Online citations, reference lists, and bibliographies.
← Back to Search

Interactive Relations Of Central Versus Total Obesity And Blood Pressure To Cognitive Function

S. Waldstein, L. Katzel
Published 2006 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Objective:To examine the potential interactive relations of central versus total obesity and blood pressure (BP) to cognitive function.Method:In all, 90 healthy, stroke, and dementia-free middle-aged and older adults (ages 54–81 years; 63% male; 93% White) underwent biomedical and neuropsychological assessment. Relations of central obesity (assessed by waist circumference (WC)) and systolic or diastolic BP to cognitive function were examined in multiple regression models. Next, body mass index (BMI) was substituted for WC in the models.Results:After statistical adjustment for age, education, gender, and other potential confounders including components of the metabolic syndrome (depending on the model), significant interactions of WC and systolic (or diastolic) BP were noted for the Grooved Pegboard – Dominant Hand and Stroop Interference scores, with marginally significant results for Grooved Pegboard – Nondominant Hand. In general, individuals with greater WC and higher BP performed most poorly on these measures. Similar results were obtained for BMI.Conclusion:Independent of other confounders including facets of the metabolic syndrome, the combination of greater WC (or BMI) and higher (systolic or diastolic) BP was associated with diminished performance on tests of motor speed and manual dexterity, and executive function (i.e. response inhibition) accounting for 3–13% of the variance in these measures. In healthy older adults, there are similar, negative relations of central and total obesity to cognitive function that are potentiated by higher BP levels.
This paper references
10.1038/sj.ijo.0801285
Neuroendocrine abnormalities in visceral obesity
P. Björntorp (2000)
10.1016/S0140-6736(02)11911-8
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.
S. Lewington (2002)
10.1038/OBY.2003.199
Methods of estimation of visceral fat: advantages of ultrasonography.
F. F. Ribeiro-Filho (2003)
10.1046/j.1532-5415.2002.50619.x
Cytokines and Cognition—The Case for A Head‐to‐Toe Inflammatory Paradigm
Craig J. Wilson (2002)
Preliminary manual for the State-Trait Personality Inventory
C. Spielberger (1979)
10.1007/BF03346266
New paradigms in neuroendocrinology: Relationships between obesity, systemic inflammation and the neuroendocrine system
R. Toni (2004)
10.1146/ANNUREV.PUBLHEALTH.25.101802.122951
Can dementia be prevented? Brain aging in a population-based context.
M. Haan (2004)
Depression Inventory: Manual
Beck AT. Beck (1987)
Are metabolic risk factors one unified syndrome? Modeling the structure of the metabolic syndrome
BJ Shen (2003)
10.1161/01.STR.0000075294.98582.2F
Abdominal Obesity and Risk of Ischemic Stroke: The Northern Manhattan Stroke Study
S. Suk (2003)
Leptin and hyperleptinemia – from friend to foe for cardiovascular function
J. Ren (2004)
10.2337/DIACARE.24.4.683
Cardiovascular morbidity and mortality associated with the metabolic syndrome.
B. Isomaa (2001)
10.1002/1098-108X(198605)5:4<701::AID-EAT2260050409>3.0.CO;2-7
Personality and cognitive findings among patients electing gastroplasty for morbid obesity
G. Chelune (1986)
10.4324/9781410600981-10
Hypertension and cognitive function.
S. Waldstein (2001)
10.1161/01.STR.32.6.1263
Stress-Induced Blood Pressure Reactivity and Incident Stroke in Middle-Aged Men
S. Everson (2001)
10.1016/S0140-6736(02)11911-8
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
K. Jamrozik (2002)
10.1046/j.1365-2796.1997.00196.x
Cognitive function, vascular risk factors and education. A cross‐sectional study based on a cohort of 70‐year‐old men
L. Kilander (1997)
Reduced intellectual performance in extreme overweight.
T. Sørensen (1982)
10.1001/ARCHINTE.162.22.2557
Body mass index and the risk of stroke in men.
T. Kurth (2002)
10.1016/S0306-4522(02)00162-8
Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents
X. Li (2002)
10.1007/s11906-004-0014-8
Metabolic syndrome X: An inflammatory condition?
U. Das (2004)
10.1037/0894-4105.14.2.224
The cognitive correlates of white matter abnormalities in normal aging: a quantitative review.
F. Gunning-Dixon (2000)
10.1677/JOE.0.0180001
Adrenocortical hyperfunction with sudden onset of hirsutism.
I. E. Bush (1959)
10.1161/01.CIR.0000115514.44135.A8
Clinical Importance of Obesity Versus the Metabolic Syndrome in Cardiovascular Risk in Women: A Report From the Women’s Ischemia Syndrome Evaluation (WISE) Study
K. Kip (2004)
10.1111/j.1749-6632.2000.tb06393.x
Cardiovascular and Other Risk Factors for Alzheimer's Disease and Vascular Dementia
J. Meyer (2000)
10.1093/AJCN/68.4.899
Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults.
F. Pi-Sunyer (1998)
10.1097/01.hjr.0000085253.65733.ef
Body mass index, coronary heart disease and stroke in Swedish women. A prospective 19-year follow-up in the BEDA∗ study
A. Rosengren (2003)
10.1037/0033-2909.110.3.451
Neuropsychological correlates of hypertension: review and methodologic considerations.
S. Waldstein (1991)
10.1038/sj.ijo.802225
Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study
M. Elias (2003)
10.1212/01.WNL.0000073620.42047.D7
Inflammatory markers and cognition in well-functioning African-American and white elders
K. Yaffe (2003)
based on a cohort of 70-year-old men
TI Sorensen (1997)
10.4324/9781315851877
Neuropsychology of Cardiovascular Disease
S. Waldstein (2000)
10.1093/OXFORDJOURNALS.AJE.A116868
Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study.
M. Elias (1993)
10.1016/S0531-5565(99)00047-9
Glucocorticoids, stress, and their adverse neurological effects: relevance to aging
R. Sapolsky (1999)
10.1161/01.STR.0000119386.22691.1C
Body Mass Index and Ischemic and Hemorrhagic Stroke: A Prospective Study in Korean Men
Y. Song (2004)
10.1161/01.STR.0000127774.43890.5b
Stress-Induced Blood Pressure Reactivity and Silent Cerebrovascular Disease
S. Waldstein (2004)
10.1001/ARCHINTE.163.13.1524
An 18-year follow-up of overweight and risk of Alzheimer disease.
D. Gustafson (2003)
10.1038/sj.ijo.0802944
Change in body mass index and its impact on blood pressure: a prospective population study
W. Drøyvold (2005)
10.1093/AJE/KWG045
Are metabolic risk factors one unified syndrome? Modeling the structure of the metabolic syndrome X.
Biing-Jiun Shen (2003)



This paper is referenced by
10.18632/aging.100942
Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet
M. Bernier (2016)
10.1177/0081246315587693
Grooved Pegboard for adult employed South Africans: socio-demographic influences
Charles H Van Wijk (2015)
10.1016/j.jns.2016.03.033
Relations of blood pressure and head injury to regional cerebral blood flow
Jason E Kisser (2016)
10.1007/s11064-012-0821-2
Grape Seed and Skin Extract Prevents High-Fat Diet-Induced Brain Lipotoxicity in Rat
K. Charradi (2012)
10.1159/000442670
Challenges in the Detection of Working Memory and Attention Decrements among Overweight Adolescent Girls
L. Bauer (2016)
10.1007/978-3-319-12125-3_41-1
Obesity, Metabolic Dysfunction, and Dementia
Ashley A. Martin (2015)
10.1080/13825585.2012.762972
Cognitive reserve preserves cognitive function in obese individuals
R. Galioto (2013)
10.1155/2016/2473081
Obesity Reduces Cognitive and Motor Functions across the Lifespan
C. Wang (2016)
10.1007/s11764-014-0404-0
Objectively measured physical activity and cognitive functioning in breast cancer survivors
Catherine R Marinac (2014)
Beliefs about the Impact of Excess Body Weight on Biopsychosocial Functioning in Multiple Sclerosis Patients
A. Norouzinia (2017)
10.4236/PSYCH.2013.41004
Body Mass Index Does Not Affect Grooved Pegboard Performance in Healthy South African Adults
Charles H. van Wijk (2013)
10.1155/2016/6178575
Impaired Visual Motor Coordination in Obese Adults
D. Gaul (2016)
10.1186/1471-2377-10-64
White matter fractional anisotropy is related to processing speed in metabolic syndrome patients: a case-control study
B. Segura (2010)
10.3390/nu7085307
Diet-Induced Cognitive Deficits: The Role of Fat and Sugar, Potential Mechanisms and Nutritional Interventions
J. E. Beilharz (2015)
10.4172/1747-0862.S1-005
Obesity and Gut's Dysbiosis Promote Neuroinflammation, Cognitive Impairment, and Vulnerability to Alzheimer's disease: New Directions and Therapeutic Implications
M. Daulatzai (2014)
10.1016/j.appet.2013.05.007
Different subtypes of impulsivity differentiate uncontrolled eating and dietary restraint
Margaret A. Leitch (2013)
10.1016/j.jpeds.2016.08.076
Neurocognitive Function in Children with Primary Hypertension
M. Lande (2017)
10.1017/S1092852900016886
Metabolic syndrome and Alzheimer's disease: a link to a vascular hypothesis?
H. Milionis (2008)
10.3389/fnagi.2013.00097
The Impact of Obesity and Exercise on Cognitive Aging
John S Y Chan (2013)
10.1111/ene.12083
Obesity and impaired cognitive functioning in the elderly: a population‐based cross‐sectional study (NEDICES)
J. Benito-León (2013)
Obesity in the Lebanese elderly: prevalence, relative risks and anthropometrical measurements.
Charbel El Bcheraoui (2008)
10.1016/j.freeradbiomed.2010.03.006
NOX activity in brain aging: exacerbation by high fat diet.
A. Bruce-Keller (2010)
10.1097/WCO.0b013e32835c4f04
Vascular cognitive impairment.
F. Rincon (2013)
10.1016/J.EVOLHUMBEHAV.2007.07.005
Waist-hip ratio and cognitive ability: Is gluteofemoral fat a privileged store of neurodevelopmental resources?
W. D. Lassek (2008)
10.12691/AJSSM-2-1-9
Effects of Daily Life Physical Activity on Obesity Indices, Cardiorespiratory Fitness and Association of the Latter Two with Academic Performance in Bengali Adolescents of India
Roan Mukherjee (2014)
10.1016/j.soard.2019.09.076
Neuroimaging correlates of cognitive changes after bariatric surgery.
Amit M Saindane (2019)
10.1038/sj.ijo.0803558
Obesity, blood pressure and cognitive function: a reply to Waldstein and Katzel
M. Boxtel (2007)
10.1016/j.biopsych.2014.07.012
Obese-type Gut Microbiota Induce Neurobehavioral Changes in the Absence of Obesity
A. Bruce-Keller (2015)
UvA-DARE ( Digital Academic Repository ) Targeting Neuroinflammation to Treat Alzheimer ' s Disease
A. Ardura-Fabregat (2017)
10.1186/s40200-015-0211-9
Study of relationship between obesity and executive functions among high school students in Bushehr, Iran
S. E. Qavam (2015)
10.3233/JAD-160640
Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer’s Disease
I. Martins (2017)
10.1177/0891988716686832
Cognitive Decline, Body Mass Index, and Waist Circumference in Community-Dwelling Elderly Participants
J. M. Rodríguez-Fernández (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar