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Improving The Efficiency Of The Diels–Alder Process By Using Flow Chemistry And Zeolite Catalysis

S. Seghers, L. Protasova, S. Mullens, J. W. Thybaut, C. V. Stevens

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The industrial application of the Diels–Alder reaction for the synthesis of (hetero)cyclic compounds constitutes an important challenge. To tackle the reagent instability problems and corresponding safety issues, the use of a high-pressure and zeolite catalysed microreactor process is presented.