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Cancer Cell Extinction Through A Magnetic Fluid Hyperthermia Treatment Produced By Superparamagnetic Co–Zn Ferrite Nanoparticles

R. Bohara, N. Thorat, A. Chaurasia, S. Pawar
Published 2015 · Materials Science

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Cobalt zinc ferrite (CZF) magnetic nanoparticles (MNPs) were synthesized by modifying a thermal decomposition method in the presence of triethylene glycol (TEG). Initially structural, morphological, and magnetic characterizations were carried out in order to confirm their size, polydispersity, colloidal stability, and magnetic property. Fourier transform infrared spectroscopy (FTIR) confirmed the presence of triethylene glycol (TEG) on the surface of CZF MNPs. The CZF MNPs has revealed a superparamagnetic nature with high saturation magnetization, good colloidal stability, high specific absorption rate (SAR), excellent biocompatibility, and a monodispersed nature. All these properties are crucial, for their use as a nanomedicine in magnetic fluid hyperthermia (MFH) treatment; which is considered to be one of the most promising cancer therapies. The prepared CZF MNPs are found to be biocompatible with MCF7 (human breast cancer) and L929 (mouse fibroblast) cell lines, when tested by MTT and SRB assays. Cell particle interaction was examined in depth, by using multiple staining techniques coupled with confocal microscopy. Finally, an in vitro hyperthermia experiment was carried out on MCF7 cells, resulting in the extinction of MCF7 cells by up to 80% within 60 min. The nature of the cell extinction was found and lastly reactive oxygen species (ROS) production was assessed, where ROS is the responsible factor for apoptosis. This research demonstrates that, prepared CZF MNPs can be used as a potential candidate for effective MFH treatment for cancer cell extinction.
This paper references
10.1039/c4nr03482a
Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer.
Aziliz Hervault (2014)
10.1016/j.msec.2014.06.016
Structured superparamagnetic nanoparticles for high performance mediator of magnetic fluid hyperthermia: synthesis, colloidal stability and biocompatibility evaluation.
N. Thorat (2014)
10.1021/am5042934
Enhanced magnetic fluid hyperthermia by micellar magnetic nanoclusters composed of Mn(x)Zn(1-x)Fe(2)O(4) nanoparticles for induced tumor cell apoptosis.
Y. Qu (2014)
10.1016/J.JMMM.2013.08.039
Study of AC magnetic heating characteristics of Co0.5Zn0.5Fe2O4 nanoparticles for magnetic hyperthermia therapy
Dipali S. Nikam (2014)
10.1002/JPS.20874
Oxidative stress and apoptosis: impact on cancer therapy.
T. Ozben (2007)
10.1016/j.biotechadv.2015.02.003
Tailored functionalization of iron oxide nanoparticles for MRI, drug delivery, magnetic separation and immobilization of biosubstances.
K. Holá (2015)
10.1088/1674-1056/23/3/037503
Magnetic iron oxide nanoparticles: Synthesis and surface coating techniques for biomedical applications
Sun Sheng-nan (2014)
10.1016/j.biomaterials.2009.11.034
Cytotoxicity and cellular uptake of iron nanowires.
Mengmeng Song (2010)
10.1039/c2dt11835a
Polyvinyl alcohol: an efficient fuel for synthesis of superparamagnetic LSMO nanoparticles for biomedical application.
N. Thorat (2012)
10.1155/2011/182543
Magnetic Properties of Co0.5Zn0.5Fe2O4 Nanoparticles Synthesized by a Template-Assisted Hydrothermal Method
H. He (2011)
10.1039/c4dt02293a
Synthesis, characterization and biocompatibility of chitosan functionalized superparamagnetic nanoparticles for heat activated curing of cancer cells.
N. Thorat (2014)
10.1016/J.JMMM.2011.10.017
Ferrite-based magnetic nanofluids used in hyperthermia applications
I. Sharifi (2012)
10.1016/j.msec.2012.09.003
The role of cobalt ferrite magnetic nanoparticles in medical science.
S. Amiri (2013)
10.1016/J.JMMM.2014.11.063
Synthesis of functionalized Co0.5Zn0.5Fe2O4 nanoparticles for biomedical applications
R. Bohara (2015)
10.2217/nnm.10.77
Facile synthesis of water-stable magnetite nanoparticles for clinical MRI and magnetic hyperthermia applications.
D. Maity (2010)
10.1016/J.JMMM.2013.11.033
Superparamagnetic iron oxide/chitosan core/shells for hyperthermia application: Improved colloidal stability and biocompatibility
Rajesh M. Patil (2014)
10.1016/j.canlet.2008.02.026
Oxidative stress, DNA methylation and carcinogenesis.
R. Franco (2008)
10.1039/C4NJ00344F
One-step synthesis of uniform and biocompatible amine functionalized cobalt ferrite nanoparticles: a potential carrier for biomedical applications
R. Bohara (2014)
10.1088/0957-4484/21/1/015706
Validity limits of the Néel relaxation model of magnetic nanoparticles for hyperthermia.
R. Hergt (2010)
10.1038/nrd2803
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
D. Trachootham (2009)
10.1021/cr300143v
Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology.
K. Sapsford (2013)
10.1016/j.colsurfb.2013.06.014
Enhanced colloidal stability of polymer coated La0.7Sr0.3MnO3 nanoparticles in physiological media for hyperthermia application.
N. Thorat (2013)
10.1016/J.JALLCOM.2009.10.217
Preparation and magnetic property analysis of monodisperse Co–Zn ferrite nanospheres
Hou Cheng-yi (2010)
10.1039/C1JM10732A
Monodisperse mesoporous cobalt ferrite nanoparticles: synthesis and application in targeted delivery of antitumor drugs
S. Mohapatra (2011)
10.1016/S0167-7012(01)00285-8
Potential problems with fluorescein diacetate assays of cell viability when testing natural products for antimicrobial activity.
J. Clarke (2001)
10.1016/j.jinorgbio.2008.12.017
Toxicological effects of inorganic nanoparticles on human lung cancer A549 cells.
S. Choi (2009)
10.1039/C3NJ00007A
Highly water-dispersible surface-functionalized LSMO nanoparticles for magnetic fluid hyperthermia application
N. Thorat (2013)
10.1016/J.JMMM.2008.11.013
Synthesis of magnetite nanoparticles via a solvent-free thermal decomposition route
D. Maity (2009)
10.1021/mp400015b
Effective elimination of cancer stem cells by magnetic hyperthermia.
Tanmoy Sadhukha (2013)
10.1039/C4RA10862K
Hyperthermia-induced protein corona improves the therapeutic effects of zinc ferrite spinel-graphene sheets against cancer
M. Hajipour (2014)
10.1039/C0JM03963B
Manganite perovskite nanoparticles for self-controlled magnetic fluid hyperthermia: about the suitability of an aqueous combustion synthesis route
R. Epherre (2011)
10.1007/s12011-014-9972-0
Iron Oxide Nanoparticles Induce Oxidative Stress, DNA Damage, and Caspase Activation in the Human Breast Cancer Cell Line
S. Alarifi (2014)
10.1186/1743-8977-6-1
Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling
P. L. Apopa (2008)
10.1038/nnano.2012.207
Biomolecular coronas provide the biological identity of nanosized materials.
M. Monopoli (2012)
10.1002/smll.201301004
Uptake kinetics and nanotoxicity of silica nanoparticles are cell type dependent.
J. Blechinger (2013)



This paper is referenced by
10.1088/1361-6528/ab3f17
Recent advancements in manganite perovskites and spinel ferrites based magnetic nanoparticles for biomedical theranostic applications.
G. Kandasamy (2019)
10.1007/s00339-020-03649-5
γ-Fe 2 O 3 /Gd 2 O 3 -chitosan magnetic nanocomposite for hyperthermia application: structural, magnetic, heating efficiency and cytotoxicity studies
O. Lemine (2020)
10.1039/c8cp00368h
Mechanistic insights into the interaction between energetic oxygen ions and nanosized ZnFe2O4: XAS-XMCD investigations.
J. Singh (2018)
10.1002/masy.201900172
Bos taurus Urine Assisted Biosynthesis of CuO Nanomaterials: A New Paradigm of Antimicrobial and Antineoplatic Therapy
M. N. Padvi (2020)
10.3390/molecules25133091
Pleurotus sajor-caju-Mediated Synthesis of Silver and Gold Nanoparticles Active against Colon Cancer Cell Lines: A New Era of Herbonanoceutics
V. Chaturvedi (2020)
10.1039/c7nr02356a
Novel nanoparticles with Cr3+ substituted ferrite for self-regulating temperature hyperthermia.
W. Zhang (2017)
10.2217/nnm-2017-0379
Applications of cobalt ferrite nanoparticles in biomedical nanotechnology.
S. Y. Srinivasan (2018)
10.1039/c6cp02793h
Temperature-dependent dynamic correlations in suspensions of magnetic nanoparticles in a broad range of concentrations: a combined experimental and theoretical study.
A. Ivanov (2016)
10.1039/c6nr01303a
Studying the effect of Zn-substitution on the magnetic and hyperthermic properties of cobalt ferrite nanoparticles.
V. Mameli (2016)
10.1016/J.JMMM.2019.165303
Presence of mixed magnetic phase in mechanically milled nanosized Co0.5Zn0.5Fe2O4: A study on structural, magnetic and hyperfine properties
K. Sarkar (2019)
10.1038/s41598-020-71552-3
In vitro hyperthermic effect of magnetic fluid on cervical and breast cancer cells
Anand Bhardwaj (2020)
10.1039/C6RA17892H
Optimum nanoscale design in ferrite based nanoparticles for magnetic particle hyperthermia
S. Lieb́ana-Viñas (2016)
10.1039/C6RA20135K
Multi-modal MR imaging and magnetic hyperthermia study of Gd doped Fe3O4 nanoparticles for integrative cancer therapy
N. Thorat (2016)
10.1016/j.colsurfb.2019.110571
Silica nano supra-assembly for the targeted delivery of therapeutic cargo to overcome chemoresistance in cancer.
N. Thorat (2019)
10.1016/J.JMMM.2015.12.051
Effect of pH value on electromagnetic loss properties of Co–Zn ferrite prepared via coprecipitation method
X. Huang (2016)
10.1016/J.MOLLIQ.2018.10.161
One-step synthesis of hydrophilic functionalized and cytocompatible superparamagnetic iron oxide nanoparticles (SPIONs) based aqueous ferrofluids for biomedical applications
G. Kandasamy (2019)
10.1038/s41598-019-54250-7
Role of zinc substitution in magnetic hyperthermia properties of magnetite nanoparticles: interplay between intrinsic properties and dipolar interactions
Yaser Hadadian (2019)
10.1016/J.MATLET.2017.02.122
Tuning the magnetic properties of ferrite nanoparticles by Zn and Co doping
M. K. Lima-Tenório (2017)
10.1039/C6RA28436A
Magnetorheology of a magnetic fluid based on Fe3O4 immobilized SiO2 core–shell nanospheres: experiments and molecular dynamics simulations
L. Pei (2017)
10.1039/d0nj01384f
Electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/polyethylene oxide (PEO) microfibers reinforced with ZnO nanocrystals for antibacterial and antibiofilm wound dressing applications
Pranjali P. Mahamuni-Badiger (2020)
10.1007/s11814-015-0120-0
Immobilization of cellulase on functionalized cobalt ferrite nanoparticles
R. Bohara (2015)
10.1016/J.JTICE.2018.07.039
Gram bean extract-mediated synthesis of Fe3O4 nanoparticles for tuning the magneto-structural properties that influence the hyperthermia performance
R. R. Koli (2019)
10.1039/C9NJ02237F
Synthesis, structure and magnetic properties of multipod-shaped cobalt ferrite nanocrystals
Mohammed Hennous (2019)
10.4028/www.scientific.net/JNanoR.59.25
Mechanically Milled Co1-xFexO4 Nanocrystalline for Magnetic Hyperthermia Application
O. Lemine (2019)
10.1039/C6RA02129H
Role of functionalization: strategies to explore potential nano-bio applications of magnetic nanoparticles
R. Bohara (2016)
10.1080/09205063.2018.1564134
Evaluation of in vitro cytotoxicity of superparamagnetic poly(thioether-ester) nanoparticles on erythrocytes, non-tumor (NIH3T3), tumor (HeLa) cells and hyperthermia studies
Paula Christina Mattos Dos Santos (2018)
10.1021/acsami.6b02616
Multimodal Superparamagnetic Nanoparticles with Unusually Enhanced Specific Absorption Rate for Synergetic Cancer Therapeutics and Magnetic Resonance Imaging.
N. Thorat (2016)
10.1007/s11051-017-3746-5
Theranostic multimodal potential of magnetic nanoparticles actuated by non-heating low frequency magnetic field in the new-generation nanomedicine
Y. I. Golovin (2017)
10.1039/C6TB02324J
Functional TiO2 nanocoral architecture for light-activated cancer chemotherapy.
H. Yadav (2017)
10.1039/c6cp03430f
Superparamagnetic iron oxide nanocargoes for combined cancer thermotherapy and MRI applications.
N. Thorat (2016)
10.1016/B978-0-08-101925-2.00007-3
Current Outlook and Perspectives on Nanoparticle-Mediated Magnetic Hyperthermia
C. Blanco-Andujar (2018)
10.1002/EJIC.201600706
Superparamagnetic Gadolinium Ferrite Nanoparticles with Controllable Curie Temperature – Cancer Theranostics for MR‐Imaging‐Guided Magneto‐Chemotherapy
N. Thorat (2016)
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