Online citations, reference lists, and bibliographies.

Optimizing The Outcomes Of Pancreatic Cancer Surgery

Oliver Strobel, John P Neoptolemos, Dirk Jaeger, Markus W. Büchler
Published 2018 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Pancreatic cancer is likely to become the second most frequent cause of cancer-associated mortality within the next decade. Surgical resection with adjuvant systemic chemotherapy currently provides the only chance of long-term survival. However, only 10–20% of patients with pancreatic cancer are diagnosed with localized, surgically resectable disease. The majority of patients present with metastatic disease and are not candidates for surgery, while surgery remains underused even in those with resectable disease owing to historical concerns regarding safety and efficacy. However, advances made over the past decade in the safety and efficacy of surgery have resulted in perioperative mortality of around 3% and 5-year survival approaching 30% after resection and adjuvant chemotherapy. Furthermore, owing to advances in both surgical techniques and systemic chemotherapy, the indications for resection have been extended to include locally advanced tumours. Many aspects of pancreatic cancer surgery, such as the management of postoperative morbidities, sequencing of resection and systemic therapy, and use of neoadjuvant therapy followed by resection for tumours previously considered unresectable, are rapidly evolving. In this Review, we summarize the current status of and new developments in pancreatic cancer surgery, while highlighting the most important research questions for attempts to further optimize outcomes.Successful surgical resection offers patients with pancreatic cancer the best chance of survival. However, many patients do not have surgically resectable disease. In this Review, the authors describe recent improvements in pancreatic cancer surgery, which have increased survival and also enabled more patients to undergo surgery.Key pointsSurgical resection in combination with systemic chemotherapy offers the only hope for long-term survival or cure in patients with nonmetastatic pancreatic cancer.Surgical resection and adjuvant multi-agent chemotherapy (gemcitabine plus capecitabine or modified FOLFIRINOX) is the standard of care in patients with resectable pancreatic cancer.Both the safety and efficacy of pancreatic cancer surgery have improved considerably in the past decade, enabling perioperative mortality of around 3% and 5-year survival approaching 30–40% after resection and chemotherapy.Important criteria for assessing the quality of pancreatic cancer surgery include perioperative morbidity and mortality, oncologically determined pancreatic resection, the proportion of patients in fact receiving and completing adjuvant therapy and — above all — long-term survival.Relationships between hospital pancreatectomy volume and outcome quality have an important role in determining the success of pancreatic cancer surgery.Owing to advances in both surgery and systemic chemotherapy, the indications for surgical resections have been extended from stage I and II to locally advanced, previously unresectable pancreatic cancer.
This paper references
CA19-9 in Potentially Resectable Pancreatic Cancer: Perspective to Adjust Surgical and Perioperative Therapy
Werner Hartwig (2012)
Propensity score‐matched comparison of oncological outcomes between laparoscopic and open distal pancreatic resection
Mustafa Raoof (2018)
8th Edition of the AJCC Cancer Staging Manual: Pancreas and Hepatobiliary Cancers
Yun Shin Chun (2017)
The More the Better—Lower Rate of Stage Migration and Better Survival in Patients With Retrieval of 20 or More Regional Lymph Nodes in Pancreatic Cancer: A Population-Based Propensity Score Matched and Trend SEER Analysis
René Warschkow (2017)
Classification of R1 resections for pancreatic cancer: the prognostic relevance of tumour involvement within 1 mm of a resection margin.
Fiona Campbell (2009)
Pancreatic Cancer
H. Kocher (2010)
Minimally invasive versus open pancreatoduodenectomy (LEOPARD-2): study protocol for a randomized controlled trial
Thijs de Rooij (2018)
Fluorouracil versus gemcitabine chemotherapy before and after fluorouracilbased chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial
Regine (2008)
Cancer statistics, 2018
Rebecca L. Siegel Mph (2018)
No Need for Routine Drainage After Pancreatic Head Resection: The Dual-Center, Randomized, Controlled PANDRA Trial (ISRCTN04937707)
Helmut Witzigmann (2016)
Variation in hospital mortality associated with inpatient surgery.
Amir A. Ghaferi (2009)
Elderly patients have similar short term outcomes and five-year survival compared to younger patients after pancreaticoduodenectomy.
Awad Shamali (2017)
Extended pancreatectomy in pancreatic ductal adenocarcinoma: definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS).
Werner Hartwig (2014)
Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial
John P Neoptolemos (2017)
Efficacy of an Absorbable Fibrin Sealant Patch (TachoSil) After Distal Pancreatectomy: A Multicenter, Randomized, Controlled Trial
Marco Montorsi (2012)
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.
H. Tiriac (2018)
Validation of at least 1 mm as cut‐off for resection margins for pancreatic adenocarcinoma of the body and tail
Thomas P. Hank (2018)
Definition and classification of chyle leak after pancreatic operation : a consensus statement by the International Study Group on Pancreatic
B. Topal
Risk-adjusted Outcomes of Clinically Relevant Pancreatic Fistula Following Pancreatoduodenectomy: A Model for Performance Evaluation
M. McMillan (2016)
S3-Leitlinie zum exokrinen Pankreaskarzinom
T. Seufferlein (2013)
Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial
Markus K Diener (2011)
Staging of pancreatic cancer based on the number of positive lymph nodes
Ignazio Tarantino (2017)
Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: a consensus statement by the International Study Group on Pancreatic Surgery (ISGPS).
Johanna A. Tol (2014)
A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer.
J. Neoptolemos (2004)
Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations
Lei Huang (2017)
Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer (PREOPANC-1): A randomized, controlled, multicenter phase III trial.
Geertjan van Tienhoven (2018)
Alternative Fistula Risk Score for Pancreatoduodenectomy (a-FRS) Design and International External Validation
Dutch Pancreatic Canc Grp (2019)
Meta‐analysis of an artery‐first approach versus standard pancreatoduodenectomy on perioperative outcomes and survival
N. Ironside (2018)
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial.
H. Oettle (2007)
Meta-analysis of radical resection rates and margin assessment in pancreatic cancer.
Manju Dashini Chandrasegaram (2015)
Meta‐analysis of prophylactic abdominal drainage in pancreatic surgery
F. Hüttner (2017)
'Artery-first' approaches to pancreatoduodenectomy.
Popat Sanjay (2012)
Early Drain Removal--The Middle Ground Between the Drain Versus No Drain Debate in Patients Undergoing Pancreaticoduodenectomy: A Prospective Validation Study.
Zhi Ven Fong (2015)
Locally Advanced Pancreatic Cancer: Neoadjuvant Therapy With Folfirinox Results in Resectability in 60% of the Patients
Thilo Hackert (2016)
High Performing Whipple Patients: Factors Associated with Short Length of Stay after Open Pancreaticoduodenectomy
G. C. Lee (2014)
Redefining the R1 resection in pancreatic cancer.
C. Verbeke (2006)
Minimally Invasive Versus Open Pancreaticoduodenectomy: A Propensity-matched Study From a National Cohort of Patients
Ibrahim Nassour (2018)
Autologous but not Fibrin Sealant Patches for Stump Coverage Reduce Clinically Relevant Pancreatic Fistula in Distal Pancreatectomy: A Systematic Review and Meta-analysis
Maximilian Weniger (2016)
Current evidence for the diagnostic value of gadoxetic acid-enhanced magnetic resonance imaging for liver metastasis.
Masakatsu Tsurusaki (2016)
Understanding Metastasis in Pancreatic Cancer: A Call for New Clinical Approaches
David A Tuveson (2012)
When to perform a pancreatoduodenectomy in the absence of positive histology? A consensus statement by the International Study Group of Pancreatic Surgery.
H. Asbun (2014)
[S3-guideline exocrine pancreatic cancer].
T. Seufferlein (2013)
Arterial Resection During Pancreatectomy for Pancreatic Cancer: A Systematic Review and Meta-Analysis
Nathan Mollberg (2011)
Trends in Racial Disparities in Pancreatic Cancer Surgery
Anand Shah (2013)
Fluorouracil-based Chemoradiation with Either Gemcitabine or Fluorouracil Chemotherapy after Resection of Pancreatic Adenocarcinoma: 5-Year Analysis of the U.S. Intergroup/RTOG 9704 Phase III Trial
William F. Regine (2011)
Neoadjuvant Therapy Followed by Resection Versus Upfront Resection for Resectable Pancreatic Cancer: A Propensity Score Matched Analysis.
Ali A Mokdad (2017)
Systematic Review and Meta-analysis of Enhanced Recovery After Pancreatic Surgery with Particular Emphasis on Pancreaticoduodenectomies
Mariëlle M. E. Coolsen (2013)
Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening
Shurong Hou (2018)
Pancreatic cancer: Clinical practice guidelines — what is the evidence?
Oliver Strobel (2016)
Somatostatin analogues for pancreatic surgery.
Kurinchi Selvan Gurusamy (2013)
Safety of pancreatic resection in the elderly: a retrospective analysis of 556 patients
Daniel Ansari (2016)
Stents for the prevention of pancreatic fistula following pancreaticoduodenectomy.
Z. Dong (2016)
Preoperative/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection Percentages
Sonja Gillen (2010)
The Impact of Positive Resection Margins on Survival and Recurrence Following Resection and Adjuvant Chemotherapy for Pancreatic Ductal Adenocarcinoma
Paula Ghaneh (2019)
ACR Appropriateness Criteria® Staging of Pancreatic Ductal Adenocarcinoma.
Expert Panel on Gastrointestinal Imaging (2017)
Hospital volume and surgical mortality in the United States.
J. Birkmeyer (2002)
Uncinate process first—a novel approach for pancreatic head resection
Thilo Hackert (2010)
CONKO-005: Adjuvant Chemotherapy With Gemcitabine Plus Erlotinib Versus Gemcitabine Alone in Patients After R0 Resection of Pancreatic Cancer: A Multicenter Randomized Phase III Trial.
Marianne Sinn (2017)
Age 80 years and over is not associated with increased morbidity and mortality following pancreaticoduodenectomy
Sandy Y Kim (2018)
A Randomized Prospective Multicenter Trial of Pancreaticoduodenectomy With and Without Routine Intraperitoneal Drainage?
Tanka Prasad Bohara (2016)
Therapeutic developments in pancreatic cancer: current and future perspectives
John P. Neoptolemos (2018)
FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis.
M. Suker (2016)
PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer.
P. Ghaneh (2018)
Cancer statistics, 2018.
Rebecca L Siegel (2018)
Pancreatogastrostomy Versus Pancreatojejunostomy for RECOnstruction After PANCreatoduodenectomy (RECOPANC, DRKS 00000767): Perioperative and Long-term Results of a Multicenter Randomized Controlled Trial.
Jianguo Qiu (2015)
Management of clinically relevant postpancreatectomy hemorrhage (PPH) over two decades - A comparative study of 1 450 consecutive patients undergoing pancreatic resection.
S. Wolk (2017)
Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial.
John P Neoptolemos (2010)
Quality Improvement of Pancreatic Surgery by Centralization in the Western Part of the Netherlands
Gea A. Gooiker (2010)
Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA): A Pan-European Propensity Score Matched Study
J. van Hilst (2019)
Predictors of Resectability and Survival in Patients with Borderline and Locally Advanced Pancreatic Cancer who Underwent Neoadjuvant Treatment with FOLFIRINOX.
Haijie Hu (2018)
Justifying vein resection with pancreatoduodenectomy.
Savio George Barreto (2016)
Definition and classification of chyle leak after pancreatic operation: A consensus statement by the International Study Group on Pancreatic Surgery
Marc G. Besselink (2017)
FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
Kevin E. Behrns (2012)
Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial.
W. Regine (2008)
Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01)
Katsuhiko Uesaka (2016)
Improvement of surgical results for pancreatic cancer.
Werner Hartwig (2013)
Diagnostic accuracy of laparoscopy following computed tomography (CT) scanning for assessing the resectability with curative intent in pancreatic and periampullary cancer.
Victoria B Allen (2013)
Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial
T. de Rooij (2017)
Evolution in the Treatment of Delayed Postpancreatectomy Hemorrhage: Surgery to Interventional Radiology
Bhavraj Khalsa (2015)
Portal or superior mesenteric vein resection in pancreatoduodenectomy for pancreatic head carcinoma.
Y. Murakami (2015)
Oncological Benefits of Neoadjuvant Chemoradiation With Gemcitabine Versus Upfront Surgery in Patients With Borderline Resectable Pancreatic Cancer: A Prospective, Randomized, Open-label, Multicenter Phase 2/3 Trial
Jin-Young Jang (2018)
Open-label, multicenter, randomized phase III trial of adjuvant chemoradiation plus interferon Alfa-2b versus fluorouracil and folinic acid for patients with resected pancreatic adenocarcinoma.
Jan Zlotnik Schmidt (2012)
Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.
Alok A Khorana (2017)
Detection of pancreatic carcinoma and liver metastases with gadoxetic acid-enhanced MR imaging: comparison with contrast-enhanced multi-detector row CT.
Utaroh Motosugi (2011)
Postoperative Complications Reduce Adjuvant Chemotherapy Use in Resectable Pancreatic Cancer
Ryan P. Merkow (2014)
Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group.
J. H. Klinkenbijl (1999)
Preoperative Biliary Drainage for Cancer of the Head of the Pancreas
Randall K. Pearson (2010)
National Failure to Operate on Early Stage Pancreatic Cancer
Jeffrey Adam Drebin (2008)
The TRIANGLE operation - radical surgery after neoadjuvant treatment for advanced pancreatic cancer: a single arm observational study.
Thilo Hackert (2017)
Relationship between hospital volume, system clinical resources, and mortality in pancreatic resection.
B. Joseph (2009)
Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection.
M. Kalser (1985)
Pancreaticoduodenectomy: ERAS recommendations.
K. Lassen (2013)
No abdominal drainage after Whipple's procedure.
Johannes Jeekel (1992)
Resection after neoadjuvant therapy for locally advanced, "unresectable" pancreatic cancer.
Oliver Strobel (2012)
Pancreatic cancer surgery: The new R-status counts
Oliver Strobel (2016)
Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) trials
John P Neoptolemos (2009)
Pancreatic anastomosis after pancreatoduodenectomy: A position statement by the International Study Group of Pancreatic Surgery (ISGPS)
S. Shrikhande (2017)
Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy for pancreatic or periampullary tumours: a multicentre randomised trial.
B. Topal (2013)
Postpancreatectomy hemorrhage (PPH)–An International Study Group of Pancreatic Surgery (ISGPS) definition
S. Vickers (2008)
Extended Versus Standard Lymphadenectomy for Pancreatic Head Cancer: Meta-Analysis of Randomized Controlled Trials
Bobby V. M. Dasari (2015)
Outcomes after extended pancreatectomy in patients with borderline resectable and locally advanced pancreatic cancer.
Werner Hartwig (2016)
Incidence, risk factors and clinical implications of chyle leak after pancreatic surgery
Oliver Strobel (2017)
Pasireotide does not prevent postoperative pancreatic fistula: a prospective study.
Irmina A. Elliott (2018)
International consensus on definition and criteria of borderline resectable pancreatic ductal adenocarcinoma 2017.
Shuji Isaji (2018)
Unicancer GI PRODIGE 24/CCTG PA.6 trial: A multicenter international randomized phase III trial of adjuvant mFOLFIRINOX versus gemcitabine (gem) in patients with resected pancreatic ductal adenocarcinomas.
Thierry Conroy (2018)
A Prospective Randomized Multicenter Trial of Distal Pancreatectomy With and Without Routine Intraperitoneal Drainage
G. Van Buren (2017)
Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS).
M. Wente (2007)
Meta‐analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer
E. Versteijne (2018)
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine.
Daniel D. Von Hoff (2013)
Trends in hospital volume and operative mortality for high-risk surgery.
Jonathan F. Finks (2011)
Pasireotide for postoperative pancreatic fistula.
Peter J. Allen (2014)
Pancreatic Adenocarcinoma, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.
Margaret A. Tempero (2017)
Pancreatic adenocarcinoma: number of positive nodes allows to distinguish several N categories.
Oliver Strobel (2015)
Neoadjuvant therapy versus upfront surgery for resected pancreatic adenocarcinoma: A nationwide propensity score matched analysis
Susanna W.L. de Geus (2017)
Effect of hospital volume on inhospital morbidity and mortality following pancreatic surgery
C. Krautz (2018)
Sphincter of Oddi botulinum toxin injection to prevent pancreatic fistula after distal pancreatectomy
T. Hackert (2017)
Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction for the prevention of postoperative pancreatic fistula following pancreaticoduodenectomy.
Y. Cheng (2017)
Effect of Hospital Volume on In-hospital Morbidity and Mortality Following Pancreatic Surgery in Germany
C. Krautz (2018)
The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After
Claudio Bassi (2017)
Re-resection for Isolated Local Recurrence of Pancreatic Cancer is Feasible, Safe, and Associated with Encouraging Survival
Oliver Strobel (2012)
Impact of centralization of pancreatic cancer surgery on resection rates and survival.
Gea A. Gooiker (2014)
Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial
Jp Neoptolemos (2001)
Most Pancreatic Cancer Resections are R1 Resections
I. Esposito (2008)
Influence of Surgical Resection and Post-Operative Complications on Survival following Adjuvant Treatment for Pancreatic Cancer in the ESPAC-1 Randomized Controlled Trial
C. Bassi (2005)
Optimal duration and timing of adjuvant chemotherapy after definitive surgery for ductal adenocarcinoma of the pancreas: ongoing lessons from the ESPAC-3 study.
J. Valle (2014)
Postoperative pancreatic fistula: an international study group (ISGPF) definition.
C. Bassi (2005)
Going the Extra Mile: Improved Survival for Pancreatic Cancer Patients Traveling to High-volume Centers
Michael E Lidsky (2017)
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States.
Lola Rahib (2014)
Prospective Randomized Clinical Trial of the Value of Intraperitoneal Drainage After Pancreatic Resection
Kevin C. P. Conlon (2001)
Teres Ligament Patch Reduces Relevant Morbidity After Distal Pancreatectomy (the DISCOVER Randomized Controlled Trial)
Matthias Hassenpflug (2016)
Persisting elevation of C-reactive protein after pancreatic resections can indicate developing inflammatory complications.
T. Welsch (2008)
Carbohydrate antigen 19.9 accurately selects patients for laparoscopic assessment to determine resectability of pancreatic malignancy.
C. M. Halloran (2008)

This paper is referenced by
Prognostic Impact of Preoperative Nutritional Risk in Patients Who Undergo Surgery for Pancreatic Adenocarcinoma
Ilaria Trestini (2020)
ASO Author Reflections: Temporary Mesocaval Shunt: Indications and Technique for Safe Resection of Pancreatic Tumors With Mesenteric Venous Occlusion
Eve Simoneau (2019)
Sulforaphane Induces miR135b-5p and Its Target Gene, RASAL2, thereby Inhibiting the Progression of Pancreatic Cancer
Libo Yin (2019)
Prognostic factors for disease-free survival in patients with pancreatic ductal adenocarcinoma after surgery: a single center experience
Xiaodong Tian (2019)
Circular RNA ADAM9 facilitates the malignant behaviours of pancreatic cancer by sponging miR-217 and upregulating PRSS3 expression
Chenju Xing (2019)
Gas Plasma-Conditioned Ringer’s Lactate Enhances the Cytotoxic Activity of Cisplatin and Gemcitabine in Pancreatic Cancer In Vitro and In Ovo
Kim-Rouven Liedtke (2020)
Clinical staging in pancreatic adenocarcinoma underestimates extent of disease.
Akhil Chawla (2020)
Girdin interaction with vimentin induces EMT and promotes the growth and metastasis of pancreatic ductal adenocarcinoma
Wulin Wang (2020)
Wnt-11 Expression Promotes Invasiveness and Correlates with Survival in Human Pancreatic Ductal Adeno Carcinoma
D. Alwyn Dart (2019)
Do Patients Diagnosed with Metastatic Pancreatic Cancer Benefit from Primary Tumor Surgery? A Propensity-Adjusted, Population-Based Surveillance, Epidemiology and End Results (SEER) Analysis
Lei Wang (2019)
Early postoperative fluid retention is a strong predictor for complications after pancreatoduodenectomy.
Daniel Åkerberg (2019)
Sarcopenia as a Predictor of Postoperative Complications andPancreatic Fistula in Patients with Pancreatic Cancer
L. O. Pererva (2020)
Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Secondary Analysis of the ESPAC-4 Randomized Adjuvant Chemotherapy Trial.
Robert P. Jones (2019)
A meta-analysis of randomized controlled trials comparing laparoscopic vs open pancreaticoduodenectomy.
F. Ausania (2019)
Diabetes mellitus is associated with unfavorable pathologic features, increased postoperative mortality, and worse long-term survival in resected pancreatic cancer.
Thomas Hank (2019)
Role of Staging Laparoscopy in Patients Undergoing Pancreaticoduodenectomy
Mohammad I Ashraf (2019)
Emerging nanomedicine-based strategies for preventing metastasis of pancreatic cancer.
Yongjiang Li (2020)
From state-of-the-art treatments to novel therapies for advanced-stage pancreatic cancer
Christopher Nevala-Plagemann (2019)
Prognostic Value of the C-Reactive Protein/Lymphocyte Ratio in Pancreatic Cancer
Zhiyao Fan (2020)
Hepatic Steatosis After Neoadjuvant Chemotherapy for Pancreatic Cancer: Incidence and Implications for Outcomes After Pancreatoduodenectomy
K. F. Flick (2020)
LncRNA H19-Derived miR-675-3p Promotes Epithelial-Mesenchymal Transition and Stemness in Human Pancreatic Cancer Cells by targeting the STAT3 Pathway
Feng Wang (2020)
Silica/gold nanoplatform combined with a thermosensitive gel for imaging-guided interventional therapy in PDX of pancreatic cancer
Ling-Xi Xing (2020)
Pancreatic cancer incidence and survival and the role of specialist centres in resection rates in England, 2000 to 2014: A population-based study.
Aimilia Exarchakou (2020)
A potential prognostic marker and therapeutic target: SPOCK1 promotes the proliferation, metastasis, and apoptosis of pancreatic ductal adenocarcinoma cells.
Jinzhuo Li (2019)
Characterization of Stem-like Circulating Tumor Cells in Pancreatic Cancer
Lei Zhu (2020)
Identification of prognostic splicing factors and exploration of their potential regulatory mechanisms in pancreatic adenocarcinoma
Min-hua Rong (2020)
Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells
Carmen Mota Reyes (2019)
Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy
Daniel Baumann (2020)
Conversion surgery for initially unresectable pancreatic cancer: current status and unresolved issues
Hideyuki Yoshitomi (2019)
Simultaneous resection of the primary tumour and liver metastases after conversion chemotherapy versus standard therapy in pancreatic cancer with liver oligometastasis: protocol of a multicentre, prospective, randomised phase III control trial (CSPAC-1)
Miaoyan Wei (2019)
Diagnosing pancreatic ductal adenocarcinoma using plasma extracellular vesicle RNA profiles
Adam Enver Frampton (2019)
Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer.
Christina Georgikou (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar