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Turning Foes To Friends: Targeting Cancer-associated Fibroblasts
Xueman Chen, Erwei Song
Published 2018 · Medicine
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Current paradigms of cancer-centric therapeutics are usually not sufficient to eradicate the malignancy, as the cancer stroma may prompt tumour relapse and therapeutic resistance. Among all the stromal cells that populate the tumour microenvironment, cancer-associated fibroblasts (CAFs) are the most abundant and are critically involved in cancer progression. CAFs regulate the biology of tumour cells and other stromal cells via cell–cell contact, releasing numerous regulatory factors and synthesizing and remodelling the extracellular matrix, and thus these cells affect cancer initiation and development. The recent characterization of CAFs based on specific cell surface markers not only deepens our insight into their phenotypic heterogeneity and functional diversity but also brings CAF-targeting therapies for cancer treatment onto the agenda. In this Review, we discuss the current knowledge of biological hallmarks, cellular origins, phenotypical plasticity and functional heterogeneity of CAFs and underscore their contribution to cancer progression. Moreover, we highlight relevant translational advances and potential therapeutic strategies that target CAFs for cancer treatment.Cancer-associated fibroblasts (CAFs) are often the most abundant cell type in the tumour microenvironment. Here, Song and colleagues discuss how to target or harness these cells for cancer therapy. They highlight the progress made to date and the remaining challenges in bringing CAF-targeted therapies to the clinic.
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Photodynamic therapy, priming and optical imaging: Potential co-conspirators in treatment design and optimization — a Thomas Dougherty Award for Excellence in PDT paper
P. D. Silva (2020)
Clinical and functional significance of tumor/stromal ATR expression in breast cancer patients
M. M. Al-Ansari (2020)
The tumor immune microenvironment transcriptomic subtypes of colorectal cancer for prognosis and development of precise immunotherapy
Yun-qiang Tang (2020)
Fibroblast Reprogramming in Gastrointestinal Cancer
Maria-Theodora Melissari (2020)
miR-9-Mediated Inhibition of EFEMP1 Contributes to the Acquisition of Pro-Tumoral Properties in Normal Fibroblasts
Giulia Cosentino (2020)
TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering
J. Ma (2020)
Epithelial Ovarian Cancer and the Immune System: Biology, Interactions, Challenges and Potential Advances for Immunotherapy
A. Macpherson (2020)
[Research Progress of Cancer-associated Fibroblasts in Lung Cancer].
Chongbiao Huang (2020)
Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy
Quoc-Viet Le (2019)
Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences
Kristin L Eckel-Mahan (2020)
The Multifaceted Effects of Autophagy on the Tumor Microenvironment.
Rui Kang (2020)
Contributions of carcinoma-associated fibroblasts to the prostate cancer microenvironment
Renee E Vickman (2020)
Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope
L. Salvioni (2019)
Survivin in breast cancer–derived exosomes activates fibroblasts by up-regulating SOD1, whose feedback promotes cancer proliferation and metastasis
Kangdi Li (2020)See more