Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Population Landscape Of Familial Cancer

C. Frank, M. Fallah, J. Sundquist, Akseli Hemminki, K. Hemminki
Published 2015 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Public perception and anxiety of familial cancer have increased demands for clinical counseling, which may be well equipped for gene testing but less prepared for counseling of the large domain of familial cancer with unknown genetic background. The aim of the present study was to highlight the full scope of familial cancer and the variable levels of risk that need to be considered. Data on the 25 most common cancers were obtained from the Swedish Family Cancer Database and a Poisson regression model was applied to estimate relative risks (RR) distinguishing between family histories of single or multiple affected first-degree relatives and their diagnostic ages. For all cancers, individual risks were significantly increased if a parent or a sibling had a concordant cancer. While the RRs were around 2.00 for most cancers, risks were up to 10-fold increased for some cancers. Familial risks were even higher when multiple relatives were affected. Although familial risks were highest at ages below 60 years, most familial cases were diagnosed at older ages. The results emphasized the value of a detailed family history as a readily available tool for individualized counseling and its preventive potential for a large domain of non-syndromatic familial cancers.
This paper references
10.3322/caac.20096
Cancer screening in the United States, 2011
R. Smith (2011)
10.1093/ACPROF:OSOBL/9780195328974.003.0004
A User’s Guide
Robert S. Leiken (2011)
10.1136/bmj.1.5450.1567
Epidemiology of Stomach Cancer
T. Hirayama (1968)
10.1002/ijc.24795
The Swedish Family‐Cancer Database 2009: prospects for histology‐specific and immigrant studies
K. Hemminki (2010)
10.1093/annonc/mdn527
Age of onset in familial cancer.
A. Brandt (2008)
Acknowledgements This work was supported by the German Cancer Aid (grant number 109896)
10.1016/j.jadohealth.2013.01.027
Exposure to chemicals and radiation during childhood and risk for cancer later in life.
D. Carpenter (2013)
10.1017/CBO9780511973420
Negative Binomial Regression: Index
J. Hilbe (2011)
10.1002/ijc.20568
Prostate cancer screening, changing age‐specific incidence trends and implications on familial risk
K. Hemminki (2005)
Scientific RepoRts | 5:12891 | DOi: 10
(1038)
10.1038/nrclinonc.2014.169
Management of familial cancer: sequencing, surveillance and society
Nardin Samuel (2014)
10.1038/nature12981
Realizing the promise of cancer predisposition genes
N. Rahman (2014)
10.1038/nrc2840
Architecture of inherited susceptibility to common cancer
O. Fletcher (2010)
www.nature.com
10.1038/sj.bjc.6605708
Familial risks in nervous system tumours: joint Nordic study
K. Hemminki (2010)
10.1159/000101759
The Comprehensiveness of Family Cancer History Assessments in Primary Care
H. Murff (2007)
10.1016/j.ejca.2009.11.016
Familial risks of breast and prostate cancers: does the definition of the at risk period matter?
A. Brandt (2010)
10.1016/j.ejca.2008.02.013
Cancer screening: evidence and practice in Europe 2008.
M. Hakama (2008)
10.1007/s10689-013-9631-1
Colorectal surveillance in Lynch syndrome families
W. H. Vos tot Nederveen Cappel (2013)
Negative Binomial Regression. 2nd edn, (Cambridge
J. M. Hilbe (2011)
10.12746/swrccc2015.0310.135
Negative Binomial Regression
J. Hilbe (2007)
Childhood social environment and Hodgkin's lymphoma: new findings from a population-based case-control study.
E. Chang (2004)
10.3322/canjclin.39.6.399
Cancer statistics
N. Dubrawsky (1989)
10.1093/neuonc/nos208
Ionizing radiation and the risk of brain and central nervous system tumors: a systematic review.
M. Braganza (2012)
10.1200/JCO.2013.50.9257
American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers.
K. Lu (2014)
Indikationskriterien für genetische DiagnostikBewertung der Validität und des klinischen Nutzens
e. V. Deutsche Gesellschaft für Humangenetik (2015)
10.3322/caac.21254
Cancer statistics, 2015
R. Siegel (2015)
Indikationskriterien für genetische Diagnostik -Bewertung der Validität und des klinischen Nutzens
Deutsche Gesellschaft Für Humangenetik
3 User's Guide
Sas Institute Inc (2011)
10.1158/1055-9965.EPI-08-0878
The Association of Tumor Microsatellite Instability Phenotype with Family History of Colorectal Cancer
B. Bapat (2009)
10.1054/BJOC.2000.1562
Pathology and Genetics of Tumours of the Nervous System
M. Brada (2001)
Indikationskriterien für genetische Diagnostik -Bewertung der Validität und des klinischen Nutzens. (2015) Available at
Deutsche Gesellschaft Für Humangenetik (2015)
10.1200/JCO.2013.51.4661
Quality of cancer family history and referral for genetic counseling and testing among oncology practices: a pilot test of quality measures as part of the American Society of Clinical Oncology Quality Oncology Practice Initiative.
M. Wood (2014)
10.1136/bmj.e8076
Familial risk of early and late onset cancer: nationwide prospective cohort study
E. Kharazmi (2012)
10.7326/0003-4819-129-9-199811010-00045
The Genetic Basis of Human Cancer
C. Rubin (1998)
10.1200/JCO.2014.56.5689
Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing.
D. Chubb (2015)
10.1080/10543409508835101
Poisson regression analysis in clinical research.
F. Kianifard (1995)
10.1111/j.1360-0443.2008.02196.x
Parental smoking and smoking experimentation in childhood increase the risk of being a smoker 20 years later: the Childhood Determinants of Adult Health Study.
S. L. Paul (2008)
10.1136/jmg.2004.022731
Clinical genetic counselling for familial cancers requires reliable data on familial cancer risks and general action plans
K. Hemminki (2004)
10.1002/ijc.28510
The population impact of familial cancer, a major cause of cancer
C. Frank (2014)
10.1038/nrurol.2013.266
The genetic epidemiology of prostate cancer and its clinical implications
R. Eeles (2014)
10.1093/annonc/mdt316
Male breast cancer: genetics, epigenetics, and ethical aspects.
P. Rizzolo (2013)
10.1146/annurev-genom-091212-153429
The genetics of melanoma: recent advances.
V. Hill (2013)
10.1200/JCO.2014.56.4336
Collection and use of family history in oncology clinics.
K. Hemminki (2014)



This paper is referenced by
10.1016/j.eururo.2016.07.031
Familial Associations Between Prostate Cancer and Other Cancers.
C. Frank (2017)
10.1186/s12916-020-01772-x
Risk of invasive breast cancer in relatives of patients with breast carcinoma in situ: a prospective cohort study
Trasias Mukama (2020)
10.1038/s41598-017-05732-z
Familial Associations of Colorectal Cancer with Other Cancers
Hongyao Yu (2017)
10.1002/ijc.32512
Familial aggregation of early‐onset cancers
S. Heikkinen (2019)
10.1182/blood.2019001362
Analysis of 153,115 patients with hematological malignancies refines the spectrum of familial risk.
A. Sud (2019)
10.1101/19003681
Redefining the Bladder Cancer Phenotype using Patterns of Familial Risk
H. Hanson (2019)
10.1007/s13187-018-1451-4
Communication About Hereditary Cancers on Social Media: A Content Analysis of Tweets About Hereditary Breast and Ovarian Cancer and Lynch Syndrome
C. Allen (2018)
10.1002/ijc.30751
Site‐specific familial risk and survival of familial and sporadic head and neck cancer
S. Renkonen (2017)
10.1038/leu.2015.279
Search for familial clustering of multiple myeloma with any cancer
C. Frank (2016)
Endocrine and metabolic sequelae of tumours with a focus on craniopharyngioma
Mark Wijnen (2018)
10.1038/s42003-019-0329-2
Genome-wide interaction and pathway-based identification of key regulators in multiple myeloma
S. Chattopadhyay (2019)
10.1093/annonc/mdy217
ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up
F. Honecker (2018)
10.1093/mutage/gez022
Genetic epidemiology of colorectal cancer and associated cancers.
Hongyao Yu (2019)
10.1016/j.jtauto.2020.100058
Familial risks between Graves disease and Hashimoto thyroiditis and other autoimmune diseases in the population of Sweden
H. Thomsen (2020)
10.1038/s41598-018-28819-7
Familial Associations in Testicular Cancer with Other Cancers
Luyao Zhang (2018)
10.1183/23120541.00006-2017
Other cancers in lung cancer families are overwhelmingly smoking-related cancers
Hongyao Yu (2017)
10.3390/jcm9061954
Dominantly Inherited Hereditary Nonpolyposis Colorectal Cancer Not Caused by MMR Genes
M. Terradas (2020)
10.1007/s12672-018-0348-3
Familial Cancer Clustering in Patients with Prolactinoma
S. Pekić (2018)
10.1158/0008-5472.CAN-19-2165
A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa
M. Harlemon (2020)
10.1002/cncr.32815
Familial risk of breast cancer by dynamic, accumulative, and static definitions of family history
Trasias Mukama (2020)
10.1158/1055-9965.EPI-19-0681
Harnessing Population Pedigree Data and Machine Learning Methods to Identify Patterns of Familial Bladder Cancer Risk
H. Hanson (2020)
10.1002/ijc.30583
Concordant and discordant familial cancer: Familial risks, proportions and population impact
C. Frank (2017)
10.1038/srep22891
Location of metastases in cancer of unknown primary are not random and signal familial clustering
K. Hemminki (2016)
10.1007/s12020-016-0868-y
Cancerous leptomeningitis and familial congenital hypopituitarism
S. Vujovic (2016)
10.1186/s12889-018-5033-5
The surprising implications of familial association in disease risk
Morten Valberg (2018)
10.1016/j.canep.2020.101807
Familial aggregation of testicular cancer among early-onset cancer survivors. A prospective observational cohort data from Finland.
Heikki A Seikkula (2020)
10.1038/bcj.2016.58
Search for familial clustering of cancer in monoclonal gammopathy of unknown significance
K. Hemminki (2016)
10.2147/CLEP.S168152
Importance of tumor location and histology in familial risk of upper gastrointestinal cancers: a nationwide cohort study
E. Kharazmi (2018)
10.1530/ERC-16-0113
Risk factors for subsequent endocrine-related cancer in childhood cancer survivors.
M. Wijnen (2016)
10.1001/jamaoncol.2019.3876
Risk-Adapted Starting Age of Screening for Relatives of Patients With Breast Cancer.
Trasias Mukama (2019)
10.1093/mutage/gez027
The missing heritability of familial colorectal cancer
Stephanie A Schubert (2019)
10.1002/ijc.30927
Familial associations of female breast cancer with other cancers
G. Zheng (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar