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A Divergent And Concise Total Synthesis Of (-)-lycoposerramine R And (+)-lycopladine A.

S. Chen, J. Wang, F. Qiu
Published 2018 · Chemistry, Medicine

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A concise, asymmetric and divergent synthesis of lycoposerramine R and lycopladine A is presented. The synthesis features the palladium-catalyzed cycloalkenylation of a silyl enol ether for assembling the 5/6-hydrindane system and generating a quaternary carbon center in one step.
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