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Highly Stretchable And Tough PH-sensitive Hydrogels With Reversible Swelling And Recoverable Deformation
X. J. Liu, H. Li, B. Y. Zhang, Y. Wang, X. Ren, S. Guan, G. H. Gao
Published 2016 · Materials Science
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Stimuli-responsive hydrogels are becoming increasingly important for controlled drug delivery, biosensing, and tissue engineering. However, few pH-sensitive hydrogels with good mechanical property have been extensively reported. In this investigation, we reported the preparation of extremely stretchable and tough pH-sensitive hydrogels by introducing a linear polysaccharide-agar into the poly(acrylamide-co-acrylic acid) (P(AM-co-AA)) network and using diacrylated PEG (PEGDA) as a chemical crosslinker based on a simultaneous interpenetrating polymer networks (IPN) structure. It was found that longer PEGDA chains would lead to the obvious increase in swelling ratio and the stretchability of hydrogels. Moreover, the content of agar, the crosslinker concentration and the pH of the external environment would significantly affect the mechanical characteristics of the hydrogels. The compression strength and dissipated energy could reach 4.56 MPa and 0.56 MJ m−3 under the deformation of 85%, respectively. Also, hydrogels exhibited excellent reversible swelling and recoverable deformation. The improved mechanical properties enable the pH-sensitive hydrogels to be potential candidates in the field of load-bearing soft tissues.
This paper references
Hybrid Crosslinked Methylcellulose Hydrogel: A Predictable and Tunable Platform for Local Drug Delivery.
Malgosia M. Pakulska (2015)
Double‐Network Hydrogels with Extremely High Mechanical Strength
J. Gong (2003)
Chiral, pH-sensitive polyacrylamide hydrogels: Preparation and enantio-differentiating release ability
R. Cheng (2015)
Recovery from applied strain in interpenetrating polymer network hydrogels with ionic and covalent cross-links
Shannon E. Bakarich (2012)
A Novel Hydrogel with High Mechanical Strength: A Macromolecular Microsphere Composite Hydrogel
Ting Huang (2007)
Hydrophobically associated hydrogels based on acrylamide and anionic surface active monomer with high mechanical strength
W. Li (2012)
Adaptive liquid microlenses activated by stimuli-responsive hydrogels
L. Dong (2006)
A Novel Highly Resilient Nanocomposite Hydrogel with Low Hysteresis and Ultrahigh Elongation
M. Zhu (2006)
Why are double network hydrogels so tough
J. Gong (2010)
Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels.
G. Cruise (1998)
Physical hydrogels composed of polyampholytes demonstrate high toughness and viscoelasticity.
Tao Sun (2013)
Effect of different sterilization processing methods on the mechanical properties of human cancellous bone allografts.
L. Vastel (2004)
Polymerized colloidal crystal hydrogel films as intelligent chemical sensing materials
J. Holtz (1997)
Phase Transitions in Ionic Gels
T. Tanaka (1980)
Photopolymerization studies using visible light photoinitiators
O. Valdes-Aguilera (1992)
New insight into agarose gel mechanical properties.
V. Normand (2000)
Investigation of a novel freeze-thaw process for the production of drug delivery hydrogels
M. Nugent (2005)
Design and Fabrication of a High-Strength Hydrogel with Ideally Homogeneous Network Structure from Tetrahedron-like Macromonomers
T. Sakai (2008)
Topology evolution and gelation mechanism of agarose gel.
J. Xiong (2005)
Release of protein from highly cross-linked hydrogels of poly(ethylene glycol) diacrylate fabricated by UV polymerization.
M. Mellott (2001)
Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers
A. Sawhney (1993)
The bioactivity of agarose-PEGDA interpenetrating network hydrogels with covalently immobilized RGD peptides and physically entrapped aggrecan.
G. Ingavle (2014)
Progress in the development of interpenetrating polymer network hydrogels.
D. Myung (2008)
Temperature- and pH-sensitive hydrogels to immobilize heparin-modified PEI/DNA complexes for sustained gene delivery
Chaohua Hu (2009)
Highly stretchable and tough hydrogels
Jeong-Yun Sun (2012)
High-strength hydrogels with integrated functions of H-bonding and thermoresponsive surface-mediated reverse transfection and cell detachment.
L. Tang (2010)
Biodegradable pH-responsive polyacrylic acid derivative hydrogels with tunable swelling behavior for oral delivery of insulin
Xiaoye Gao (2013)
Poly(ethylene oxide) macromonomers. 7. Micellar polymerization in water
K. Ito (1991)
Synthesis and swelling behaviors of sodium carboxymethyl cellulose-g-poly(AA-co-AM-co-AMPS)/MMT superabsorbent hydrogel
Y. Bao (2011)
3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures.
Sungmin Hong (2015)
Design and applications of interpenetrating polymer network hydrogels. A review
E. Dragan (2014)
Intermolecular hydrogen bonding strategy to fabricate mechanically strong hydrogels with high elasticity and fatigue resistance
J. Zhang (2013)
Superabsorbent polymeric materials. I. Swelling behaviors of crosslinked poly(sodium acrylate‐co‐hydroxyethyl methacrylate) in aqueous salt solution
W. Lee (1996)
Collapse of Gels in an Electric Field
T. Tanaka (1982)
25th anniversary article: Rational design and applications of hydrogels in regenerative medicine.
Nasim Annabi (2014)
Kuckling and H.J.P. Adler, Macromol
M. F. Zhu (2006)
Synthesis and characteristics of pH-sensitive semi-interpenetrating polymer network hydrogels based on konjac glucomannan and poly(aspartic acid) for in vitro drug delivery
C. Liu (2010)
Hybrid Hydrogels with Extremely High Stiffness and Toughness
J. Li (2014)
Optically- and thermally-responsive programmable materials based on carbon nanotube-hydrogel polymer composites.
X. Zhang (2011)
The Polyrotaxane Gel: A Topological Gel by Figure‐of‐Eight Cross‐links
Y. Okumura (2001)
Temperature and pH-dependent swelling and copper(II) adsorption of poly(N-isopropylacrylamide) copolymer hydrogel
J. Cheng (2015)
Expansion–contraction of photoresponsive artificial muscle regulated by host–guest interactions
Y. Takashima (2012)
Simple approach to reinforce hydrogels with cellulose nanocrystals.
J. Yang (2014)
A multistimuli-responsive photochromic metal-organic gel.
Shi-chao Wei (2014)
Physically crosslinked alginate/N,O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs.
Y. Lin (2005)
Nanocomposite Hydrogel with High Toughness for Bioactuators
M. K. Shin (2009)
Mass transfer in rapidly photopolymerized poly(ethylene glycol) hydrogels used for chemical sensing
R. Russell (2001)
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
D. Discher (2009)
A robust, one-pot synthesis of highly mechanical and recoverable double network hydrogels using thermoreversible sol-gel polysaccharide.
Q. Chen (2013)
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Rapid formation of highly stretchable and notch-insensitive hydrogels
Q. Su (2016)
Phase transition of temperature sensitive hydrogel under mechanical constraint
Zheng Shoujing (2018)
Bioinspired fabrication of high strength hydrogels from non-covalent interactions
W. Wang (2017)
Enhancing the self-recovery and mechanical property of hydrogels by macromolecular microspheres with thermal and redox initiation systems
C. Huang (2017)
Controlling surface properties and permeability of polyglycerol network films
A. Bianco (2017)
Recovery property of double-network hydrogel containing mussel-inspired adhesive moiety and nano-silicate.
Y. Liu (2016)
Reinforcement of thermoplastic chitosan hydrogel using chitin whiskers optimized with response surface methodology.
Guohui Sun (2018)
Hydrophobic association hydrogels based on N-acryloyl-alanine and stearyl acrylate using gelatin as emulsifier
Z. Cui (2016)
Ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels.
F. J. Zhao (2019)
Preparation and characterization of pH-sensitive semi-interpenetrating network hybrid hydrogels with sodium humate and kaolin
Elif Yılmaz (2018)
* Thermosensitive Poly(N-vinylcaprolactam) Injectable Hydrogels for Cartilage Tissue Engineering.
Renata L. Sala (2017)
Effect of size of latex particles on the mechanical properties of hydrogels reinforced by latex particles
L. Liu (2019)
Stretchable sensors for environmental monitoring
Y. Yang (2019)
GelMa/PEGDA containing graphene oxide as an IPN hydrogel with superior mechanical performance
K. R. Mamaghani (2018)
Rapidly recoverable, anti-fatigue, super-tough double-network hydrogels reinforced by macromolecular microspheres.
Jiliang Hou (2017)
An implanted pH sensor read using radiography.
M. Arifuzzaman (2019)
The fast homogeneous diffusion of hydrogel under different stimuli
S. Zheng (2018)