Online citations, reference lists, and bibliographies.
← Back to Search

Detection Of Curcumin And Its Metabolites In Hepatic Tissue And Portal Blood Of Patients Following Oral Administration

G. Garcea, D. L. Jones, R. Singh, A. Dennison, P. Farmer, R. Sharma, W. Steward, A. Gescher, D. Berry
Published 2004 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Studies in vitro and in animal models of colorectal and hepatocellular cancers suggest that curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether oral administration of curcumin results in concentrations of the agent in normal and malignant human liver tissue, which are sufficient to elicit pharmacological activity. In total, 12 patients with hepatic metastases from colorectal cancer received 450–3600 mg of curcumin daily, for 1 week prior to surgery. Levels of curcumin and its metabolites were measured by HPLC in portal and peripheral blood, bile and liver tissue. Curcumin was poorly available, following oral administration, with low nanomolar levels of the parent compound and its glucuronide and sulphate conjugates found in the peripheral or portal circulation. While curcumin was not found in liver tissue, trace levels of products of its metabolic reduction were detected. In patients who had received curcumin, levels of malondialdehyde-DNA (M1G) adduct, which reflect oxidative DNA changes, were not decreased in post-treatment normal and malignant liver tissue when compared to pretreatment samples. The results suggest that doses of curcumin required to furnish hepatic levels sufficient to exert pharmacological activity are probably not feasible in humans.
This paper references
Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine.
C. Ireson (2002)
Phase I clinical trial
AL Cheng (2001)
Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis.
S. Perkins (2002)
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
A. Cheng (2001)
Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells.
M. Kuo (1996)
Pharmacodynamic effects of dietary curcumin on glutathione Stransferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels
RA Sharma (2001)
Cancer patients who experienced diagnostic genetic testing for cancer susceptibility: reactions and behavior after the disclosure of a positive test result.
V. Bonadona (2002)
Disposition and metabolism of the cancer chemopreventive agent curcumin in rodents and humans
C. Ireson (2002)
Correspondence re: Somasunaram et al, Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer
TM Mitchell (2003)
Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.
A. K. Chaudhary (1994)
Phase I clinical trials.
S. Carter (1977)
Phase I clinical trial of curcumin , a chemopreventive agent , in patients with high - risk or premalignant lesions
AL Cheng (2001)
Oxygen radical scavenging activity of curcumin
Elizabeth Kunchandy (1990)
Phase I Clinical Trial of Oral Curcumin
R. Sharma (2004)
Role of TNFa in the pathophysiologic alterations after hepatic ischemia / reperfusion injury in the rat
LM Colletti (1990)
Protective Effect of Curcumin in Rat Liver Injury Induced by Carbon Tetrachloride
E. J. Park (2000)
Effect of different curcumin dosages on human gall bladder.
A. Rasyid (2002)
Enhanced Kupffer cell activity after hepatic arterial ischemia in an experimental model
LQ Wang (1994)
Biomarkers of the chemopreventive efficacy of curcumin in the Min/+ mouse
S Perkins (2002)
Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model.
S. Busquets (2001)
Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.
L. Colletti (1990)
Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.
T. Kawamori (1999)
Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer.
Sivagurunathan Somasundaram (2002)
Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes.
A. Nanji (2003)
Prevention of radiation-induced mammary tumors.
H. Inano (2002)
Curcumin and its metabolites in hepatic tissue and portal blood G Garcea et al
Studies on curcumin and curcuminoids. XXII: Curcumin as a reducing agent and as a radical scavenger
Hanne Hjorth Tc̵nnesen (1992)
Diminution of singlet oxygen-induced DNA damage by curcumin and related antioxidants.
M. Subramanian (1994)
No prevention of liver and kidney tumors in Long-Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases.
N. Frank (2003)
Enhanced Kupffer cell activity after repeated hepatic arterial ischaemia in an experimental model
L. Wang (1994)
Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in rat plasma and evaluation of their ability to inhibit cyclooxygenase-2 expression
CR Ireson (2001)
Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes
A. C. Pulla Reddy (2004)
Curcumin Is an In Vivo Inhibitor of Angiogenesis
J. Arbiser (1998)
Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds.
L. Menon (1995)
Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels.
R. Sharma (2001)
Antioxidant activity of curcumin and related compounds.
O. Sharma (1976)
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.
R. Sharma (2001)
Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex
S. Plummer (1999)
Determination of malondialdehyde-induced DNA damage in human tissues using an immunoslot blot assay.
C. Leuratti (1998)
Strategy and planning for chemopreventive drug development: Clinical development plans
Gary J. Kelloff (1996)
Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production.
C. Ireson (2001)
The effect of curcumin and placebo on human gall‐bladder function: an ultrasound study
Rasyid (1999)
Correspondence re: Somasundaram et al., Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res., 62: 3868-3875, 2002.
Terri M Mitchell (2003)
Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.
M. Huang (1991)
Inhibition of lung metastasis in mice induced by B16F10 melanoma by polyphenols
LG Menon (1995)

This paper is referenced by
Sentinel Lymph Node Biopsy in Intraductal Carcinoma of the Breast with Microinvasion
M. Intra (2005)
10 Curcumin — Biological and Medicinal Properties
B. Aggarwal (2006)
Cellular foundation of curcumin-induced apoptosis in follicular lymphoma cell lines.
J. Skommer (2006)
Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity.
S. Levari (2006)
Curcumin Alone and in Combination for Prevention of Colorectal Cancer
Nataly Shemesh (2014)
Tetrahydrocurcumin inhibits HT1080 cell migration and invasion via downregulation of MMPs and uPA
S. Yodkeeree (2008)
Turmeric and Chinese goldthread synergistically inhibit prostate cancer cell proliferation and NF-kB signaling
Y. Zhao (2014)
Development and Validation of a Reversed Phase HPLC Method for Simultaneous Determination of Curcumin and Piperine in Human Plasma for Application in Clinical Pharmacological Studies
Prerana Sethi (2009)
Effect of Curcumin and α-Lipoic Acid in Attenuating Weight Gain and Adiposity
Evgeniy Panzhinskiy (2019)
Tumor growth inhibition through targeting liposomally bound curcumin to tumor vasculature.
G. Mondal (2013)
Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993)
J. Reid (2014)
Turmeric: An Overview of Potential Health Benefits
K. Singletary (2010)
Curcumin as "Curecumin": from kitchen to clinic.
A. Goel (2008)
Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
G. Liang (2009)
Protective Effect of Curcumin and its Combination with Piperine (Bioavailability Enhancer) Against Haloperidol-Associated Neurotoxicity: Cellular and Neurochemical Evidence
M. Bishnoi (2010)
Structure-Activity Relationship and Pharmacokinetic Studies of 1,5-Diheteroarylpenta-1,4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents.
Rubing Wang (2015)
Bioavailability of dietary polyphenols: Factors contributing to their clinical application in CNS diseases
M. D. Pandareesh (2015)
Cancer chemoprevention: factors influencing attitudes towards chemopreventive agents in high-risk populations
Chinenye Iwuji (2014)
A multi-targeted approach to suppress tumor-promoting inflammation.
A. Samadi (2015)
Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus
A. Mohammed (2018)
Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions
Jeffry Adiwidjaja (2017)
Clinical studies with curcumin.
C. Hsu (2007)
Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model.
Binqiang Tian (2008)
Curcumin loaded poly (lactic-co-glycolic) acid nanofiber for the treatment of carcinoma.
M. Sampath (2014)
One-step, ultrasonication-mobilized, solvent-free extraction/synthesis of nanocurcumin from turmeric
Judy Gopal (2015)
Curcumin and its derivatives inhibit 2,3,7,8,-tetrachloro-dibenzo-p-dioxin-induced expression of drug metabolizing enzymes through aryl hydrocarbon receptor-mediated pathway
R. Nakai (2018)
Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice.
R. Verbeek (2005)
A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation
H. Shi (2012)
Molecular Mechanisms Underlying Curcumin-Mediated Therapeutic Effects in Type 2 Diabetes and Cancer
M. Wojcik (2018)
Regulation of Toll-Like Receptor (TLR) Signaling Pathway by Polyphenols in the Treatment of Age-Linked Neurodegenerative Diseases: Focus on TLR4 Signaling
Shofiul Azam (2019)
Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin
Panchanan Maiti (2014)
Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas
S. Curic (2013)
See more
Semantic Scholar Logo Some data provided by SemanticScholar