10.1016/J.BCP.2003.08.045
Modulation of A1 adenosine receptor signaling by peroxynitrite.
Janette Giuntini (2004)
10.1016/J.BBRC.2004.06.019
Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1.
T. Nomiyama (2004)
10.1016/S0006-291X(03)01132-X
Amphiphilic properties of (-)-epicatechin and their significance for protection of cells against peroxynitrite.
P. Schroeder (2003)
10.1021/IC011089S
Peroxynitrite decomposition activity of iron porphyrin complexes.
M. P. Jensen (2002)
10.1038/sj.cdd.4401831
Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells
J. Shacka (2006)
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo.
K. Faulkner (1994)
10.1016/j.febslet.2004.06.080
Human peroxiredoxin 5 is a peroxynitrite reductase
M. Dubuisson (2004)
10.1016/0014-5793(96)00977-5
Sensitivity of human pancreatic islets to peroxynitrite‐induced cell dysfunction and death
C. Delaney (1996)
10.1074/jbc.M610800200
Prevention of Peroxynitrite-induced Apoptosis of Motor Neurons and PC12 Cells by Tyrosine-containing Peptides*
Yaozu Ye (2007)
10.1016/J.BBRC.2005.10.106
Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure.
A. Daiber (2005)
10.1042/BJ3520219
Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts.
L. O. Klotz (2000)
10.1016/J.FREERADBIOMED.2005.09.006
Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase.
H. Heijnen (2006)
10.1074/jbc.273.23.14085
Inactivation of Human Manganese-superoxide Dismutase by Peroxynitrite Is Caused by Exclusive Nitration of Tyrosine 34 to 3-Nitrotyrosine*
F. Yamakura (1998)
10.1080/10715760100300471
Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction
S. A. Greenacre (2001)
10.1016/J.FREERADBIOMED.2006.08.010
Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons.
Mariana Pehar (2006)
The oxidation of alpha-tocopherol in human low-density lipoprotein by the simultaneous generation of superoxide and nitric oxide.
N. Hogg (1993)
10.1136/gut.42.2.180
Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis
H. Kimura (1998)
10.1016/J.LFS.2005.02.026
Immunological studies on peroxynitrite modified human DNA.
K. Dixit (2005)
10.1038/sj.bjp.0705811
Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats#
M. Thiyagarajan (2004)
10.1021/TX049879C
Nitric oxide, oxygen, and superoxide formation and consumption in macrophage cultures.
N. Nalwaya (2005)
10.1006/BBRC.2001.5448
Peroxynitrite-induced tyrosine nitration and inhibition of protein kinase C.
L. T. Knapp (2001)
10.2337/DIABETES.51.2.347
A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone.
J. Piganelli (2002)
10.1080/15216540500137701
Reactivity of Peroxynitrite and Nitric Oxide with LDL
H. Botti (2005)
10.1002/ana.20552
Manganese porphyrin given at symptom onset markedly extends survival of ALS mice
J. Crow (2005)
10.1016/J.FREERADBIOMED.2005.03.014
Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid.
M. Trujillo (2005)
10.1016/S0014-5793(98)01223-X
Peroxynitrite oxidises catechols to o‐quinones
N. Kerry (1998)
10.1016/J.JVS.2005.11.021
Activation of the peroxynitrite-poly(adenosine diphosphate-ribose) polymerase pathway during neointima proliferation: a new target to prevent restenosis after endarterectomy.
C. Beller (2006)
10.1016/j.neulet.2006.03.046
Competing approaches to excitotoxic neuroprotection by inert and catalytic antioxidant porphyrins
J. Tauskela (2006)
10.1056/NEJMOA052980
NXY-059 for acute ischemic stroke.
K. Lees (2006)
10.1016/0891-5849(94)90138-4
Peroxynitrite-mediated oxidation of dihydrorhodamine 123.
N. Kooy (1994)
10.1016/0014-5793(95)00322-Z
Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo
C. Szabo (1995)
10.1016/j.neuropharm.2004.10.002
The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia
M. Banno (2005)
10.1021/BI052142H
Peroxynitrite-mediated tau modifications stabilize preformed filaments and destabilize microtubules through distinct mechanisms.
M. Reynolds (2006)
10.1097/00003246-200101000-00055
The stable nitroxide, tempol, attenuates the effects of peroxynitrite and oxygen-derived free radicals.
C. Thiemermann (2001)
10.1016/S0006-2952(97)00542-X
Protection by organotellurium compounds against peroxynitrite-mediated oxidation and nitration reactions.
K. Briviba (1998)
10.1023/B:PHAM.0000045224.97323.8b
Reactivity of 1,4-Dihydropyridines Toward SIN-1-Derived Peroxynitrite
C. Lx00F3pez-Alarcx00F3n (2004)
10.1074/JBC.M302227200
Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols
Nermin Kuzkaya (2003)
10.1021/MP0500667
Design of manganese porphyrin modified with mitochondrial signal peptide for a new antioxidant.
S. Asayama (2006)
10.1016/S0166-2236(00)01981-0
Superoxide dismutase and the death of motoneurons in ALS
J. Beckman (2001)
10.1046/j.1471-4159.2002.00975.x
Intranuclear localization of apoptosis‐inducing factor (AIF) and large scale dna fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite
X. Zhang (2002)
10.1016/S0891-5849(02)00979-6
Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia.
H. Sheng (2002)
10.1023/B:NERE.0000014828.32200.bd
Peroxynitrite Mediates Nitric Oxide–Induced Blood–Brain Barrier Damage
Kian H. Tan (2004)
10.1006/NIOX.1997.0143
DNA damage induced by peroxynitrite: subsequent biological effects.
C. Szabo (1997)
10.1097/00001756-200011090-00038
Nitric oxide activation of TrkB through peroxynitrite
E. Yuen (2000)
10.1016/j.neulet.2004.05.050
Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy
H. Sheng (2004)
10.1016/J.FREERADBIOMED.2007.01.009
Interactions between nitric oxide and peroxynitrite during prostaglandin endoperoxide H synthase-1 catalysis: a free radical mechanism of inactivation.
A. Trostchansky (2007)
10.1016/J.IJROBP.2005.05.026
A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.
B. Moeller (2005)
10.1186/1742-2094-2-20
Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration
P. Mander (2005)
10.1152/AJPCELL.2000.279.2.C341
Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells.
S. Zhuang (2000)
10.1006/BBRC.1999.1422
Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function.
S. Milstien (1999)
10.1021/TX980254M
DNA damage in deoxynucleosides and oligonucleotides treated with peroxynitrite.
S. Burney (1999)
10.1006/ABBI.1999.1424
Interaction of peroxynitrite with carotenoids in human low density lipoproteins.
O. Panasenko (2000)
10.1002/(SICI)1520-7560(199907/08)15:4<283::AID-DMRR42>3.0.CO;2-U
Nitric oxide and its role in lipid peroxidation
F. Violi (1999)
10.1016/S0076-6879(02)49318-4
Reactions of manganese porphyrins and manganese-superoxide dismutase with peroxynitrite.
G. Ferrer-Sueta (2002)
10.1016/0003-9861(92)90431-U
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase.
H. Ischiropoulos (1992)
Nitric oxide : biology and pathobiology
L. Ignarro (2000)
Peroxynitrite causes DNA damage and oxidation of thiols in rat thymocytes [corrected].
M. G. Salgo (1995)
Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.
A. Hausladen (1994)
10.1016/0014-5793(94)00596-6
Mechanism of covalent modification of glyceraldehyde‐3‐phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents
S. Mohr (1994)
10.1016/J.FREERADBIOMED.2004.06.006
Inactivation of human Cu,Zn superoxide dismutase by peroxynitrite and formation of histidinyl radical.
B. Álvarez (2004)
10.1016/J.FREERADBIOMED.2003.07.004
Peroxynitrite flux-mediated LDL oxidation is inhibited by manganese porphyrins in the presence of uric acid.
A. Trostchansky (2003)
10.1161/01.CIR.0000038365.78031.9C
Poly(ADP-Ribose) Polymerase Is Activated in Subjects at Risk of Developing Type 2 Diabetes and Is Associated With Impaired Vascular Reactivity
C. Szabo (2002)
MITOCHONDRIA, NO AND PEROXYNITRITE
Christoph Richter (1999)
10.2337/diab.46.5.907
Development of Autoimmune Diabetes in NOD Mice Is Associated With the Formation of Peroxynitrite in Pancreatic Islet β-Cells
W. Suarez-Pinzon (1997)
10.1021/BI027434M
Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite.
S. Carballal (2003)
10.1124/PR.54.3.375
The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors
L. Virág (2002)
10.1016/J.FREERADBIOMED.2006.04.034
Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo.
S. Levrand (2006)
10.1007/s003950200050
Immunocytochemical evidence for inducible nitric oxide synthase and cyclooxygenase-2 expression with nitrotyrosine formation in human hibernating myocardium
C. Baker (2002)
10.1074/jbc.M511178200
Activation of Protein Kinase Cζ by Peroxynitrite Regulates LKB1-dependent AMP-activated Protein Kinase in Cultured Endothelial Cells*
Z. Xie (2006)
Effect of peroxynitrite on glutaredoxin
G. Aykac-Toker (2001)
10.1016/J.BBRC.2005.05.178
Hydrogen peroxide and peroxynitrite enhance Ca2+ mobilization and aggregation in platelets from type 2 diabetic patients.
P. Redondo (2005)
10.1016/S0891-5849(02)01008-0
A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.
R. Bowler (2002)
10.1016/J.NIOX.2005.05.011
Mitochondrial NO and reactive nitrogen species production: does mtNOS exist?
Z. Lacza (2006)
10.1016/J.EJPHAR.2005.06.027
Potential role of nitration and oxidation reactions in the effects of peroxynitrite on the function of beta-adrenoceptor sub-types in the rat.
S. J. Lewis (2005)
10.1073/PNAS.91.26.12383
Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart.
L. M. Villa (1994)
10.1074/JBC.M105564200
Nitration and Inactivation of Tyrosine Hydroxylase by Peroxynitrite*
B. Blanchard-Fillion (2001)
10.1097/01.tp.0000181099.20099.d1
Role of Peroxynitrite Anion in Renal Hypothermic Preservation Injury
M. Mangino (2005)
10.1021/BI060363X
Mechanistic studies of peroxynitrite-mediated tyrosine nitration in membranes using the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester.
S. Bartesaghi (2006)
10.1016/0014-5793(96)00087-7
Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger
C. Szabo (1996)
10.1021/TX000099N
Reactivity of peroxynitrite versus simultaneous generation of (*)NO and O(2)(*)(-) toward NADH.
S. Goldstein (2000)
10.1016/S0891-5849(96)00401-7
Clinical evidence of peroxynitrite formation in chronic renal failure patients with septic shock.
N. Fukuyama (1997)
10.1016/S0008-6363(00)00307-2
Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure.
M. Mihm (2001)
10.1016/S0006-8993(00)02582-8
Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury
S. Cuzzocrea (2000)
10.1016/J.FREERADBIOMED.2007.01.019
Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria.
I. Spasojević (2007)
10.1016/S0014-5793(02)03059-4
Nitration of PPARγ inhibits ligand‐dependent translocation into the nucleus in a macrophage‐like cell line, RAW 264
A. Shibuya (2002)
10.1042/BJ20020339
Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity.
S. Lanone (2002)
Peroxynitrite decomposition catalysts
M. K. Stern (1996)
10.1007/978-1-4615-6111-8_30
The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases
J. Schulz (1997)
10.1016/J.TIPS.2005.02.005
Mitochondrial nitric oxide synthase.
P. Ghafourifar (2007)
10.1097/00007890-199912150-00031
Quantitative analysis of cardiac 3-L-nitrotyrosine during acute allograft rejection in an experimental heart transplantation.
M. Sakurai (1999)
10.1089/NEU.2005.22.1123
Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin.
Danxia Liu (2005)
10.1161/CIRCULATIONAHA.105.602532
Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
U. Förstermann (2006)



This paper is referenced by
10.1517/14728222.2012.723694
The uric acid metabolism pathway as a therapeutic target in hyperuricemia related to metabolic syndrome
A. Simão (2012)
10.1007/s00775-009-0575-8
A peroxynitrite complex of copper: formation from a copper–nitrosyl complex, transformation to nitrite and exogenous phenol oxidative coupling or nitration
G. Y. Park (2009)
10.1002/9783527682386.CH5
Mechanisms of Dysbiosis in the Inflamed Gut
Sebastian E Winter (2016)
10.17750/KMJ2016-250
Effect of L-arginine and L-name on lysosomal cysteine proteases activity and lysosomal membranes permeability in rat aorta
A. I. Arapova (2016)
10.1016/j.ajme.2017.09.001
First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid
O. M. Ighodaro (2018)
Analysis of Volatile Biomarkers of Airway Inflammation in Breath
Jack Dummer (2010)
Antihyperanaemic and antihyperlipidemic activities of Artocarpus altilis fruit based-diet on alloxan-induced diabetic rats
(2017)
10.1016/j.freeradbiomed.2013.07.003
Oxidative stress and vascular inflammation in aging.
M. El Assar (2013)
10.1016/j.freeradbiomed.2013.05.042
Reprint of: revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse.
Rita Perfeito (2013)
Minimizing the Contribution of Oxidative Stress to Disease and Aging
M. Mccarty (2010)
10.1007/s10495-008-0263-0
Specific protein nitration in nitric oxide-induced apoptosis of human monocytes
C. Natal (2008)
10.1152/ajpheart.00273.2009
Inhibition of matrix metalloproteinase activity in vivo protects against vascular hyporeactivity in endotoxemia.
J. Cena (2010)
10.1016/j.freeradbiomed.2010.06.016
Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies.
R. Stavniichuk (2010)
Electrochemical Evaluation of Platinum and Diamond Electrodes for Neural Stimulation
Eric M Hudak (2011)
10.1089/ars.2010.3433
Anti-atherogenic effect of laminar shear stress via Nrf2 activation.
W. Takabe (2011)
Contributo para o estudo dos determinantes genéticos na suscetibilidade e resposta à terapêutica na asma
Faculdade Estadual de Ciências (2012)
10.1021/ja305046u
A three-channel fluorescent probe that distinguishes peroxynitrite from hypochlorite.
Quanjuan Zhang (2012)
10.3892/IJMM_00000166
Peripheral neuropathy in mice with neuronal nitric oxide synthase gene deficiency.
I. Vareniuk (2009)
The role of nitric oxide in hindlimb remote ischaemic preconditioning of the liver
M. Abu-amara (2011)
10.1097/SHK.0b013e3182168d8f
Increased Poly(ADP-Ribosyl)ation in Skeletal Muscle Tissue of Pediatric Patients with Severe Burn Injury: Prevention by Propranolol Treatment
G. Oláh (2011)
10.1093/cvr/cvp085
High glucose sensitizes adult cardiomyocytes to ischaemia/reperfusion injury through nitrative thioredoxin inactivation.
R. Luan (2009)
10.1021/acs.chemrev.5b00018
Gaseous O2, NO, and CO in signal transduction: structure and function relationships of heme-based gas sensors and heme-redox sensors.
T. Shimizu (2015)
10.1016/J.SNB.2017.10.170
A highly specific far-red fluorescent probe for imaging endogenous peroxynitrite in the mitochondria of living cells
B. Zhu (2018)
10.3233/NUA-140043
The impact of Champagne wine consumption on vascular and cognitive functions.
Giulia Corona (2014)
Pro-inflammatory cytokines downregulate Hsp 27 and cause apoptosis of human retinal capillary endothelial cells
R. Nahomi (2014)
2 pushed the development of mechanisms to protect the genetic investment in the metabolic pathway that drive the “
O. Augusto (2011)
10.1097/SHK.0b013e3181e7e9ba
PATHOPHYSIOLOGICAL ROLES OF PEROXYNITRITE IN CIRCULATORY SHOCK
C. Szabo (2010)
IN VITRO EVALUATION OF ANTI-OXIDANT PROPERTIES OF CUCUMIS MELO L. EXTRACTS OF LEAVES AND FRUIT
T. M. Krishna (2013)
10.5772/INTECHOPEN.72217
Role of Antioxidant Phytochemicals in Prevention, Formation and Treatment of Cancer
A. Kocyigit (2017)
10.1021/acs.chemrev.7b00205
Chemical Biology of H2S Signaling through Persulfidation.
M. Filipovic (2018)
10.1128/microbiolspec.MBP-0008-2014
The Roles of Inflammation, Nutrient Availability and the Commensal Microbiota in Enteric Pathogen Infection.
B. Stecher (2015)
10.1152/ajpheart.00772.2013
Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved postischemic myocardial performance via inhibiting MMP-2 activation.
L. Gao (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar