Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Hyperbranched Polyglycerol Conjugated Fluorescent Carbon Dots With Improved In Vitro Toxicity And Red Blood Cell Compatibility For Bioimaging

Sha Li, Z. Guo, R. Feng, Y. Zhang, W. Xue, Z. Liu
Published 2017 · Chemistry

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Fluorescent carbon dots (CDs) have a variety of biomedical applications such as bio-imaging. Successful application of CDs in clinic greatly depends on their biocompatibility and favorable bio-functions. In the present study, we report a facile and efficient method to synthesize a CDs-based nanohybrid bearing a multi-hydroxy hyperbranched polyglycerol (HPG) shell by combing a “grafting from” method with an anionic ring-opening polymerization technique. The resultant CDs-g-HPG had high water-dispersibility, low cytotoxicity, improved hemocompatibility and strong green fluorescence. The results demonstrate that the CDs-g-HPG possesses promising potential for bio-imaging.
This paper references
10.1016/j.biomaterials.2015.07.056
Hydrophilic packaging of iron oxide nanoclusters for highly sensitive imaging.
C. E. Smith (2015)
10.1016/j.jconrel.2011.04.016
Hemocompatibility assessment of poly(2-dimethylamino ethylmethacrylate) (PDMAEMA)-based polymers.
B. Cerda-Cristerna (2011)
10.1002/cmmi.1661
Multi-modal magnetic resonance imaging and histology of vascular function in xenografts using macromolecular contrast agent hyperbranched polyglycerol (HPG-GdF).
J. H. Baker (2016)
10.1002/chem.201406330
Carbon dots (C-dots) from cow manure with impressive subcellular selectivity tuned by simple chemical modification.
Cintya D'Angelis do E S Barbosa (2015)
10.1016/j.biomaterials.2012.09.060
Effects of the gene carrier polyethyleneimines on structure and function of blood components.
Dagen Zhong (2013)
10.1021/ac5001338
Synthesis-modification integration: one-step fabrication of boronic acid functionalized carbon dots for fluorescent blood sugar sensing.
Pengfei Shen (2014)
10.1021/MZ400474V
Hyperbranched Polymer Functionalized Carbon Dots with Multistimuli-Responsive Property
J. Yin (2013)
10.1021/bm300796q
Bioimaging of hyaluronic acid derivatives using nanosized carbon dots.
Eun Ji Goh (2012)
10.1021/acsami.5b04866
Blood Compatibility Evaluations of Fluorescent Carbon Dots.
S. Li (2015)
10.1021/am500980z
Multihydroxy dendritic upconversion nanoparticles with enhanced water dispersibility and surface functionality for bioimaging.
L. Zhou (2014)
10.1002/adma.201200650
Light-triggered theranostics based on photosensitizer-conjugated carbon dots for simultaneous enhanced-fluorescence imaging and photodynamic therapy.
P. Huang (2012)
10.1021/am406061x
Highly colloidally stable hyperbranched polyglycerol grafted red fluorescent silicon nanoparticle as bioimaging probe.
P. Das (2014)
10.1016/j.biomaterials.2012.01.052
Nano-carrier for gene delivery and bioimaging based on carbon dots with PEI-passivation enhanced fluorescence.
C. Liu (2012)
10.1002/mabi.201400152
Hybrid polyglycerols with long blood circulation: synthesis, biocompatibility, and biodistribution.
Muhammad Imran ul-haq (2014)
10.1021/bm4017176
Modification of cellulose nanofibrils with luminescent carbon dots.
Karoliina Junka (2014)
10.1021/acsami.5b00405
Mitochondria-targeting nanoplatform with fluorescent carbon dots for long time imaging and magnetic field-enhanced cellular uptake.
Y. Zhang (2015)
10.1007/s10856-013-5094-z
In vitro biocompatibility evaluations of hyperbranched polyglycerol hybrid nanostructure as a candidate for nanomedicine applications
A. Zarrabi (2013)
10.1016/j.bios.2014.12.037
A simple and sensitive fluorescent sensor for methyl parathion based on L-tyrosine methyl ester functionalized carbon dots.
Juying Hou (2015)
10.1021/bc8000408
Conjugation to hyperbranched polyglycerols improves RGD-mediated inhibition of platelet function in vitro.
J. G. Zhang (2008)
10.1016/J.CARBON.2014.06.056
High photoluminescent carbon nanodots and quercetin-Al3+ construct a ratiometric fluorescent sensing system
Y. Zou (2014)
10.1002/anie.200906623
Luminescent carbon nanodots: emergent nanolights.
S. N. Baker (2010)
10.1039/c0cc04096g
Clickable polyglycerol hyperbranched polymers and their application to gold nanoparticles and acid-labile nanocarriers.
Andrew T. Zill (2011)
10.1186/s12951-014-0058-0
Fluorescent carbon dots as an efficient siRNA nanocarrier for its interference therapy in gastric cancer cells
Q. Wang (2014)
10.1002/MACP.200900134
Efficient Grafting of Hyperbranched Polyglycerol from Hydroxyl-Functionalized Multiwalled Carbon Nanotubes by Surface-Initiated Anionic Ring-Opening Polymerization
Li Zhou (2009)
10.1039/c1cc14860e
Intrinsically fluorescent carbon dots with tunable emission derived from hydrothermal treatment of glucose in the presence of monopotassium phosphate.
Zheng-Chun Yang (2011)
10.1007/s00604-014-1302-x
Highly fluorescent carbon dots as nanoprobes for sensitive and selective determination of 4-nitrophenol in surface waters
G. Ahmed (2014)
10.1016/j.biomaterials.2010.11.042
Multifunctional polyglycerol-grafted Fe₃O₄@SiO₂ nanoparticles for targeting ovarian cancer cells.
Liang Wang (2011)



This paper is referenced by
10.1007/s00604-018-2953-9
Surface modification and chemical functionalization of carbon dots: a review
F. Yan (2018)
10.1002/ADMI.201800587
Nanogenerators Begin to Light Up: A Novel Poling‐Free Piezoelectric System with Multicolor Photoluminescence as an Efficient Mechatronics Development Platform
S. Ma (2018)
10.1007/s10895-019-02474-1
Ecofriendly Synthesis of Fluorescent Nitrogen-Doped Carbon Dots from Coccinia grandis and its Efficient Catalytic Application in the Reduction of Methyl Orange
P. Chandrasekaran (2019)
10.1021/ACSSUSCHEMENG.7B00292
Hyperbranched Polyglycerol Grafting on the Surface of Silica-Coated Nanoparticles for High Colloidal Stability and Low Nonspecific Interaction
Prasanta Panja (2017)
10.1080/15583724.2020.1720233
Polyglycidol of Linear or Branched Architecture Immobilized on a Solid Support for Biomedical Applications
M. Bochenek (2020)
10.1016/j.ijhydene.2020.07.262
Electrocatalytic performance of carbon dots/palladium nanoparticles composite towards hydrogen evolution reaction in acid medium
P. Chandrasekaran (2020)
10.1039/C7TB02515G
Hyperbranched polyglycerols: recent advances in synthesis, biocompatibility and biomedical applications.
Srinivas Abbina (2017)
10.1002/wnan.1670
Recent advances in development of dendriticpolymer-based nanomedicines for cancer diagnosis.
Haonan Li (2020)
10.1016/j.drudis.2018.01.006
Carbon dots: emerging theranostic nanoarchitectures.
Vijay Mishra (2018)
Evaluation of the safety and drug delivery efficacy of carbon dots in in vitro and in vivo models
Jiahui Fan (2018)
10.1039/C7NJ01762F
N-Doped CDs–GP nanospheres as a drug delivery nanocarrier system with carbon dots and a fluorescent tracer
Y. Ping (2017)
10.1002/JCTB.5617
Synthesis of polyglycerol mediated covalent construction of a core‐satellite superparamagnetic mesoporous carbon nanocomposite: application on dye adsorption
X. Yang (2018)
10.3390/c6010012
Hemocompatibility of Carbon Nanostructures
M. Fedel (2020)
10.1002/9781119373476.CH2
Using Polymers to Enhance the Carbon Nanomaterial Biointerface
G. Pramanik (2018)
10.1016/j.tiv.2019.104649
A novel aspect of functionalized graphene quantum dots in cytotoxicity studies.
Bahare Mehrdad Vahdati (2019)
10.1088/2043-6254/ab9191
Application of functionalized carbon dots in detection, diagnostic, disease treatment, and desalination: a review
H. Ehtesabi (2020)
10.1016/J.POLYMER.2017.07.061
Hyperbranched polyglycerol nanoparticles based multifunctional, nonmigrating hindered phenolic macromolecular antioxidants: Synthesis, characterization and its stabilization effect on poly(vinyl chloride)
G. Kasza (2017)
10.3390/jnt1010006
Nanotheranostic Carbon Dots as an Emerging Platform for Cancer Therapy
Sumiya Haque Adrita (2020)
10.3390/ma11081479
Single-Step Metal-Free Grafting of Cationic Polymer Brushes on Fluorescent Nanodiamonds
Shingo Sotoma (2018)
10.1039/C7PY01419H
Encapsulation property of hyperbranched polyglycerols as prospective drug delivery systems
H. Wu (2018)
10.1016/j.jcis.2017.10.095
Facile approach to synthesize highly fluorescent multicolor emissive carbon dots via surface functionalization for cellular imaging.
A. Kundu (2018)
Semantic Scholar Logo Some data provided by SemanticScholar