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The Cumulative Risk Of Lung Cancer Among Current, Ex- And Never-smokers In European Men

A. Crispo, P. Brennan, K.-H. Joeckel, A. Schaffrath-Rosario, H. Wichmann, F. Nyberg, L. Simonato, F. Merletti, F. Forastiere, P. Boffetta, S. Darby
Published 2004 · Medicine

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Recent analyses based on UK data indicate that people who stop smoking, even well into middle age, avoid most of their subsequent risk of lung cancer. We investigated whether similar absolute risks of lung cancer in men are found in other European countries with different smoking patterns and at different stages of their lung cancer epidemic. Using data for men from a multicentre case–control study of lung cancer in the UK, Germany, Italy and Sweden, and including 6523 lung cancer cases and 9468 controls, we combined odds ratio estimates with estimates of national lung cancer incidence rates to calculate the cumulative risk of lung cancer among men by age 75. Lung cancer cumulative risks by age 75 among continuing smokers were similar for the UK, Germany and Italy at 15.7, 14.3 and 13.8% respectively, whereas the cumulative risk among Swedish male smokers was 6.6%. The proportion of the risk of lung cancer avoided by quitting smoking before the age of 40 was comparable between the four countries, at 80% in Italy and 91% in the UK, Germany and Sweden. Similarly, the proportion of the excess risk avoided by quitting before the age of 50 ranged from 57% in Italy to 69% in Germany. Our results support the important conclusion that for long-term smokers, giving up smoking in middle age avoids most of the subsequent risk of lung cancer, and that lung cancer mortality in European men over the next three decades will be determined by the extent to which current smokers can successfully quit smoking.
This paper references
10.1016/0959-8049(93)90227-7
Cancer incidence in five continents, vol. VI
F. Levi (1993)
10.1207/S15327914NC4601_04
The Protective Effect of the Mediterranean Diet on Lung Cancer
C. Fortes (2003)
Cancer Incidence, Mortality and Prevalence Worldwide, Version 1.0 (IARC
J Ferlay (2001)
10.1093/IJE/27.4.549
Occupational risk factors for lung cancer: a case-control study in West Germany.
K. Jöckel (1998)
Lung cancer mortality rates in birth cohorts in the United States from
DM Mannino (2001)
10.1097/01.ede.0000152522.80261.e3
Residential Radon and Risk of Lung Cancer: A Combined Analysis of 7 North American Case-Control Studies
D. Krewski (2005)
10.1002/1097-0215(200102)9999:9999<::AID-IJC1139>3.0.CO;2-7
Lung cancer and cigarette smoking in Europe: An update of risk estimates and an assessment of inter‐country heterogeneity
L. Simonato (2001)
10.1097/00001648-200009000-00002
Urban Air Pollution and Lung Cancer in Stockholm
F. Nyberg (2000)
10.2307/2981542
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
N. Breslow (1980)
Lung cancer and cigarette smoking in Europe: an update of risk
L Simonato (2001)
10.1093/AJE/153.1.42
Case-control study on lung cancer and residential radon in western Germany.
L. Kreienbrock (2001)
10.1136/bmj.38142.554479.AE
Mortality in relation to smoking: 50 years' observations on male British doctors
R. Doll (2004)
10.1097/01.ede.0000071410.26053.c4
Residential Radon and Risk of Lung Cancer in Eastern Germany
M. Kreuzer (2003)
10.1002/SIM.1485
Improved estimates of floating absolute risk.
M. Plummer (2004)
10.1002/ijc.11020
Lung cancer rates convergence in young men and women in the United States: Analysis by birth cohort and histologic type
A. Jemal (2003)
10.1093/AJE/152.1.32
Occupational exposure and lung cancer risk: a population-based case-referent study in Sweden.
P. Gustavsson (2000)
A method for estimating comparative rates from clinical
J Cornfield (1951)
10.1093/JNCI/91.8.697
Cigar and pipe smoking and lung cancer risk: a multicenter study from Europe.
P. Boffetta (1999)
10.2307/2983104
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies.
N. Breslow (1987)
10.1093/ACPROF:OSO/9780198508564.001.0001
International Smoking Statistics
B. Forey (2002)
Lung cancer and cigarette smoking in Europe : an update of risk estimates and an assessment of intercountry heterogeneity
L Simonato (2001)
10.1136/tc.12.4.349
Effect of smokeless tobacco (snus) on smoking and public health in Sweden
J. Foulds (2003)
10.1016/S0959-8049(98)00312-8
Variation in survival of patients with lung cancer in Europe, 1985-1989. EUROCARE Working Group.
M. Janssen-Heijnen (1998)
10.1093/JNCI/11.6.1269
A method of estimating comparative rates from clinical data; applications to cancer of the lung, breast, and cervix.
J. Cornfield (1951)
10.1016/0140-6736(92)91600-D
Mortality from tobacco in developed countries: indirect estimation from national vital statistics
R. Peto (1992)
10.1002/SIM.4780100703
Floating absolute risk: an alternative to relative risk in survival and case-control analysis avoiding an arbitrary reference group.
D. Easton (1991)
10.1038/BJC.1996.46
Mortality from smoking in developed countries 1950-2000
L. Kinlen (1996)
10.1002/IJC.2910330504
Patterns of lung cancer risk according to type of cigarette smoked
J. Lubin (1984)
10.1016/S0169-5002(00)00170-7
Lung cancer mortality rates in birth cohorts in the United States from 1960 to 1994.
D. Mannino (2001)
10.2307/2530192
Statistical methods in cancer research. Vol. 1. The analysis of case-control studies.
N. Breslow (1980)
10.1023/B:CACO.0000024223.91059.ed
Occupational Risk Factors for Lung Cancer in Men and Women: A Population-Based Case–Control Study in Italy
L. Richiardi (2004)
Globocan 2000 : cancer incidence, mortality and prevalence worldwide
J. Ferlay (2001)
10.1136/bmj.309.6959.901
Mortality in relation to smoking: 40 years' observations on male British doctors
R. Doll (1994)
Statistical Methods in Cancer
NE Breslow (1987)
Lyon: International Agency for Research on Cancer Forey B
N E Breslow (1980)
10.1136/bmj.321.7257.323
Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies
R. Peto (2000)



This paper is referenced by
10.1158/1055-9965.EPI-06-0509
Smoking Relapse during the First Year after Treatment for Early-Stage Non–Small-Cell Lung Cancer
M. Walker (2006)
Metabolism of Nicotine and the Tobacco Carcinogen 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK): Genetic and Phenotypic Variation
Jeannette Zinggeler Berg (2009)
10.1097/01.HP.0000363842.62922.58
Multifactorial Study of the Risk of Lung Cancer among French Uranium Miners: Radon, Smoking and Silicosis
Jean-Christophe Amabile (2009)
10.7314/APJCP.2012.13.8.3569
Importance of social support in cancer patients.
Y. Y. Usta (2012)
10.1002/ijc.22694
Trends in lung cancer among young European women: The rising epidemic in France and Spain
F. Levi (2007)
10.1007/s00408-013-9517-x
Lung Cancer Screening: Review and Performance Comparison Under Different Risk Scenarios
J. Tota (2013)
10.1667/RR2819.1
Radiation and Smoking Effects on Lung Cancer Incidence by Histological Types Among Atomic Bomb Survivors
H. Egawa (2012)
10.1037/cfp0000078
Characteristics of Cigarette Smoking in Individuals in Smoking Concordant and Smoking Discordant Couples
E. M. Tooley (2017)
10.1007/s00761-006-1126-3
Rauchen, Passivrauchen und Krebserkrankungen
M. Kreuzer (2006)
10.1001/jamanetworkopen.2019.9292
Association of Germline Variants in Natural Killer Cells With Tumor Immune Microenvironment Subtypes, Tumor-Infiltrating Lymphocytes, Immunotherapy Response, Clinical Outcomes, and Cancer Risk
Xue Xu (2019)
10.1016/j.cger.2011.09.001
Cancer and age: general considerations.
S. Hoffe (2012)
10.1037/adb0000051
Behavioral couples therapy for smoking cessation: A pilot randomized clinical trial.
Heather LaChance (2015)
10.1093/AJE/KWM318
Tobacco smoking, smoking cessation, and cumulative risk of upper aerodigestive tract cancers.
C. Bosetti (2008)
10.1186/1471-2296-11-18
Impact of vital signs screening & clinician prompting on alcohol and tobacco screening and intervention rates: a pre-post intervention comparison
J. Seale (2010)
Variation in Nicotine and Nitrosamine Pharmacology Genes and Smoking-associated Lung Cancer
C. Wassenaar (2015)
10.1093/jnci/djx119
Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3)
Anouar Fanidi (2018)
10.5114/kitp.2019.83940
Impact of smoking history on postoperative complications after lung cancer surgery – a study based on 286 cases
M. Kozub (2019)
10.1002/9781118312513.CH1
Epidemiology of Cancer in the Older‐Aged Person
L. Balducci (2013)
ANTI-CANCER ACTIONS IN COMMONLY USED DRUGS: EPIDEMIOLOGY LED BY LABORATORY SCIENCE
A. Walker (2011)
10.1177/030089160609200511
Diagnostic Imaging of Lung Cancer after Heart Transplantation
A. La Fianza (2006)
10.1007/978-1-4614-5586-8_23
Integrating Prevention and Screening for Lung Cancer into Clinical Practice
W. Hocking (2013)
10.1667/RR2083.1
Radiation and Smoking Effects on Lung Cancer Incidence among Atomic Bomb Survivors
K. Furukawa (2010)
10.1259/bjr/13017671
Current management of prostate cancer: dilemmas and trials.
C. O'Hanlon Brown (2012)
10.1002/ijc.22331
Lung cancer risk prediction: A tool for early detection
A. Cassidy (2007)
10.7314/APJCP.2012.13.4.1225
Nurses' perspective on positive attitudes to cancer patients in Turkey: a qualitative study.
Yasemin Yilirim Usta (2012)
10.1093/carcin/bgr090
CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression.
Annette M. Krais (2011)
10.1002/ijc.26162
Genetic variability in the metabolism of the tobacco‐specific nitrosamine 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) to 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol (NNAL)
M. Ter-Minassian (2012)
10.1158/1055-9965.EPI-07-0236
Combinations of Cytochrome P450 Gene Polymorphisms Enhancing the Risk for Sporadic Colorectal Cancer Related to Red Meat Consumption
Sébastien Küry (2007)
10.1200/JCO.2006.07.2983
Lung cancer incidence in never smokers.
H. Wakelee (2007)
10.1007/174_2011_491
Radiation Risk Associated with Lung Cancer Screening
C. Schaefer-Prokop (2011)
10.7554/eLife.49979
The hazards of smoking and the benefits of cessation: a critical summation of the epidemiological evidence in high-income countries
P. Jha (2020)
Review Article Nicotiana Tabacum - Current Scenario of Tobacco
Chidambaram Ramasamy (2013)
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