← Back to Search
Post-infiltration And Subsequent Photo-crosslinking Strategy For Layer-by-layer Fabrication Of Stable Dendrimers Enabling Repeated Loading And Release Of Hydrophobic Molecules.
Y. Wang, Qi An, Y. Zhou, Y. Niu, R. Akram, Y. Zhang, F. Shi
Published 2015 · Materials Science, Medicine
Download PDFAnalyze on Scholarcy
The layer-by-layer (LbL) technique has been intensively investigated as a straightforward method for the incorporation of drug molecules or other bioactive species, enabling retarded release in drug delivery devices, in bioactive interfaces, in tissue engineering, and in regenerative medicine. The preparation of crosslinked LbL multilayers with embedded drug reservoirs for delayed release remains a challenging task, however. In the present study we have developed a method for the simultaneous utilisation of covalent interlayer linkages and drug reservoirs that can hold model drug molecules. A strategy of post-infiltration of photoactive bifunctional small molecules followed by UV irradiation has been employed for crosslinking the LbL multilayers, incorporating poly(amido amine) (PAMAM) molecules, which serve as a drug reservoir. The covalent linkage significantly alters the release profile of the model drug from the multilayers, with retarded release of hydrophobic molecules from a solvent, and enabling the loaded multilayers to withstand rinsing with 75% ethanol, the most commonly used sterilization procedure.
This paper references
Micropatterning of polymer thin films with pH-sensitive and cross-linkable hydrogen-bonded polyelectrolyte multilayers.
S. Y. Yang (2002)
Electrostatically assembled polyelectrolyte/dendrimer multilayer films as ultrathin nanoreservoirs
A. Khopade (2002)
Dendrimer-based nanodevices for targeted drug delivery applications.
J. Zhu (2013)
Layer-by-layer deposition of polymeric microgel films on surgical sutures for loading and release of ibuprofen.
Lin Wang (2009)
A facile method for the construction of stable polymer–inorganic nanoparticle composite multilayers
Yong Zhou (2013)
Layer-by-layer assembled thin films composed of carboxyl-terminated poly(amidoamine) dendrimer as a pH-sensitive nano-device.
S. Tomita (2008)
Ultrathin Multilayered Films that Promote the Release of Two DNA Constructs with Separate and Distinct Release Profiles.
Xianghui Liu (2008)
Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: a concise overview.
S. Mignani (2013)
Covalent molecular assembly of multilayer dendrimer ultrathin films in supercritical medium.
S. R. Puniredd (2007)
Bioorthogonal layer-by-layer encapsulation of pancreatic islets via hyperbranched polymers.
K. M. Gattás-Asfura (2013)
Dendrimer as nanocarrier for drug delivery
P. Kesharwani (2014)
Mussel-inspired chemistry for robust and surface-modifiable multilayer films.
J. Wu (2011)
A facile method to prepare molecularly imprinted layer-by-layer nanostructured multilayers using postinfiltration and a subsequent photo-cross-linking strategy.
Y. Zhou (2013)
Layer-by-layer assembled microgel films with high loading capacity: reversible loading and release of dyes and nanoparticles.
L. Wang (2008)
Fabrication of an alternative regenerated silk fibroin nanofiber and carbonated hydroxyapatite multilayered composite via layer-by-layer
H. Cao (2012)
Synthesis of Passivating, Nylon-Like Coatings through Cross-Linking of Ultrathin Polyelectrolyte Films
J. Harris (1999)
Tunable DNA release from cross-linked ultrathin DNA/PLL multilayered films.
K. Ren (2006)
Enhanced resistance of polyelectrolyte multilayer microcapsules to pepsin erosion and release properties of encapsulated indomethacin.
C. Wang (2007)
Constructing metal nanoparticle multilayers with polyphenylene dendrimer/gold nanoparticles via "click" chemistry.
Huiqiang Li (2013)
Layer-by-layer assembly for rapid fabrication of thick polymeric films.
Y. Li (2012)
Modulating the release kinetics through the control of the permeability of the layer-by-layer assembly: a review
S. Mansouri (2009)
Dendrimers in Layer-by-Layer Assemblies: Synthesis and Applications
K. Sato (2013)
Silver nanocomposite layer-by-layer films based on assembled polyelectrolyte/dendrimer.
Zelin Liu (2005)
Poly(acrylic acid)-bearing photoreactive azido groups for stabilizing multilayer films.
G. Wu (2009)
Layer-by-layer assembled polyampholyte microgel films for simultaneous release of anionic and cationic molecules.
Xu Wang (2010)
Facile method for the fabrication of robust polyelectrolyte multilayers by post-photo-cross-linking of azido groups.
X. Zhang (2012)
Polyelectrolyte multilayers containing photoreactive groups
A. Laschewsky (1997)
A facile method for the fabrication of covalently linked PAH/PSS layer-by-layer films
Q. An (2014)
Layers of opportunity: nanostructured polymer assemblies for the delivery of macromolecular therapeutics.
D. Lynn (2006)
Single polyelectrolyte microcapsules fabricated by glutaraldehyde-mediated covalent layer-by-layer assembly
W. Tong (2006)
Hydrogen-bonding induced alternating thin films of dendrimer and block copolymer micelle
C. Park (2007)
Multilayer Thin Films
Gero Decher (2002)
Smart controlled preparation of multilayered hydrogel for releasing bioactive molecules
J. Choi (2009)
Surface-modification of polyelectrolyte multilayer-coated particles for biological applications
A. Khopade (2003)
Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium.
Patricia Urban (2014)
Investigation of the Factors Influencing the Formation of Dendrimer/Polyanion Multilayer Films
A. Khopade (2002)
Fabrication of a covalently attached multilayer via photolysis of layer-by-layer self-assembled films containing diazo-resins
Junqi Sun (1998)
Electrostatic Multilayer Deposition of a Gold−Dendrimer Nanocomposite
Jinan He (1999)
This paper is referenced by
Layer-by-Layer Assembled Chitosan-Based Antibacterial Films with Improved Stability under Alkaline Conditions
Fanqin Ji (2016)
Controlled Interfacial Permeation, Nanostructure Formation, Catalytic Efficiency, Signal Enhancement Capability, and Cell Spreading by Adjusting Photochemical Cross-Linking Degrees of Layer-by-Layer Films.
Xinglong Luan (2016)
The polyacrylic acid/modified chitosan capsules with tunable release of small hydrophobic probe and drug
Lucia Ya. Zakharova (2015)
Covalent layer-by-layer films: chemistry, design, and multidisciplinary applications.
Q. An (2018)
Fabrication of robust gold superhydrophobic surface on iron substrate with properties of corrosion resistance, self-cleaning and mechanical durability
Shuo Cui (2017)
Efficient modification with flexible spacing coating for in situ reversible assembly of semirigid macroscopic objects through hierarchical metal coordination
R. Akram (2018)
Using a biocompatible diazidecrosslinker to fabricate a robust polyelectrolyte multilayer film with enhanced effects on cell proliferation.
Y. Wang (2017)
Hybrids of Polymer Multilayers, Lipids, and Nanoparticles: Mimicking the Cellular Microenvironment.
A. Vikulina (2019)
Layer-by-layer Polyelectrolytes Coating of Alginate Microgels for Sustained Release of Sodium Benzoate and Zosteric Acid.
Q. Wang (2018)
Free-standing few-layered graphene oxide films: selective, steady and lasting permeation of organic molecules with adjustable speeds.
T. Huang (2016)
Influence of cross-linking in loading/release applications of polyelectrolyte multilayer assemblies. A review.
Claudiu-Augustin Ghiorghita (2019)
Fabrication of superhydrophobic Pt 3 Fe/Fe surface for its application
Shuo Cui (2017)
A facile avenue to modify polyelectrolyte multilayers on anion exchange membranes to enhance monovalent selectivity and durability simultaneously
Huimin Liu (2017)
Preparation of Highly Loaded PAA/PAH Layer-by-layer Films by Combining Acid Transformation and Templating Methods
Q. Xia (2019)
Drug delivery mediated by confined nanosystems: structure-activity relations and factors responsible for the efficacy of formulations
L. Y. Zakharova (2017)
A versatile and efficient method to fabricate durable superhydrophobic surfaces on wood, lignocellulosic fiber, glass, and metal substrates
Y. Wu (2016)
Introducing a high gravity field to enhance infiltration of small molecules into polyelectrolyte multilayers.
Xiaolin Liu (2015)
A New Way to Promote Molecular Drug Release during Medical Treatment: A Polyelectrolyte Matrix on a Piezoelectric-Dielectric Energy Conversion Substrate.
Y. Zhang (2018)
Combined “post-infiltration, subsequent photochemical cross-linking” and “cross-linking and selective etching” strategies to fabricate nanoporous layer-by-layer assembled multilayers
H. Du (2016)