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Paramagnetic, PH And Temperature-sensitive Polymeric Particles For Anticancer Drug Delivery And Brain Tumor Magnetic Resonance Imaging

Ruiqing Liu, S. Liang, C. Jiang, X. Wang, Y. Gong, P. Li, Zushun Xu, Haibo Xu, P. Chu
Published 2015 · Chemistry

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Smart polymer-based theranostic agents often have the problem of a low drug release rate and it is difficult for them to reach the site of brain tumors for magnetic resonance imaging (MRI). To synthesize a theranostic agent for brain tumor MRI with a high drug release rate, paramagnetic, pH and temperature-sensitive polymeric particles (PPPs) are synthesized using a simplified processes in this work. These dually sensitive polymeric particles show negligible cytotoxicity against HeLa and glioma (C6) cells. The obtained polymeric particles can effectively be loaded with the anticancer drug doxorubicin (DOX). In vitro drug release measurements exhibit retarded release profiles when subjected to varying pH or temperature. Moreover, DOX-loaded PPPs exhibit obvious antitumor properties for C6 cells. The percentage of cumulative DOX release is higher than 95% when both pH and temperature are changed. The T1-weighted relaxivity values at 3 T are 12.41 mM−1 s−1 (pH = 6.3) and 10.75 mM−1 s−1 (pH = 7.4). In vivo MRI reveals that the PPPs can be effectively imaged in brain tumors (gliomas). These results indicate that the PPPs have great potential in diagnosing and treating glioma.
This paper references
Dual-targeting upconversion nanoprobes across the blood-brain barrier for magnetic resonance/fluorescence imaging of intracranial glioblastoma.
D. Ni (2014)
Influence of microgel architecture and oil polarity on stabilization of emulsions by stimuli-sensitive core-shell poly(N-isopropylacrylamide-co-methacrylic acid) microgels: Mickering versus Pickering behavior?
S. Schmidt (2011)
Active loading and tunable release of doxorubicin from block copolymer vesicles.
A. Choucair (2005)
Advanced materials and processing for drug delivery: the past and the future.
Y. Zhang (2013)
Responsive polymers in controlled drug delivery
A. Bajpai (2008)
An Asymmetrical Polymer Vesicle Strategy for Significantly Improving T1 MRI Sensitivity and Cancer-Targeted Drug Delivery
Qiuming Liu (2015)
Strategies for increasing the sensitivity of gadolinium based MRI contrast agents.
P. Caravan (2006)
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
S. Hobbs (1998)
Chlorotoxin-modified macromolecular contrast agent for MRI tumor diagnosis.
R. Huang (2011)
Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging.
X. Li (2011)
Smart thermo/pH responsive magnetic nanogels for the simultaneous delivery of doxorubicin and methotrexate.
R. Salehi (2015)
Thermo- and pH-responsive polymers in drug delivery.
D. Schmaljohann (2006)
Magnetic, fluorescent, and thermo-responsive Fe(3)O(4)/rare earth incorporated poly(St-NIPAM) core-shell colloidal nanoparticles in multimodal optical/magnetic resonance imaging probes.
Haie Zhu (2013)
Functional group distributions in carboxylic acid containing poly(N-isopropylacrylamide) microgels.
T. Hoare (2004)
Swelling Behavior of Multiresponsive Poly(methacrylic acid)‐block‐‐poly(N‐isopropylacrylamide) Brushes Synthesized Using Surface‐Initiated Photoiniferter‐Mediated Photopolymerization
Santosh B. Rahane (2008)
In vitro studies of the interaction of poly(NIPAm/MAA) nanoparticles with proteins and cells
J. Moselhy (2000)
Long-term survival with glioblastoma multiforme.
D. Krex (2007)
A choline derivate-modified nanoprobe for glioma diagnosis using MRI
J. Li (2013)
A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle.
K. Kim (2014)
Polyelectrolyte multilayers of weak polyacid and cationic copolymer: Competition of hydrogen-bonding and electrostatic interactions
Eugenia Kharlampieva (2003)
Promising strategies for Gd-based responsive magnetic resonance imaging contrast agents.
Clara Shen (2013)
Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients
J. Kobayashi (2008)
pH and thermo dual-stimuli-responsive drug carrier based on mesoporous silica nanoparticles encapsulated in a copolymer-lipid bilayer.
X. Wu (2013)
pH-responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy.
Yi-Ting Chiang (2014)
Multistage nanovectors: from concept to novel imaging contrast agents and therapeutics.
B. Godin (2011)
Unibody core-shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging.
Lin-Chen Ho (2015)
Theranostic vesicles based on bovine serum albumin and poly(ethylene glycol)-block-poly(L-lactic-co-glycolic acid) for magnetic resonance imaging and anticancer drug delivery.
Qiuming Liu (2014)
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma
J. Huse (2010)
Molecular imaging in drug discovery and development
M. Rudin (2003)
Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging.
L. Zhou (2014)
Longitudinal assessment of blood–brain barrier leakage during epileptogenesis in rats. A quantitative MRI study
E. V. Vliet (2014)
Polymeric theranostics: using polymer-based systems for simultaneous imaging and therapy.
T. Krasia-Christoforou (2013)
Nanoprobes visualizing gliomas by crossing the blood brain tumor barrier.
Xihui Gao (2014)
Remote and local control of stimuli responsive materials for therapeutic applications.
A. Chan (2013)
Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications.
P. Caravan (1999)
Stimulus-sensitive polymeric nanoparticles and their applications as drug and gene carriers.
Y. Li (2013)
MR imaging of tumor angiogenesis using sterically stabilized Gd-DTPA liposomes targeted to CD105.
Dong Zhang (2009)

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