Online citations, reference lists, and bibliographies.
← Back to Search

Surfactant-free Polymeric Nanoparticles Composed Of PEG, Cholic Acid And A Sucrose Moiety.

Carina I. C. Crucho, M. Barros
Published 2014 · Materials Science, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Polymer-based nanomedicine is a large and fast growing field that has gained plenty of research attention during recent decades. In the present study, new amphiphilic polymers were designed and synthesized by chemical modification of poly(ethylene glycol) (PEG) conjugated with sucrose and a cholic acid moiety (abbreviated as Suc-PEG-Chol). Two series of polymers with different PEG chain lengths were synthesized and their structures were confirmed by 1H-NMR, 13C-NMR and MALDI-TOF analysis. The fluorescence spectroscopy data of these conjugates showed that they are able to self-assemble in water and the critical association concentration (CAC) value was found to be in the range of 0.06-0.13 g L-1. Owing to their amphiphilic characteristics in aqueous solution, polymeric nanoparticles (PNPs) of Suc-PEG-Chol polymers were prepared by a nanoprecipitation method without any surfactants. The particle size distribution was determined by dynamic light scattering (DLS) and the result was 117 nm for the Suc-PEG2000-Chol conjugate and 96 nm for the PEG4000 analog, both with relatively narrow particle size distribution. All of the obtained PNPs showed a negative surface charge and no size dependence on the polymer concentration forming stable nanoparticle suspensions. From the atomic force microscopy (AFM) and scanning electron microscopy (SEM) observations, the PNPs were spherically shaped with a relatively smooth surface. Our results suggest that these PEGylated nanoparticles formulated with cholic acid and sucrose as biocompatible building blocks can be considered a potential candidate for biomedical applications.
This paper references
Prog
J. P. Rao (2011)
10.1039/c0ob00389a
Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands.
D. Deniaud (2011)
10.1002/EJOC.200300699
Use of Bile Acids in Pharmacological and Supramolecular Applications
E. Virtanen (2004)
Eur
E. Virtanen (2004)
10.1016/J.PROGPOLYMSCI.2011.01.001
Polymer nanoparticles: Preparation techniques and size-control parameters
J. D. Rao (2011)
10.1155/2012/103973
Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications
S. Banerjee (2012)
10.1038/nnano.2008.30
Nanoparticle-mediated cellular response is size-dependent.
W. Jiang (2008)
Chem
N. Kamaly (2012)
10.1039/c2cs15327k
Design of polymeric nanoparticles for biomedical delivery applications.
Mahmoud Elsabahy (2012)
Nat
K. Strebhardt (2008)
10.1039/c2cs15344k
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation.
Nazila Kamaly (2012)
and P
R. Webster (2009)
Nat
W. Jiang (2008)
Int
C. K. Song (2009)
10.1136/BJO.46.11.704
A and V
R. Stephenson (1962)
Org
D. Deniaud (2011)
10.1039/C0PY00149J
A spoonful of sugar: the application of glycopolymers in therapeutics
Sebastian G Spain (2011)
Macromol
I.-S. Kim (2000)
10.1038/nrc2394
Paul Ehrlich's magic bullet concept: 100 years of progress
K. Strebhardt (2008)
10.1016/0040-4039(92)88048-A
Modified bile acids: preparation of 7α,12α-dihydroxy-3β- and 7α,12α-dihydroxy-3α-(2-hydroxyethoxy)-5β-cholanic acid and their biological activity
G. Wess (1992)
10.1016/S0378-5173(03)00128-5
Development of polymeric nanoparticulate drug delivery systems: evaluation of nanoparticles based on biotinylated poly(ethylene glycol) with sugar moiety.
I. Kim (2003)
Nanomed
C. Pinto Reis (2006)
10.1016/J.NANO.2005.12.003
Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles.
C. Reis (2006)
10.1016/j.ijpharm.2009.07.014
Disaccharide-modified liposomes and their in vitro intracellular uptake.
C. K. Song (2009)
10.1515/9783111576855-015
J
Seguin Hen (1824)
10.1002/APP.29900
Synthesis and Characterization of Cholic Acid-Containing Biodegradable Hydrogels by Photoinduced Copolymerization
Jin-Qing Hao (2009)
10.1016/J.NANTOD.2011.02.003
Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies
T. Iversen (2011)
and X
S. Goui (1996)
10.1016/j.addr.2011.12.006
Polymeric nanoparticles for drug delivery to the central nervous system.
T. Patel (2012)
10.1021/mp200394t
Nanomedicine(s) under the microscope.
R. Duncan (2011)
Int
I.-S. Kim (2003)
10.1002/JPS.20094
Solid-state solubility influences encapsulation and release of hydrophobic drugs from PLGA/PLA nanoparticles.
J. Panyam (2004)
10.1016/J.IJPHARM.2005.10.010
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles.
Donald E. Owens (2006)
10.1002/1521-3927(20001101)21:17<1272::AID-MARC1272>3.0.CO;2-0
Preparation of polymeric nanoparticles composed of cholic acid and poly(ethylene glycol) end-capped with a sugar moiety
I. Kim (2000)
Drug delivery and targeting.
R. Langer (1998)
10.1016/S0378-5173(00)00375-6
Defining the drug incorporation properties of PLA-PEG nanoparticles.
T. Govender (2000)
10.1021/JO048957Y
Regioselective copolymerization of acryl sucrose monomers.
M. Barros (2004)
and W
G. Wess (1992)
10.1515/9783111576855-009
D
Saskia Bonjour (1824)
Adv
T. Patel (2012)
10.1016/S0039-128X(96)00187-0
Synthesis of 3α- and 3β-dimers from selected bile acids
S. Gouin (1996)
Int
H. Fessi (1989)
10.1515/9783111413426-013
L
Il Liceo (1824)
Int
D. E. Owens (2006)
and K
T.-G. Ibersen (2011)
Polym
S. G. Spain (2011)
10.3390/molecules16097909
Pyrene: A Probe to Study Protein Conformation and Conformational Changes
Gursharan K Bains (2011)
10.1016/0378-5173(89)90281-0
Nanocapsule formation by interfacial polymer deposition following solvent displacement
H. Fessi (1989)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar