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Construction Of Chiral Quaternary Carbon Center Via Catalytic Asymmetric Aza-Henry Reaction With α-substituted Nitroacetates

Minghua Li, Nan Ji, Ting Lan, Wei He, Rui Liu

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The catalytic enantioselective aza-Henry reaction of N-Boc aldimines 2 and 2-nitropropionic acid ethyl ester 3 in mixed solvents were catalyzed by cinchona quaternary ammonium salts to form a new quaternary carbon center. High yields (up to 90%), excellent enantioselectivities (up to 99% ee) and diastereoselectivities ratio (up to 22 : 1) were successfully obtained with mild conditions.