Online citations, reference lists, and bibliographies.
← Back to Search

NF-κB, Chemokine Gene Transcription And Tumour Growth

A. Richmond
Published 2002 · Biology

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
The constitutive expression of angiogenic and tumorigenic chemokines by tumour cells facilitates the growth of tumours. The transcription of these angiogenic and tumorigenic chemokine genes is modulated, in part, by the nuclear factor-κB (NF-κB) family of transcription factors. In some tumours, there is constitutive activation of the kinases that modulate the activity of inhibitor of NF-κB (IκB) kinase (IKK), which leads to the constitutive activation of members of the NF-κB family. This activation of NF-κB is associated with the dysregulation of transcription of genes that encode cytokines, chemokines, adhesion factors and inhibitors of apoptosis. In this review, I discuss the factors that lie upstream of the NF-κB cascade that are activated during tumorigenesis and the role of the putative NF-κB enhanceosome in constitutive chemokine gene transcription during tumorigenesis.
This paper references
Melanoma growth stimulatory activity, a novel growth factor with a tissue distribution not restricted to melanoma tissue
A. Richmond (1986)
Melanoma growth stimulatory activity: Isolation from human melanoma tumors and characterization of tissue distribution
A. Richmond (1988)
Effects of MGSA/GRO alpha on melanocyte transformation.
E. Balentien (1991)
I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.
A. Beg (1992)
Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma.
B. Bottazzi (1992)
a mechanism for cytoplasmic retention
Beg (1992)
Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.
K. A. Higgins (1993)
IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor.
D. Schadendorf (1993)
Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.
B. Stein (1993)
Transcription factors NF-IL6andNF-KBsynergistically activate transcription oftheinflammatory cytokines, interleukin 6and
T. Matsusaka (1993)
IL-8 gene expression and production in human keratinocytes and their modulation by UVB.
S. Kondo (1993)
Genomic structure, characterization, and identification of the promoter of the human IL-8 receptor A gene.
H. Sprenger (1994)
Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice.
R. Singh (1994)
The NF-kappa B transcription factor and cancer: high expression of NF-kappa B- and I kappa B-related proteins in tumor cell lines.
V. Bours (1994)
MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells.
R. L. Shattuck (1994)
Autocrine and paracrine roles for growth factors in melanoma.
I. Shih (1994)
Rearranged NFKB2 gene in the HUT78 T-lymphoma cell line codes for a constitutively nuclear factor lacking transcriptional repressor functions.
J. Zhang (1994)
Constitutive and Cytokine-induced Expression of the Melanoma Growth Stimulatory Activity/GROα Gene Requires Both NF-κB and Novel Constitutive Factors (*)
L. Wood (1995)
Granulocyte-Colony Stimulating Factor and Lipopolysaccharide Regulate the Expression of Interleukin 8 Receptors on Polymorphonuclear Leukocytes (*)
A. Lloyd (1995)
Highly-expressed p100/p52 (NFKB2) sequesters other NF-kappa B-related proteins in the cytoplasm of human breast cancer cells.
E. Dejardin (1995)
Phosphorylation of IκBα precedes but is not sufficient for its dissociation from NF-κB
J. DiDonato (1995)
HMGI(Y) and Sp1 in addition to NF-κB regulate transcription of the MGSA/GROα gene
L. Wood (1995)
Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B.
J. DiDonato (1995)
Ultraviolet B irradiation promotes tumorigenic and metastatic properties in primary cutaneous melanoma via induction of interleukin 8.
R. Singh (1995)
Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma.
T. Mukhopadhyay (1995)
Rel/NF-kappaB/IkappaB proteins and cancer.
T. Gilmore (1996)
The human cut homeodomain protein can repress gene expression by two distinct mechanisms: active repression and competition for binding site occupancy.
F. Mailly (1996)
Functional analysis of Drosophila and mammalian cut proteins in files.
C. Ludlow (1996)
Metastatic potential of human melanoma cells in nude mice--characterisation of phenotype, cytokine secretion and tumour-associated antigens.
D. Schadendorf (1996)
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.
J. DiDonato (1996)
Mapping of the inducible I-κB phosphorylation sites that signal its ubiquitination and degradation
J DiDonato (1996)
Enhanced Degradation of I-κBα Contributes to Endogenous Activation of NF-κB in Hs294T Melanoma Cells
R. Shattuck-Brandt (1997)
Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation*
T. S. Finco (1997)
Antisense targeting of basic fibroblast growth factor and dibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth
Yiping Wang (1997)
Activation of Nuclear Transcription Factor NF-κB by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit*
Timothy A. Bird (1997)
Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.
M. Sovak (1997)
Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator
N. Perkins (1997)
Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFκB p65 protein expression
R. Visconti (1997)
MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1
N. Malinin (1997)
Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression
J. Luan (1997)
The role of Rel/NF-κB proteins in viral oncogenesis and the regulation of viral transcription
G. Mosialos (1997)
Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.
M. Mayo (1997)
Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
H. Nakano (1998)
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300.
H. Zhong (1998)
PKC-dependent modulation of IkB alpha-NFkB pathway in low metastatic B16F1 murine melanoma cells and in highly metastatic BL6 cells.
C. L. La Porta (1998)
The mammalian Cut homeodomain protein functions as a cell‐cycle‐dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase
O. Coqueret (1998)
Activation of NF-κB by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade
J. Troppmair (1998)
NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176
L. Ling (1998)
The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta.
Z. Chu (1998)
HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation
M. Yin (1998)
Human T-Cell Leukemia Virus Type 1 Tax Induction of NF-κB Involves Activation of the IκB Kinase α (IKKα) and IKKβ Cellular Kinases
R. Geleziunas (1998)
HTLV-1 Tax protein binds to MEKK1 to stimulate IκB kinase activity and NF-κB activation
Yin (1998)
Elevated Constitutive IκB Kinase Activity and IκB-α Phosphorylation in Hs294T Melanoma Cells Lead to Increased Basal MGSA/GRO-α Transcription
M. Devalaraja (1999)
A Role of Poly (ADP-Ribose) Polymerase in NF- B Transcriptional Activation
P. Hassa (1999)
Interleukin-1-induced Nuclear Factor-κB-IκBα Autoregulatory Feedback Loop in Hepatocytes
Youqi Han (1999)
Efficient adenoviral transfer of NF‐κB inhibitor sensitizes melanoma to tumor necrosis factor‐mediated apoptosis
T. Bakker (1999)
Increased expression of p50-NF-κB and constitutive activation of NF-κB transcription factors during mouse skin carcinogenesis
I. Budunova (1999)
Oncogenic Ras Enhances NF-κB Transcriptional Activity through Raf-dependent and Raf-independent Mitogen-activated Protein Kinase Signaling Pathways*
J. Norris (1999)
The Nuclear Factor-κB Engages CBP/p300 and Histone Acetyltransferase Activity for Transcriptional Activation of the Interleukin-6 Gene Promoter*
W. Vanden Berghe (1999)
Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness.
M. Kunz (1999)
Multiple chemotactic factors: fine control or redundancy?
M. Devalaraja (1999)
IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain*
H. Sakurai (1999)
The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice
U. Mrowietz (1999)
Regulation of NF-κB RelA Phosphorylation and Transcriptional Activity by p21 ras and Protein Kinase Cζ in Primary Endothelial Cells*
J. Anrather (1999)
Protein kinase C–dependent activation of NF-κB in enterocytes is independent of IκB degradation
L. Wilson (1999)
Transcriptional Repression of the Cystic Fibrosis Transmembrane Conductance Regulator Gene, Mediated by CCAAT Displacement Protein/cut Homolog, Is Associated with Histone Deacetylation*
S. Li (1999)
Interleukin-1-induced nuclear factor-κB–IκB-α autoregulatory feedback loop in hepatocytes. A role for protein kinase Cα in post-transcriptional regulation of IκB-α resynthesis
Y. Han (1999)
The biology of chemokines and their receptors.
D. Rossi (2000)
Epigenetic PTEN silencing in malignant melanomas without PTEN mutation.
X. Zhou (2000)
Growth Regulated Oncogene-α expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC Receptor-2 dependent mechanism
E. Loukinova (2000)
Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP.
S. Li (2000)
Induction of Functional IL-8 Receptors by IL-4 and IL-13 in Human Monocytes1
R. Bonecchi (2000)
Coordinate modulation of Sp1, NF‐kappa B, and p53 in confluent human malignant melanoma cells after ionizing radiation
C. Yang (2000)
Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation.
J. Cusack (2000)
Signalling pathways: Kinase regulation in inflammatory response
M. Delhase (2000)
The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance.
M. Mayo (2000)
MGSA/GRO-mediated melanocyte transformation involves induction of Ras expression
D. Wang (2000)
Alymphoplasia (aly)-Type Nuclear Factor κB–Inducing Kinase (Nik) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-Associated Lymphatic Tissue System
S. Fagarasan (2000)
Selective inhibition of NF-κB activation by a peptide that blocks the interaction of NEMO with the IκB kinase complex
M. May (2000)
Nuclear Factor-κB Activity Correlates with Growth, Angiogenesis, and Metastasis of Human Melanoma Cells in Nude Mice
Suyun Huang (2000)
Signal-dependent and -independent Degradation of Free and NF-κB-bound IκBα*
M. Pando (2000)
p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-κB activity and Fas expression
V. Ivanov (2000)
Level of interleukin-8 expression by metastatic human melanoma cells directly correlates with constitutive NF-kappaB activity.
S. Huang (2000)
Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3
P. Cogswell (2000)
p300 Collaborates with Sp1 and Sp3 in p21 waf1/cip1 Promoter Activation Induced by Histone Deacetylase Inhibitor*
H. Xiao (2000)
Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300.
T. Kundu (2000)
Regulation of RANTES Chemokine Gene Expression Requires Cooperativity Between NF-κB and IFN-Regulatory Factor Transcription Factors1
P. Génin (2000)
Upregulation of interleukin‐8 and polarized epithelial expression of interleukin‐8 receptor A in ovarian carcinomas
K. Ivarsson (2000)
Identification of PTEN mutations in metastatic melanoma specimens
J. Celebi (2000)
NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100
G. Xiao (2001)
Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38*
L. Madrid (2001)
Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma.
H. E. Wiley (2001)
A Role for Poly(ADP-ribose) Polymerase in the Transcriptional Regulation of the Melanoma Growth Stimulatory Activity (CXCL1) Gene Expression*
C. Nirodi (2001)
Involvement of chemokine receptors in breast cancer metastasis
A. Müller (2001)
Chemokines: Not just leukocyte chemoattractants in the promotion of cancer
R. Strieter (2001)
Expression of Functional Chemokine Receptors CXCR3 and CXCR4 on Human Melanoma Cells*
M. Robledo (2001)
Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.
J. Sunwoo (2001)
26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer
S. Shah (2001)
Constitutive IκB Kinase Activity Correlates with Nuclear Factor-κB Activation in Human Melanoma Cells
Jingqing Yang (2001)
Molecular Machinations: Chemokine Signals in Host-Pathogen Interactions
S. Chensue (2001)
Enhanced IκB kinase activity is responsible for the augmented activity of NF-κB in human head and neck carcinoma cells
T. Tamatani (2001)
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
U. Senftleben (2001)
Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition.
J. Cusack (2001)
Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials.
A. Li (2001)
Nuclear Factor-κB Activation by the CXC Chemokine Melanoma Growth-stimulatory Activity/Growth-regulated Protein Involves the MEKK1/p38 Mitogen-activated Protein Kinase Pathway*
D. Wang (2001)
The Role of CDP in the Negative Regulation ofCXCL1 Gene Expression*
C. Nirodi (2001)
Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer.
Y. Yamamoto (2001)
The NF-κB Repressing Factor Is Involved in Basal Repression and Interleukin (IL)-1-induced Activation of IL-8 Transcription by Binding to a Conserved NF-κB-flanking Sequence Element*
M. Nourbakhsh (2001)
Tumor Suppressor MMAC/PTEN Inhibits Cytokine-induced NFκB Activation without Interfering with the IκB Degradation Pathway*
D. Koul (2001)
Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines
A. Mukhopadhyay (2001)
NF-κB-Inducing Kinase Is Dispensable for Activation of NF-κB in Inflammatory Settings but Essential for Lymphotoxin β Receptor Activation of NF-κB in Primary Human Fibroblasts1
Clive Smith (2001)
Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kappaB signal pathway.
G. Dong (2001)
The nuclear factor kappa B (NF-κB): A potential therapeutic target for estrogen receptor negative breast cancers
D. Biswas (2001)
International Union of Immunological Societies/World Health Organization Subcommittee on Chemokine Nomenclature. Chemokine/chemokine receptor nomenclature
C. S. Nirodi (2001)
Role of poly (ADP-ribose) polymerase (PARP) in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene
C. S. Nirodi (2001)
a potential therapeutic target for estrogen receptor-negative breast cancers
Biswas (2001)
Chemokines: agents for the immunotherapy of cancer?
B. Homey (2002)
Chemokine/chemokine receptor nomenclature.
K. Bacon (2002)
The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity.
E. Azenshtein (2002)
Proteasome inhibitor PS-341, a potential therapeutic agent for adult T-cell leukemia.
Chalet Tan (2002)
NF-κB at the crossroads of life and death
M. Karin (2002)
Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.
N. Sizemore (2002)
The role of chemokines in linking innate and adaptive immunity.
A. Luster (2002)
NFκB-dependent signaling pathways
Xiaoxia Li (2002)
NF-κB as a Therapeutic Target in Multiple Myeloma*
T. Hideshima (2002)
Proteasome inhibition: a novel approach to cancer therapy.
J. Adams (2002)
Sulindac Enhances Tumor Necrosis Factor-α-mediated Apoptosis of Lung Cancer Cell Lines by Inhibition of Nuclear Factor-κB
K. Berman (2002)
A Novel NF-κB-inducing Kinase-MAPK Signaling Pathway Up-regulates NF-κB Activity in Melanoma Cells*
P. Dhawan (2002)
The role of chemokines in melanoma tumor growth and metastasis.
A. Payne (2002)
The role of endogenous NIK and MEKK1 in the constitutive activation of NF-κB in human melanomas
P. Dhawan (2002)
Human MCAF Gene Transfer Enhances the Metastatic Capacity of a Mouse Cachectic Adenocarcinoma Cell Line in Vivo
E. Nakashima (2004)
Control of oncogenesis and cancer therapy resistance
R. Perona (2004)

This paper is referenced by
Functional Mechanisms of Green Tea Polyphenols and Their Molecular Targets in Prevention of Multiple Cancers
Z. Hafeez (2021)
A robust platform for high-throughput screening of therapeutic strategies for acute and chronic spinal cord injury
Vaibhav Patil (2021)
Intrapulmonary administration of purified NEIL2 abrogates NF-κB–mediated inflammation
Nisha Tapryal (2021)
Quercetin Inhibits Colorectal Cancer Cells Induced-Angiogenesis in Both Colorectal Cancer Cell and Endothelial Cell through Downregulation of VEGF-A/VEGFR2
Tamonwan Uttarawichien (2021)
Pentagalloyl glucose inhibits TNF‐α‐activated CXCL1/GRO-α expression and induces apoptosis‐related genes in triple-negative breast cancer cells
Patricia Mendonca (2021)
The CXCL12/CXCR4/ACKR3 Response Axis in Chronic Neurodegenerative Disorders of the Central Nervous System: Therapeutic Target and Biomarker.
Yudie Yan (2021)
The Hallmarks of Flavonoids in Cancer
Luis Gustavo Saboia Ponte (2021)
How Macrophages Become Transcriptionally Dysregulated: A Hidden Impact of Antitumor Therapy
Galina F. Medvedeva (2021)
Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/Dermatophagoides farinae Extract-Induced BALB/c Mice
Jinjoo Kang (2021)
OVOL2 attenuates the expression of MAP3K8 to suppress epithelial mesenchymal transition in colorectal cancer.
L. Xia (2021)
Proinflammatory Signaling Pathways and Genomic Signatures in Head and Neck Cancers
Zhong Chen (2021)
B-cell activating factor (BAFF) expression is associated with Crohn's disease and can serve as a potential prognostic indicator of disease response to Infliximab treatment.
Nikolaos-Panagiotis Andreou (2020)
Role of Oxidative Stress in Pathophysiology of Diseases
P. Maurya (2020)
Safrana l Prevents Prostate Cancer Recurrence by Blocking the Re-activation of Quiescent Cancer Cells via Downregulation of S-Phase Kinase-Associated Protein 2
Xue Jiang (2020)
Macrophages employ quorum licensing to regulate collective activation
J. J. Muldoon (2020)
Catcher in the rel: Nanoparticles-antibody conjugate as NF-κB nuclear translocation blocker.
Yi-Ping Chen (2020)
Correlation between CXCR4, CXCR5 and CCR7 expression and survival outcomes in patients with clinical T1N0M0 non‐small cell lung cancer
Zhao Yue (2020)
Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers
H. Do (2020)
Inflammatory Bowel Disease: The Emergence of New Trends in Lifestyle and Nanomedicine as the Modern Tool for Pharmacotherapy
Eden Mariam Jacob (2020)
Effects of Radiation on the Tumor Microenvironment.
A. Monjazeb (2020)
Molecular Biology of Iris
Kambiz Thomas Moazed (2020)
Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways
Mao-Lin Wan (2020)
CXCR2 signaling promotes secretory cancer‐associated fibroblasts in pancreatic ductal adenocarcinoma
M. Awaji (2020)
LincRNA-p21 promotes classical macrophage activation in acute respiratory distress syndrome by activating NF-κB
Xiao-yu Zhang (2020)
Cocaine-induced changes in CX3CL1 and inflammatory signaling pathways in the hippocampus: Association with IL1β
J. Montesinos (2020)
Angiotensin II and leukocyte trafficking: New insights for an old vascular mediator. Role of redox-signaling pathways.
L. Piqueras (2020)
Role of Chemokines in the Biology of Cholangiocarcinoma
A. Caligiuri (2020)
Radiation-enhanced expression of CCL22 in nasopharyngeal carcinoma is associated with CCR4+ CD8 T cell recruitment.
Hanghang Li (2020)
Oxidative Stress and Inflammation Can Fuel Cancer
Foram U Vaidya (2020)
The phosphatase regulator NIPP1 restrains chemokine-driven skin inflammation.
Iris Verbinnen (2020)
Mapping the intracellular molecular mechanisms of chemokine signalling within cancer
Gerald Keil (2019)
Oncogenic Ras mutant causes the hyperactivation of NF‐κB via acceleration of its transcriptional activation
K. Tago (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar