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Paramagnetic, PH And Temperature-sensitive Polymeric Particles For Anticancer Drug Delivery And Brain Tumor Magnetic Resonance Imaging

Ruiqing Liu, S. Liang, C. Jiang, X. Wang, Y. Gong, P. Li, Zushun Xu, Haibo Xu, P. Chu
Published 2015 · Chemistry

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Smart polymer-based theranostic agents often have the problem of a low drug release rate and it is difficult for them to reach the site of brain tumors for magnetic resonance imaging (MRI). To synthesize a theranostic agent for brain tumor MRI with a high drug release rate, paramagnetic, pH and temperature-sensitive polymeric particles (PPPs) are synthesized using a simplified processes in this work. These dually sensitive polymeric particles show negligible cytotoxicity against HeLa and glioma (C6) cells. The obtained polymeric particles can effectively be loaded with the anticancer drug doxorubicin (DOX). In vitro drug release measurements exhibit retarded release profiles when subjected to varying pH or temperature. Moreover, DOX-loaded PPPs exhibit obvious antitumor properties for C6 cells. The percentage of cumulative DOX release is higher than 95% when both pH and temperature are changed. The T1-weighted relaxivity values at 3 T are 12.41 mM−1 s−1 (pH = 6.3) and 10.75 mM−1 s−1 (pH = 7.4). In vivo MRI reveals that the PPPs can be effectively imaged in brain tumors (gliomas). These results indicate that the PPPs have great potential in diagnosing and treating glioma.
This paper references
10.1021/nn406197c
Dual-targeting upconversion nanoprobes across the blood-brain barrier for magnetic resonance/fluorescence imaging of intracranial glioblastoma.
D. Ni (2014)
10.1021/la201823b
Influence of microgel architecture and oil polarity on stabilization of emulsions by stimuli-sensitive core-shell poly(N-isopropylacrylamide-co-methacrylic acid) microgels: Mickering versus Pickering behavior?
S. Schmidt (2011)
10.1021/LA050710O
Active loading and tunable release of doxorubicin from block copolymer vesicles.
A. Choucair (2005)
10.1016/j.addr.2012.10.003
Advanced materials and processing for drug delivery: the past and the future.
Y. Zhang (2013)
10.1016/J.PROGPOLYMSCI.2008.07.005
Responsive polymers in controlled drug delivery
A. Bajpai (2008)
10.1021/MA502255S
An Asymmetrical Polymer Vesicle Strategy for Significantly Improving T1 MRI Sensitivity and Cancer-Targeted Drug Delivery
Qiuming Liu (2015)
10.1039/B510982P
Strategies for increasing the sensitivity of gadolinium based MRI contrast agents.
P. Caravan (2006)
10.1073/PNAS.95.8.4607
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
S. Hobbs (1998)
10.1016/j.biomaterials.2011.03.075
Chlorotoxin-modified macromolecular contrast agent for MRI tumor diagnosis.
R. Huang (2011)
10.1016/j.biomaterials.2011.05.049
Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging.
X. Li (2011)
10.1016/j.ijpharm.2015.04.051
Smart thermo/pH responsive magnetic nanogels for the simultaneous delivery of doxorubicin and methotrexate.
R. Salehi (2015)
10.1016/J.ADDR.2006.09.020
Thermo- and pH-responsive polymers in drug delivery.
D. Schmaljohann (2006)
10.1016/j.biomaterials.2012.11.056
Magnetic, fluorescent, and thermo-responsive Fe(3)O(4)/rare earth incorporated poly(St-NIPAM) core-shell colloidal nanoparticles in multimodal optical/magnetic resonance imaging probes.
Haie Zhu (2013)
10.1021/LA0351562
Functional group distributions in carboxylic acid containing poly(N-isopropylacrylamide) microgels.
T. Hoare (2004)
10.1002/ADFM.200701411
Swelling Behavior of Multiresponsive Poly(methacrylic acid)‐block‐‐poly(N‐isopropylacrylamide) Brushes Synthesized Using Surface‐Initiated Photoiniferter‐Mediated Photopolymerization
Santosh B. Rahane (2008)
10.1163/156856200743616
In vitro studies of the interaction of poly(NIPAm/MAA) nanoparticles with proteins and cells
J. Moselhy (2000)
10.1093/BRAIN/AWM204
Long-term survival with glioblastoma multiforme.
D. Krex (2007)
10.1038/srep01623
A choline derivate-modified nanoprobe for glioma diagnosis using MRI
J. Li (2013)
10.1016/j.biomaterials.2013.10.004
A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle.
K. Kim (2014)
10.1021/MA0350821
Polyelectrolyte multilayers of weak polyacid and cationic copolymer: Competition of hydrogen-bonding and electrostatic interactions
Eugenia Kharlampieva (2003)
10.1016/j.cbpa.2012.10.031
Promising strategies for Gd-based responsive magnetic resonance imaging contrast agents.
Clara Shen (2013)
10.1186/1479-5876-7-1
Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients
J. Kobayashi (2008)
10.1021/am403092m
pH and thermo dual-stimuli-responsive drug carrier based on mesoporous silica nanoparticles encapsulated in a copolymer-lipid bilayer.
X. Wu (2013)
10.1016/j.biomaterials.2014.03.046
pH-responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy.
Yi-Ting Chiang (2014)
10.1021/ar200077p
Multistage nanovectors: from concept to novel imaging contrast agents and therapeutics.
B. Godin (2011)
10.1016/j.biomaterials.2014.10.006
Unibody core-shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging.
Lin-Chen Ho (2015)
10.1021/bm500438x
Theranostic vesicles based on bovine serum albumin and poly(ethylene glycol)-block-poly(L-lactic-co-glycolic acid) for magnetic resonance imaging and anticancer drug delivery.
Qiuming Liu (2014)
10.1038/nrc2818
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma
J. Huse (2010)
10.1038/nrd1007
Molecular imaging in drug discovery and development
M. Rudin (2003)
10.1016/j.biomaterials.2014.05.051
Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging.
L. Zhou (2014)
10.1016/j.nbd.2013.11.019
Longitudinal assessment of blood–brain barrier leakage during epileptogenesis in rats. A quantitative MRI study
E. V. Vliet (2014)
10.1039/C3TB20191K
Polymeric theranostics: using polymer-based systems for simultaneous imaging and therapy.
T. Krasia-Christoforou (2013)
10.1002/smll.201301673
Nanoprobes visualizing gliomas by crossing the blood brain tumor barrier.
Xihui Gao (2014)
10.1016/j.addr.2012.07.007
Remote and local control of stimuli responsive materials for therapeutic applications.
A. Chan (2013)
10.1021/CR980440X
Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications.
P. Caravan (1999)
10.1002/adhm.201200313
Stimulus-sensitive polymeric nanoparticles and their applications as drug and gene carriers.
Y. Li (2013)
10.1016/j.ejrad.2008.04.022
MR imaging of tumor angiogenesis using sterically stabilized Gd-DTPA liposomes targeted to CD105.
Dong Zhang (2009)



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