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Hyperbranched Polyglycerol Conjugated Fluorescent Carbon Dots With Improved In Vitro Toxicity And Red Blood Cell Compatibility For Bioimaging
Sha Li, Z. Guo, R. Feng, Y. Zhang, W. Xue, Z. Liu
Published 2017 · Chemistry
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Fluorescent carbon dots (CDs) have a variety of biomedical applications such as bio-imaging. Successful application of CDs in clinic greatly depends on their biocompatibility and favorable bio-functions. In the present study, we report a facile and efficient method to synthesize a CDs-based nanohybrid bearing a multi-hydroxy hyperbranched polyglycerol (HPG) shell by combing a “grafting from” method with an anionic ring-opening polymerization technique. The resultant CDs-g-HPG had high water-dispersibility, low cytotoxicity, improved hemocompatibility and strong green fluorescence. The results demonstrate that the CDs-g-HPG possesses promising potential for bio-imaging.
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