Online citations, reference lists, and bibliographies.
← Back to Search

Biomimetic Adhesive Containing Nanocomposite Hydrogel With Enhanced Materials Properties

S. Skelton, Michael Bostwick, Kyle O'connor, Shari Konst, Samuel Casey, B. P. Lee
Published 2013 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
Chemically crosslinked polyacrylamide (PAAm) nanocomposite hydrogels were prepared with inorganic nano-silicate, Laponite, and dopamine methacrylamide (DMA). DMA consists of a biomimetic adhesive side chain covalently linked to a polymerizable methacrylate monomer. Copolymerizing DMA into a PAAm hydrogel strongly enhanced the interfacial interaction between the polymer network and Laponite. Nanocomposite hydrogels demonstrated reduced water content and increased materials properties that were dependent on both the Laponite and DMA contents. While increasing Laponite content alone improved materials properties moderately, these improvements were drastically enhanced when DMA is incorporated as measured by both unconfined compression testing and oscillatory rheometry. DMA-containing nanocomposite hydrogels demonstrated increased stiffness as well as excellent energy dissipation capability. Nanocomposite hydrogels with relatively low DMA and Laponite contents (2 to 3 wt% for each) demonstrated maximum compressive stress, elastic modulus, toughness, and storage and loss moduli values that were over an order of magnitude higher than control gels. DMA-containing nanocomposite hydrogels also demonstrated improved fracture resistance to compressive loading, capable of repeated compressed to 80% strain without rest for over 10 times while exhibiting compressive stress of over 1.1 MPa. The catechol side chain of DMA likely formed strong physical bonds with Laponite, which can dissipate fracture energy while minimizing permanent damage to the network architecture.
This paper references
10.1080/02648725.1996.10647926
Marine adhesive proteins and some biotechnological applications.
H. Yamamoto (1996)
10.1038/PJ.2010.141
Synthesis and properties of soft nanocomposite materials with novel organic/inorganic network structures
K. Haraguchi (2011)
10.1088/0957-4484/22/32/325706
Interfacial energy dissipation in a cellulose nanowhisker composite.
R. Rusli (2011)
10.1073/pnas.1015862108
pH-induced metal-ligand cross-links inspired by mussel yield self-healing polymer networks with near-covalent elastic moduli
Niels Holten-Andersen (2011)
10.1021/CM060513Q
Nanocomposite Fiber Systems Processed from Fluorinated Single-Walled Carbon Nanotubes and a Polypropylene Matrix
D. McIntosh (2006)
10.1021/MA0518959
Rapid Gel Formation and Adhesion in Photocurable and Biodegradable Block Copolymers with High DOPA Content
B. P. Lee (2006)
10.1039/C0SM00067A
PEG/clay nanocomposite hydrogel: a mechanically robust tissue engineering scaffold
Chien-Wen Chang (2010)
10.1021/LA048626G
Protein resistance of titanium oxide surfaces modified by biologically inspired mPEG-DOPA.
J. Dalsin (2005)
10.1016/S0924-4247(02)00052-3
Effect of surface roughness on liquid property measurements using mechanically oscillating sensors.
Mahaveer Jain (2002)
10.1021/bm1007794
Adhesive performance of biomimetic adhesive-coated biologic scaffolds.
J. L. Murphy (2010)
10.1073/pnas.0605552103
Single-molecule mechanics of mussel adhesion
H. Lee (2006)
10.1097/00006534-199902000-00025
Transdermal photopolymerized adhesive for seroma prevention.
R. Silverman (1999)
10.1063/1.2963491
Determination of the stiffness of cellulose nanowhiskers and the fiber-matrix interface in a nanocomposite using Raman spectroscopy
R. Rusli (2008)
10.1021/JA0284963
Mussel adhesive protein mimetic polymers for the preparation of nonfouling surfaces.
J. Dalsin (2003)
10.1021/nl902212q
Ultrastable iron oxide nanoparticle colloidal suspensions using dispersants with catechol-derived anchor groups.
E. Amstad (2009)
10.1016/J.COMPOSITESB.2008.01.002
Effects of particle size, particle/matrix interface adhesion and particle loading on mechanical properties of particulate–polymer composites
S. Fu (2008)
10.1021/JP205050K
Fate of L-DOPA in the Presence of Inorganic Matrices: Vectorization or Composite Material Formation?
M. Jaber (2011)
10.1002/APP.31705
Rheological behavior of polymer–clay nanocomposite hydrogels: Effect of nanoscale interactions
Suzan Abdurrahmanoglu (2010)
10.1021/MA034366I
Compositional effects on mechanical properties of Nanocomposite hydrogels composed of poly(N, N-dimethylacrylamide) and clay
K. Haraguchi (2003)
10.1021/ic701687k
Binding of catechols to mononuclear titanium(IV) and to 1- and 5-nm TiO2 nanoparticles.
C. Creutz (2008)
10.1016/j.biomaterials.2011.01.018
An injectable vehicle for nucleus pulposus cell-based therapy.
E. Collin (2011)
10.1007/s11051-012-0912-7
Multiple magnetic characteristics in pure and Mn porphyrin-doped single-walled carbon nanotubes
G. Sáfar (2012)
10.1007/s11051-011-0715-2
Polymer-supported metals and metal oxide nanoparticles: synthesis, characterization, and applications
Sudipta Sarkar (2012)
10.1021/LA0476985
Interaction of catechol and gallic acid with titanium dioxide in aqueous suspensions. 1. Equilibrium studies.
Paula Z. Araujo (2005)
10.1088/1748-6041/6/1/015014
Biomechanical properties of Achilles tendon repair augmented with a bioadhesive-coated scaffold.
Michael Brodie (2011)
10.1016/J.COMPOSITESB.2009.01.001
Swelling behavior of polyacrylamide/laponite clay nanocomposite hydrogels: pH-sensitive property
Peng Li (2009)
10.1016/0021-9797(92)90254-J
The nature of laponite and its aqueous dispersions
D. Thompson (1992)
10.1146/ANNUREV-MATSCI-062910-100429
Mussel-Inspired Adhesives and Coatings.
B. P. Lee (2011)
10.1016/J.CPLETT.2005.03.029
Density functional study of the TiO2–dopamine complex
Manuel Vega-Arroyo (2005)
10.1021/JP3094148
Adsorption of l-DOPA Intercalated in Hydrated Na-Saponite Clay: A Combined Experimental and Theoretical Study
Khaled El Adraa (2012)
10.1163/156856204323005307
Synthesis of 3,4-dihydroxyphenylalanine (DOPA) containing monomers and their co-polymerization with PEG-diacrylate to form hydrogels
B. P. Lee (2004)
10.1038/nature05968
A reversible wet/dry adhesive inspired by mussels and geckos
H. Lee (2007)
10.1021/CM800035K
Intercalation of l-Dopa into Layered Double Hydroxides: Enhancement of Both Chemical and Stereochemical Stabilities of a Drug through Host−Guest Interactions
M. Wei (2008)
10.1021/MA200562K
Mechanically Tough Pluronic F127/Laponite Nanocomposite Hydrogels from Covalently and Physically Cross-Linked Networks
C. Wu (2011)
10.1098/rspa.2007.0250
Rheological behaviour of aqueous suspensions of laponite: new insights into the ageing phenomena
Y. Joshi (2007)
10.1248/CPB.26.74
Microscopic Acid Dissociation Constants of 3, 4-Dihydroxyphenethylamine (Dopamine)
T. Ishimitsu (1978)
10.1002/mabi.200800252
A water-borne adhesive modeled after the sandcastle glue of P. californica.
H. Shao (2009)
10.1016/j.jcrs.2008.11.035
Synthesis and characterization of a chondroitin sulfate‐polyethylene glycol corneal adhesive
I. Strehin (2009)
10.1016/S0736-0266(01)00054-7
Controlled‐release of IGF‐I and TGF‐β1 in a photopolymerizing hydrogel for cartilage tissue engineering
J. Elisseeff (2001)
10.1021/BM700762W
Rheological study of genipin cross-linked chitosan hydrogels.
M. J. Moura (2007)
10.1038/NMAT1890
Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration.
D. Wang (2007)
10.1021/BM025546N
Synthesis and gelation of DOPA-modified poly(ethylene glycol) hydrogels.
B. P. Lee (2002)
10.1016/0143-7496(87)90048-0
Nature's underwater adhesive specialist
J. H. Waite (1987)
10.1016/0006-2952(96)00101-3
Iron coordination by catechol derivative antioxidants.
T. Kawabata (1996)
10.1126/science.1181044
Iron-Clad Fibers: A Metal-Based Biological Strategy for Hard Flexible Coatings
Matthew J. Harrington (2010)
10.1007/s00396-012-2588-z
Novel polymer nanocomposite hydrogel with natural clay nanotubes
M. Liu (2012)
10.1126/SCIENCE.1147241
Mussel-Inspired Surface Chemistry for Multifunctional Coatings
H. Lee (2007)
10.1088/1748-6041/2/4/001
Thermal gelation and tissue adhesion of biomimetic hydrogels.
Seán Burke (2007)
10.1021/JP1070538
Density Functional Theory Study of Catechol Adhesion on Silica Surfaces
S. A. Mian (2010)
10.1021/MA001192L
Compressive Elastic Modulus of Polyacrylamide Hydrogels and Semi-IPNs with Poly(N-isopropylacrylamide)
E. C. Muniz (2001)
10.1021/bm200027z
Highly extensible, tough, and elastomeric nanocomposite hydrogels from poly(ethylene glycol) and hydroxyapatite nanoparticles.
A. Gaharwar (2011)
10.1016/S0168-3659(01)00557-0
Temperature-responsive and degradable hyaluronic acid/Pluronic composite hydrogels for controlled release of human growth hormone.
Mee Ryang Kim (2002)
10.1016/j.juro.2009.06.008
Anti-adhesive coating and clearance of device associated uropathogenic Escherichia coli cystitis.
Andrea Pechey (2009)
10.1021/BM015650P
Synthesis and characterization of self-assembling block copolymers containing bioadhesive end groups.
K. Huang (2002)
10.1021/JZ900020M
A New Nanocomposite: L-DOPA/Laponite
M. Jaber (2010)
10.1039/C1SM06484C
Large deformation behavior and effective network chain density of swollen poly(N-isopropylacrylamide)–Laponite nanocomposite hydrogels
T. Wang (2012)
10.1016/J.CLAY.2009.10.007
Improved mechanical and swelling behavior of the composite hydrogels prepared by ionic monomer and acid-activated Laponite
Peng Li (2009)
10.1007/S00214-011-0982-0
Adsorption of catechol on a wet silica surface: density functional theory study
S. A. Mian (2011)



This paper is referenced by
DOI : 10 . 4172 / 2321-6212 . 1000191 Self-Healing Hydrogels as Biomedical Scaffolds for Cell , Gene and Drug Delivery
Weizhong Yuan (2018)
10.1016/j.jmbbm.2017.07.029
Strain rate dependent hyperelastic stress-stretch behavior of a silica nanoparticle reinforced poly (ethylene glycol) diacrylate nanocomposite hydrogel.
Yuexing Zhan (2017)
10.1002/9783527675821.CH12
Current approaches to designing nanomaterials inspired by mussel adhesive proteins
Hao Meng (2014)
10.1021/bm500701u
Effect of pH on the Rate of Curing and Bioadhesive Properties of Dopamine Functionalized Poly(ethylene glycol) Hydrogels
M. Cencer (2014)
10.1039/C6TB01828A
Recovery property of double-network hydrogel containing mussel-inspired adhesive moiety and nano-silicate.
Yang Liu (2016)
10.1088/1748-6041/11/1/014104
Hydrogels 2.0: improved properties with nanomaterial composites for biomedical applications.
Adnan Memic (2015)
10.1007/978-3-319-46082-6_15
Biomimetic Adhesives and Coatings Based on Mussel Adhesive Proteins
Yuan Liu (2016)
10.1016/J.EURPOLYMJ.2014.04.019
Shape memory polyurethane with polydopamine-coated nanosheets: Simultaneous enhancement of recovery stress and strain recovery ratio and the underlying mechanisms
Si Lei Phua (2014)
10.3390/md13116792
Biomedical and Clinical Importance of Mussel-Inspired Polymers and Materials
N. Kaushik (2015)
10.1002/PAT.4367
Sodium alginate/magnesium oxide nanocomposite scaffolds for bone tissue engineering
B. Nasri-Nasrabadi (2018)
10.1039/c9bm01848d
Mussel-inspired bioadhesives in healthcare: design parameters, current trends, and future perspectives.
Nikhil Pandey (2020)
10.1002/MACP.201500010
Nitro-Group Functionalization of Dopamine and its Contribution to the Viscoelastic Properties of Catechol-Containing Nanocomposite Hydrogels.
Xiaochu Ding (2015)
10.1002/adma.201306137
Novel hydrogel actuator inspired by reversible mussel adhesive protein chemistry.
B. P. Lee (2014)
10.1021/am504566v
Injectable Dopamine-Modified Poly(ethylene glycol) Nanocomposite Hydrogel with Enhanced Adhesive Property and Bioactivity
Y. Liu (2014)
10.1016/j.actbio.2015.02.002
Hydrogen peroxide generation and biocompatibility of hydrogel-bound mussel adhesive moiety.
Hao Meng (2015)
10.1002/smll.201900242
Highly Dynamic Nanocomposite Hydrogels Self-Assembled by Metal Ion-Ligand Coordination.
Kunyu Zhang (2019)
10.1021/bm5016333
Effect of Nitro-Functionalization on the Cross-Linking and Bioadhesion of Biomimetic Adhesive Moiety
M. Cencer (2015)
10.1007/s10570-014-0364-6
Modification of cellulose nanocrystal-reinforced composite hydrogels: effects of co-crosslinked and drying treatment
Jun Yang (2014)
10.1016/J.PROGPOLYMSCI.2018.04.002
Recent advances in the synthesis of catechol-derived (bio)polymers for applications in energy storage and environment
N. Patil (2018)
10.1021/acs.biomac.5b00451
Catechol-Functionalized Synthetic Polymer as a Dental Adhesive to Contaminated Dentin Surface for a Composite Restoration
Sangbae Lee (2015)
10.1007/s10967-020-07071-2
Influence of embedded boron nitride nanosheets on Fe3+ diffusion in Fricke gel dosimeter and its response to γ rays
Siyuan Zhao (2020)
10.1002/mabi.201400363
Self-assembled monolayers and nanocomposite hydrogels of functional nanomaterials for tissue engineering applications.
Nermin Seda Kehr (2015)
10.1007/978-981-10-6077-9_16
Hydrogels from Catechol-Conjugated Polymeric Materials
Sâad Moulay (2018)
10.1002/adhm.201801568
Multifunctional Biomedical Adhesives.
Rattapol Pinnaratip (2019)
10.3390/ma9060443
Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage
Charlotte M. Beddoes (2016)
10.4172/2321-6212.1000191
Self-Healing Hydrogels as Biomedical Scaffolds for Cell, Gene and Drug Delivery
Weizhong Yuan (2017)
10.1007/s10856-015-5649-2
Mussel-inspired soft-tissue adhesive based on poly(diol citrate) with catechol functionality
Yali Ji (2015)
10.1002/advs.201400010
Nanoparticle–Hydrogel Composites: Concept, Design, and Applications of These Promising, Multi‐Functional Materials
Praveen Thoniyot (2015)
10.1016/j.actbio.2018.10.037
Biomimetic recyclable microgels for on-demand generation of hydrogen peroxide and antipathogenic application.
Hao Meng (2019)
REVERSIBLY SWITCHING ADHESION OF SMART ADHESIVES INSPIRED BY MUSSEL ADHESIVE CHEMISTRY
Ameya R Narkar (2018)
10.1002/pola.28368
Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein
Pegah Kord Forooshani (2017)
10.1016/j.carbpol.2014.03.058
In situ hydrogel constructed by starch-based nanoparticles via a Schiff base reaction.
Yangling Li (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar